Survey of NF1 inactivation by surrogate immunohistochemistry in ovarian carcinomas

Authors: Köbel, Martin, Yang, Rui Zhe, Kang, Eun Young, Al-Shamma, Zainab, Cook, Linda S., Kinloch, Mary, Carey, Mark S., Hopkins, Laura, Nelson, Gregg S., McManus, Kirk J., Vizeacoumar, Frederick S., Vizeacoumar, Franco J., Freywald, Andrew, Fu, YangXin, Reuss, David E., Lee, Cheng-Han

Source: In Gynecologic Oncology November 2023 178:80-88

Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer

Authors: Liu, Qian, Huang, Shujun, Desautels, Danielle, McManus, Kirk J., Murphy, Leigh, Hu, Pingzhao

Source: In Computational and Structural Biotechnology Journal 2023 21:2940-2949

DREAM, a possible answer to the estrogen paradox of the Women's Health Initiative Trial

Authors: Hugh, Judith C., Haddon, Lacey S.J., Githaka, John Maringa, Bigras, Gilbert, Hu, Xiuying, Madden, Brittney, Hanson, John, Gabos, Zsolt, Giannakopoulos, Nadia V., Huang, Fleur, Hitt, Mary M., McManus, Kirk J., Olson, David, Dabbs, Kelly, Mackey, John R.

Source: In Heliyon January 2022 8(1)

Chromosome instability is prevalent and dynamic in high-grade serous ovarian cancer patient samples

Authors: Morden, Claire R., Farrell, Ally C., Sliwowski, Mirka, Lichtensztejn, Zelda, Altman, Alon D., Nachtigal, Mark W., McManus, Kirk J.

Source: In Gynecologic Oncology June 2021 161(3):769-778

Reduced RBX1 expression induces chromosome instability and promotes cellular transformation in high-grade serous ovarian cancer precursor cells

Authors: Bungsy, Manisha, Palmer, Michaela C.L., Jeusset, Lucile M., Neudorf, Nicole M., Lichtensztejn, Zelda, Nachtigal, Mark W., McManus, Kirk J.

Source: In Cancer Letters 1 March 2021 500:194-207

Aberrant HMGA2 Expression Sustains Genome Instability That Promotes Metastasis and Therapeutic Resistance in Colorectal Cancer.

Authors: Campos Gudiño, Rubi^1,2 (AUTHOR), McManus, Kirk J.^1,2 (AUTHOR), Hombach-Klonisch, Sabine³ (AUTHOR) sabine.hombach-klonisch@umanitoba.ca

Source: Cancers. Mar2023, Vol. 15 Issue 6, p1735. 18p.

Subject Terms: *PROTEINS, *BIOMARKERS, *CANCER chemotherapy, *METASTASIS, *DRUG resistance, *COLORECTAL cancer, *GENE expression, *CELL survival, *GENOMES, *CELL proliferation, *GENES, *TRANSCRIPTION factors

Loss of EMI1 compromises chromosome stability and is associated with cellular transformation in colonic epithelial cell contexts.

Authors: Campos Gudiño, Rubi, Neudorf, Nicole M., Andromidas, Demi, Lichtensztejn, Zelda, McManus, Kirk J.

Source: British Journal of Cancer; Nov2024, Vol. 131 Issue 9, p1516-1528, 13p

Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers

Authors: Cisyk, Amy L., Nugent, Zoann, Wightman, Robert H., Singh, Harminder, McManus, Kirk J.

Source: In Neoplasia September 2018 20(9):943-950

The relationship between histone H3 phosphorylation and acetylation throughout the mammalian cell cycle.

Authors: McManus, Kirk J., Hendzel, Michael J.

Source: Biochemistry & Cell Biology; August 2006, Vol. 84 Issue 4, p640-657, 18p

Specific Synthetic Lethal Killing of RAD54B-Deficient Human Colorectal Cancer Cells by FEN1 Silencing

Authors: McManus, Kirk J., Barrett, Irene J., Nouhi, Yasaman, Hieter, Philip, Petes, Thomas D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Mar 01. 106(9), 3276-3281.

Access URL: https://www.jstor.org/stable/40443306

Chromatid Cohesion Defects May Underlie Chromosome Instability in Human Colorectal Cancers

Authors: Barber, Thomas D., McManus, Kirk, Yuen, Karen W. Y., Reis, Marcelo, Parmigiani, Giovanni, Shen, Dong, Barrett, Irene, Nouhi, Yasaman, Spencer, Forrest, Markowitz, Sanford, Velculescu, Victor E., Kinzler, Kenneth W., Vogelstein, Bert, Lengauer, Christoph, Hieter, Philip

Source: Proceedings of the National Academy of Sciences of the United States of America, 2008 Mar 01. 105(9), 3443-3448.

