Decoding the anti-Leishmania braziliensis activity of 1,10-phenanthroline-5,6-dione and its silver- and copper-based complexes: In vitro and in vivo approaches

Authors: André L.S. Santos, Ana Karina C. Lima, Simone S.C. Oliveira, Rosiane F. dos Santos, Michael Devereux, Malachy McCann, Marta H. Branquinha, Patrícia M.L. Dutra

Source: European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100093- (2022)

Subject Terms: Leishmania, Chemotherapy, Coordination complexes, 1,10-Phenanthroline-5,6-dione, Virulence, Infection, Pharmacy and materia medica, RS1-441, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772417422000656; https://doaj.org/toc/2772-4174

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Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions

Authors: Louise Gallagher, Alanna Smith, Kevin Kavanagh, Michael Devereux, John Colleran, Carmel Breslin, Karl G. Richards, Malachy McCann, A. Denise Rooney

Source: Chemistry, Vol 3, Iss 2, Pp 672-686 (2021)

Subject Terms: hydrogel, alginate, BSA, glutaraldehyde, silver, antimicrobial, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/2624-8549/3/2/47; https://doaj.org/toc/2624-8549

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Silver(I) and Copper(II) 1,10-Phenanthroline-5,6-dione Complexes as Promising Antivirulence Strategy against Leishmania: Focus on Gp63 (Leishmanolysin)

Authors: Simone S. C. Oliveira, Claudyane A. Correia, Vanessa S. Santos, Elaine F. F. da Cunha, Alexandre A. de Castro, Teodorico C. Ramalho, Michael Devereux, Malachy McCann, Marta H. Branquinha, André L. S. Santos

Source: Tropical Medicine and Infectious Disease, Vol 8, Iss 7, p 348 (2023)

Subject Terms: Leishmania amazonensis, alternative chemotherapy, antivirulence strategy, coordination compounds, gp63, virulence, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2414-6366/8/7/348; https://doaj.org/toc/2414-6366

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Peptidases Are Potential Targets of Copper(II)-1,10-Phenanthroline-5,6-dione Complex, a Promising and Potent New Drug against Trichomonas vaginalis

Authors: Graziela Vargas Rigo, Fernanda Gomes Cardoso, Matheus Mendonça Pereira, Michael Devereux, Malachy McCann, André L. S. Santos, Tiana Tasca

Source: Pathogens, Vol 12, Iss 5, p 745 (2023)

Subject Terms: Trichomonas vaginalis, metallopeptidases, cytolysis, proteolytic activity, copper-phendione, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/12/5/745; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/471b5edb6059449eb946dfcaf077010c

Silver(I) 1,10-Phenanthroline Complexes Are Active against Fonsecaea pedrosoi Viability and Negatively Modulate Its Potential Virulence Attributes

Authors: Ingrid S. Sousa, Tatiana D. P. Vieira, Rubem F. S. Menna-Barreto, Allan J. Guimarães, Pauraic McCarron, Malachy McCann, Michael Devereux, André L. S. Santos, Lucimar F. Kneipp

Source: Journal of Fungi, Vol 9, Iss 3, p 356 (2023)

Subject Terms: chromoblastomycosis, metal-based drugs, antifungal activity, virulence factors, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2309-608X/9/3/356; https://doaj.org/toc/2309-608X

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Potential interactions between metal-based phenanthroline drugs and the unfolded protein response endoplasmic reticulum stress pathway

Authors: Tadhg O’Leary, Pauraic McCarron, Michael Devereux, Steve Meaney, Eray Metin Guler

Source: Experimental Results, Vol 3 (2022)

Subject Terms: Metal-Phenanthroline drugs, ER Stress, Cytotoxicity, Anti-cancer, Technology, Medicine, Science

File Description: electronic resource

Relation: https://www.cambridge.org/core/product/identifier/S2516712X2200020X/type/journal_article; https://doaj.org/toc/2516-712X

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The Anti-Leishmania amazonensis and Anti-Leishmania chagasi Action of Copper(II) and Silver(I) 1,10-Phenanthroline-5,6-dione Coordination Compounds

Authors: Simone S. C. Oliveira, Vanessa S. Santos, Michael Devereux, Malachy McCann, André L. S. Santos, Marta H. Branquinha

Source: Pathogens, Vol 12, Iss 1, p 70 (2023)

Subject Terms: leishmaniasis, coordination compounds, 1,10-phenanthroline-5,6-dione, metal ions, proliferation, apoptosis, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/12/1/70; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/cc77a5854ed94492a6992c727955172b

