Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia

Authors: Manzoni, Claudia, Kia, Demis A., Ferrari, Raffaele, Leonenko, Ganna, Costa, Beatrice, Saba, Valentina, Jabbari, Edwin, Tan, Manuela MX., Albani, Diego, Alvarez, Victoria, Alvarez, Ignacio, Andreassen, Ole A., Angiolillo, Antonella, Arighi, Andrea, Baker, Matt, Benussi, Luisa, Bessi, Valentina, Binetti, Giuliano, Blackburn, Daniel J., Boada, Merce, Boeve, Bradley F., Borrego-Ecija, Sergi, Borroni, Barbara, Bråthen, Geir, Brooks, William S., Bruni, Amalia C., Caroppo, Paola, Bandres-Ciga, Sara, Clarimon, Jordi, Colao, Rosanna, Cruchaga, Carlos, Danek, Adrian, de Boer, Sterre CM., de Rojas, Itziar, di Costanzo, Alfonso, Dickson, Dennis W., Diehl-Schmid, Janine, Dobson-Stone, Carol, Dols-Icardo, Oriol, Donizetti, Aldo, Dopper, Elise, Durante, Elisabetta, Ferrari, Camilla, Forloni, Gianluigi, Frangipane, Francesca, Fratiglioni, Laura, Kramberger, Milica G., Galimberti, Daniela, Gallucci, Maurizio, García-González, Pablo, Ghidoni, Roberta, Giaccone, Giorgio, Graff, Caroline, Graff-Radford, Neill R., Grafman, Jordan, Halliday, Glenda M., Hernandez, Dena G., Hjermind, Lena E., Hodges, John R., Holloway, Guy, Huey, Edward D., Illán-Gala, Ignacio, Josephs, Keith A., Knopman, David S., Kristiansen, Mark, Kwok, John B., Leber, Isabelle, Leonard, Hampton L., Libri, Ilenia, Lleo, Alberto, Mackenzie, Ian R., Madhan, Gaganjit K., Maletta, Raffaele, Marquié, Marta, Maver, Ales, Menendez-Gonzalez, Manuel, Milan, Graziella, Miller, Bruce L., Morris, Christopher M., Morris, Huw R., Nacmias, Benedetta, Newton, Judith, Nielsen, Jørgen E., Nilsson, Christer, Novelli, Valeria, Padovani, Alessandro, Pal, Suvankar, Pasquier, Florence, Pastor, Pau, Perneczky, Robert, Peterlin, Borut, Petersen, Ronald C., Piguet, Olivier, Pijnenburg, Yolande AL., Puca, Annibale A., Rademakers, Rosa, Rainero, Innocenzo, Reus, Lianne M., Richardson, Anna MT., Riemenschneider, Matthias, Rogaeva, Ekaterina, Rogelj, Boris, Rollinson, Sara, Rosen, Howard, Rossi, Giacomina, Rowe, James B., Rubino, Elisa, Ruiz, Agustin, Salvi, Erika, Sanchez-Valle, Raquel, Sando, Sigrid Botne, Santillo, Alexander F., Saxon, Jennifer A., Schlachetzki, Johannes CM., Scholz, Sonja W., Seelaar, Harro, Seeley, William W., Serpente, Maria, Sorbi, Sandro, Sordon, Sabrina, St George-Hyslop, Peter, Thompson, Jennifer C., Van Broeckhoven, Christine, Van Deerlin, Vivianna M., Van der Lee, Sven J., Van Swieten, John, Tagliavini, Fabrizio, van der Zee, Julie, Veronesi, Arianna, Vitale, Emilia, Waldo, Maria Landqvist, Yokoyama, Jennifer S., Nalls, Mike A., Momeni, Parastoo, Singleton, Andrew B., Hardy, John, Escott-Price, Valentina

