Ribonucleotide reductase, a novel drug target for gonorrhea

Authors: Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom

Source: eLife, Vol 11 (2022)

Subject Terms: neisseria gonorrhoeae, gonorrhea, ribonucleotide reductase, multidrug resistance, 2-pyridone, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/67447; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/e2f24e41f41645fe97c9ca6615d7120b

Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.

Authors: Melissa Dumble, Ming-Chih Crouthamel, Shu-Yun Zhang, Michael Schaber, Dana Levy, Kimberly Robell, Qi Liu, David J Figueroa, Elisabeth A Minthorn, Mark A Seefeld, Meagan B Rouse, Sridhar K Rabindran, Dirk A Heerding, Rakesh Kumar

Source: PLoS ONE, Vol 9, Iss 6, p e100880 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4076210?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/332f1cf8dcff42b69e7e64f5dde37d45

Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors.

Authors: Jesús R. Medina, Christopher J. Becker, Charles W. Blackledge, Celine Duquenne, Yanhong Feng, Seth W. Grant, Dirk Heerding, William H. Li, William H. Miller, Stuart P. Romeril, Daryl Scherzer, Arthur Shu, Mark A. Bobko, Antony R. Chadderton, Melissa Dumble, Christine M. Gardiner, Seth Gilbert, Qi Liu, Sridhar K. Rabindran, Valery Sudakin

Source: Journal of Medicinal Chemistry; Mar2011, Vol. 54 Issue 6, p1871-1895, 25p

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

Authors: Bonnie Nannenga, Xiongbin Lu, Melissa Dumble, Marc Van Maanen, Thuy‐Ai Nguyen, Richard Sutton, T. Rajendra Kumar, Lawrence A. Donehower

Source: Molecular Carcinogenesis; Aug2006, Vol. 45 Issue 8, p594-604, 11p