Antitussive effects of NaV 1.7 blockade in Guinea pigs

Authors: Yu, Li, Tsuji, Kojun, Ujihara, Izumi, Liu, Qi, Pavelkova, Nikoleta, Tsujimura, Takanori, Inoue, Makoto, Meeker, Sonya, Nisenbaum, Eric, McDermott, Jeff S., Krajewski, Jeff, Undem, Bradley J., Kollarik, Marian, Canning, Brendan J.

Source: In European Journal of Pharmacology 15 September 2021 907

Heterogeneity of synaptic NMDA receptor responses within individual lamina I pain‐processing neurons across sex in rats and humans.

Authors: Dedek, Annemarie, Topcu, Emine, Dedek, Christopher, McDermott, Jeff S., Krajewski, Jeffrey L., Tsai, Eve C., Hildebrand, Michael E.

Source: Journal of Physiology; Oct2024, Vol. 602 Issue 20, p5309-5327, 19p

Subject Terms: HETEROGENEITY, METHYL aspartate receptors, NEURONS, POSTSYNAPTIC potential, ELECTROPHYSIOLOGY

The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement

Authors: La, Daniel S., Peterson, Emily A., Bode, Christiane, Boezio, Alessandro A., Bregman, Howard, Chu-Moyer, Margaret Y., Coats, James, DiMauro, Erin F., Dineen, Thomas A., Du, Bingfan, Gao, Hua, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Fremeau, Robert, Huang, Xin, Ilch, Christopher, Kornecook, Thomas J., Kreiman, Charles, Ligutti, Joseph, Jasmine Lin, Min-Hwa, McDermott, Jeff S., Marx, Isaac, Matson, David J., McDonough, Stefan I., Moyer, Bryan D., Nho Nguyen, Hanh, Taborn, Kristin, Yu, Violeta, Weiss, Matthew M.

Source: Bioorganic & medicinal chemistry letters. 27(15):3477-3485

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100049670042.0x000001&indx=1&recIds=ETOCvdc_100049670042.0x000001

Cardiac ion channels

Authors: Priest, Birgit T, McDermott, Jeff S

Source: Channels. 9(6):352-359

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100028955683.0x000001&indx=1&recIds=ETOCETOCvdc_100028955683.0x000001

Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons.

Authors: Bin Wu¹, McDermott, Jeff S.², Krajewski, Jeffrey L.², Knopp, Kelly L.², Nisenbaum, Eric S.², Cummins, Theodore R.^1,3, Zhi-Yong Tan¹ zt2@iupui.edu

Source: Molecular Pain. 4/5/2019, Vol. 15, p1-13. 13p.

Subject Terms: *EXTRACELLULAR signal-regulated kinases, *DORSAL root ganglia, *INFLAMMATORY mediators, *PROTEIN kinase C, *PTERYGOPALATINE ganglion, *GLUCOSE-regulated proteins, *NEURONS, *PROTEIN kinases

Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

Authors: Gao, BaoXi, Hierl, Markus, Clarkin, Kristie, Juan, Todd, Nguyen, Hung, Valk, Marissa van der, Deng, Hong, Guo, Wenhong, Lehto, Sonya G., Matson, David, McDermott, Jeff S., Knop, Johannes, Gaida, Kevin, Cao, Lei, Waldon, Dan, Albrecht, Brian K., Boezio, Alessandro A., Copeland, Katrina W., Harmange, Jean-Christophe, Springer, Stephanie K., Malmberg, Annika B., McDonough, Stefan I.

Source: In Pain 2010 149(1):33-49

The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and d, l-sotalol

Authors: Limberis, James T., McDermott, Jeff S., Salmen, Heinz J., Su, Zhi, Mikhail, Ann, Green, Jonathon R., Cox, Bryan F., Gintant, Gary A., Martin, Ruth L.

Source: In Journal of Pharmacological and Toxicological Methods 2007 56(1):11-17

Stimulus intensity-dependent recruitment of NaV1 subunits in action potential initiation in nerve terminals of vagal C-fibers innervating the esophagus.

