Fatty acid synthase (FASN) inhibition cooperates with BH3 mimetic drugs to overcome resistance to mitochondrial apoptosis in pancreatic cancer

Authors: Steen, Travis Vander ^a, Espinoza, Ingrid ^{b, c}, Duran, Cristina ^d, Casadevall, Guillem ^d, Serrano-Hervás, Eila ^{e, f}, Cuyàs, Elisabet ^{e, f}, Verdura, Sara ^{e, f}, Kemble, George ^g, Kaufmann, Scott H. ^{h, i, j}, McWilliams, Robert ^{h, i}, Osuna, Sílvia ^{d, k}, Billadeau, Daniel D. ^{h, j, l, m}, Menendez, Javier A. ^{e, f, ⁎⁎}, Lupu, Ruth ^{a, h, l, ⁎}

Source: In Neoplasia April 2025 62

Early vs conventional onset pancreatic ductal adenocarcinoma: analysis of surgical and oncologic outcomes in patients undergoing curative intent resection

Authors: Zironda, Andrea, Zhang, Chi, Day, Courtney, McWilliams, Robert R., Starlinger, Patrick, Warner, Susanne G., Smoot, Rory L., Cleary, Sean P., Kendrick, Micheal L., Truty, Mark J., Thiels, Cornelius A.

Source: In HPB January 2024 26(1):145-153

Metastatic site and clinical outcome of patients with deficient mismatch repair metastatic colorectal cancer treated with an immune checkpoint inhibitor in the first-line setting

Authors: Saberzadeh-Ardestani, Bahar, Jones, Jeremy C., McWilliams, Robert R., Tougeron, David, Halfdanarson, Thorvardur R., Guimbaud, Rosine, Hubbard, Joleen M., Flecchia, Clémence, Shi, Qian, Alouani, Emily, Sonbol, Mohamad B., Ticku, Jonathan, Jin, Zhaohui, Taieb, Julien, Sinicrope, Frank A.

Source: In European Journal of Cancer January 2024 196

Anorectal melanoma

Authors: Fastner, Suzanne, Hieken, Tina J., McWilliams, Robert R., Hyngstrom, John

Source: Journal of surgical oncology. 128(4):635-644

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189977754.0x000001&indx=1&recIds=ETOCvdc_100189977754.0x000001

Sinonasal mucosal melanoma: An analysis of treatment‐related adverse events and associated factors

Authors: Johnson, Brian J., Guo, Ruifeng, Moore, Eric J., Price, Daniel L., Van Abel, Kathryn M., Van Gompel, Jamie J., Link, Michael J., Peris‐Celda, Maria, Stokken, Janalee K., Pinheiro‐Neto, Carlos, Kottschade, Lisa, Markovic, Svetomir, Block, Matthew, McWilliams, Robert, Montane, Heather, Dimou, Anastasios, Gergelis, Kimberly, Gamez, Mauricio E., Choby, Garret

Source: International forum of allergy & rhinology. 13(6):1037-1041

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184488721.0x000001&indx=1&recIds=ETOCvdc_100184488721.0x000001

Reducing Cancer Drug Cost: 3-Year Analysis of Automated Dose Rounding in Electronic Health Records.

Authors: Shah, Vishal S., Irvine, Clayton, McWilliams, Robert R., Singh, Parminder, Soefje, Scott A.

Source: JCO Oncology Practice; Mar2025, Vol. 21 Issue 3, p400-407, 8p

Subject Terms: COST control, PHARMACEUTICAL arithmetic, RESEARCH funding, ANTINEOPLASTIC agents, MEDICAL wastes, RETROSPECTIVE studies, DESCRIPTIVE statistics, CANCER chemotherapy, ELECTRONIC health records, MEDICAL records, ACQUISITION of data, DATA analysis software, MEDICAL care costs, ECONOMICS

Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma.

Authors: Yao, Yuan, Yan, Yiyi, Suman, Vera J., Dietz, Allan B., Erskine, Courtney L., Dimou, Anastasios, Markovic, Svetomir N., McWilliams, Robert R., Montane, Heather N., Block, Matthew S.

