Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics

Authors: Joanna Mikulak, Sara Terzoli, Paolo Marzano, Valentina Cazzetta, Giampaolo Martiniello, Rocco Piazza, Maria Estefania Viano, Domenico Vitobello, Rosalba Portuesi, Fabio Grizzi, Mohamed A. A. A. Hegazi, Barbara Fiamengo, Gianluca Basso, Lara Parachini, Laura Mannarino, Maurizio D’Incalci, Sergio Marchini, Domenico Mavilio

Source: Cell Death and Disease, Vol 16, Iss 1, Pp 1-16 (2025)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/f671a280d2d24675823620934136b144

Mechanism of efficacy of trabectedin against myxoid liposarcoma entails detachment of the FUS-DDIT3 transcription factor from its DNA binding sites

Authors: Ilaria Craparotta, Laura Mannarino, Riccardo Zadro, Sara Ballabio, Sergio Marchini, Giulio Pavesi, Marta Russo, Salvatore Lorenzo Renne, Marina Meroni, Marianna Ponzo, Ezia Bello, Roberta Sanfilippo, Paolo G. Casali, Maurizio D’Incalci, Roberta Frapolli

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)

Subject Terms: Trabectedin, Liposarcoma, Myxoid, Chromatin immunoprecipitation sequencing, Adipogenesis, Heterografts, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/203a629155c7470eac352f802f75c616

Distribution of pamiparib, a novel inhibitor of poly(ADP-ribose)-polymerase (PARP), in tumor tissue analyzed by multimodal imaging

Authors: Lavinia Morosi, Sara Timo, Rosy Amodeo, Monica Lupi, Marina Meroni, Ezia Bello, Roberta Frapolli, Giuseppe Martano, Maurizio D'Incalci

Source: Journal of Pharmaceutical Analysis, Vol 15, Iss 3, Pp 101079- (2025)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S209517792400176X; https://doaj.org/toc/2095-1779

Access URL: https://doaj.org/article/f469acbd9a5b4a299350acea5dbc8069

Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations

Authors: Laura Mannarino, Federica Mirimao, Nicolò Panini, Lara Paracchini, Sergio Marchini, Luca Beltrame, Rosy Amodeo, Federica Grosso, Roberta Libener, Irene De Simone, Giovanni L. Ceresoli, Paolo A. Zucali, Monica Lupi, Maurizio D’Incalci

Source: Cell Death and Disease, Vol 13, Iss 7, Pp 1-9 (2022)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/5bde7304069647c4a6e5b02fd41387ae

Modulation of gene expression associated with copy number variation identifies key regulatory programs in high-grade serous ovarian carcinoma

Authors: Martina Vescio, Lara Paracchini, Luca Beltrame, Maurizio D’Incalci, Sergio Marchini, Linda Pattini

Source: Advances in Cancer Biology - Metastasis, Vol 7, Iss , Pp 100088- (2023)

Subject Terms: High-grade serous ovarian carcinoma, Gene expression, Copy number variation, Systems biology, Cancer informatics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667394023000023; https://doaj.org/toc/2667-3940

Access URL: https://doaj.org/article/6fc85128e64f4a40b87e1afa50f762cf

Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma

Authors: Elisabeth Digifico, Marco Erreni, Laura Mannarino, Sergio Marchini, Aldo Ummarino, Clément Anfray, Luca Bertola, Camilla Recordati, Daniela Pistillo, Massimo Roncalli, Paola Bossi, Paolo Andrea Zucali, Maurizio D’Incalci, Cristina Belgiovine, Paola Allavena

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: osteopontin (OPN), MPM (malignant pleural mesothelioma), immune system and cancer, immunotherapy, novel therapeutic approach, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1116430/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/68711fac11ea42e48295576f8070971b

Knowledge and attitudes towards clinical trials among women with ovarian cancer: results of the ACTO study

Authors: Paola Mosconi, Anna Roberto, Nicoletta Cerana, Nicoletta Colombo, Florence Didier, Maurizio D’Incalci, Domenica Lorusso, Fedro Alessandro Peccatori, Network of Clinicians and Participants (1)

Source: Journal of Ovarian Research, Vol 15, Iss 1, Pp 1-9 (2022)

Subject Terms: Ovarian Cancer, Knowledge, Advocacy group, Survey, Gynecology and obstetrics, RG1-991

