IRAK4 Is Overexpressed in Hidradenitis Suppurativa Skin and Correlates with Inflammatory Biomarkers

Authors: McDonald, Alice ^{1, ∗}, Karnik, Rahul ¹, Campbell, Veronica ¹, Davis, Jeff ¹, Chavoshi, Sara ², Slavin, Anthony ¹, Sharma, Kirti ¹, Gollob, Jared ¹, Alavi, Afsaneh ³

Source: In Journal of Investigative Dermatology February 2025 145(2):323-333

Resource allocation in transboundary tuna fisheries : A global analysis

Authors: Seto, Katherine, Galland, Grantly R., McDonald, Alice, Abolhassani, Angela, Azmi, Kamal, Sinan, Hussain, Timmiss, Trent, Bailey, Megan, Hanich, Quentin

Source: Ambio, 2021 Jan 01. 50(1), 242-259.

Access URL: https://www.jstor.org/stable/48739037

Discovery of KT-474a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.

Authors: Zheng, Xiaozhang, Ji, Nan, Campbell, Veronica, Slavin, Anthony, Zhu, Xiao, Chen, Dapeng, Rong, Haojing, Enerson, Brad, Mayo, Michele, Sharma, Kirti, Browne, Chris M., Klaus, Christine R., Li, Haoran, Massa, Ginny, McDonald, Alice A., Shi, Yatao, Sintchak, Mike, Skouras, Stephanie, Walther, Dirk M., Yuan, Karen

Source: Journal of Medicinal Chemistry; 10/24/2024, Vol. 67 Issue 20, p18022-18037, 16p

Resource allocation in transboundary tuna fisheries: A global analysis

Authors: Seto, Katherine, Galland, Grantly R., McDonald, Alice, Abolhassani, Angela, Azmi, Kamal, Sinan, Hussain, Timmiss, Trent, Bailey, Megan, Hanich, Quentin

Source: Ambio. 50(1):242-259

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190807528.0x000001&indx=1&recIds=ETOCvdc_100190807528.0x000001

Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B‑Cell Lymphoma.

Authors: Weiss, Matthew M., Zheng, Xiaozhang, Ji, Nan, Browne, Chris M., Campbell, Veronica, Chen, Dapeng, Enerson, Brad, Fei, Xue, Huang, Xin, Klaus, Christine R., Li, Haoran, Mayo, Michele, McDonald, Alice A., Paul, Atanu, Rong, Haojing, Sharma, Kirti, Shi, Yatao, Slavin, Anthony, Walther, Dirk M., Yuan, Karen

Source: Journal of Medicinal Chemistry; 7/11/2024, Vol. 67 Issue 13, p10548-10566, 19p

Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study

Authors: Italiano, Antoine, Soria, Jean-Charles, Toulmonde, Maud, Michot, Jean-Marie, Lucchesi, Carlo, Varga, Andrea, Coindre, Jean-Michel, Blakemore, Stephen J, Clawson, Alicia, Suttle, Benjamin, McDonald, Alice A, Woodruff, Mark, Ribich, Scott, Hedrick, Eric, Keilhack, Heike, Thomson, Blythe, Owa, Takashi, Copeland, Robert A, Ho, Peter T C, Ribrag, Vincent

Source: In The Lancet Oncology May 2018 19(5):649-659

Prediction of pharmacokinetics and pharmacodynamics in human for IRAK4 targeted protein degrader

Authors: Chen, Dapeng, Rong, Haojing, Mayo, Michele, McDonald, Alice, Campbell, Veronica, Zheng, Xiaozhang, Agarwal, Sagar, Weiss, Matt, Slavin, Anthony

Source: In Drug Metabolism and Pharmacokinetics April 2024 55 Supplement

Social and Language Skills in the Human Sciences Era: A Cost-Benefit Simulator.

Authors: Somasundaram, Jay, McDonald, Alice

Source: South East Asian Association for Institutional Research Conference Proceedings; 2024, Vol. 24, p47-56, 10p

Subject Terms: SOCIAL skills, LANGUAGE ability, SOCIAL sciences, COST benefit analysis, CURRICULUM, EDUCATIONAL technology

Two Models to Conduct Nonphysician-led Exercise Stress Testing in Low to Intermediate Risk Patients

Authors: Scott, Adam, Whitman, Mark, McDonald, Alice, Webster, Meghan, Jenkins, Carly

Source: Critical pathways in cardiology. 16(1):1-6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184291241.0x000001&indx=1&recIds=ETOCvdc_100184291241.0x000001

Flora, the fur trader's daughter

Play Authors: Mcdonald, Alice

Precision Targeting of MYD88 Mutant DLBCL Using the Novel Combination of Irakimids and BCL2 Inhibition

Authors: Grilo, Andre M. ^*, Klaus, Christine ^*, McDonald, Alice ^*, Gollob, Jared ^*, Weiss, Matt ^*, O'Connor, Owen A., Salles, Gilles, Chaudhuri, Jayanta ^*, Lue, Jennifer Kimberly

Source: In Blood 15 November 2022 140 Supplement 1:8862-8864

Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

Authors: Milhollen, Michael A., Thomas, Michael P., Narayanan, Usha, Traore, Tary, Riceberg, Jessica, Amidon, Benjamin S., Bence, Neil F., Bolen, Joseph B., Brownell, James, Dick, Lawrence R., Loke, Huay-Keng, McDonald, Alice A., Ma, Jingya, Manfredi, Mark G., Sells, Todd B., Sintchak, Mike D., Yang, Xiaofeng, Xu, Qing, Koenig, Erik M., Gavin, James M., Smith, Peter G.

