Genetic modifiers of Huntington disease differentially influence motor and cognitive domains

Authors: Lee, Jong-Min, Huang, Yuan, Orth, Michael, Gillis, Tammy, Siciliano, Jacqueline, Hong, Eunpyo, Mysore, Jayalakshmi Srinidhi, Lucente, Diane, Wheeler, Vanessa C., Seong, Ihn Sik, McLean, Zachariah L., Mills, James A., McAllister, Branduff, Lobanov, Sergey V., Massey, Thomas H., Ciosi, Marc, Landwehrmeyer, G. Bernhard, Paulsen, Jane S., Dorsey, E. Ray, Shoulson, Ira, Sampaio, Cristina, Monckton, Darren G., Kwak, Seung, Holmans, Peter, Jones, Lesley, MacDonald, Marcy E., Long, Jeffrey D., Gusella, James F.

Source: In The American Journal of Human Genetics 5 May 2022 109(5):885-899

Posttranscriptional regulation of FAN1 by miR-124-3p at rs3512 underlies onset-delaying genetic modification in Huntington's disease.

Authors: Kyung-Hee Kim, Eun Pyo Hong, Yukyeong Lee, McLean, Zachariah L., Elezi, Emanuela, Lee, Ramee, Seung Kwak, McAllister, Branduff, Massey, Thomas H., Lobanov, Sergey, Holmans, Peter, Orth, Michael, Ciosi, Marc, Monckton, Darren G., Long, Jeffrey D., Lucente, Diane, Wheeler, Vanessa C., MacDonald, Marcy E., Gusella, James F., Jong-Min Lee

Source: Proceedings of the National Academy of Sciences of the United States of America; 4/16/2024, Vol. 121 Issue 16, p1-9, 18p

Subject Terms: HUNTINGTON disease, LOCUS (Genetics), GENE expression, GENETIC variation, MESSENGER RNA

Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat.

Authors: McLean, Zachariah L., Gao, Dadi, Correia, Kevin, Roy, Jennie C. L., Shibata, Shota, Farnum, Iris N., Valdepenas-Mellor, Zoe, Kovalenko, Marina, Rapuru, Manasa, Morini, Elisabetta, Ruliera, Jayla, Gillis, Tammy, Lucente, Diane, Kleinstiver, Benjamin P., Lee, Jong-Min, MacDonald, Marcy E., Wheeler, Vanessa C., Mouro Pinto, Ricardo, Gusella, James F.

Source: Nature Communications; 4/12/2024, Vol. 15 Issue 1, p1-17, 17p

Testes of DAZL null neonatal sheep lack prospermatogonia but maintain normal somatic cell morphology and marker expression.

Authors: McLean, Zachariah L., Appleby, Sarah J., Wei, Jingwei, Snell, Russell G., Oback, Björn

Source: Molecular Reproduction & Development; Jan2021, Vol. 88 Issue 1, p3-14, 12p

Front Cover Image, Volume 88, Issue 1, January 2021.

Authors: McLean, Zachariah L., Appleby, Sarah J., Wei, Jingwei, Snell, Russell G., Oback, Björn

Source: Molecular Reproduction & Development; Jan2021, Vol. 88 Issue 1, pi-i, 1p