Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231

Authors: Aguilar-Rojas Arturo, Huerta-Reyes Maira, Maya-Núñez Guadalupe, Arechavaleta-Velásco Fabián, Conn P Michael, Ulloa-Aguirre Alfredo, Valdés Jesús

Source: BMC Cancer, Vol 12, Iss 1, p 550 (2012)

Subject Terms: Gonadotropin-releasing hormone receptor (GnRHR), Gonadotropin-releasing hormone (GnRH), RhoA GTPase, Cell migration, Cell adhesion, Buserelin, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.biomedcentral.com/1471-2407/12/550; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/ad1b06cde22b481ca36e6ca382f7df6b

Activation of human gonadotropin-releasing hormone receptor promotes down regulation of ARHGAP18 and regulates the cell invasion of MDA-MB-231 cells

Authors: Aguilar-Rojas, Arturo, Maya-Núñez, Guadalupe, Huerta-Reyes, Maira, Pérez-Solis, Marco Allán, Silva-García, Raúl, Guillén, Nancy, Olivo-Marin, Jean-Christophe

Source: In Molecular and Cellular Endocrinology 15 January 2018 460:94-103

Editorial: New insights into prostate cancer: new biomarkers, molecular mechanisms, and therapeutic approaches.

Authors: Perri, Anna, Rago, Vittoria, Maya-Núñez, Guadalupe

Source: Frontiers in Endocrinology; 2024, p1-3, 3p

Subject Terms: CASTRATION-resistant prostate cancer, EXPERIMENTAL medicine, SURGICAL margin, G protein coupled receptors, PROSTATE cancer patients

Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism

Authors: Maya-Núñez, Guadalupe, Janovick, Jo Ann, Aguilar-Rojas, Arturo, Jardón-Valadez, Eduardo, Leaños-Miranda, Alfredo, Zariñan, Teresa, Ulloa-Aguirre, Alfredo, Conn, P. Michael

Source: In Molecular and Cellular Endocrinology 2011 337(1):16-23

Dominant negative effects of human follicle-stimulating hormone receptor expression-deficient mutants on wild-type receptor cell surface expression. Rescue of oligomerization-dependent defective receptor expression by using cognate decoys

Authors: Zariñán, Teresa, Perez-Solís, Marco A., Maya-Núñez, Guadalupe, Casas-González, Patricia, Conn, P. Michael, Dias, James A., Ulloa-Aguirre, Alfredo

Source: In Molecular and Cellular Endocrinology 2010 321(2):112-122

Increased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine

Authors: Janovick, Jo Ann, Maya-Núñez, Guadalupe, Ulloa-Aguirre, Alfredo, Huhtaniemi, Ilpo T., Dias, James A., Verbost, Pieter, Conn, P. Michael

Source: In Molecular and Cellular Endocrinology 2009 298(1):84-88

Gonadotropin-Releasing Hormone Receptor Gene, Mutation of

Authors: Ulloa-Aguirre, Alfredo, Maya-Núñez, Guadalupe, Söderlund, Daniela, Conn, P. Michael

Source: Encyclopedia of Endocrine Diseases. 2004, v. 2, p317-321.

Subject Terms: Cellular signal transduction, Puberty, Gonadorelin, Hypogonadism, Structure-activity relationships (Biochemistry), Binding proteins, Human genetics, Luteinizing hormone, Gene mutation, Hormone receptors, Ligands (Biochemistry), Protein structure, Phenotypes

Membrane Receptor Signaling in Health and Disease

Authors: Ulloa-Aguirre, Alfredo, Maya-Núñez, Guadalupe, Timossi, Carlos

Source: Encyclopedia of Hormones. 2003, v. 2, p644-657.

Subject Terms: Ligands (Biochemistry), Glycoproteins, G proteins, Ion channels, Cell membranes

Transcriptional regulation of the GnRH receptor gene by glucocorticoids

Authors: Maya-Núñez, Guadalupe, Conn, P.Michael ^*

Source: In Molecular and Cellular Endocrinology 2003 200(1):89-98

Somatic and Germinal Mosaicism for the Steroid Sulfatase Gene Deletion in a Steroid Sulfatase Deficiency Carrier

Authors: Cuevas-Covarrubias, Sergio Alberto ^*, Jiménez-Vaca, Ana Luisa, González-Huerta, Luz María, del Refugio Rivera-Vega, Maria, Kofman-Alfaro, Susana H., Valdes-Flores, Margarita ^*, Maya-Nunez, Guadalupe

Source: In Journal of Investigative Dermatology October 2002 119(4):972-975

Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization

Authors: Brothers, Shaun P., Janovick, Jo Ann, Maya-Nunez, Guadalupe, Cornea, Anda, Han, Xin-Bing, Conn, P.Michael ^*

Source: In Molecular and Cellular Endocrinology 2002 190(1):19-27

Editorial: GnRH system contribution in cancer regulation and clinical treatment.

Authors: Avila, Euclides, Fiordelisio, Tatiana, Allán Pérez-Solis, Marco, Maya-Núñez, Guadalupe

Source: Frontiers in Endocrinology; 2024, p1-2, 2p

Subject Terms: GONADOTROPIN releasing hormone, BREAST, LUTEINIZING hormone receptors, HYPOTHALAMIC-pituitary-gonadal axis

Gonadotropin-releasing Hormone Receptor Microaggregation: RATE MONITORED BY FLUORESCENCE RESONANCE ENERGY TRANSFER

Authors: Cornea, Anda, Janovick, Jo Ann, Maya-Núñez, Guadalupe, Conn, P. Michael ^‡

Source: In Journal of Biological Chemistry 19 January 2001 276(3):2153-2158

Treatment of Breast Cancer With Gonadotropin-Releasing Hormone Analogs.

Authors: Huerta-Reyes, Maira, Maya-Núñez, Guadalupe, Pérez-Solis, Marco Allán, López-Muñoz, Eunice, Guillén, Nancy, Olivo-Marin, Jean-Christophe, Aguilar-Rojas, Arturo

Source: Frontiers in Oncology; 10/1/2019, p1-17, 17p

Subject Terms: LUTEINIZING hormone releasing hormone receptors, BREAST cancer, CANCER treatment, DIRECT action, TUMOR growth

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Pharmacological Chaperones Correct Misfolded GPCRs and Rescue Function: Protein Trafficking as a Therapeutic Target.

Authors: Maya-Núñez, Guadalupe, Ulloa-Aguirre, Alfredo, Janovick, Jo Ann, Conn, P. Michael

Source: GPCR Signalling Complexes - Synthesis, Assembly, Trafficking & Specificity; 2012, p263-289, 27p

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Combined modification of intracellular and extracellular loci on human gonadotropin-releasing hormone receptor provides a mechanism for enhanced expression.

Authors: Maya-Núñez, Guadalupe, Janovick, Jo, Conn, P.

Source: Endocrine (1355008X); Dec2000, Vol. 13 Issue 3, p401-407, 7p

Contiguous gene syndrome due to deletion of the first three exons of the Kallmann gene and complete deletion of the steroid sulphatase gene.

Authors: Maya-Núñez, Guadalupe, Cuevas-Covarrubias, Sergio, Carlos Zenteno, Juan, Ulloa-Aguirre, Alfredo, Kofman-Alfaro, Susana, Pablo Méndez, Juan

Source: Clinical Endocrinology. Jun1998, Vol. 48 Issue 6, p713-718. 6p.

Subject Terms: *GENETIC disorders, *MOLECULAR diagnosis, *ICHTHYOSIS, *SOMATOTROPIN, *X chromosome abnormalities