DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition

Authors: Madeline N. Hayes, Sarah Cohen-Gogo, Lynn Kee, Xueting Xiong, Alex Weiss, Mehdi Layeghifard, Yagnesh Ladumor, Ivette Valencia-Sama, Anisha Rajaselvam, David R. Kaplan, Anita Villani, Adam Shlien, Daniel A. Morgenstern, Meredith S. Irwin

Source: Cell Reports, Vol 44, Iss 4, Pp 115537- (2025)

Subject Terms: CP: Cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124725003080; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/06eab5d9187a412ebad7e636e2c2a160

DNA repair and replicative stress addiction in neuroblastoma

Authors: Kaat Durinck, Meredith S. Irwin

Source: EJC Paediatric Oncology, Vol 4, Iss , Pp 100177- (2024)

Subject Terms: Neuroblastoma, DNA damage repair, Replication stress, Targeted therapy, Clinical trials, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772610X24000369; https://doaj.org/toc/2772-610X

Access URL: https://doaj.org/article/9b1033142cff4c34b35ba99c25cc2db3

Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma

Authors: Miriam I. Rosenberg, Erez Greenstein, Martin Buchkovich, Ayelet Peres, Eric Santoni-Rugiu, Lei Yang, Martin Mikl, Zalman Vaksman, David L. Gibbs, Dan Reshef, Amy Salovin, Meredith S. Irwin, Arlene Naranjo, Igor Ulitsky, Pedro A. de Alarcon, Katherine K. Matthay, Victor Weigman, Gur Yaari, Jessica A. Panzer, Nir Friedman, John M. Maris

Source: Cell Reports, Vol 42, Iss 8, Pp 112879- (2023)

Subject Terms: CP: Cancer, CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723008902; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/506516905d124cd99326d2bc5f05f4f1

Temporal clustering of neuroblastic tumours in children and young adults from Ontario, Canada

Authors: Louise Hayes, Nermine Basta, Colin R. Muirhead, Jason D. Pole, Paul Gibson, Bruna Di Monte, Meredith S. Irwin, Mark Greenberg, Deborah A. Tweddle, Richard J. Q. McNally

Source: Environmental Health, Vol 21, Iss 1, Pp 1-8 (2022)

Subject Terms: Epidemiology, Neuroblastic tumours, Temporal clustering, Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1476-069X

Access URL: https://doaj.org/article/a0e8da9152674a64a60380bb85c96530

The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors

Authors: Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L. Udaskin, Ahmet Mentes, Richard Huang, Betty P. K. Poon, Wenguang He, Ivette Valencia-Sama, Claire M. Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S. Irwin, Jeffrey E. Lee, Ming-Sound Tsao, Brian Raught, Christopher B. Marshall, Michael Ohh, Mitsuhiko Ikura

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/adc5eaa39af340409424aef1fcf1144b

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

Authors: Ana S. Guerreiro Stucklin, Scott Ryall, Kohei Fukuoka, Michal Zapotocky, Alvaro Lassaletta, Christopher Li, Taylor Bridge, Byungjin Kim, Anthony Arnoldo, Paul E. Kowalski, Yvonne Zhong, Monique Johnson, Claire Li, Arun K. Ramani, Robert Siddaway, Liana Figueiredo Nobre, Pasqualino de Antonellis, Christopher Dunham, Sylvia Cheng, Daniel R. Boué, Jonathan L. Finlay, Scott L. Coven, Inmaculada de Prada, Marta Perez-Somarriba, Claudia C. Faria, Michael A. Grotzer, Elisabeth Rushing, David Sumerauer, Josef Zamecnik, Lenka Krskova, Miguel Garcia Ariza, Ofelia Cruz, Andres Morales La Madrid, Palma Solano, Keita Terashima, Yoshiko Nakano, Koichi Ichimura, Motoo Nagane, Hiroaki Sakamoto, Maria Joao Gil-da-Costa, Roberto Silva, Donna L. Johnston, Jean Michaud, Bev Wilson, Frank K. H. van Landeghem, Angelica Oviedo, P. Daniel McNeely, Bruce Crooks, Iris Fried, Nataliya Zhukova, Jordan R. Hansford, Amulya Nageswararao, Livia Garzia, Mary Shago, Michael Brudno, Meredith S. Irwin, Ute Bartels, Vijay Ramaswamy, Eric Bouffet, Michael D. Taylor, Uri Tabori, Cynthia Hawkins