Access URL: https://www.jstor.org/stable/25461254

Navigating the Blood–Brain Barrier: Challenges and Therapeutic Strategies in Breast Cancer Brain Metastases.

Authors: Terceiro, Lucas E. L., Ikeogu, Nnamdi M., Lima, Matheus F., Edechi, Chidalu A., Nickel, Barbara E., Fischer, Gabor, Leygue, Etienne, McManus, Kirk J., Myal, Yvonne

Source: International Journal of Molecular Sciences; Aug2023, Vol. 24 Issue 15, p12034, 22p

Subject Terms: BLOOD-brain barrier, NOTCH signaling pathway, BRAIN metastasis

Exploring the role of a multidisciplinary hereditary gynecologic oncology clinic in epithelial ovarian cancer risk‐reducing surgical decision‐making practices: A mixed‐methods study.

Authors: Casalino, Selina, Bruce, Sharon, Serfas, Kim, Altman, Alon D., Kean, Sarah, Lambert, Pascal, McManus, Kirk J., Hartley, Jessica N., Nachtigal, Mark W.

Source: Journal of Genetic Counseling; Jun2023, Vol. 32 Issue 3, p728-743, 16p

Catalytic Function of the PR-Set7 Histone H4 Lysine 20 Monomethyltransferase Is Essential for Mitotic Entry and Genomic Stability

Authors: Houston, Sabrina I., McManus, Kirk J., Adams, Melissa M., Sims, Jennifer K., Carpenter, Phillip B., Hendzel, Michael J., Rice, Judd C.

Source: In Journal of Biological Chemistry 11 July 2008 283(28):19478-19488

Referral, Genetic Counselling, and BRCA Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019.

Authors: Winchar, Kelcey, Lambert, Pascal, McManus, Kirk J., Chodirker, Bernie, Kean, Sarah, Serfas, Kim, Decker, Kathleen, Nachtigal, Mark W., Altman, Alon D.

Source: Current Oncology; Dec2022, Vol. 29 Issue 12, p9365-9376, 12p, 5 Charts, 2 Graphs

Subject Terms: OVARIAN cancer, BRCA genes, GENETICS, GENETIC testing, TUMOR treatment

Reduced SKP2 Expression Adversely Impacts Genome Stability and Promotes Cellular Transformation in Colonic Epithelial Cells.

Authors: Neudorf, Nicole M., Thompson, Laura L., Lichtensztejn, Zelda, Razi, Tooba, McManus, Kirk J.

Source: Cells (2073-4409); Dec2022, Vol. 11 Issue 23, p3731, 20p

Subject Terms: CELL transformation, GENE expression, EPITHELIAL cells, SMALL interfering RNA, PROTEOLYSIS

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer.

Authors: Jeusset, Lucile M-P.^1,2 jeussetl@myumanitoba.ca, McManus, Kirk J.^1,2 Kirk.McManus@umanitoba.ca

Source: Cancers. Dec2017, Vol. 9 Issue 12, p167. 17p.

Subject Terms: *TUMOR suppressor genes, *DRUG delivery systems, *GENE expression, *HISTONES, *GENETIC mutation, *ONCOGENES, *PROTEOLYTIC enzymes, *TUMORS, *PROTEASE inhibitors, *SEQUENCE analysis

Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition.

Authors: Guppy, Brent, McManus, Kirk Kirk.McManus@umanitoba.ca

Source: Cellular Oncology (2211-3428). Jun2017, Vol. 40 Issue 3, p281-292. 12p.

Subject Terms: *CANCER treatment, *GENE silencing, *POLYMERASES, *GENE targeting, *CARCINOGENESIS

Characterizing and exploiting the many roles of aberrant H2B monoubiquitination in cancer pathogenesis.

Authors: Jeusset, Lucile M.^1,2 (AUTHOR), McManus, Kirk J.^1,2 (AUTHOR) Kirk.McManus@umanitoba.ca

Source: Seminars in Cancer Biology. Nov2022:Part 3, Vol. 86, p782-798. 17p.

Subject Terms: *CARCINOGENESIS, *DEUBIQUITINATING enzymes, *UBIQUITIN ligases, *POST-translational modification, *DNA repair

Dynamic Changes in Histone H3 Lysine 9 Methylations: IDENTIFICATION OF A MITOSIS-SPECIFIC FUNCTION FOR DYNAMIC METHYLATION IN CHROMOSOME CONGRESSION AND SEGREGATION

Authors: McManus, Kirk J., Biron, Vincent L., Heit, Ryan, Underhill, D. Alan, Hendzel, Michael J.

Source: In Journal of Biological Chemistry 31 March 2006 281(13):8888-8897