Refining chimeric antigen receptors via barcoded protein domain combination pooled screening

Authors: Rios, Xavier, Pardias, Osmay, Morales, Marc A., Bhattacharya, Pradyot, Chen, Yibin, Guo, Linjie, Zhang, Chunchao, Di Pierro, Erica J., Tian, Gengwen, Barragan, Gabriel A., Sumazin, Pavel, Metelitsa, Leonid S.

Source: In Molecular Therapy 1 November 2023 31(11):3210-3224

Natural killer T cells and other innate-like T lymphocytes as emerging platforms for allogeneic cancer cell therapy

Authors: Courtney, Amy N., Tian, Gengwen, Metelitsa, Leonid S.

Source: In Blood 23 February 2023 141(8):869-876

Long-term follow-up for the development of subsequent malignancies in patients treated with genetically modified IECs

Authors: Steffin, David H.M. ^{*, *}, Muhsen, Ibrahim N. ^*, Hill, LaQuisa C., Ramos, Carlos A., Ahmed, Nabil, Hegde, Meenakshi, Wang, Tao, Wu, Mengfen, Gottschalk, Stephen, Whittle, Sarah B., Lulla, Premal D., Mamonkin, Maksim, Omer, Bilal, Rouce, Rayne H., Heczey, Andras, Metelitsa, Leonid S., Grilley, Bambi J., Robertson, Catherine, Torrano, Virginia, Lapteva, Natalia, Gee, Adrian P., Rooney, Cliona M., Brenner, Malcolm K., Heslop, Helen E.

Source: In Blood 7 July 2022 140(1):16-24

Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonistElectronic supplementary information (ESI) available. See DOI: 10.1039/C8OB02982B

Authors: ComptonThese authors contributed equally., Benjamin J., Farrand, Kathryn J., Tang, Ching-wen, Osmond, Taryn L., Speir, Mary, Authier-Hall, Astrid, Wang, Jing, Ferguson, Peter M., Chan, Susanna T. S., Anderson, Regan J., Cooney, Taylor R., Hayman, Colin M., Williams, Geoffrey M., Brimble, Margaret A, Brooks, Collin R., Yong, Lin-Kin, Metelitsa, Leonid S., Zajonc, Dirk M., Godfrey, Dale I., Gasser, Olivier, Weinkove, Robert, Painter, Gavin F., Hermans, Ian F.

Source: Organic & biomolecular chemistry. 17(5):1225-1237

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100076246604.0x000001&indx=1&recIds=ETOCvdc_100076246604.0x000001

IL-21 Selectively Protects CD62L^+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy

Authors: Ngai, Ho, Tian, Gengwen, Courtney, Amy N., Ravari, Soodeh B., Guo, Linjie, Liu, Bin, Jin, Jingling, Shen, Elise T., Di Pierro, Erica J., Metelitsa, Leonid S.

Source: Journal of immunology. 201(7):2141-2153

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617418710&indx=1&recIds=ETOCRN617418710

A milestone method to make natural killer T cells: Immunotherapy.

Authors: Metelitsa, Leonid S.¹ (AUTHOR) lsmeteli@texaschildrens.org

Source: Nature Biotechnology. Mar2025, Vol. 43 Issue 3, p302-303. 2p.

Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy

Authors: Heczey, Andras, Liu, Daofeng, Tian, Gengwen, Courtney, Amy N., Wei, Jie, Marinova, Ekaterina, Gao, Xiuhua, Guo, Linjie, Yvon, Eric, Hicks, John, Liu, Hao, Dotti, Gianpietro, Metelitsa, Leonid S. ^*

Source: In Blood 30 October 2014 124(18):2824-2833

Long Term Follow up for the Development of Subsequent Malignancies in Patients Treated with Genetically Modified Immune Effectors

Authors: Steffin, David H.M., Muhsen, Ibrahim N., Ahmed, Nabil M, Hegde, Meena, Dakhova, Olga, Wang, Tao, Wu, Jesse, Gottschalk, Stephen, Whittle, Sarah, Lulla, Premal D., Mamonkin, Maksim, Omer, Bilal, Rouce, Rayne Helen, Heczey, Andras, Metelitsa, Leonid S., Hill, LaQuisa, Ramos, Carlos A., Rooney, Cliona M., Brenner, Malcolm K., Heslop, Helen E.

Source: Transplantation and Cellular Therapy. 28(S):S200-S201

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157890612.0x000001&indx=1&recIds=ETOCvdc_100157890612.0x000001

Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells

Authors: Liu, Daofeng, Song, Liping, Brawley, Vita S., Robison, Nathan, Wei, Jie, Gao, Xiuhua, Tian, Gengwen, Margol, Ashley, Ahmed, Nabil, Asgharzadeh, Shahab, Metelitsa, Leonid S.

Source: In Clinical Immunology October 2013 149(1):55-64

Anti-tumor potential of type-I NKT cells against CD1d-positive and CD1d-negative tumors in humans

Authors: Metelitsa, Leonid S.

Source: In Clinical Immunology 2011 140(2):119-129

Selective gene transfection of individual cells in vitro with plasmonic nanobubbles

Authors: Lukianova-Hleb, Ekaterina Y., Samaniego, Adam P., Wen, Jianguo, Metelitsa, Leonid S., Chang, Chung-Che, Lapotko, Dmitri O.

