Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells

Authors: Myers, Chloe G., Viswambharan, Hema, Haywood, Natalie J., Bridge, Katherine, Turvey, Samuel, Armstrong, Tom, Lunn, Lydia, Meakin, Paul J., Porter, Karen E., Clavane, Eva M., Beech, David J., Cubbon, Richard M., Wheatcroft, Stephen B., McPhillie, Martin J., Issad, Tarik, Fishwick, Colin WG., Kearney, Mark T., Simmons, Katie J.

Source: In Molecular and Cellular Endocrinology 1 December 2024 594

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulatorsElectronic supplementary information (ESI) available. See DOI: 10.1039/d1md00300c

Authors: Turvey, Samuel J., McPhillie, Martin J., Kearney, Mark T., Muench, Stephen P., Simmons, Katie J., Fishwick, Colin W. G.

Source: RSC medicinal chemistry. 13(4):360-374

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150175932.0x000001&indx=1&recIds=ETOCvdc_100150175932.0x000001

De novo design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding regionElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00049k

Authors: Orritt, Kyle M., Feng, Lipeng, Newell, Juliette F., Sutton, Jack N., Grossman, Scott, Germe, Thomas, Abbott, Lauren R., Jackson, Holly L., Bury, Benjamin K. L., Maxwell, Anthony, McPhillie, Martin J., Fishwick, Colin W. G.

Source: RSC medicinal chemistry. 13(7):831-839

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156145190.0x000001&indx=1&recIds=ETOCvdc_100156145190.0x000001

Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia

Authors: Dokla, Eman M.E., Abdel-Aziz, Amal Kamal, Milik, Sandra N., McPhillie, Martin J., Minucci, Saverio, Abouzid, Khaled A.M.

Source: In Bioorganic & Medicinal Chemistry 15 February 2022 56

Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancer

Authors: Dokla, Eman M.E., Abdel-Aziz, Amal Kamal, Milik, Sandra N., Mahmoud, Amr H., Saadeldin, Mona Kamal, McPhillie, Martin J., Minucci, Saverio, Abouzid, Khaled A.M.

Source: In Bioorganic Chemistry December 2021 117

Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?

Authors: Shimizu, Jacqueline Farinha, Martins, Daniel Oliveira Silva, McPhillie, Martin J., Roberts, Grace C., Zothner, Carsten, Merits, Andres, Harris, Mark, Jardim, Ana Carolina Gomes

Source: In Acta Tropica July 2020 207

SAR investigation and optimization of benzimidazole-based derivatives as antimicrobial agents against Gram-negative bacteria

Authors: Dokla, Eman M.E., Abutaleb, Nader S., Milik, Sandra N., Kandil, Ezzat A.E.A., Qassem, Omar M., Elgammal, Yehia, Nasr, Maha, McPhillie, Martin J., Abouzid, Khaled A.M., Seleem, Mohamed N., Imming, Peter, Adel, Mai

Source: European journal of medicinal chemistry. 247

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180122063.0x000001&indx=1&recIds=ETOCvdc_100180122063.0x000001

N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites

Authors: Chandrabalan, Arundhasa, McPhillie, Martin J., Morice, Alyn H., Boa, Andrew N., Sadofsky, Laura R.

Source: In European Journal of Medicinal Chemistry 15 May 2019 170:141-156

Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM

Authors: Rawson, Shaun, Bisson, Claudine, Hurdiss, Daniel L., Fazal, Asif, McPhillie, Martin J., Sedelnikova, Svetlana E., Baker, Patrick J., Rice, David W., Muench, Stephen P.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Feb . 115(8), 1795-1800.

Access URL: https://www.jstor.org/stable/26507560

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV.

Authors: Grossman, Scott, Fishwick, Colin W. G., McPhillie, Martin J.

Source: Pharmaceuticals (14248247); Feb2023, Vol. 16 Issue 2, p261, 17p

Subject Terms: DNA topoisomerase I, DNA topoisomerase inhibitors, ADENOSINE triphosphatase, ANTI-infective agents, DRUG resistance in bacteria, SINGLE nucleotide polymorphisms, ANTIBIOTICS

Computational Methods to Identify New Antibacterial Targets.

Authors: McPhillie, Martin J.¹, Cain, Ricky M.¹, Narramore, Sarah¹, Fishwick, Colin W. G.¹, Simmons, Katie J.¹

Source: Chemical Biology & Drug Design. Jan2015, Vol. 85 Issue 1, p22-29. 8p.

Subject Terms: *ANTIBACTERIAL agents, *DRUG resistance, *CHEMINFORMATICS, *DATABASES, *LIGAND binding (Biochemistry), *DRUG development, *ALGORITHMS

De novodesign of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding regionElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00049k

Authors: Orritt, Kyle M., Feng, Lipeng, Newell, Juliette F., Sutton, Jack N., Grossman, Scott, Germe, Thomas, Abbott, Lauren R., Jackson, Holly L., Bury, Benjamin K. L., Maxwell, Anthony, McPhillie, Martin J., Fishwick, Colin W. G.

Source: MedChemComm; 2022, Vol. 13 Issue: 7 p831-839, 9p

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites.

Authors: McPhillie, Martin J., Zhou, Ying, Hickman, Mark R., Gordon, James A., Weber, Christopher R., Li, Qigui, Lee, Patty J., Amporndanai, Kangsa, Johnson, Rachel M., Darby, Heather, Woods, Stuart, Li, Zhu-hong, Priestley, Richard S., Ristroph, Kurt D., Biering, Scott B., El Bissati, Kamal, Hwang, Seungmin, Hakim, Farida Esaa, Dovgin, Sarah M., Lykins, Joseph D.

Source: Frontiers in Cellular & Infection Microbiology; 6/17/2020, Vol. 10, p1-27, 27p

Subject Terms: CYTOCHROME b, TOXOPLASMA gondii, PARASITES, PLASMODIUM falciparum, TOXOPLASMOSIS

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The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

Authors: Wilkinson, Craig, McPhillie, Martin J., Zhou, Ying, Woods, Stuart, Afanador, Gustavo A., Rawson, Shaun, Khaliq, Farzana, Prigge, Sean T., Roberts, Craig W., Rice, David W., McLeod, Rima, Fishwick, Colin W., Muench, Stephen P.

Source: In Bioorganic & Medicinal Chemistry Letters 1 February 2014 24(3):911-916

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides

Authors: Muench, Stephen P., Stec, Jozef, Zhou, Ying, Afanador, Gustavo A., McPhillie, Martin J., Hickman, Mark R., Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Prigge, Sean T., Rice, David W., McLeod, Rima

Source: In Bioorganic & Medicinal Chemistry Letters 15 June 2013 23(12):3551-3555

1,4-Diazepines

Authors: Boa, Andrew N., McPhillie, Martin J.

Source: In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 2013

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Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations.

Authors: El Bissati, Kamal, Redel, Henry, Ting, Li-Min, Lykins, Joseph D., McPhillie, Martin J., Upadhya, Rajendra, Woster, Patrick M., Yarlett, Nigel, Kim, Kami, Weiss, Louis M.

Source: Frontiers in Cellular & Infection Microbiology; 2/14/2019, Vol. 9, pN.PAG-N.PAG, 9p

Subject Terms: PLASMODIUM falciparum, ANTIMALARIALS, PLASMODIUM, SPERMIDINE, POLYAMINES

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