File Description: electronic resource

Relation: https://doaj.org/toc/1757-2215

Access URL: https://doaj.org/article/83c46fbba09d4a3b94cac994cca3615b

Editorial: Trabectedin, lurbinectedin, and other marine-derived anticancer alkaloids on solid cancer: Mechanisms of action, clinical impact, and future perspectives

Authors: Alberto Zambelli, Maurizio D’Incalci

Source: Frontiers in Oncology, Vol 12 (2023)

Subject Terms: marine drugs, trabectedin, lurbinectedin, eribulin and related compounds, solid tumor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.1115342/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/ab3b71e1ffd54de58f220e469e0ab383

PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models

Authors: Lavinia Morosi, Marina Meroni, Paolo Ubezio, Ilaria Fuso Nerini, Lucia Minoli, Luca Porcu, Nicolò Panini, Marika Colombo, Barbara Blouw, David W. Kang, Enrico Davoli, Massimo Zucchetti, Maurizio D’Incalci, Roberta Frapolli

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-13 (2021)

Subject Terms: Mass spectrometry imaging, Drug distribution, Extracellular matrix, Hyaluronan, Solid tumours, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/4214b5ab153e4739bc53c7865dca3750

Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis

Authors: Francesca Sanges, Matteo Floris, Paolo Cossu-Rocca, Maria R. Muroni, Giovanna Pira, Silvana Anna Maria Urru, Renata Barrocu, Silvano Gallus, Cristina Bosetti, Maurizio D’Incalci, Alessandra Manca, Maria Gabriela Uras, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Dolores Palmas, Francesco Atzori, Angelo Zinellu, Francesca Cambosu, Tiziana Moi, Massimo Ghiani, Vincenzo Marras, Maria Cristina Santona, Luisa Canu, Enrichetta Valle, Maria Giuseppina Sarobba, Daniela Onnis, Anna Asunis, Sergio Cossu, Sandra Orrù, Maria Rosaria De Miglio

Source: BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)

Subject Terms: Triple negative breast cancer, Clinico-pathological features, Prognosis, Histologic special type, Tumor size, Metastatic lymph node, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-020-06998-9; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/ae814c38082d403bbe0df6d096104f57

Effects of the Anti-Tumor Agents Trabectedin and Lurbinectedin on Immune Cells of the Tumor Microenvironment

Authors: Paola Allavena, Cristina Belgiovine, Elisabeth Digifico, Roberta Frapolli, Maurizio D’Incalci

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: tumor-associated macrophages, trabectedin, lurbinectedin, tumor micro-environment, immunity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.851790/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/bc8de55f925e4464964dc8cdca572932

Tumor Immune Microenvironment and Genetic Alterations in Mesothelioma

Authors: Stefanie Hiltbrunner, Laura Mannarino, Michaela B. Kirschner, Isabelle Opitz, Angelica Rigutto, Alexander Laure, Michela Lia, Paolo Nozza, Antonio Maconi, Sergio Marchini, Maurizio D’Incalci, Alessandra Curioni-Fontecedro, Federica Grosso

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: mesothelioma, tumor microenvironment, genetic alterations, immunotherapy, targeted therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.660039/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/6ff52d24fb5a455594cd6f686950112c

Low Expression of Claudin-7 as Potential Predictor of Distant Metastases in High-Grade Serous Ovarian Carcinoma Patients

Authors: Chiara Romani, Valentina Zizioli, Marco Silvestri, Laura Ardighieri, Mattia Bugatti, Michela Corsini, Paola Todeschini, Sergio Marchini, Maurizio D'Incalci, Laura Zanotti, Antonella Ravaggi, Fabio Facchetti, Angela Gambino, Franco Odicino, Enrico Sartori, Alessandro Davide Santin, Stefania Mitola, Eliana Bignotti, Stefano Calza

Source: Frontiers in Oncology, Vol 10 (2020)

Subject Terms: high grade serous ovarian carcinoma, fallopian tube epithelium, claudins, distant metastases, hematogenous spread, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2020.01287/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/8a3b8f139a7a4efa94b6ab8f116c19a7

Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

Authors: Silvana Anna Maria Urru, Silvano Gallus, Cristina Bosetti, Tiziana Moi, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Francesca Sanges, Giovanna Pira, Alessandra Manca, Dolores Palmas, Matteo Floris, Anna Maria Asunis, Francesco Atzori, Ciriaco Carru, Maurizio D’Incalci, Massimo Ghiani, Vincenzo Marras, Daniela Onnis, Maria Cristina Santona, Giuseppina Sarobba, Enrichetta Valle, Luisa Canu, Sergio Cossu, Alessandro Bulfone, Paolo Cossu Rocca, Maria Rosaria De Miglio, Sandra Orrù