Source: In Journal of Controlled Release 2011 152(2):286-293

Allogeneic NKT Cells Expressing a CD19-Specific CAR in Patients with Relapsed or Refractory B-Cell Malignancies

Authors: Ramos, Carlos A., Courtney, Amy N., Robinson, Simon N., Dakhova, Olga, Lulla, Premal D., Kamble, Rammurti T., Carrum, George, Wang, Tao, Zhang, Chunchao, Di Pierro, Erica J., Metelitsa, Leonid S.

Source: Transplantation and Cellular Therapy. 28(S):S54-S54

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157891864.0x000001&indx=1&recIds=ETOCvdc_100157891864.0x000001

Off-the-Shelf CD19-Specific CAR-NKT Cells in Patients with Relapsed or Refractory B-Cell Malignancies

Authors: Ramos, Carlos A., Courtney, Amy N., Lulla, Premal D., Hill, LaQuisa Chimere, Kamble, Rammurti T., Carrum, George, Wang, Tao, Pierro, Erica J. Di, Brenner, Malcolm K., Heslop, Helen E., Metelitsa, Leonid S.

Source: In Transplantation and Cellular Therapy February 2024 30(2) Supplement:S41-S42

Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results

Authors: Heczey, Andras, Xu, Xin, Courtney, Amy N., Tian, Gengwen, Barragan, Gabriel A., Guo, Linjie, Amador, Claudia Martinez, Ghatwai, Nisha, Rathi, Purva, Wood, Michael S., Li, Yanchuan, Zhang, Chunchao, Demberg, Thorsten, Di Pierro, Erica J., Sher, Andrew C., Zhang, Huimin, Mehta, Birju, Thakkar, Sachin G., Grilley, Bambi, Wang, Tao, Weiss, Brian D., Montalbano, Antonino, Subramaniam, Meena, Xu, Chenling, Sachar, Chirag, Wells, Daniel K., Dotti, Gianpietro, Metelitsa, Leonid S.

Source: Nature Medicine; June 2023, Vol. 29 Issue: 6 p1379-1388, 10p

Distinct homeostatic requirements of CD4+ and CD4- subsets of Vα24-invariant natural killer T cells in humans

Authors: Baev, Denis V., Peng, Xiao-hui, Song, Liping, Barnhart, Jerry R., Crooks, Gay M., Weinberg, Kenneth I., Metelitsa, Leonid S.

Source: In Blood 15 December 2004 104(13):4150-4156

Flow cytometry for natural killer T cells: multi-parameter methods for multifunctional cells

Authors: Metelitsa, Leonid S ^*

Source: In Clinical Immunology 2004 110(3):267-276

245 - Long Term Follow up for the Development of Subsequent Malignancies in Patients Treated with Genetically Modified Immune Effectors

Authors: Steffin, David H.M., Muhsen, Ibrahim N., Ahmed, Nabil M, Hegde, Meena, Dakhova, Olga, Wang, Tao, Wu, Jesse, Gottschalk, Stephen, Whittle, Sarah, Lulla, Premal D., Mamonkin, Maksim, Omer, Bilal, Rouce, Rayne Helen, Heczey, Andras, Metelitsa, Leonid S., Hill, LaQuisa, Ramos, Carlos A., Rooney, Cliona M., Brenner, Malcolm K., Heslop, Helen E.

Source: In Transplantation and Cellular Therapy March 2022 28(3) Supplement:S200-S201

63 - Allogeneic NKT Cells Expressing a CD19-Specific CAR in Patients with Relapsed or Refractory B-Cell Malignancies

Authors: Ramos, Carlos A., Courtney, Amy N., Robinson, Simon N., Dakhova, Olga, Lulla, Premal D., Kamble, Rammurti T., Carrum, George, Wang, Tao, Zhang, Chunchao, Di Pierro, Erica J., Metelitsa, Leonid S.

Source: In Transplantation and Cellular Therapy March 2022 28(3) Supplement:S54-S54

Antidisialoganglioside/granulocyte macrophage–colony-stimulating factor fusion protein facilitates neutrophil antibody-dependent cellular cytotoxicity and depends on FcγRII (CD32) and Mac-1 (CD11b/CD18) for enhanced effector cell adhesion and azurophil granule exocytosis

Authors: Metelitsa, Leonid S., Gillies, Stephen D., Super, Michael, Shimada, Hiroyuki, Reynolds, C. Patrick, Seeger, Robert C.

Source: In Blood 1 June 2002 99(11):4166-4173

Allogeneic NKT Cells Expressing a CD19-Specific CAR in Patients with Relapsed or Refractory B-Cell Malignancies: An Interim Analysis

Authors: Ramos, Carlos A., Courtney, Amy N., Robinson, Simon N., Dakhova, Olga, Lulla, Premal D., Kamble, Rammurti, Carrum, George, Wang, Tao, Zhang, Chunchao, Di Pierro, Erica, Metelitsa, Leonid S.

Source: In Blood 23 November 2021 138 Supplement 1:2819-2819