Source: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1dd77b35b12f4fbfa3be4dbd3feb1c2b

Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

Authors: Hao Huang, Alexander Gont, Lynn Kee, Ruben Dries, Kathrin Pfeifer, Bandana Sharma, David N. Debruyne, Matthew Harlow, Satyaki Sengupta, Jikui Guan, Caleb M. Yeung, Wenchao Wang, Bengt Hallberg, Ruth H. Palmer, Meredith S. Irwin, Rani E. George

Source: Cell Reports, Vol 36, Iss 2, Pp 109363- (2021)

Subject Terms: ALK, receptor tyrosine kinase, neuroblastoma, cleavage, MMP-9, migration, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721007610; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/4d42e574c9364bf5b62295a7b9c9fc0b

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation

Authors: Yoshihito Kano, Teklab Gebregiworgis, Christopher B. Marshall, Nikolina Radulovich, Betty P. K. Poon, Jonathan St-Germain, Jonathan D. Cook, Ivette Valencia-Sama, Benjamin M. M. Grant, Silvia Gabriela Herrera, Jinmin Miao, Brian Raught, Meredith S. Irwin, Jeffrey E. Lee, Jen Jen Yeh, Zhong-Yin Zhang, Ming-Sound Tsao, Mitsuhiko Ikura, Michael Ohh

Source: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/811fdf81e7164853822f6750cc8b6260

Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation

Authors: Nicolas Waespe, Machiel Van Den Akker, Robert J. Klaassen, Lani Lieberman, Meredith S. Irwin, Salah S. Ali, Mohamed Abdelhaleem, Bozana Zlateska, Mira Liebman, Michaela Cada, Tal Schechter, Yigal Dror

Source: Haematologica, Vol 101, Iss 12 (2016)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7907; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/37ef0007e3a14ca8bf8fa7427028dba0

In Vivo Antitumor and Antimetastatic Activity of Sunitinib in Preclinical Neuroblastoma Mouse Model

Authors: Libo Zhang, Kristen M. Smith, Amy Lee Chong, Diana Stempak, Herman Yeger, Paula Marrano, Paul S. Thorner, Meredith S. Irwin, David R. Kaplan, Sylvain Baruchel

Source: Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 5, Pp 426-435 (2009)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558609800511; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

Access URL: https://doaj.org/article/4faecf779bcd4660b737eff0c7b3940e

Tissue Microenvironment Modulates CXCR4 Expression and Tumor Metastasis in Neuroblastoma

Authors: Libo Zhang, Herman Yeger, Bikul Das, Meredith S. Irwin, Sylvain Baruchel

Source: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 1, Pp 36-46 (2007)

Subject Terms: Neuroblastoma, metastasis, chemokine receptor, tissue microenvironment, CXCR4, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558607801060; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

Access URL: https://doaj.org/article/ee96965593aa40bb864a76cb338d7c7e

Ubiquitin and Ubiquitin-Like Modifications of the p53 Family

Authors: Ian R. Watson, Meredith S. Irwin

Source: Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 8, Pp 655-666 (2006)

Subject Terms: p63, p73, ubiquitin, SUMO, NEDD8, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558606800047; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

Access URL: https://doaj.org/article/77edd734683544e8adfeaccd233b0db1

COVID‐19: a pandemic experience that illuminates potential reforms to health research

Authors: Hannah N Kozlowski, Michael E Farkouh, Meredith S Irwin, Laszlo G Radvanyi, Aaron D Schimmer, Uri Tabori, Norman D Rosenblum

Source: EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-4 (2020)

Subject Terms: Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/562f1d8665274226afee97ac54c94821

Diagnostic practices and disease surveillance in Canadian children with congenital central hypoventilation syndrome

Authors: Reshma Amin, Theo J Moraes, Amy Skitch, Meredith S Irwin, Stephen Meyn, Manisha Witmans

Source: Canadian Respiratory Journal, Vol 20, Iss 3, Pp 165-170 (2013)

Subject Terms: Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1198-2241

Access URL: https://doaj.org/article/bec1a7b3caff44ec977016185ff7d222

Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity.

Authors: Alvaro Blanch, Fiona Robinson, Ian R Watson, Lynn S Cheng, Meredith S Irwin

Source: PLoS ONE, Vol 8, Iss 6, p e66436 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3682968?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b25259b0db3446f3a48d144d9e13069b