Source: In Cancer Cell 20 March 2012 21(3):388-401

Cenários de desmatamento para a Amazônia

Authors: Soares-Filho, Britaldo Silveira, Nepstad, Daniel Curtis, Curran, Lisa, Cerqueira, Gustavo Coutinho, Garcia, Ricardo Alexandrino, Ramos, Claudia Azevedo, Voll, Eliane, McDonald, Alice, Lefebvre, Paul, Schlesinger, Peter, McGrath, David

Source: Estudos Avançados. August 2005 19(54)

Subject Terms: Modelagem, simulação, cenários, desmatamento, Amazônia

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-40142005000200008

Anti-GCC antibody molecules and methods for use of same

Methane emissions from trees planted on a closed landfill site.

Authors: Fraser-McDonald, Alice, Boardman, Carl, Gladding, Toni, Burnley, Stephen, Gauci, Vincent

Source: Waste Management & Research: The Journal for a Sustainable Circular Economy; Nov2022, Vol. 40 Issue 11, p1618-1628, 11p

Subject Terms: TREE planting, LANDFILLS, SOIL air, METHANE, HAWTHORNS

Geographic Terms: UNITED Kingdom

IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial

Authors: Ackerman, Lindsay, Acloque, Gerard, Bacchelli, Sandro, Schwartz, Howard, Feinstein, Brian J., La Stella, Phillip, Alavi, Afsaneh, Gollerkeri, Ashwin, Davis, Jeffrey, Campbell, Veronica, McDonald, Alice, Agarwal, Sagar, Karnik, Rahul, Shi, Kelvin, Mishkin, Aimee, Culbertson, Jennifer, Klaus, Christine, Enerson, Bradley, Massa, Virginia, Kuhn, Eric, Sharma, Kirti, Keaney, Erin, Barnes, Randy, Chen, Dapeng, Zheng, Xiaozhang, Rong, Haojing, Sabesan, Vijay, Ho, Chris, Mainolfi, Nello, Slavin, Anthony, Gollob, Jared A.

Source: Nature Medicine; 20230101, Issue: Preprints p1-10, 10p

The Steap proteins are metalloreductases

Authors: Ohgami, Robert S., Campagna, Dean R., McDonald, Alice, Fleming, Mark D.

Source: In Blood 15 August 2006 108(4):1388-1394

Phase 1 Study of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates, in Adult Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Authors: Lue, Jennifer Kimberly, Stevens, Don A., Williams, Michael E., Westin, Jason, Ewesuedo, Reggie ^*, McDonald, Alice ^*, Agarwal, Sagar ^*, Henrick, Patrick ^*, Perea, Rachelle ^*, Gollob, Jared ^*

Source: In Blood 15 November 2022 140 Supplement 1:12143-12144

Development of KT-253, a Highly Potent and Selective Heterobifunctional MDM2 Degrader for the Treatment of Acute Myeloid Leukemia

Authors: Mayo, Michele ^*, Chutake, Yogesh ^*, Karnik, Rahul ^*, McDonald, Alice ^*, Cho, Patricia S. ^*, Filiatrault, Jessica ^*, Chen, Dapeng ^*, Dixit, Vaishali ^*, Proctor, William ^*, Breitkopf, Susanne ^*, Qi, Frank ^*, Hu, Kan-Nian ^*, Sharma, Kirti ^*, Ewesuedo, Reggie ^*, Weiss, Matt ^*, Growney, Joseph D. ^*, Williams, Juliet ^*, Schalm, Stefanie S ^*

Source: In Blood 15 November 2022 140 Supplement 1:6239-6240

Interim Update from a Phase 2 Multicenter Study of Tazemetostat, an EZH2 Inhibitor, in Patients with Relapsed or Refractory (R/R) Follicular Lymphoma (FL)

Authors: Pagel, John, Morschhauser, Franck, Herve, Tilly, Chaidos, Aristeidis, Phillips, Tycel, Ribrag, Vincent, Campbell, Phillip, Fruchart, Christophe, Jurczak, Wojciech, McKay, Pamela, Opat, Stephen, Radford, John, McDonald, Alice, Howell, Haley, Newberry, Kate, Woodruff, Mark, Clawson, Alicia, Larus, John, Blakemore, Stephen, Miao, Harry, Salles, Gilles

Source: Clinical lymphoma, myeloma & leukemia. 18(S1):S278-S279

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100081576597.0x000001&indx=1&recIds=ETOCvdc_100081576597.0x000001