Lack of factor VIII detection in humans and dogs with an intron 22 inversion challenges hypothesis regarding inhibitor risk

Authors: Vir, Pooja, Gunasekera, Devi, Dorjbal, Batsukh, McDaniel, Dennis, Agrawal, Atul, Merricks, Elizabeth P., Ragni, Margaret V., Leissinger, Cindy A., Stering, Allen I., Lieuw, Kenneth, Nichols, Timothy C., Pratt, Kathleen P.

Source: In Journal of Thrombosis and Haemostasis December 2024 22(12):3415-3430

Viscoelastic Response Ultrasound Detects Changes in Degree of Mechanical Anisotropy with Renal Fibrosis in Pig Model

Authors: Hossain, Md Murad, Nichols, Timothy C., Merricks, Elizabeth P., Bellinger, Dwight A., Wimsey, Lauren E., Caughey, Melissa C., Montgomery, Stephanie A., Gallippi, Caterina M.

Source: 2019 IEEE International Ultrasonics Symposium (IUS) Ultrasonics Symposium (IUS), 2019 IEEE International. :415-418 Oct, 2019

Relation: 2019 IEEE International Ultrasonics Symposium (IUS)

AAV gene therapy in companion dogs with severe hemophilia: Real-world long-term data on immunogenicity, efficacy, and quality of life

Authors: Doshi, Bhavya S., Samelson-Jones, Benjamin J., Nichols, Timothy C., Merricks, Elizabeth P., Siner, Joshua I., French, Robert A., Lee, Ben J., Arruda, Valder R., Callan, Mary Beth

Source: In Molecular Therapy - Methods & Clinical Development 14 March 2024 32(1)

Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog

Authors: Van Gorder, Lucas, Doshi, Bhavya S., Willis, Elinor, Nichols, Timothy C., Cook, Emma, Everett, John K., Merricks, Elizabeth P., Arruda, Valder R., Bushman, Frederic D., Callan, Mary Beth, Samelson-Jones, Benjamin J.

Source: In Molecular Therapy - Methods & Clinical Development 14 December 2023 31

Recombinant von Willebrand factor and tranexamic acid for heavy menstrual bleeding in patients with mild and moderate von Willebrand disease in the USA (VWDMin): a phase 3, open-label, randomised, crossover trial

Authors: Ragni, Margaret V ^*, Rothenberger, Scott D, Feldman, Robert, Nance, Danielle, Leavitt, Andrew D, Malec, Lynn, Kulkarni, Roshni, Sidonio, Robert, Jr, Kraut, Eric, Lasky, Joseph, Pruthi, Rajiv, Angelini, Dana, Philipp, Claire, Hwang, Nina, Wheeler, Allison P, Seaman, Craig, Machin, Nicoletta, Xavier, Frederico, Meyer, Michael, Bellissimo, Daniel, Humphreys, Gregory, Smith, Kenneth J, Merricks, Elizabeth P, Nichols, Timothy C, Ivanco, Dana, Vehec, Deborah, Koerbel, Glory, Althouse, Andrew D

Source: In The Lancet Haematology August 2023 10(8):e612-e623

In vivo ARFI surveillance of subcutaneous hemorrhage (ASSH) for monitoring rcFVIII dose response in hemophilia A dogs

Authors: Geist, Rebecca E., Gallippi, Caterina M., Nichols, Timothy C., Merricks, Elizabeth P., Caughey, Melissa C.

Source: 2014 IEEE International Ultrasonics Symposium Ultrasonics Symposium (IUS), 2014 IEEE International. :2296-2299 Sep, 2014

Relation: 2014 IEEE International Ultrasonics Symposium (IUS)

Dexamethasone Transiently Enhances Transgene Expression in the Liver When Administered at Late-Phase Post Long-Term Adeno-Associated Virus Transduction

Authors: Chai, Zheng, Zhang, Xintao, Dobbins, Amanda Lee, Samulski, Richard Jude, Merricks, Elizabeth P., Nichols, Timothy C., Li, Chengwen

Source: Human gene therapy. 33(3/4):119-130

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140726935.0x000001&indx=1&recIds=ETOCvdc_100140726935.0x000001

In vivo detection of hemorrhage rate in dog models of hemophilia and VWD and at human femoral arteriotomy by ARFI ultrasound

Authors: Scola, Mallory R., Baggesen, Leslie M., Behler, Russel H., Nichols, Timothy C., Zhu, Hongtu, Caughey, Melissa C., Merricks, Elizabeth P., Raymer, Robin A., Margaritis, Paris, High, Katherine A., Gallippi, Caterina M.

Source: 2011 IEEE International Ultrasonics Symposium Ultrasonics Symposium (IUS), 2011 IEEE International. :660-663 Oct, 2011

Relation: 2011 IEEE International Ultrasonics Symposium (IUS)

ARFI beam sequence performance as evaluated by trained readers: Plaque detection

Authors: Behler, Russell H., Gallippi, Caterina M., Wu, Chih-Da, Zhu, Hongtu, Merricks, Elizabeth P., Nichols, Timothy C.