Source: In The American Journal of Human Genetics 11 July 2024 111(7):1316-1329

Smoking is associated with age at disease onset in Parkinson's disease

Authors: Adarmes-Gómez, Astrid D., Aguilar, Miquel, Alvarez, Ignacio, Barrero, Francisco Javier, Bergareche Yarza, Jesús Alberto, Bonilla-Toribio, Marta, Botía, Juan A., Boungiorno, María Teresa, Buiza-Rueda, Dolores, Cámara, Ana, Carrillo, Fátima, Cerdan, Debora, Clarimón, Jordi, Compta, Yaroslau, Diez-Fairen, Monica, Dols-Icardo, Oriol, de Fabregues, Oriol, Cartagena, Pilar Sanz, Duarte, Jacinto, Duran, Raquel, Escamilla-Sevilla, Francisco, Ezquerra, Mario, Feliz, Cici, Fernández-Santiago, Rubén, Fernández, Manel, García-Ruiz, Pedro, Gómez-Garre, Pilar, Gomez Heredia, Maria Jose, Gonzalez-Aramburu, Isabel, Gorostidi, Ana, Hoenicka, Janet, Infante, Jon, Jesús, Silvia, Jimenez-Escrig, Adriano, Kulisevsky, Jaime, Labrador-Espinosa, Miguel A., Lopez-Sendon, Jose Luis, López de Munain, Adolfo, Macias-Garcia, Daniel, Martínez-Torres, Irene, Marín, Juan, Marti, Maria Jose, Martínez-Castrillo, Juan Carlos, Álvarez-Santullano, Marina Mata, Mínguez-Castellanos, Adolfo, Mir, Pablo, Rezola, Elisabet Mondragon, Muñoz, Esteban, Pagonabarraga, Javier, Pastor, Pau, Errazquin, Francisco Perez, Periñán, Maria Teresa, Ruiz-Martínez, Javier, Ruz, Clara, Rodriguez, Antonio Sanchez, Sierra, María, Tabernero, Cesar, Tartari, Juan Pablo, Tolosa, Eduard, Valldeoriola, Francesc, Vela, Lydia, Vives, Francisco, Pascual-Sedano, Berta, Hernández-Vara, Jorge, Rolán, Dolores Vilas, Bandrés-Ciga, Sara, Rosas, Irene, Morís, Germán, Coto, Eliecer, Blázquez-Estrada, Marta, Suárez, Esther, García-Fernández, Ciara, Martínez, Carmen, Herrera, Israel Duarte, Pérez-Oliveira, Sergio, Álvarez, Victoria, Menéndez-González, Manuel

Source: In Parkinsonism and Related Disorders April 2022 97:79-83

HTT, ATXN1 and ATXN2 CAG triplet repeat sizes: exploring their role in the disease risk and cancer comorbidity in Parkinson's disease.

Authors: Pérez-Oliveira, Sergio, Álvarez, Ignacio, Menéndez-González, Manuel, Duarte-Herrera, Israel David, Blázquez-Estrada, Marta, Castilla-Silgado, Juan, Suárez, Esther, García-Fernández, Ciara, Siso-García, Pablo, García-González, Pablo, Rosende-Roca, Maitee, Boada, Mercè, Ruiz, Agustín, Infante, Jon, Casa-Fages, Beatriz De la, González-Aramburu, Isabel, Álvarez, Victoria, Pastor, Pau

Source: Brain Communications; 2025, Vol. 7 Issue 1, p1-12, 12p

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Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications

Authors: Menéndez-González Manuel, Bogdan-Ionel Tamba, Maxime Leclere, Mostafa Mabrouk, Thomas-Gabriel Schreiner, Romeo Ciobanu, Tomás-Zapico Cristina

Source: Pharmaceutics, Vol 15, Iss 3, p 768 (2023)

Subject Terms: drug delivery systems, intrathecal pseudodelivery, neurodegenerative diseases, intrathecal device, nanoporous membranes, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/3/768; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/21988781a83d4e678aa64d3dc4e2f24f

Analysis of the Influence of Depression on the Occupational Performance of People Diagnosed with Multiple Sclerosis and Its Impact on Caregiver Burden.

Authors: Rodríguez Menéndez, Sergio, Perez-de-Heredia-Torres, Marta, Jaraba Berné, David, Menéndez González, Manuel, Martínez-Piédrola, Rosa Mª, Liu, Xinqiao

Source: Depression & Anxiety (1091-4269); 8/9/2024, Vol. 2024, p1-5, 5p

Subject Terms: BURDEN of care, MULTIPLE sclerosis, DEGENERATION (Pathology), MENTAL depression, SYMPTOMS

Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights.