Authors: Fei Ru, Pavelkova, Nikoleta, Krajewski, Jeffrey L., McDermott, Jeff S., Undem, Bradley J., Kollarik, Marian

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology; Oct2020, Vol. 319 Issue 4, pG443-G453, 11p, 1 Chart, 6 Graphs

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The discovery of aminopyrazines as novel, potent Nav1.7 antagonists: Hit-to-lead identification and SAR

Authors: Bregman, Howard, Nguyen, Hanh Nho, Feric, Elma, Ligutti, Joseph, Liu, Dong, McDermott, Jeff S., Wilenkin, Ben, Zou, Anruo, Huang, Liyue, Li, Xingwen, McDonough, Stefan I., DiMauro, Erin F.

Source: In Bioorganic & Medicinal Chemistry Letters 1 March 2012 22(5):2033-2042

Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Nav1.7 antagonists

Authors: Chakka, Nagasree, Bregman, Howie, Du, Bingfan, Nguyen, Hanh Nho, Buchanan, John L., Feric, Elma, Ligutti, Joseph, Liu, Dong, McDermott, Jeff S., Zou, Anruo, McDonough, Stefan I., DiMauro, Erin F.

Source: In Bioorganic & Medicinal Chemistry Letters 1 March 2012 22(5):2052-2062

Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists

Authors: Nguyen, Hanh Nho, Bregman, Howie, Buchanan, John L., Du, Bingfan, Feric, Elma, Huang, Liyue, Li, Xingwen, Ligutti, Joseph, Liu, Dong, Malmberg, Annika B., Matson, David J., McDermott, Jeff S., Patel, Vinod F., Wilenkin, Ben, Zou, Anruo, McDonough, Stefan I., DiMauro, Erin F.

Source: In Bioorganic & Medicinal Chemistry Letters 15 January 2012 22(2):1055-1060

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Synthesis and activity of substituted carbamates as potentiators of the α4β2 nicotinic acetylcholine receptor

Authors: Springer, Stephanie K., Woodin, Katrina S., Berry, Virginia, Boezio, Alessandro A., Cao, Lei, Clarkin, Kristie, Harmange, Jean-Christophe, Hierl, Markus, Knop, Johannes, Malmberg, Annika B., McDermott, Jeff S., Nguyen, Hung Q., Waldon, Daniel, Albrecht, Brian K., McDonough, Stefan I.

Source: In Bioorganic & Medicinal Chemistry Letters 2008 18(20):5643-5647

Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators

Authors: Albrecht, Brian K., Berry, Virginia, Boezio, Alessandro A., Cao, Lei, Clarkin, Kristie, Guo, Wenhong, Harmange, Jean-Christophe, Hierl, Markus, Huang, Liyue, Janosky, Brett, Knop, Johannes, Malmberg, Annika, McDermott, Jeff S., Nguyen, Hung Q., Springer, Stephanie K., Waldon, Daniel, Woodin, Katrina, McDonough, Stefan I.

Source: In Bioorganic & Medicinal Chemistry Letters 2008 18(19):5209-5212

Tetrodotoxin-Resistant Sodium Channels in Sensory Neurons Generate Slow Resurgent Currents That Are Enhanced by Inflammatory Mediators.

Authors: Zhi-Yong Tan, Piekarz, Andrew D., Priest, Birgit T., Knopp, Kelly L., Krajewski, Jeffrey L., McDermott, Jeff S., Nisenbaum, Eric S., Cummins, Theodore R.

Source: Journal of Neuroscience; 5/21/2014, Vol. 34 Issue 21, p7190-7197, 8p

Subject Terms: TETRODOTOXIN, SODIUM channels, DRUG resistance, SENSORY neurons, NEURONS, INFLAMMATORY mediators

The Canine Purkinje Fiber: An In Vitro Model System for Acquired Long QT Syndrome and Drug-Induced Arrhythmogenesis.

Authors: Gintant, Gary A., Limberis, James T., McDermott, Jeff S., Wegner, Craig D., Cox, Bryan F.

Source: Journal of Cardiovascular Pharmacology; May2001, Vol. 37 Issue 5, p607-618, 12p

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The Utility of hERG and Repolarization Assays in Evaluating Delayed Cardiac Repolarization Influence of Multi-Channel Block

Authors: Martin, Ruth L., McDermott, Jeff S., Salmen, Heinz J., Palmatier, Jason, Cox, Bryan F., Gintant, Gary A.

Source: Journal of Cardiovascular Pharmacology; March 2004, Vol. 43 Issue: 3 p369-379, 11p