(E)-6,6′-(Diazene-1,2-diyl)bis(1,10-phenanthrolin-5-ol) trichloromethane disolvate: a superconjugated ligand

Authors: Muhib Ahmed, Michael Devereux, Vickie McKee, Malachy McCann, A. Denise Rooney

Source: Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 8, Pp 1224-1227 (2019)

Subject Terms: crystal structure, diazo, phenanthroline, superconjugated ligand, Crystallography, QD901-999

File Description: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S205698901900954X; https://doaj.org/toc/2056-9890

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Distinctive waves of innate immune response in the retina in experimental autoimmune encephalomyelitis

Authors: Andrés Cruz-Herranz, Frederike C. Oertel, Kicheol Kim, Ester Cantó, Garrett Timmons, Jung H. Sin, Michael Devereux, Nicholas Baker, Brady Michel, Ryan D. Schubert, Lakshmisahithi Rani, Christian Cordano, Sergio E. Baranzini, Ari J. Green

Source: JCI Insight, Vol 6, Iss 11 (2021)

Subject Terms: Neuroscience, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/01c7e3c7a8404c0582e553222861c0db

Silver(I) and Copper(II) Complexes of 1,10-Phenanthroline-5,6-Dione Against Phialophora verrucosa: A Focus on the Interaction With Human Macrophages and Galleria mellonella Larvae

Authors: Marcela Q. Granato, Thaís P. Mello, Renata S. Nascimento, Marcos D. Pereira, Thabatta L. S. A. Rosa, Maria C. V. Pessolani, Malachy McCann, Michael Devereux, Marta H. Branquinha, André L. S. Santos, Lucimar F. Kneipp

Source: Frontiers in Microbiology, Vol 12 (2021)

Subject Terms: 1,10-phenanthroline-5,6-dione, chromoblastomycosis, dematiaceous fungi, antifungal activity, cellular interaction, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.641258/full; https://doaj.org/toc/1664-302X

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In Vivo Activity of Metal Complexes Containing 1,10-Phenanthroline and 3,6,9-Trioxaundecanedioate Ligands against Pseudomonas aeruginosa Infection in Galleria mellonella Larvae

Authors: Megan O’Shaughnessy, Magdalena Piatek, Pauraic McCarron, Malachy McCann, Michael Devereux, Kevin Kavanagh, Orla Howe

Source: Biomedicines, Vol 10, Iss 2, p 222 (2022)

Subject Terms: Pseudomonas aeruginosa, Galleria mellonella, in vivo model, infection, metal complexes, 1,10-phenanthroline, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/2/222; https://doaj.org/toc/2227-9059

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In vivo Activity of Copper(II), Manganese(II), and Silver(I) 1,10-Phenanthroline Chelates Against Candida haemulonii Using the Galleria mellonella Model

Authors: Rafael M. Gandra, Pauraic McCarron, Livia Viganor, Mariana Farias Fernandes, Kevin Kavanagh, Malachy McCann, Marta H. Branquinha, André L. S. Santos, Orla Howe, Michael Devereux

Source: Frontiers in Microbiology, Vol 11 (2020)

Subject Terms: Candida haemulonii, metal-1, 10-phenanthroline chelates, Galleria mellonella, antifungal activity, immunomodulation, Microbiology, QR1-502

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Relation: https://www.frontiersin.org/article/10.3389/fmicb.2020.00470/full; https://doaj.org/toc/1664-302X

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Imaging correlates of visual function in multiple sclerosis.

Authors: Eduardo Caverzasi, Christian Cordano, Alyssa H Zhu, Chao Zhao, Antje Bischof, Gina Kirkish, Daniel J Bennett, Michael Devereux, Nicholas Baker, Justin Inman, Hao H Yiu, Nico Papinutto, Jeffrey M Gelfand, Bruce A C Cree, Stephen L Hauser, Roland G Henry, Ari J Green

Source: PLoS ONE, Vol 15, Iss 8, p e0235615 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/50f2d42b968541a38bc789831e43ca08

Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target

Authors: Anna Clara M. Galdino, Lívia Viganor, Alexandre A. de Castro, Elaine F. F. da Cunha, Thaís P. Mello, Larissa M. Mattos, Marcos D. Pereira, Mary C. Hunt, Megan O’Shaughnessy, Orla Howe, Michael Devereux, Malachy McCann, Teodorico C. Ramalho, Marta H. Branquinha, André L. S. Santos

