Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer

Authors: Civenni, Gianluca, Bosotti, Roberto, Timpanaro, Andrea, Vàzquez, Ramiro, Merulla, Jessica, Pandit, Shusil, Rossi, Simona, Albino, Domenico, Allegrini, Sara, Mitra, Abhishek, Mapelli, Sarah N., Vierling, Luca, Giurdanella, Martina, Marchetti, Martina, Paganoni, Alyssa, Rinaldi, Andrea, Losa, Marco, Mira-Catò, Enrica, D'Antuono, Rocco, Morone, Diego, Rezai, Keyvan, D'Ambrosio, Gioacchino, Ouafik, L’Houcine, Mackenzie, Sarah, Riveiro, Maria E., Cvitkovic, Esteban, Carbone, Giuseppina M., Catapano, Carlo V.

Source: In Cell Metabolism 6 August 2019 30(2):303-318

Transcriptional Reprogramming and Inhibition of Tumor-propagating Stem-like Cells by EC-8042 in ERG-positive Prostate Cancer

Authors: Shinde, Dheeraj, Albino, Domenico, Zoma, Marita, Mutti, Azzurra, Mapelli, Sarah N., Civenni, Gianluca, Kokanovic, Aleksandra, Merulla, Jessica, Perez-Escuredo, Jhudit, Costales, Paula, Morìs, Francisco, Catapano, Carlo V., Carbone, Giuseppina M.

Source: In European Urology Oncology July 2019 2(4):415-424

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

Authors: Genini, Davide, Brambilla, Lara, Laurini, Erik, Merulla, Jessica, Civenni, Gianluca, Pandit, Shusil, D’Antuono, Rocco, Perez, Laurent, Levy, David E., Pricl, Sabrina, Carbone, Giuseppina M., Catapano, Carlo V.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jun . 114(25), E4924-E4933.

Access URL: https://www.jstor.org/stable/26484947

Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

Authors: Brambilla, Lara, Genini, Davide, Laurini, Erik, Merulla, Jessica, Perez, Laurent, Fermeglia, Maurizio, Carbone, Giuseppina M., Pricl, Sabrina, Catapano, Carlo V.

Source: In Molecular Oncology June 2015 9(6):1194-1206

Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer

Authors: Albino, Domenico, Falcione, Martina, Uboldi, Valeria, Temilola, Dada Oluwaseyi, Sandrini, Giada, Merulla, Jessica, Civenni, Gianluca, Kokanovic, Aleksandra, Stürchler, Alessandra, Shinde, Dheeraj, Garofalo, Mariangela, Mestre, Ricardo Pereira, Constâncio, Vera, Wium, Martha, Burrello, Jacopo, Baranzini, Nicolò, Grimaldi, Annalisa, Theurillat, Jean-Philippe, Bossi, Daniela, Barile, Lucio, Henrique, Rui M., Jeronimo, Carmen, Zerbini, Luiz Fernando, Catapano, Carlo V., Carbone, Giuseppina M.

Source: Communications biology. 4(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193170128.0x000001&indx=1&recIds=ETOCvdc_100193170128.0x000001

EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.

Authors: Zoma, Marita, Curti, Laura, Shinde, Dheeraj, Albino, Domenico, Mitra, Abhishek, Sgrignani, Jacopo, Mapelli, Sarah N., Sandrini, Giada, Civenni, Gianluca, Merulla, Jessica, Chiorino, Giovanna, Kunderfranco, Paolo, Cacciatore, Alessia, Kokanovic, Aleksandra, Rinaldi, Andrea, Cavalli, Andrea, Catapano, Carlo V., Carbone, Giuseppina M.

Source: Nature Communications; 7/6/2021, Vol. 12 Issue 1, p1-19, 19p

Subject Terms: PROSTATE cancer, CASTRATION-resistant prostate cancer, GENE fusion, METHYLATION, LABORATORY mice, POST-translational modification

Specificity and Regulation of the Endoplasmic Reticulum-Associated Degradation Machinery.

Authors: Merulla, Jessica^1,2, Fasana, Elisa¹, Soldà, Tatiana¹, Molinari, Maurizio^1,3

Source: Traffic. Jul2013, Vol. 14 Issue 7, p767-777. 11p. 3 Diagrams.

Subject Terms: *ENDOPLASMIC reticulum, *PROTEOLYSIS, *DENATURATION of proteins, *CELL physiology, *LIPID synthesis, *BACTERIAL diseases, *POST-translational modification

The Development and Prototype Feedback of Digital Cancer 101 Videos to Enhance Cancer Education for Marginalized Communities With Limited Health Literacy.

Authors: Valera, Pamela, Acuna, Nicholas, Alzate-Duque, Luis, Liang, Laura E., Cupertino, Paula, Merulla, Jessica

Source: Cancer Control: Journal of the Moffitt Cancer Center; 3/31/2021, p1-10, 10p

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Transcriptional Reprogramming and Novel Therapeutic Approaches for Targeting Prostate Cancer Stem Cells.

Authors: Civenni, Gianluca, Albino, Domenico, Shinde, Dheeraj, Vázquez, Ramiro, Merulla, Jessica, Kokanovic, Aleksandra, Mapelli, Sarah N., Carbone, Giuseppina M., Catapano, Carlo V.

Source: Frontiers in Oncology; 5/9/2019, pN.PAG-N.PAG, 16p

Subject Terms: PROSTATE cancer, ANDROGEN drugs, CANCER stem cells, TRANSCRIPTION factors, PHENOTYPES

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Mitochondrial Plasticity Promotes Resistance to Sorafenib and Vulnerability to STAT3 Inhibition in Human Hepatocellular Carcinoma.

Authors: Pandit, Shusil K., Sandrini, Giada, Merulla, Jessica, Nobili, Valentina, Wang, Xin, Zangari, Alessia, Rinaldi, Andrea, Shinde, Dheeraj, Carbone, Giuseppina M., Catapano, Carlo V.

Source: Cancers; Dec2021, Vol. 13 Issue 23, p6029, 1p

Subject Terms: MITOCHONDRIAL physiology, STAT proteins, CANCER patients, SORAFENIB, GENE expression profiling, CELL lines, DRUG resistance in cancer cells, HEPATOCELLULAR carcinoma, PHOSPHORYLATION, CHEMICAL inhibitors

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