Source: Frontiers in Immunology; 2025, p1-9, 9p

Subject Terms: BRUTON tyrosine kinase, IMMUNE checkpoint inhibitors, OVERALL survival, PROGRESSION-free survival, BIOMARKERS

Incidence and survival trends in small bowel adenocarcinoma (SBA) from 2000-2019 in the United States.

Authors: Sears, James Jerod, Xu, Yifei, Liu, Jingxia, Fiala, Mark Aaron, McWilliams, Robert R., Overman, Michael J., Pedersen, Katrina Sophia

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p801-801, 6p

Clinical outcomes and molecular characteristics of patients with locoregional ampullary carcinoma.

Authors: Eslinger, Cody, Chang, Isabela, Fonseca, Rodrigo, Sahvan, Oudai, Yee, Claire I., Truman, Mia, McWilliams, Robert R., Babiker, Hani M., Pai, Rish, Wu, Christina, Ahn, Daniel H., Borad, Mitesh, Bekaii-Saab, Tanios S., Sonbol, Mohamad B.

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p732-732, 121p

Phase II study of niraparib and dostarlimab for the treatment of germline or somatic homologous recombination repair mutated (HRD) metastatic pancreatic cancer.

Authors: Jazieh, Khalid, Babiker, Hani M., Foster, Nathan R., Fruth, Briant, Carr, Ryan Michael, Alberts, Steven R, Conboy, Caitlin, Tran, Nguyen H., Hartgers, Mindy L., Halfdanarson, Thorvardur Ragnar, Starr, Jason S., Sonbol, Mohamad Bassam, Jones, Jeremy Clifton, Ahn, Daniel H., Kankeu Fonkoua, Lionel Aurelien, Wu, Christina, Pedersen, Katrina Sophia, Bekaii-Saab, Tanios S., McWilliams, Robert R.

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p727-727, 121p

Social determinants of health and financial burden among patients with pancreatic cancer at a tertiary cancer center.

Authors: Jazieh, Khalid, Lee, Minji K, Steinert, Kimberly O., Lin, Miranda, McWilliams, Robert R.

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p678-678, 121p

First line atezolizumab + bevacizumab (atezo/bev) or durvalumab ± tremelimumab (durva±treme) in unresectable hepatocellular carcinoma (HCC): A real world, multi-institutional retrospective cohort study.

Authors: Kournoutas, Ioannis, Marell, Paulina S, Peersen, Anina, Gupta, Garima, Akce, Mehmet, Yang, Ju Dong, Chen, Pin-Jung, Naleid, Nikolas, Mahipal, Amit, Sahai, Vaibhav, Thompson, Scott, Jin, Zhaohui, Venkatesh, Sudhakar, Borad, Mitesh J., Babiker, Hani M., Bekaii-Saab, Tanios S., McWilliams, Robert R., Halfdanarson, Thorvardur Ragnar, Ou, Fang-Shu, Tran, Nguyen H.

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p532-532, 132p

BRAF V600 Mutation Detection in Plasma Cell-Free DNA: NCCTG N0879 (Alliance)

Authors: Slostad, Jessica A., Liu, Minetta C., Allred, Jacob B., Erickson, Lori A., Rumilla, Kandelaria M., Block, Matthew S., Keppen, Michael, King, David, Markovic, Svetomir N., McWilliams, Robert R.

Source: In Mayo Clinic Proceedings: Innovations, Quality & Outcomes December 2021 5(6):1012-1020

Osteoclast-Like Giant Cell Tumors of the Pancreas

Authors: Ueberroth, Benjamin E., Liu, Alex J., Graham, Rondell P., Bekaii-Saab, Tanios S., McWilliams, Robert R., Mahipal, Amit, Truty, Mark J., Mody, Kabir, Sonbol, M. Bassam, Halfdanarson, Thorvardur R.

Source: Pancreas. 50(7):952-956

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182314985.0x000001&indx=1&recIds=ETOCvdc_100182314985.0x000001

Tumor-Informed Circulating Tumor DNA for Minimal Residual Disease Detection in the Management of Colorectal Cancer.