Authors: Pérez‐Oliveira, Sergio, Castilla‐Silgado, Juan, Painous, Cèlia, Aldecoa, Iban, Menéndez‐González, Manuel, Blázquez‐Estrada, Marta, Corte, Daniela, Tomás‐Zapico, Cristina, Compta, Yaroslau, Muñoz, Esteban, Lladó, Albert, Balasa, Mircea, Aragonès, Gemma, García‐González, Pablo, Rosende‐Roca, Maitée, Boada, Mercè, Ruíz, Agustín, Pastor, Pau, De la Casa‐Fages, Beatriz, Rabano, Alberto

Source: Brain Pathology; Jul2024, Vol. 34 Issue 4, p1-15, 15p

Subject Terms: TAUOPATHIES, PROGRESSIVE supranuclear palsy, ALZHEIMER'S disease, HUNTINGTON disease, NEURODEGENERATION

NFKB1 variants were associated with the risk of Parkinson´s disease in male.

Authors: Perez-Oliveira, Sergio, Vazquez-Coto, Daniel, Pardo, Sara, Blázquez-Estrada, Marta, Menéndez-González, Manuel, Siso, Pablo, Suárez, Esther, García-Fernández, Ciara, Fages, Beatriz de la Casa, Coto, Eliecer, Álvarez, Victoria

Source: Journal of Neural Transmission; Jul2024, Vol. 131 Issue 7, p773-779, 7p

Subject Terms: PARKINSON'S disease, NF-kappa B, GENDER differences (Sociology), PATIENTS, LINKAGE disequilibrium

Genetic variation in APOE, GRN, and TP53 are phenotype modifiers in frontotemporal dementia

Authors: Rosas, Irene, Martínez, Carmen, Coto, Eliecer, Clarimón, Jordi, Lleó, Alberto, Illán-Gala, Ignacio, Dols-Icardo, Oriol, Borroni, Barbara, Almeida, Maria Rosário, van der Zee, Julie, Van Broeckhoven, Christine, Bruni, Amalia C., Anfossi, Maria, Bernardi, Livia, Maletta, Raffaele, Serpente, María, Galimberti, Daniela, Scarpini, Elio, Rossi, Giacomina, Caroppo, Paola, Benussi, Luisa, Ghidoni, Roberta, Binetti, Giuliano, Nacmias, Benedetta, Sorbi, Sandro, Piaceri, Irene, Bagnoli, Silvia, Antonell, Anna, Sánchez-Valle, Raquel, De la Casa-Fages, Beatriz, Grandas, Francisco, Diez-Fairen, Mónica, Pastor, Pau, Ferrari, Raffaele, Queimaliños-Perez, Daniel, Pérez-Oliveira, Sergio, Álvarez, Victoria, Menéndez-González, Manuel

Source: In Neurobiology of Aging March 2021 99:99-99

Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease

Authors: Rosas, Irene, Martínez, Carmen, Clarimón, Jordi, Lleó, Alberto, Illán-Gala, Ignacio, Dols-Icardo, Oriol, Borroni, Barbara, Almeida, Maria Rosário, van der Zee, Julie, Van Broeckhoven, Christine, Bruni, Amalia C., Anfossi, Maria, Bernardi, Livia, Maletta, Raffaele, Serpente, María, Galimberti, Daniela, Scarpini, Elio, Rossi, Giacomina, Caroppo, Paola, Benussi, Luisa, Ghidoni, Roberta, Binetti, Giuliano, Nacmias, Benedetta, Sorbi, Sandro, Piaceri, Irene, Bagnoli, Silvia, Antonell, Anna, Sánchez-Valle, Raquel, De la Casa-Fages, Beatriz, Grandas, Francisco, Diez-Fairen, Mónica, Pastor, Pau, Ferrari, Raffaele, Álvarez, Victoria, Menéndez-González, Manuel

Source: In Neurobiology of Aging March 2020 87:139-139

Chapter 7 - Liquorpheresis: CSF filtering therapy

Authors: Menendez-Gonzalez, Manuel

Source: In Cerebrospinal Fluid and Subarachnoid Space 2023:93-97

HTT gene intermediate alleles in neurodegeneration: evidence for association with Alzheimer's disease

Authors: Menéndez-González, Manuel, Clarimón, Jordi, Rosas-Allende, Irene, Blázquez, Marta, San Martín, Esther Suárez, García-Fernández, Ciara, Lleó, Alberto, Dols-Icardo, Oriol, Illán-Gala, Ignacio, Morís, Germán, Ribacoba, Renée, Álvarez, Victoria, Martínez, Carmen

Source: In Neurobiology of Aging April 2019 76:215-215

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A Nanostructured Protein Filtration Device for Possible Use in the Treatment of Alzheimer's Disease—Concept and Feasibility after In Vivo Tests.

