System and methods for deriving gene signature biomarkers of response to PD-1 antagonists

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

Authors: Cristescu, Razvan, Mogg, Robin, Ayers, Mark, Albright, Andrew, Murphy, Erin, Yearley, Jennifer, Sher, Xinwei, Liu, Xiao Qiao, Lu, Hongchao, Nebozhyn, Michael, Zhang, Chunsheng, Lunceford, Jared, Joe, Andrew, Cheng, Jonathan, Webber, Andrea L., Ibrahim, Nageatte, Plimack, Elizabeth R., Ott, Patrick A., Seiwert, Tanguy, Ribas, Antoni, McClanahan, Terrill K., Tomassini, Joanne E., Loboda, Andrey, Kaufman, David

Source: Science, 2018 Oct 01. 362(6411), 197-197.

Access URL: https://www.jstor.org/stable/26568333

LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

Authors: Bauché, David, Joyce-Shaikh, Barbara, Jain, Renu, Grein, Jeff, Ku, Karin S., Blumenschein, Wendy M., Ganal-Vonarburg, Stephanie C., Wilson, Douglas C., McClanahan, Terrill K., Malefyt, Rene de Waal, Macpherson, Andrew J., Annamalai, Lakshmanan, Yearley, Jennifer H., Cua, Daniel J.

Source: In Immunity 21 August 2018 49(2):342-352

Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction

Authors: Bhagwat, Bhagyashree, Cherwinski, Holly, Sathe, Manjiri, Seghezzi, Wolfgang, McClanahan, Terrill K., de Waal Malefyt, Rene, Willingham, Aarron

Source: In Journal of Immunological Methods May 2018 456:7-14

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells

Authors: Jain, Renu, Chen, Yi, Kanno, Yuka, Joyce-Shaikh, Barbara, Vahedi, Golnaz, Hirahara, Kiyoshi, Blumenschein, Wendy M., Sukumar, Selvakumar, Haines, Christopher J., Sadekova, Svetlana, McClanahan, Terrill K., McGeachy, Mandy J., O’Shea, John J., Cua, Daniel J.

Source: In Immunity 19 January 2016 44(1):131-142

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

Authors: Lee, Jacob S., Tato, Cristina M., Joyce-Shaikh, Barbara, Gulen, Muhammet F., Cayatte, Corinne, Chen, Yi, Blumenschein, Wendy M., Judo, Michael, Ayanoglu, Gulesi, McClanahan, Terrill K., Li, Xiaoxia, Cua, Daniel J.

Source: In Immunity 20 October 2015 43(4):727-738

Cancer-induced Expansion and Activation of CD11b+Gr-1+ Cells Predispose Mice to Adenoviral-triggered Anaphylactoid-type Reactions

Authors: Pande, Kalyan, Ueda, Roanna, Machemer, Todd, Sathe, Manjiri, Tsai, Van, Brin, Elena, Delano, Matthew J, Van Rooijen, Nico, McClanahan, Terrill K, Talmadge, James E, Moldawer, Lyle L, Phillips, Joseph H, LaFace, Drake M

Source: In Molecular Therapy March 2009 17(3):508-515

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

Authors: Elson, Charles O., Cong, Yingzi, Weaver, Casey T., Schoeb, Trenton R., McClanahan, Terrill K., Fick, Robert B., Kastelein, Robert A.

Source: In Gastroenterology 2007 132(7):2359-2370

USE OF CYTOKINE EXPRESSION TO PREDICT SKIN INFLAMMATION; METHODS OF TREATMENT

MAMMALIAN GENES; RELATED REAGENTS AND METHODS

Method of treating skin inflammation

Nucleic acid encoding TNFx protein

USES OF IL-23 AGONISTS AND ANTAGONISTS; RELATED REAGENTS

ISOLATED MAMMALIAN MONOCYTE CELL GENES; RELATED REAGENTS

Methods of inhibiting tumor growth using blocking antibodies to IL-23R

Antibodies that bind DNAX leukocyte associated immunoglobulin-like receptor

MAMMALIAN GENES; RELATED REAGENTS AND METHODS

Use of Cytokine Expression to Predict Skin Inflammation; Methods of Treatment

ISOLATED MAMMALIAN MONOCYTE CELL GENES; RELATED REAGENTS

Method of treating skin inflammation