Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression

Authors: Ricardo C. Ferreira, Xaquin Castro Dopico, João J. Oliveira, Daniel B. Rainbow, Jennie H. Yang, Dominik Trzupek, Sarah A. Todd, Mhairi McNeill, Maristella Steri, Valeria Orrù, Edoardo Fiorillo, Daniel J. M. Crouch, Marcin L. Pekalski, Francesco Cucca, Tim I. Tree, Tim J. Vyse, Linda S. Wicker, John A. Todd

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: regulatory T cells (Tregs), systemic lupus erythematosus (SLE), autoimmunity, FOXP3, PTPN22 Arg620Trp, PD-1, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02606/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/491641df1e794e1fa267f30eab0edc3f