Source: Frontiers in Microbiology, Vol 10 (2019)

Subject Terms: Pseudomonas aeruginosa, elastase B, metal-based compounds, 1,10-phenanthroline-5,6-dione, anti-virulence therapy, theoretical calculations, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2019.01701/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/d5bd907c6bd14d5183fd0f1747dd8c52

The Antibacterial and Anti-Biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of Pseudomonas aeruginosa from Irish Cystic Fibrosis Patients

Authors: Megan O’Shaughnessy, Pauraic McCarron, Livia Viganor, Malachy McCann, Michael Devereux, Orla Howe

Source: Antibiotics, Vol 9, Iss 10, p 674 (2020)

Subject Terms: Pseudomonas aeruginosa, biofilm, metal complexes, 3,6,9-trioxaundecanedioic acid, 1,10-phenanthroline, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/9/10/674; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/6d15e3e3678d44ebb555cb2234b0af76

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

Authors: Lucas Schirmer, Wiebke Möbius, Chao Zhao, Andrés Cruz-Herranz, Lucile Ben Haim, Christian Cordano, Lawrence R Shiow, Kevin W Kelley, Boguslawa Sadowski, Garrett Timmons, Anne-Katrin Pröbstel, Jackie N Wright, Jung Hyung Sin, Michael Devereux, Daniel E Morrison, Sandra M Chang, Khalida Sabeur, Ari J Green, Klaus-Armin Nave, Robin JM Franklin, David H Rowitch

Source: eLife, Vol 7 (2018)

Subject Terms: Kir4.1 (KCNJ10), oligodendrocytes, neurobiology, visual System, white matter, neurodegeneration, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/36428; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/08a072ddc3c447a1bdecec41fc96cfc9

Unprecedented in Vitro Antitubercular Activitiy of Manganese(II) Complexes Containing 1,10-Phenanthroline and Dicarboxylate Ligands: Increased Activity, Superior Selectivity, and Lower Toxicity in Comparison to Their Copper(II) Analogs

Authors: Pauraic McCarron, Malachy McCann, Michael Devereux, Kevin Kavanagh, Ciaran Skerry, Petros C. Karakousis, Ana C. Aor, Thaís P. Mello, André L. S. Santos, Débora L. Campos, Fernando R. Pavan

Source: Frontiers in Microbiology, Vol 9 (2018)

Subject Terms: Mycobacterium tuberculosis, manganese(II), 10-phenanthroline, metal-based complex, antimicrobial agent, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2018.01432/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/5f4c72292eb843b38dcc1e79d8775504

Antifungal Potential of Copper(II), Manganese(II) and Silver(I) 1,10-Phenanthroline Chelates Against Multidrug-Resistant Fungal Species Forming the Candida haemulonii Complex: Impact on the Planktonic and Biofilm Lifestyles

Authors: Rafael M. Gandra, Pauraic Mc Carron, Mariana F. Fernandes, Lívia S. Ramos, Thaís P. Mello, Ana Carolina Aor, Marta H. Branquinha, Malachy McCann, Michael Devereux, André L. S. Santos

Source: Frontiers in Microbiology, Vol 8 (2017)

Subject Terms: Candida haemulonii complex, metal-based drugs, 1,10-phenanthroline, antifungal activity, anti-virulence, biofilm, Microbiology, QR1-502

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fmicb.2017.01257/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/5811d6e5a8fa4524adc2583045325d02

A Modified Szilard's Engine: Measurement, Information, and Maxwell's Demon

Authors: Michael Devereux

Source: Entropy, Vol 6, Iss 1, Pp 102-115 (2004)

Subject Terms: Szilard's engine, Maxwell's demon, quantum measurement, information theory, Science, Astrophysics, QB460-466, Physics, QC1-999

File Description: electronic resource

Relation: http://www.mdpi.com/1099-4300/6/1/102/; https://doaj.org/toc/1099-4300

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Synthesis and X-ray crystal structure of a tetracyclic gem-cis-bis(aminal) formed from N,N'-bis(2-aminophenyl)ethylenediamine and 1,10-phenanthroline-5,6-dione

Authors: Barry Coyle, Malachy McCann, Vickie McKee, Michael Devereux

Source: ARKIVOC, Vol 2003, Iss 7, Pp 59-66 (2003)

Subject Terms: Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0004.707; https://doaj.org/toc/1551-7004; https://doaj.org/toc/1551-7012

Access URL: https://doaj.org/article/3cdfa0758fd74edcb52cba52e25694bc