CKD-Associated Pruritus and Clinical Outcomes in Nondialysis CKD

Authors: Lopes, Antonio, Pecoits-Filho, Roberto, Combe, Christian, Jacquelinet, Christian, Massy, Ziad, Stengel, Benedicte, Duttlinger, Johannes, Fliser, Danilo, Lonnemann, Gerhard, Reichel, Helmut, Wada, Takashi, Yamagata, Kunihiro, Pisoni, Ron, Robinson, Bruce, Calice da Silva, Viviane, Sesso, Ricardo, Speyer, Elodie, Asahi, Koichi, Hoshino, Junichi, Narita, Ichiei, Perlman, Rachel, Port, Friedrich, Sukul, Nidhi, Wong, Michelle, Young, Eric, Zee, Jarcy, Scherer, Jennifer S., Tu, Charlotte, Pisoni, Ronald L., Lopes, Antonio A., Wen, Warren, Menzaghi, Frederique, Cirulli, Joshua, Alencar de Pinho, Natalia, Karaboyas, Angelo

Source: In Kidney Medicine January 2024 6(1)

A phase 2 study of oral difelikefalin in subjects with chronic kidney disease and moderate-to-severe pruritus

Authors: Yosipovitch, Gil, Awad, Ahmed, Spencer, Robert H., Munera, Catherine, Menzaghi, Frédérique

Source: Journal of the American Academy of Dermatology. 89(2):261-268

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194201436.0x000001&indx=1&recIds=ETOCvdc_100194201436.0x000001

Assessment of the physical dependence potential of difelikefalin: Randomized placebo‐controlled study in patients receiving hemodialysis

Authors: Spencer, Robert H., Munera, Catherine, Shram, Megan J., Menzaghi, Frédérique

Source: Clinical and translational science. 16(9):1559-1568

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192718374.0x000001&indx=1&recIds=ETOCvdc_100192718374.0x000001

The Burden of Pruritus Associated With CKD: A Mixed Methods Analysis Among Patients Undergoing Dialysis

Authors: Menzaghi, Frédérique, Vernon, Margaret K., Mattera, Maria, Cirulli, Joshua, Wen, Warren, Spencer, Robert H., Munera, Catherine

Source: In Kidney Medicine September 2023 5(9)

Safety and Effectiveness of Difelikefalin in Patients With Moderate-to-Severe Pruritus Undergoing Hemodialysis: An Open-Label, Multicenter Study

Authors: Weiner, Daniel E., Vervloet, Marc G., Walpen, Sebastian, Schaufler, Thilo, Munera, Catherine, Menzaghi, Frédérique, Wen, Warren, Bhaduri, Sarbani, Germain, Michael J.

Source: In Kidney Medicine October 2022 4(10)

Evaluation of the abuse potential of difelikefalin, a selective kappa‐opioid receptor agonist, in recreational polydrug users

Authors: Shram, Megan J., Spencer, Robert H., Qian, Jenny, Munera, Catherine L., Lewis, Michael E., Henningfield, Jack E., Webster, Lynn, Menzaghi, Frédérique

Source: Clinical and translational science. 15(2):535-547

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141601744.0x000001&indx=1&recIds=ETOCvdc_100141601744.0x000001

Safety and Tolerability of Difelikefalin for the Treatment of Moderate to Severe Pruritus in Hemodialysis Patients: Pooled Analysis From the Phase 3 Clinical Trial Program

Authors: Fishbane, Steven, Wen, Warren, Munera, Catherine, Lin, Rong, Bagal, Sukirti, McCafferty, Kieran, Menzaghi, Frédérique, Goncalves, Joana

Source: In Kidney Medicine August 2022 4(8)

Efficacy of Difelikefalin for the Treatment of Moderate to Severe Pruritus in Hemodialysis Patients: Pooled Analysis of KALM-1 and KALM-2 Phase 3 Studies

Authors: Topf, Joel, Wooldridge, Thomas, McCafferty, Kieran, Schömig, Michael, Csiky, Botond, Zwiech, Rafal, Wen, Warren, Bhaduri, Sarbani, Munera, Catherine, Lin, Rong, Jebara, Alia, Cirulli, Joshua, Menzaghi, Frédérique

Source: In Kidney Medicine August 2022 4(8)

Utility of a Single Itch-Related Question and the Skindex-10 Questionnaire for Assessing Pruritus and Predicting Health-Related Quality of Life in Patients Receiving Hemodialysis

Authors: Lopes, Marcelo Barreto, Karaboyas, Angelo, Sukul, Nidhi, Tsuruya, Kazuhiko, Al Salmi, Issa, Asgari, Elham, Alyousef, Anas, Schaufler, Thilo, Walpen, Sebastian, Menzaghi, Frederique, Pisoni, Ronald

Source: In Kidney Medicine June 2022 4(6)

Self-reported Pruritus and Clinical, Dialysis-Related, and Patient-Reported Outcomes in Hemodialysis Patients

Authors: Sukul, Nidhi, Karaboyas, Angelo, Csomor, Philipp A., Schaufler, Thilo, Wen, Warren, Menzaghi, Frédérique, Rayner, Hugh C., Hasegawa, Takeshi, Al Salmi, Issa, Al-Ghamdi, Saeed M.G., Guebre-Egziabher, Fitsum, Ureña-Torres, Pablo-Antonio, Pisoni, Ronald L.

