Replacing serum with dried blood microsampling for pharmacokinetics, viral neutralisation and immunogenicity bioanalysis supporting future paediatric development of RSM01, a candidate respiratory syncytial virus neutralising monoclonal antibody

Authors: Joleen T. White, Jonne Terstappen, Micha Levi, Andrijana Radivojevic, Robert Noble, Aparna B. Anderson, Gwendolyn Wise-Blackman, Michael W. Dunne

Source: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-10 (2024)

Subject Terms: Patient-centered, Dried blood, Monoclonal antibody, Neutralising antibodies, Viral neutralising activity, Pharmacokinetics, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/2b61813bba4b4f269164e169e747e51d

RSM01, a novel respiratory syncytial virus monoclonal antibody: preclinical characterization and results of a first-in-human, randomised clinical trial

Authors: Aurelio Bonavia, Micha Levi, Harald Rouha, Adriana Badarau, Jonne Terstappen, Shayne Watson, Aparna B. Anderson, Joleen T. White, Jintanat Ananworanich, Dale Taylor, Andrijana Radivojevic, Michael Shaffer, Luisa M. Stamm, Michael W. Dunne

Source: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-18 (2024)

Subject Terms: RSV, Lower respiratory tract infection, Monoclonal antibody, LMIC, Infants, Children, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/3ffe0c8237c54af09d428ce7e5dc02ba

stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments

Authors: Roberto Visintainer, Anna Fochesato, Daniele Boaretti, Stefano Giampiccolo, Shayne Watson, Micha Levi, Federico Reali, Luca Marchetti

Source: Frontiers in Pharmacology, Vol 15 (2025)

Subject Terms: physiologically based modeling, pharmacokinetics, pharmacodynamics, ADME, tuberculosis, web interface, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1462193/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/e1c8a2f7de3842a684be1fc97dbd8ac9

A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis

Authors: Federico Reali, Anna Fochesato, Chanchala Kaddi, Roberto Visintainer, Shayne Watson, Micha Levi, Véronique Dartois, Karim Azer, Luca Marchetti

Source: Frontiers in Pharmacology, Vol 14 (2024)

Subject Terms: minimal PBPK model, mPBPK, antituberculosis agents, modeling, simulation, tuberculosis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1272091/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/43f89e564cbe44c49eaf849a38b5aefa

Analysis of hepatitis C virus decline during treatment with the protease inhibitor danoprevir using a multiscale model.

Authors: Libin Rong, Jeremie Guedj, Harel Dahari, Daniel J Coffield, Micha Levi, Patrick Smith, Alan S Perelson

Source: PLoS Computational Biology, Vol 9, Iss 3, p e1002959 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3597560?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/fc3a932b93274776ae3558a58bbb938d

Population Pharmacokinetics of Nicotine and Its Metabolites I. Model Development.

Authors: Micha Levi, Delia Dempsey, Neal Benowitz

Source: Journal of Pharmacokinetics & Pharmacodynamics; Feb2007, Vol. 34 Issue 1, p5-21, 17p

Disposition of WR-1065 in the liver of tumor-bearing rats following regional vs systemic administration of amifostine.

Authors: Micha Levi, Susan J. DeRemer¹, Chunzhi Dou¹

Source: Biopharmaceutics & Drug Disposition. Jan2004, Vol. 25 Issue 1, p27-35. 9p.

Subject Terms: *PRODRUGS, *METABOLITES, *ALKALINE phosphatase, *LIVER tumors, *THERAPEUTICS

Regional pharmacokinetics of amifostine in anesthetized dogs: role of the liver, gastrointestinal tract, lungs, and kidneys.

Authors: Micha, Levi, A, Knol James, D, Ensminger William, J, DeRemer Susan, Chunzhi, Dou, M, Lunte Susan, S, Bonner Heather, M, Shaw Leslie, E, Smith David

Source: Drug Metabolism and Disposition; December 2002, Vol. 30 Issue: 12 p1425-30, 6p