Authors: Schreiner, Thomas Gabriel^1,2,3 (AUTHOR) schreiner.thomasgabriel@yahoo.com, Menéndez-González, Manuel^4,5,6 (AUTHOR), Adam, Maricel³ (AUTHOR), Popescu, Bogdan Ovidiu^1,7,8 (AUTHOR), Szilagyi, Andrei⁹ (AUTHOR), Stanciu, Gabriela Dumitrita⁹ (AUTHOR), Tamba, Bogdan Ionel^2,9 (AUTHOR), Ciobanu, Romeo Cristian³ (AUTHOR) schreiner.thomasgabriel@yahoo.com

Source: Bioengineering (Basel). Nov2023, Vol. 10 Issue 11, p1303. 21p.

Subject Terms: *ALZHEIMER'S disease, *FILTERS & filtration, *CRYSTAL filters, *CENTRAL nervous system, *CEREBROSPINAL fluid, *NEURODEGENERATION

Reply to comment on “A series of cases with Huntington-like phenotype and intermediate repeats in HTT” by Acuña and colleagues

Authors: Menéndez-González, Manuel

Source: In Journal of the Neurological Sciences 15 November 2022 442

Refining Stereotaxic Neurosurgery Techniques and Welfare Assessment for Long-Term Intracerebroventricular Device Implantation in Rodents.

Authors: Pérez-Martín, Ester, Coto-Vilcapoma, Almudena, Castilla-Silgado, Juan, Rodríguez-Cañón, María, Prado, Catuxa, Álvarez, Gabriel, Álvarez-Vega, Marco Antonio, Fernández-García, Benjamín, Menéndez-González, Manuel, Tomás-Zapico, Cristina

Source: Animals (2076-2615); Aug2023, Vol. 13 Issue 16, p2627, 25p

Subject Terms: STEREOTAXIC techniques, ANIMAL welfare, DRUG storage, SURGICAL complications, RODENTS, OPTICAL disks, DEEP brain stimulation, NEUROSCIENCES, ARTIFICIAL implants

Toward a new nosology of neurodegenerative diseases.

Authors: Menéndez‐González, Manuel

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Aug2023, Vol. 19 Issue 8, p3731-3737, 7p

A series of cases with Huntington-like phenotype and intermediate repeats in HTT

Authors: Reguera Acuña, Antía, Suárez San Martín, Esther, García Fernández, Ciara, Fernández Menéndez, Santiago, Blázquez Estrada, Marta, Amorín Díaz, Manuel, Menéndez González, Manuel, Álvarez Martínez, Victoria

Source: In Journal of the Neurological Sciences 15 June 2021 425

Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer's Disease Aetiopathogenesis in Men.

Authors: García-González, Pablo, de Rojas, Itziar, Moreno-Grau, Sonia, Montrreal, Laura, Puerta, Raquel, Alarcón-Martín, Emilio, Quintela, Inés, Orellana, Adela, Andrade, Victor, Adami, Pamela V. Martino, Heilmann-Heimbach, Stefanie, Gomez-Garre, Pilar, Periñán, María Teresa, Alvarez, Ignacio, Diez-Fairen, Monica, Nuñez Llaves, Raul, Olivé Roig, Claudia, Garcia-Ribas, Guillermo, Menéndez-González, Manuel, Martínez, Carmen

Source: International Journal of Molecular Sciences; Jan2023, Vol. 24 Issue 2, p898, 17p

Subject Terms: Y chromosome, ALZHEIMER'S disease, DISEASE risk factors, MOSAICISM, MILD cognitive impairment, TAU proteins

FEASIBILITY AND SAFETY OF LONG-TERM INTRATHECAL PSEUDODELIVERY OF IMMUNOTHERAPY FOR SELECTIVE CLEARANCE OF CSF AMYLOID-Β IN A MOUSE MODEL OF ALZHEIMER’S DISEASE

Authors: Menéndez, Gabriel Álvarez, Prado, Catuxa, Rodríguez-Cañón, María, Coto-Vilcapoma, María Almudena, Castilla-Silgado, Juan, Pinto-Hernández, Paola, Menéndez-González, Manuel, Tomás-Zapico, Cristina

Source: In IBRO Neuroscience Reports October 2023 15 Supplement 1:S475-S475