Source: In Kidney Medicine January-February 2021 3(1):42-53

Impact of renal impairment on the pharmacokinetic profile of intravenous difelikefalin, a kappa opioid receptor agonist for the treatment of pruritus.

Authors: Spencer, Robert H., Noonan, Patrick K., Marbury, Thomas, Menzaghi, Frédérique

Source: BMC Nephrology; 10/14/2024, Vol. 25 Issue 1, p1-10, 10p

Subject Terms: OPIOID receptors, CHRONIC kidney failure, KIDNEY physiology, KIDNEY diseases, ITCHING

Chronic kidney disease–associated pruritus and quality of life with difelikefalin treatment: a post hoc analysis of phase 3 data using the Skindex-10 questionnaire.

Authors: Ständer, Sonja, Fishbane, Steven, Schaufler, Thilo, Ruessmann, Despina, Morin, Isabelle, Menzaghi, Frédérique, Wen, Warren, Kalantar-Zadeh, Kamyar

Source: Clinical Kidney Journal; Oct2024, Vol. 17 Issue 10, p1-12, 12p

Subject Terms: CLINICAL trials, CHRONIC kidney failure, SOCIAL skills, QUALITY of life, HEMODIALYSIS patients, ITCHING

Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients

Authors: Aaronson, Michael, Alford, Kelly, Awad, Ahmed, Bhat, Premila, Broumand, Varshab, Calhoun, Wesley, Darwish, Riad, Dua, Sohan, Dukes, Carl, Erinle, Ayodele, Hadley, Alexander, Hsieh, John, Kashif, Mohammad, Kopyt, Nelson, Kumar, Jayant, Kusnir, Jorge, Lee, Jean, Maasarani, Essam, Miller, Richard, Mizani, M. Reza, Navarro, Jesus, Podoll, Amber, Pohlman, Thomas, Rivers, Denise, Robinson, Derrick, Rich, Lisa, Shirazian, Shayan, Silva, Arnold, Smith, Mark, Topf, Joel, Tumlin, James, Ungar, Scott, Zeig, Steven, Fishbane, Steven, Mathur, Vandana, Germain, Michael J., Bhaduri, Sarbani, Munera, Catherine, Spencer, Robert H., Menzaghi, Frédérique

Source: In Kidney International Reports May 2020 5(5):600-610

Randomized Controlled Trial of Difelikefalin for Chronic Pruritus in Hemodialysis Patients

Authors: Fishbane, Steven, Mathur, Vandana, Germain, Michael J., Shirazian, Shayan, Bhaduri, Sarbani, Munera, Catherine, Spencer, Robert H., Menzaghi, Frédérique

Source: Kidney international reports. 5(5):600-610

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117631028.0x000001&indx=1&recIds=ETOCvdc_100117631028.0x000001

Difelikefalin improves itch-related sleep disruption in patients undergoing haemodialysis.

Authors: Weiner, Daniel E, Schaufler, Thilo, McCafferty, Kieran, Kalantar-Zadeh, Kamyar, Germain, Michael, Ruessmann, Despina, Morin, Isabelle, Menzaghi, Frédérique, Wen, Warren, Ständer, Sonja

Source: Nephrology Dialysis Transplantation; Jul2024, Vol. 39 Issue 7, p1125-1137, 13p

Subject Terms: SLEEP interruptions, SLEEP quality, HEMODIALYSIS patients, RANK correlation (Statistics), QUALITY of life

Clinically meaningful change in itch intensity scores: An evaluation in patients with chronic kidney disease–associated pruritus

Authors: Vernon, Margaret, Ständer, Sonja, Munera, Catherine, Spencer, Robert H., Menzaghi, Frédérique

Source: Journal of the American Academy of Dermatology. 84(4):1132-1134

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182480925.0x000001&indx=1&recIds=ETOCvdc_100182480925.0x000001

Sites of Neocortical Reorganization Critical for Remote Spatial Memory

Authors: Maviel, Thibault, Durkin, Thomas P., Menzaghi, Frédérique, Bontempi, Bruno

Source: Science, 2004 Jul 01. 305(5680), 96-99.

Access URL: https://www.jstor.org/stable/3837313

Difelikefalin in Black/African American Hemodialysis Patients with Moderate-to-Severe Pruritus: Post hoc Analysis of KALM-1 and KALM-2.

Authors: Fishbane, Steven, Clegg, Deborah J., Lerma, Edgar V., Rastogi, Anjay, Budden, Jeffrey, Morin, Isabelle, Wen, Warren, Menzaghi, Frédérique, Topf, Joel

Source: American Journal of Nephrology; 2024, Vol. 55 Issue 3, p329-333, 5p

Subject Terms: HEMODIALYSIS patients, AFRICAN Americans, ITCHING, KIDNEY failure

Pharmacokinetics, Metabolism, and Excretion of Intravenous [14C]Difelikefalin in Healthy Subjects and Subjects on Hemodialysis.

Authors: Stark, Jeffrey G., Noonan, Patrick K., Spencer, Robert H., Bhaduri, Sarbani, O'Connor, Stephen J., Menzaghi, Frédérique

Source: Clinical Pharmacokinetics; Sep2023, Vol. 62 Issue 9, p1231-1241, 11p

Subject Terms: ITCHING, EXCRETION, KIDNEY physiology, METABOLISM, CHRONIC kidney failure, PHARMACOKINETICS

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