The hanging heart : How KRAS lures its prey to the membrane

Authors: Kessler, Dirk, McConnell, Darryl B.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Oct . 117(43), 26556-26558.

Access URL: https://www.jstor.org/stable/26970596

Stopping the beating heart of cancer: KRAS reviewed

Authors: Herdeis, Lorenz, Gerlach, Daniel, McConnell, Darryl B., Kessler, Dirk

Source: In Current Opinion in Structural Biology December 2021 71:136-147

Targeting Son of Sevenless 1: The pacemaker of KRAS

Authors: Kessler, Dirk, Gerlach, Daniel, Kraut, Norbert, McConnell, Darryl B.

Source: In Current Opinion in Chemical Biology June 2021 62:109-118

Transforming targeted cancer therapy with PROTACs: A forward-looking perspective

Authors: Farnaby, William, Koegl, Manfred, McConnell, Darryl B., Ciulli, Alessio

Source: In Current Opinion in Pharmacology April 2021 57:175-183

Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods

Authors: Kessler, Dirk, Mayer, Moriz, Zahn, Stephan K., Zeeb, Markus, Wöhrle, Simon, Bergner, Andreas, Bruchhaus, Jens, Ciftci, Tuncay, Dahmann, Georg, Dettling, Maike, Döbel, Sandra, Fuchs, Julian E., Geist, Leonhard, Hela, Wolfgang, Kofink, Christiane, Kousek, Roland, Moser, Franziska, Puchner, Teresa, Rumpel, Klaus, Scharnweber, Maximilian, Werni, Patrick, Wolkerstorfer, Bernhard, Breitsprecher, Dennis, Baaske, Philipp, Pearson, Mark, McConnell, Darryl B., Böttcher, Jark

Source: ChemMedChem. 16(9):1420-1424

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121031213.0x000001&indx=1&recIds=ETOCvdc_100121031213.0x000001

A Step toward NRF2‐DNA Interaction Inhibitors by Fragment‐Based NMR Methods

Authors: Brüschweiler, Sven, Fuchs, Julian E., Bader, Gerd, McConnell, Darryl B., Konrat, Robert, Mayer, Moriz

Source: ChemMedChem. 16(23):3576-3587

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135992214.0x000001&indx=1&recIds=ETOCvdc_100135992214.0x000001

REPLY TO TRAN ET AL. : Dimeric KRAS protein–protein interaction stabilizers

Authors: Kessler, Dirk, Gollner, Andreas, Gmachl, Michael, Mantoulidis, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Feb . 117(7), 3365-3367.

Access URL: https://www.jstor.org/stable/26928963

Drugging an undruggable pocket on KRAS

Authors: Kesslera, Dirk, Gmachla, Michael, Mantoulidisa, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Gollner, Andreas, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Aug 01. 116(32), 15823-15829.

Access URL: https://www.jstor.org/stable/26848431

PI by NMR: Probing CH–π Interactions in Protein–Ligand Complexes by NMR Spectroscopy

Authors: Platzer, Gerald, Mayer, Moriz, Beier, Andreas, Brüschweiler, Sven, Fuchs, Julian E., Engelhardt, Harald, Geist, Leonhard, Bader, Gerd, Schörghuber, Julia, Lichtenecker, Roman, Wolkerstorfer, Bernhard, Kessler, Dirk, McConnell, Darryl B., Konrat, Robert

Source: Angewandte Chemie. 132(35):14971-14978

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115828738.0x000001&indx=1&recIds=ETOCvdc_100115828738.0x000001

Drugging all RAS isoforms with one pocket

Authors: Kessler, Dirk, Bergner, Andreas, Böttcher, Jark, Fischer, Gerhard, Döbel, Sandra, Hinkel, Melanie, Müllauer, Barbara, Weiss-Puxbaum, Alexander, McConnell, Darryl B

Source: Future medicinal chemistry. 12(21):1911-1923

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186783194.0x000001&indx=1&recIds=ETOCvdc_100186783194.0x000001

The sixth international RASopathies symposium: Precision medicine—From promise to practice

Authors: Gripp, Karen W., Schill, Lisa, Schoyer, Lisa, Stronach, Beth, Bennett, Anton M., Blaser, Susan, Brown, Amanda, Burdine, Rebecca, Burkitt‐Wright, Emma, Castel, Pau, Darilek, Sandra, Dias, Alwyn, Dyer, Tuesdi, Ellis, Michelle, Erickson, Gregg, Gelb, Bruce D., Green, Tamar, Gross, Andrea, Ho, Alan, Holder, James Lloyd, Inoue, Shin‐Ichi, Jelin, Angie C., Kennedy, Annie, Klein, Richard, Kontaridis, Maria I., Magoulas, Pilar, McConnell, Darryl B., McCormick, Frank, Neel, Benjamin G., Prada, Carlos E., Rauen, Katherine A., Roberts, Amy, Rodriguez‐Viciana, Pablo, Rosen, Neal, Rumbaugh, Gavin, Sablina, Anna, Solman, Maja, Tartaglia, Marco, Thomas, Angelica, Timmer, William C., Venkatachalam, Kartik, Walsh, Karin S., Wolters, Pamela L., Yi, Jae‐Sung, Zenker, Martin, Ratner, Nancy

Source: American journal of medical genetics.Part A. 182(3):597-606

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102869186.0x000001&indx=1&recIds=ETOCvdc_100102869186.0x000001

12 - The emergence of pan-KRAS drugs

Authors: McConnell, Darryl B., Kraut, Norbert

Source: In RAS Drug Discovery 2025:311-340

Probing Protein–Ligand Methyl−π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups.

