Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists

Authors: Metcalf, Talibah U., Wilkinson, Peter A., Cameron, Mark J., Ghneim, Khader, Chiang, Cindy, Wertheimer, Anne M., Hiscott, John B., Nikolich-Zugich, Janko, Haddad, Elias K.

Source: Journal of immunology. 199(4):1405-1417

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Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors.

Authors: Metcalf, Talibah U.¹, Cubas, Rafael A.¹, Ghneim, Khader², Cartwright, Michael J.¹, Grevenynghe, Julien Van³, Richner, Justin M.^4,5, Olagnier, David P.¹, Wilkinson, Peter A.², Cameron, Mark J.², Park, Byung S.⁶, Hiscott, John B.¹, Diamond, Michael S.^4,5, Wertheimer, Anne M.^7,8, Nikolich‐Zugich, Janko^7,8, Haddad, Elias K.¹

Source: Aging Cell. Jun2015, Vol. 14 Issue 3, p421-432. 12p.

Subject Terms: *CELLULAR aging, *NATURAL immunity, *PATHOGENIC microorganisms, *DISEASE susceptibility, *NUMERICAL analysis

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection.

Authors: Richner, Justin M.¹, Gmyrek, Grzegorz B.¹, Govero, Jennifer¹, Tu, Yizheng¹, van der Windt, Gerritje J. W.², Metcalf, Talibah U.³, Haddad, Elias K.³, Textor, Johannes⁴, Miller, Mark J.¹, Diamond, Michael S.^1,2,5, diamond@borcim.wustl.edu

Source: PLoS Pathogens; 7/23/2015, Vol. 11 Issue 7, p1-29, 29p

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