Neuronal TDP-43 aggregation drives changes in microglial morphology prior to immunophenotype in amyotrophic lateral sclerosis

Authors: Molly E. V. Swanson, Miran Mrkela, Clinton Turner, Maurice A. Curtis, Richard L. M. Faull, Adam K. Walker, Emma L. Scotter

Source: Acta Neuropathologica Communications, Vol 13, Iss 1, Pp 1-16 (2025)

Subject Terms: Amyotrophic lateral sclerosis, Microglia, TDP-43, Iba1, CD68, Ramified, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/a8d38c9fdfd24f599f603281a6b47697

N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson’s disease

Authors: James A. Wiseman, YuHong Fu, Richard L. M. Faull, Clinton P. Turner, Maurice A. Curtis, Glenda M. Halliday, Birger V. Dieriks

Source: Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-16 (2024)

Subject Terms: α-Synuclein, Lewy body diseases, Parkinson’s disease, Multiple system atrophy, N-terminus, Epitope-specific, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9158

Access URL: https://doaj.org/article/e697ebcde2bb4b079af3799f42277155

Visualizing the human olfactory projection and ancillary structures in a 3D reconstruction

Authors: Victoria F. Low, Chinchien Lin, Shan Su, Mahyar Osanlouy, Mona Khan, Soroush Safaei, Gonzalo Maso Talou, Maurice A. Curtis, Peter Mombaerts

Source: Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/0fffb32c714942ebac31aebcf505004d

Elucidating cortical neurovascular involvement in Huntington's disease using human brain tissue microarrays

Authors: Adelie Y.S. Tan, Lance C.M.G. Martinez, Helen C. Murray, Nasim F. Mehrabi, Lynette J. Tippett, Clinton P. Turner, Maurice A. Curtis, Richard L.M. Faull, Mike Dragunow, Malvindar K. Singh-Bains

Source: Neurobiology of Disease, Vol 206, Iss , Pp 106829- (2025)

Subject Terms: Huntington's disease, Middle temporal gyrus, Human brain, Tissue microarrays, Vascular system, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996125000452; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/0f0ecece2f7548e790dce22ca0d3fb30

Astrocytic proteins involved in regulation of the extracellular environment are increased in the Alzheimer's disease middle temporal gyrus

Authors: Henry Liu, Adelie Y.S. Tan, Nasim F. Mehrabi, Clinton P. Turner, Maurice A. Curtis, Richard L.M. Faull, Mike Dragunow, Malvindar K. Singh-Bains, Amy M. Smith

Source: Neurobiology of Disease, Vol 204, Iss , Pp 106749- (2025)

Subject Terms: Alzheimer's disease, Astrocytes, Tissue microarray, Inwardly rectifying potassium channel 4.1 (Kir4.1), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996124003516; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/2d117239cff24b55ad18c2e4f29d2f10

Microglial proliferation and astrocytic protein alterations in the human Huntington's disease cortex

Authors: Adelie Y.S. Tan, Lynette J. Tippett, Clinton P. Turner, Molly E.V. Swanson, Thomas I.H. Park, Maurice A. Curtis, Richard L.M. Faull, Mike Dragunow, Malvindar K. Singh-Bains

Source: Neurobiology of Disease, Vol 198, Iss , Pp 106554- (2024)

Subject Terms: Huntington's disease, Gliosis, Human brain tissue, Proliferation, Middle temporal gyrus, Tissue microarrays, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996124001530; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/b55a6aaec4d04011a25fb03e9a9414ad

Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson’s disease brains

Authors: Florian Ermini, Victoria F. Low, Jennifer J. Song, Adelie Y. S. Tan, Richard L. M. Faull, Michael Dragunow, Maurice A. Curtis, Stephen S. Dominy

Source: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/e8b7aafa120347438648a23f9c4049de

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration

Authors: Rebecca San Gil, Dana Pascovici, Juliana Venturato, Heledd Brown-Wright, Prachi Mehta, Lidia Madrid San Martin, Jemma Wu, Wei Luan, Yi Kit Chui, Adekunle T. Bademosi, Shilpa Swaminathan, Serey Naidoo, Britt A. Berning, Amanda L. Wright, Sean S. Keating, Maurice A. Curtis, Richard L. M. Faull, John D. Lee, Shyuan T. Ngo, Albert Lee, Marco Morsch, Roger S. Chung, Emma Scotter, Leszek Lisowski, Mehdi Mirzaei, Adam K. Walker

Source: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4c4d2aa5f2d24e1cbc0429058653faa3

Aggregate-prone brain regions in Parkinson’s disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility

Authors: James A. Wiseman, Helen C. Murray, Richard L. M. F. Faull, Michael Dragunow, Clinton P. Turner, Birger Victor Dieriks, Maurice A. Curtis

Source: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-18 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/bfdc8b86e92a4efbb9294b4b59a33ad1

ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer’s disease

Authors: Christopher E. Ramsden, Daisy Zamora, Mark S. Horowitz, Jahandar Jahanipour, Elizabeth Calzada, Xiufeng Li, Gregory S. Keyes, Helen C. Murray, Maurice A. Curtis, Richard M. Faull, Andrea Sedlock, Dragan Maric

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-31 (2023)

Subject Terms: ApoER2, ApoE, Dab1, Alzheimer's disease, P85α, LIMK1, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/e3736605578a4ed187f90e071e5def20

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain

Authors: Molly E. V. Swanson, Miran Mrkela, Helen C. Murray, Maize C. Cao, Clinton Turner, Maurice A. Curtis, Richard L. M. Faull, Adam K. Walker, Emma L. Scotter

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-22 (2023)

Subject Terms: Amyotrophic lateral sclerosis, Microglia, TDP-43, CD68, L-ferritin, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/ffaa51da88b7483d88b75ccc62336f16

A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue

Authors: Maize C. Cao, Brigid Ryan, Jane Wu, Maurice A. Curtis, Richard L.M. Faull, Mike Dragunow, Emma L. Scotter

Source: Neurobiology of Disease, Vol 185, Iss , Pp 106245- (2023)

Subject Terms: Amyotrophic lateral sclerosis, Frontotemporal dementia, TDP-43, mRNA, Splicing, Cryptic exon, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996123002607; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/8e5f99125ab542caac7f334399448b57

Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress

Authors: Taylor J. Stevenson, Rebecca H. Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C. D. Smyth, Helen C. Murray, Richard L. M. Faull, Jason Correia, Patrick Schweder, Peter Heppner, Clinton Turner, Ronald Melki, Birger V. Dieriks, Maurice A. Curtis, Michael Dragunow

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0a4e76a833d74d76a95832207eacbaf4

Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature

Authors: Helen C. Murray, Chelsie Osterman, Paige Bell, Luca Vinnell, Maurice A. Curtis

Source: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-20 (2022)

Subject Terms: Chronic traumatic encephalopathy, Dementia pugilistica, Neuropathology, Systematic review, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/ed98e3bde86544d7b56337b616ff2911

Persistent cortical and white matter inflammation after therapeutic hypothermia for ischemia in near-term fetal sheep

Authors: Kelly Q. Zhou, Laura Bennet, Guido Wassink, Alice McDouall, Maurice A. Curtis, Blake Highet, Taylor J. Stevenson, Alistair J. Gunn, Joanne O. Davidson

Source: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-20 (2022)

Subject Terms: Hypoxia-ischemia, Therapeutic hypothermia, Neuroinflammation, Microglial phenotype, Gitter cells, Electroencephalogram, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/16799a8ccd7745eaba4417366db113e7

Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease

Authors: Leon C. D. Smyth, Helen C. Murray, Madison Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Bruce Mockett, Malvindar K. Singh-Bains, Vanessa K. Morris, Andrew N. Clarkson, Maurice A. Curtis, Wickliffe C. Abraham, Stephanie M. Hughes, Richard L. M. Faull, Anthony J. Kettle, Mike Dragunow, Mark B. Hampton

Source: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)

Subject Terms: Alzheimer’s disease, Neutrophil, Neutrophil extracellular trap, Blood–brain barrier, Myeloperoxidase, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/4881c6c2cd424db9be6a4d32261c425f

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease

Authors: Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow

Source: Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/ac4315ac00c245ed917bf0edddaef79a

Lamina-specific immunohistochemical signatures in the olfactory bulb of healthy, Alzheimer’s and Parkinson’s disease patients

Authors: Helen C. Murray, Kory Johnson, Andrea Sedlock, Blake Highet, Birger Victor Dieriks, Praju Vikas Anekal, Richard L. M. Faull, Maurice A. Curtis, Alan Koretsky, Dragan Maric

Source: Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/4e92955a464b4b988c6b5cc67bfa5f33

N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease

Authors: Florence E. Layburn, Adelie Y.S. Tan, Nasim F. Mehrabi, Maurice A. Curtis, Lynette J. Tippett, Clinton P. Turner, Nathan Riguet, Lorène Aeschbach, Hilal A. Lashuel, Mike Dragunow, Richard L.M. Faull, Malvindar K. Singh-Bains

Source: Neurobiology of Disease, Vol 174, Iss , Pp 105884- (2022)

Subject Terms: Huntington's disease, Middle temporal gyrus, Cortex, Human brain, Tissue microarrays, Immunohistochemistry, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996122002765; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/682f2366ef5b465c8aba8d90bd1270c5

Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS

Authors: Sarah Waters, Molly E. V. Swanson, Birger V. Dieriks, Yibin B. Zhang, Natasha L. Grimsey, Helen C. Murray, Clinton Turner, Henry J. Waldvogel, Richard L. M. Faull, Jiyan An, Robert Bowser, Maurice A. Curtis, Mike Dragunow, Emma Scotter

Source: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)

Subject Terms: Blood–brain barrier, Blood-spinal cord barrier, TDP-43, ALS, Hemoglobin, Human, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/075e0657417440b8988eb257ce9ef0e0