Source: BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)

Subject Terms: Clinicopathologic factors, Prognostic factors, Stage, Survival, Triple-negative breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-017-3969-y; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/f09b6cc659d74fc5b059479e4e479c12

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Authors: Elena Campaner, Alessandra Rustighi, Alessandro Zannini, Alberto Cristiani, Silvano Piazza, Yari Ciani, Ori Kalid, Gali Golan, Erkan Baloglu, Sharon Shacham, Barbara Valsasina, Ulisse Cucchi, Agnese Chiara Pippione, Marco Lucio Lolli, Barbara Giabbai, Paola Storici, Paolo Carloni, Giulia Rossetti, Federica Benvenuti, Ezia Bello, Maurizio D’Incalci, Elisa Cappuzzello, Antonio Rosato, Giannino Del Sal

Source: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e607d20382804710bdbe82d915bc8ddd

MAL gene overexpression as a marker of high-grade serous ovarian carcinoma stem-like cells that predicts chemoresistance and poor prognosis

Authors: Laura Zanotti, Chiara Romani, Laura Tassone, Paola Todeschini, Renata Alessandra Tassi, Elisabetta Bandiera, Giovanna Damia, Francesca Ricci, Laura Ardighieri, Stefano Calza, Sergio Marchini, Luca Beltrame, Germana Tognon, Maurizio D’Incalci, Sergio Pecorelli, Enrico Sartori, Franco Odicino, Antonella Ravaggi, Eliana Bignotti

Source: BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)

Subject Terms: Cancer stem cells, Epithelial ovarian cancer, Chemoresistance, MAL, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-017-3334-1; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/87f29fb63e524c3b83dd910c29002f5f

FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients

Authors: Renata A. Tassi, Paola Todeschini, Eric R. Siegel, Stefano Calza, Paolo Cappella, Laura Ardighieri, Moris Cadei, Mattia Bugatti, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Laura Tassone, Donatella Guarino, Concetta Santonocito, Ettore D. Capoluongo, Luca Beltrame, Eugenio Erba, Sergio Marchini, Maurizio D’Incalci, Carla Donzelli, Alessandro D. Santin, Sergio Pecorelli, Enrico Sartori, Eliana Bignotti, Franco Odicino, Antonella Ravaggi

Source: Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-18 (2017)

Subject Terms: Epithelial ovarian cancer, Subtype, Prognosis, Chemoresistance, FOXM1, Cell line, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13046-017-0536-y; https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/7abd7f5bedb6495f962c0a510f2fcd71

Venetoclax penetrates in cerebrospinal fluid and may be effective in chronic lymphocytic leukemia with central nervous system involvement

Authors: Gianluigi Reda, Ramona Cassin, Gabriela Dovrtelova, Cristina Matteo, Juri Giannotta, Maurizio D’Incalci, Agostino Cortelezzi, Massimo Zucchetti

Source: Haematologica, Vol 104, Iss 5 (2019)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8914; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/3d9a1b67498c48c3896a07621e3c41dc

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

Authors: Valentina Iori, Anand M. Iyer, Teresa Ravizza, Luca Beltrame, Lara Paracchini, Sergio Marchini, Milica Cerovic, Cameron Hill, Mariella Ferrari, Massimo Zucchetti, Monica Molteni, Carlo Rossetti, Riccardo Brambilla, H. Steve White, Maurizio D'Incalci, Eleonora Aronica, Annamaria Vezzani

Source: Neurobiology of Disease, Vol 99, Iss , Pp 12-23 (2017)

Subject Terms: Neuroinflammation, Epilepsy, Seizures, Disease-modification, Hyperexcitability, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996116302881; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/6e1282d045224c0cb2029a5afa349aa9

Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype

Authors: Simone Borgoni, Andrea Iannello, Santina Cutrupi, Paola Allavena, Maurizio D'Incalci, Francesco Novelli, Paola Cappello

Source: OncoImmunology, Vol 7, Iss 2 (2018)

Subject Terms: epigenetics, pancreatic cancer, t cells, trabectedin, tumor microenvironment, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/04914c4231fb423caf5c8245cfb935b0