Authors: Beier, Andreas, Platzer, Gerald, Höfurthner, Theresa, Ptaszek, Aleksandra L., Lichtenecker, Roman J., Geist, Leonhard, Fuchs, Julian E., McConnell, Darryl B., Mayer, Moriz, Konrat, Robert

Source: Journal of Medicinal Chemistry; 8/8/2024, Vol. 67 Issue 15, p13187-13196, 10p

KRAS Binders Hidden in Nature

Authors: Bergner, Andreas, Cockcroft, Xiaoling, Fischer, Gerhard, Gollner, Andreas, Hela, Wolfgang, Kousek, Roland, Mantoulidis, Andreas, Martin, Laetitia J., Mayer, Moriz, Müllauer, Barbara, Siszler, Gabriella, Wolkerstorfer, Bernhard, Kessler, Dirk, McConnell, Darryl B.

Source: Chemistry. 25(52):12037-12041

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100089387611.0x000001&indx=1&recIds=ETOCvdc_100089387611.0x000001

Targeted Synthesis of Complex Spiro[3H‐indole‐3, 2′‐pyrrolidin]‐2(1H)‐ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2–p53 Inhibitors

Authors: Gollner, Andreas, Weinstabl, Harald, Fuchs, Julian E., Rudolph, Dorothea, Garavel, Geraldine, Hofbauer, Karin S., Karolyi‐Oezguer, Jale, Gmaschitz, Gerhard, Hela, Wolfgang, Kerres, Nina, Grondal, Elisabeth, Werni, Patrick, Ramharter, Juergen, Broeker, Joachim, McConnell, Darryl B.

Source: ChemMedChem. 14(1):88-93

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123094492.0x000001&indx=1&recIds=ETOCvdc_100123094492.0x000001

Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays.

Authors: Gerstberger, Thomas, Berger, Helmut, Büttner, Frank H., Gmachl, Michael, Kessler, Dirk, Koegl, Manfred, Lucas, Simon, Martin, Laetitia J., Mayer, Moriz, McConnell, Darryl B., Mitzner, Sophie, Scholz, Guido, Treu, Matthias, Wolkerstorfer, Bernhard, Zahn, Stephan, Zak, Krzysztof M., Jaeger, Philipp A., Ettmayer, Peter

Source: Journal of Medicinal Chemistry; 7/25/2024, Vol. 67 Issue 14, p11701-11711, 11p

¹³Cβ‐Valine and ¹³Cγ‐Leucine Methine Labeling To Probe Protein Ligand Interaction.

Authors: Toscano, Giorgia, Höfurthner, Theresa, Nagl, Benjamin, Beier, Andreas, Mayer, Moriz, Geist, Leonhard, McConnell, Darryl B., Weinstabl, Harald, Konrat, Robert, Lichtenecker, Roman J.

Source: ChemBioChem; Mar2024, Vol. 25 Issue 6, p1-8, 8p

Synthesis of a ¹³C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics.

Authors: Höfurthner, Theresa, Toscano, Giorgia, Kontaxis, Georg, Beier, Andreas, Mayer, Moriz, Geist, Leonhard, McConnell, Darryl B., Weinstabl, Harald, Lichtenecker, Roman, Konrat, Robert

Source: Journal of Biomolecular NMR; Mar2024, Vol. 78 Issue 1, p1-8, 8p

Subject Terms: PROTEIN-protein interactions, ISOLEUCINE, PROTEIN-ligand interactions, QUANTUM wells, METHYLENE compounds

Ligand ¹H NMR Chemical Shifts as Accurate Reporters for Protein‐Ligand Binding Interfaces in Solution.

Authors: Platzer, Gerald, Ptaszek, Aleksandra L., Böttcher, Jark, Fuchs, Julian E., Geist, Leonhard, Braun, Daniel, McConnell, Darryl B., Konrat, Robert, Sánchez‐Murcia, Pedro A., Mayer, Moriz

Source: ChemPhysChem; 1/2/2024, Vol. 25 Issue 1, p1-10, 10p

Contributors

Authors: Aguirre, Andrew J., Ambrogio, Chiara, Boumelha, Jesse, Casey, Patrick J., Chugh, Seema, Cotesta, Simona, Cregg, James, Der, Channing J., Dow, Lukas E., Downward, Julian, Edwards, Anne V., Giddens, John P., Gill, Adrian L., Hansen, Rasmus, Janes, Matthew R., Jean-Francois, Frantz Louis, Knox, John E., Koltun, Elena S., Kraut, Norbert, Lanman, Brian A., Li, Liansheng, Lindsay, Colin R., Liu, Yi, Marquez, Abby, Marx, Mathew A., McConnell, Darryl B., McCormick, Frank, Milin, Anthony N., Molina-Arcas, Miriam, Nadal, Ernest, Patny, Akshay, Peters, Ulf, Philips, Mark R., Pota, Kristof, Ren, Pingda, Santamaria, David, Shiraishi, Takuya, Shokat, Kevan M., Simanshu, Dhirendra K., Simon, Daniel, Singh, Mallika, Tamayo, Nuria A., Tanada, Mikimasa, Tapioles, Cristina Nuevo, Tomlinson, Aidan, Wang, Mei, Wang, Xiaolun, Wurz, Ryan P., Zécri, Frédéric J., Zhang, Ziyang

Source: In RAS Drug Discovery 2025:xv-xviii