Source: 2010 IEEE International Ultrasonics Symposium Ultrasonics Symposium (IUS), 2010 IEEE. :483-486 Oct, 2010

Relation: 2010 IEEE Ultrasonics Symposium (IUS)

Evolutionary insights into coagulation factor IX Padua and other high-specific-activity variants

Authors: Samelson-Jones, Benjamin J., Finn, Jonathan D., Raffini, Leslie J., Merricks, Elizabeth P., Camire, Rodney M., Nichols, Timothy C., Arruda, Valder R.

Source: In Blood Advances 9 March 2021 5(5):1324-1332

Development of AAV Variants with Human Hepatocyte Tropism and Neutralizing Antibody Escape Capacity

Authors: Pei, Xiaolei, Shao, Wenwei, Xing, Allene, Askew, Charles, Chen, Xiaojing, Cui, Caibin, Abajas, Yasmina L., Gerber, David A., Merricks, Elizabeth P., Nichols, Timothy C., Li, Wuping, Samulski, R. Jude, Li, Chengwen

Source: In Molecular Therapy - Methods & Clinical Development 11 September 2020 18:259-268

Reflected shear wave imaging of atherosclerosis

Authors: Behler, Russell H., Nichols, Timothy C., Merricks, Elizabeth P., Gallippi, Caterina M.

Source: 2009 IEEE International Ultrasonics Symposium Ultrasonics Symposium (IUS), 2009 IEEE International. :2445-2448 Sep, 2009

Relation: 2009 IEEE International Ultrasonics Symposium

Comparison of multiple beam sequences in arterial ARFI imaging, ex vivo

Authors: Behler, Russell H., Gallippi, Caterina M., Merricks, Elizabeth P., Nichols, Timothy C.

Source: 2008 IEEE Ultrasonics Symposium Ultrasonics Symposium, 2008. IUS 2008. IEEE. :2003-2008 Nov, 2008

Relation: 2008 IEEE Ultrasonics Symposium (IUS)

An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs

Authors: Sun, Junjiang, Shao, Wenwei, Chen, Xiaojing, Merricks, Elizabeth P., Wimsey, Lauren, Abajas, Yasmina L., Niemeyer, Glenn P., Lothrop, Clinton D., Monahan, Paul E., Samulski, R. Jude, Nichols, Timothy C., Li, Chengwen

Source: In Molecular Therapy - Methods & Clinical Development 21 September 2018 10:257-267

Complete correction of hemophilia B phenotype by FIX-Padua skeletal muscle gene therapy in an inhibitor-prone dog model

Authors: French, Robert A., Samelson-Jones, Benjamin J., Niemeyer, Glenn P., Lothrop, Clinton D., Jr, Merricks, Elizabeth P., Nichols, Timothy C., Arruda, Valder R.

Source: In Blood Advances 13 March 2018 2(5):505-508

Influence of diabetes on the foreign body response to nitric oxide-releasing implants

Authors: Soto, Robert J., Merricks, Elizabeth P., Bellinger, Dwight A., Nichols, Timothy C., Schoenfisch, Mark H.

Source: In Biomaterials March 2018 157:76-85

Mechanical Anisotropy Assessment in Kidney Cortex Using ARFI Peak Displacement: Preclinical Validation and Pilot In Vivo Clinical Results in Kidney Allografts

Authors: Hossain, Md Murad, Detwiler, Randal K., Chang, Emily H., Caughey, Melissa C., Fisher, Melrose W., Nichols, Timothy C., Merricks, Elizabeth P., Raymer, Robin A., Whitford, Margaret, Bellinger, Dwight A., Wimsey, Lauren E., Gallippi, Caterina M.

Source: IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 66(3):551-562

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108430271.0x000001&indx=1&recIds=ETOCvdc_100108430271.0x000001

Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce

Authors: Herzog, Roland W., Nichols, Timothy C., Su, Jin, Zhang, Bei, Sherman, Alexandra, Merricks, Elizabeth P., Raymer, Robin, Perrin, George Q., Häger, Mattias, Wiinberg, Bo, Daniell, Henry

Source: In Molecular Therapy 1 February 2017 25(2):512-522

Soy Phosphatidylinositol–Containing Lipid Nanoparticle Prolongs the Plasma Survival and Hemostatic Efficacy of B-domain–Deleted Recombinant Canine Factor VIII in Hemophilia A Dogs

Authors: Shetty, Krithika A., Merricks, Elizabeth P., Raymer, Robin, Rigsbee, Natalie, Nichols, Timothy C., Balu-Iyer, Sathy V.

Source: In Journal of Pharmaceutical Sciences August 2016 105(8):2459-2464

Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.

Authors: Strilchuk, Amy W., Hur, Woosuk S., Batty, Paul, Sang, Yaqiu, Abrahams, Sara R., Yong, Alyssa S.M., Leung, Jerry, Silva, Lakmali M., Schroeder, Jocelyn A., Nesbitt, Kate, de Laat, Bas, Moutsopoulos, Niki M., Bugge, Thomas H., Shi, Qizhen, Cullis, Pieter R., Merricks, Elizabeth P., Wolberg, Alisa S., Flick, Matthew J., Lillicrap, David, Nichols, Timothy C.

Source: Science Translational Medicine; 2/21/2024, Vol. 16 Issue 735, p1-9, 9p

Subject Terms: PLASMINOGEN, FIBRINOLYSIS, SMALL interfering RNA, LABORATORY mice, SAPHENOUS vein, TRANEXAMIC acid