Authors: Emiloju, Oluwadunni E., Storandt, Michael, Zemla, Tyler, Tran, Nguyen, Jethwa, Krishan, Mahipal, Amit, Mitchell, Jessica, Thiels, Cornelius, Mathis, Kellie, McWilliams, Robert, Hubbard, Joleen, Sinicrope, Frank, Shi, Qian, Jin, Zhaohui

Source: JCO Precision Oncology; 12/1/2024, Vol. 8, p1-10, 10p

Subject Terms: CIRCULATING tumor DNA, CARCINOEMBRYONIC antigen, COLORECTAL cancer, MEDICAL records, DISEASE management

Real-world evidence on efficacy and toxicity of targeted therapy in older melanoma patients treated in a tertiary-hospital setting.

Authors: Stoff, Ronen, Markovic, Svetomir N., McWilliams, Robert R., Kottschadea, Lisa A., Montane, Heather N., Dimou, Anastasios, Dudek, Arkadiusz Z., Tan, Winston, Dronca, Roxana S., Seetharam, Mahesh, Ruqin Chen, Block, Matthew S.

Source: Melanoma Research; Dec2024, Vol. 34 Issue 6, p510-518, 9p

Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study

Authors: Marabelle, Aurélien ^*, Fakih, Marwan, Lopez, Juanita, Shah, Manisha, Shapira-Frommer, Ronnie, Nakagawa, Kazuhiko, Chung, Hyun Cheol, Kindler, Hedy L, Lopez-Martin, Jose A, Miller, Wilson H, Jr, Italiano, Antoine, Kao, Steven, Piha-Paul, Sarina A, Delord, Jean-Pierre, McWilliams, Robert R, Fabrizio, David A, Aurora-Garg, Deepti, Xu, Lei, Jin, Fan, Norwood, Kevin, Bang, Yung-Jue

Source: In The Lancet Oncology October 2020 21(10):1353-1365

Tu1420 INCIDENCE AND EFFECT DURATION OF IMMUNE CHECKPOINT INHIBITOR RELATED PANCREAS ADVERSE EVENTS

Authors: Gleeson, Ferga C., Kottschade, Lisa, Dunleavy, Katie A., Carr, Ryan M., Hartgers, Mindy, Levy, Michael J., Ma, Wen Wee, McWilliams, Robert, Egan, Aoife

Source: Gastroenterology. 164(6):S-1049-S-1049

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194459965.0x000001&indx=1&recIds=ETOCvdc_100194459965.0x000001

Understanding Suboptimal Response to Immune Checkpoint Inhibitors

Authors: Zhu, Mojun, Zhang, Henan, Pedersen, Katrina S., Foster, Nathan R., Jaszewski, Brandy L., Liu, Xin, Hirdler, Jacob B., An, Zesheng, Bekaii‐Saab, Tanios S., Halfdanarson, Thorvardur R., Boland, Patrick M., Yan, Yiyi, Hubbard, Joleen H., Ma, Wen Wee, Yoon, Harry H., Revzin, Alexander, Fernandez‐Zapico, Martin E., Overman, Michael J., McWilliams, Robert R., Dong, Haidong

Source: Advanced biology. 7(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181410950.0x000001&indx=1&recIds=ETOCvdc_100181410950.0x000001

Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer

Authors: McCleary-Wheeler, Angela L., Carr, Ryan M., Palmer, Shanique R., Smyrk, Thomas C., Allred, Jacob B., Almada, Luciana L., Tolosa, Ezequiel J., Lamberti, Maria J., Marks, David L., Borad, Mitesh J., Molina, Julian R., Qi, Yingwei, Lingle, Wilma L., Grothey, Axel, Pitot, Henry C., Jatoi, Aminah, Northfelt, Donald W., Bryce, Alan H., McWilliams, Robert R., Okuno, Scott H., Haluska, Paul, Kim, George P., Colon-Otero, Gerardo, Lowe, Val J., Callstrom, Matthew R., Ma, Wen We, Bekaii-Saab, Tanios, Hung, Mien-Chie, Erlichman, Charles, Fernandez-Zapico, Martin E.

Source: In Pancreatology January 2020 20(1):101-109