Does supplementation of oocytes with additional mtDNA influence developmental outcome?

Authors: McIlfatrick, Stephen, O’Leary, Sean, Okada, Takashi, Penn, Alexander, Nguyen, Vy Hoang Thao, McKenny, Lisa, Huang, Shang-Yu, Andreas, Eryk, Finnie, John, Kirkwood, Roy, St. John, Justin C.

Source: In iScience 17 February 2023 26(2)

Mitochondrial DNA Deficiency and Supplementation in Sus scrofa Oocytes Influence Transcriptome Profiles in Oocytes and Blastocysts.

Authors: Okada, Takashi¹ (AUTHOR), McIlfatrick, Stephen¹ (AUTHOR), St. John, Justin C.¹ (AUTHOR) jus.stjohn@adelaide.edu.au

Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 4, p3783. 26p.

Subject Terms: *MITOCHONDRIAL DNA, *WILD boar, *CELL cycle, *OVUM, *MEIOSIS, *BLASTOCYST, *RNA metabolism

Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts.

Authors: Okada, Takashi¹ (AUTHOR), McIlfatrick, Stephen¹ (AUTHOR), Hin, Nhi² (AUTHOR), Aryamanesh, Nader^2,3 (AUTHOR), Breen, James² (AUTHOR), St. John, Justin C.¹ (AUTHOR) jus.stjohn@adelaide.edu.au

Source: Epigenetics & Chromatin. 4/15/2022, Vol. 15 Issue 1, p1-20. 20p.

Subject Terms: *GENE expression profiling, *DNA methylation, *WILD boar, *OVUM, *BLASTOCYST, *MITOCHONDRIAL DNA

Energy balance influences number of ovulations rather than embryo quality in the pig

Authors: Langendijk, Pieter, Chen, Tai-Yuan, McIlfatrick, Stephen M., Nottle, Mark B.

Source: In Theriogenology 1 September 2016 86(4):1008-1013

A micro-fabricated device (microICSI) improves porcine blastocyst development and procedural efficiency for both porcine intracytoplasmic sperm injection and human microinjection.

Authors: McLennan, Hanna J., Heinrich, Shauna L., Inge, Megan P., Wallace, Samuel J., Blanch, Adam J., Hails, Llewelyn, O'Connor, John P., Waite, Michael B., McIlfatrick, Stephen, Nottle, Mark B., Dunning, Kylie R., Gardner, David K., Thompson, Jeremy G., Love, Allison K.

Source: Journal of Assisted Reproduction & Genetics; Feb2024, Vol. 41 Issue 2, p297-309, 13p

Subject Terms: INTRACYTOPLASMIC sperm injection, MICROINJECTIONS, BLASTOCYST, LABORATORY management, SETUP time, WORKFLOW management

Characterisation of transgenic pigs expressing a human T cell‐depleting anti‐CD2 monoclonal antibody.

Authors: Salvaris, Evelyn J., Fisicaro, Nella, McIlfatrick, Stephen, Thomas, Adwin, Fuller, Erin, Lew, Andrew M., Nottle, Mark B., Hawthorne, Wayne J., Cowan, Peter J.

Source: Xenotransplantation; Jan2024, Vol. 31 Issue 1, p1-9, 9p

Subject Terms: SOMATIC cell nuclear transfer, MONOCLONAL antibodies, SWINE, WHOLE genome sequencing, TYPE 1 diabetes

Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9

Authors: Nottle, Mark, Salvaris, Evelyn, Fisicaro, Nella, McIlfatrick, Stephen, Vassiliev, Ivan, Hawthorne, Wayne, O'Connell, Philip, Brady, Jamie, Lew, Andrew, Cowan, Peter

Source: Scientific reports. 7(1):1-8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175110753.0x000001&indx=1&recIds=ETOCvdc_100175110753.0x000001

Low guanine content and biased nucleotide distribution in vertebrate mtDNA can cause overestimation of non-CpG methylation.

Authors: Okada, Takashi, Sun, Xin, McIlfatrick, Stephen, St. John, Justin C

Source: NAR Genomics & Bioinformatics; Mar2022, Vol. 4 Issue 1, p1-17, 17p

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Production of homozygous α-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer.

Authors: Nottle, Mark B., Beebe, Luke F. S., Harrison, Sharon J., McIlfatrick, Stephen M., Ashman, Rodney J., O'Connell, Phillip J., Salvaris, Evelyn J., Fisicaro, Nella, Pommey, Sandra, Cowan, Peter J., d'Apice, Anthony J. F.

Source: Xenotransplantation; Jul2007, Vol. 14 Issue 4, p339-344, 6p, 1 Color Photograph, 1 Diagram, 1 Graph

Subject Terms: ANIMAL models in research, BREEDING, SOMATIC cells, TRANSPLANTATION of cell nuclei, FIBROBLASTS, ANIMAL breeding

Effect of 6-dimethylaminopurine on electrically activated in vitro matured porcine oocytes.

Authors: Grupen, Christopher G., Mau, James C., McIlfatrick, Stephen M., Maddocks, Simon, Nottle, Mark B.

Source: Molecular Reproduction & Development; 2002, Vol. 62 Issue 3, p387-396, 10p

In vitro development of porcine nuclear transfer embryos constructed using fetal fibroblasts.

Authors: Verma, Paul J., Du, Zhong-Tao, Crocker, Lesley, Faast, Renate, Grupen, Christopher G., McIlfatrick, Stephen M., Ashman, Rodney J., Lyons, Ian G., Nottle, Mark B.

Source: Molecular Reproduction & Development; 2000, Vol. 57 Issue 3, p262-269, 8p

In Vitroand In VivoCharacterization of Putative Porcine Embryonic Stem Cells

Authors: Vassiliev, Ivan, Vassilieva, Svetlana, Beebe, Luke F.S., Harrison, Sharon J., McIlfatrick, Stephen M., Nottle, Mark B.

Source: Cellular Reprogramming; April 2010, Vol. 12 Issue: 2 p223-230, 8p

An Efficient Method for Producing α(1,3)-Galactosyltransferase Gene Knockout Pigs

Authors: Harrison, Sharon, Boquest, Andrew, Grupen, Christopher, Faast, Renate, Guildolin, Angelo, Giannakis, Christopher, Crocker, Lesley, McIlfatrick, Stephen, Ashman, Rodney, Wengle, James, Lyons, Ian, Tolstoshev, Paul, Cowan, Peter, Robins, Allan, O'Connell, Philip, D'Apice, Anthony J.F., Nottle, Mark

Source: Cloning and Stem Cells (formerly Cloning: Science and Policy); Winter 2004, Vol. 6 Issue: 4 p327-331, 5p

Relationship between donor animal age, follicular fluid steroid content and oocyte developmental competence in the pig

Authors: Grupen, Christopher G., McIlfatrick, Stephen M., Ashman, Rodney J., Boquest, Andrew C., Armstrong, David T., Nottle, Mark B.

Source: Reproduction, Fertility and Development; 2003, Vol. 15 Issue: 2 p81-87, 7p

Production of cloned pigs from cultured fetal fibroblast cells.

Authors: Boquest, Andrew C, Grupen, Christopher G, Harrison, Sharon J, McIlfatrick, Stephen M, Ashman, Rodney J, d'Apice, Anthony J F, Nottle, Mark B

Source: Biology of Reproduction; May 2002, Vol. 66 Issue: 5 p1283-1287, 5p