Relationship of binding-site occupancy, transthyretin stabilisation and disease modification in patients with tafamidis-treated transthyretin amyloid cardiomyopathy

Authors: Tess, David A., Maurer, Tristan S., Li, Zhenhong, Bulawa, Christine, Fleming, James, Moody, Amy T.

Source: Amyloid. 30(2):208-219

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Designing small molecules for therapeutic success: A contemporary perspective

Authors: Maurer, Tristan S., Edwards, Martin, Hepworth, David, Verhoest, Patrick, Allerton, Charlotte M.N.

Source: Drug discovery today. 27(2):538-546

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The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization

Authors: Thorarensen, Atli, Balbo, Paul, Banker, Mary E., Czerwinski, Robert M., Kuhn, Max, Maurer, Tristan S., Telliez, Jean-Baptiste, Vincent, Fabien, Wittwer, Arthur J.

Source: In Bioorganic & Medicinal Chemistry 1 January 2021 29

In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier

Authors: Trapa, Patrick E., Troutman, Matthew D., Lau, Thomas Y., Wager, Travis T., Maurer, Tristan S., Patel, Nandini C., West, Mark A., Umland, John P., Carlo, Anthony A., Feng, Bo, Liras, Jennifer L. ^*

Source: In Drug Metabolism and Disposition April 2019 47(4):405-411

Modeling Exposure to Understand and Predict Kidney Injury

Authors: Li, Zhenhong ^*, Fisher, Ciaran, Gardner, Iain, Ghosh, Avijit, Litchfield, John, Maurer, Tristan S. ^*

Source: In Seminars in Nephrology March 2019 39(2):176-189

Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition

Authors: Chang, Cheng ^{1, *}, Fonseca, Kari R. ¹, Li, Cheryl, Horner, Weldon, Zawadzke, Laura E., Salafia, Michelle A., Welch, Kathryn A., Strick, Christine A., Campbell, Brian M., Gernhardt, Steve S., Rong, Haojing, Sawant-Basak, Aarti, Liras, Jennifer, Dounay, Amy, Tuttle, Jamison B., Verhoest, Patrick, Maurer, Tristan S.

Source: In Molecular Pharmacology August 2018 94(2):823-833

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects

Authors: Li, Rui ^*, Niosi, Mark, Johnson, Nathaniel, Tess, David A., Kimoto, Emi, Lin, Jian, Yang, Xin, Riccardi, Keith A., Ryu, Sangwoo, El-Kattan, Ayman F., Maurer, Tristan S., Tremaine, Larry M., Di, Li

Source: In Drug Metabolism and Disposition April 2018 46(4):346-356

Nonspecific Binding Considerations in the Rational Design and Development of Small Molecule COVID‐19 Therapeutics

Authors: Maurer, Tristan S.

Source: Clinical pharmacology & therapeutics. 110(2):294-296

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Quantitative Model‐Based Assessment of Multiple Sickle Cell Disease Therapeutic Approaches Alone and in Combination.

Authors: Moody, Amy T., Narula, Jatin, Maurer, Tristan S.

Source: Clinical Pharmacology & Therapeutics; May2024, Vol. 115 Issue 5, p1114-1121, 8p

Subject Terms: SICKLE cell anemia, FETAL hemoglobin, ERYTHROCYTES, OXIMETRY, THERAPEUTICS, OXYGEN saturation, HEMOGLOBINS

In Vitro–In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein–Cannulated Monkey

Authors: Trapa, Patrick E., Beaumont, Kevin, Atkinson, Karen, Eng, Heather, King-Ahmad, Amanda, Scott, Dennis O., Maurer, Tristan S., Di, Li

Source: In Journal of Pharmaceutical Sciences March 2017 106(3):898-905

Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells

Authors: Chien, Huan-Chieh, Zur, Arik A, Maurer, Tristan S, Yee, Sook Wah, Tolsma, John, Jasper, Paul, Scott, Dennis O, Giacomini, Kathleen M ^*

Source: In Drug Metabolism and Disposition March 2016 44(3):356-364

PF-1355, a Mechanism-Based Myeloperoxidase Inhibitor, Prevents Immune Complex Vasculitis and Anti–Glomerular Basement Membrane Glomerulonephritis

Authors: Zheng, Wei, Warner, Roscoe, Ruggeri, Roger, Su, Chunyan, Cortes, Christian, Skoura, Athanasia, Ward, Jessica, Ahn, Kay, Kalgutkar, Amit, Sun, Dexue, Maurer, Tristan S., Bonin, Paul D., Okerberg, Carlin, Bobrowski, Walter, Kawabe, Thomas, Zhang, Yanwei, Coskran, Timothy, Bell, Sammy, Kapoor, Bhupesh, Johnson, Kent, Buckbinder, Leonard ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics May 2015 353(2):288-298

Physiologically Based Pharmacokinetic Prediction of Telmisartan in Human

Authors: Li, Rui, Ghosh, Avijit, Maurer, Tristan S., Kimoto, Emi, Barton, Hugh A. ^*

Source: In Drug Metabolism and Disposition October 2014 42(10):1646-1655

Toward a Unified Model of Passive Drug Permeation II: The Physiochemical Determinants of Unbound Tissue Distribution with Applications to the Design of Hepatoselective Glucokinase Activators

Authors: Ghosh, Avijit ^*, Maurer, Tristan S., Litchfield, John, Varma, Manthema V., Rotter, Charles, Scialis, Renato, Feng, Bo, Tu, Meihua, Guimaraes, Cris R. W, Scott, Dennis O.

Source: In Drug Metabolism and Disposition October 2014 42(10):1599-1610

Towards a unified model of passive drug permeation I: Origins of the unstirred water layer with applications to ionic permeation

Authors: Ghosh, Avijit, Scott, Dennis O., Maurer, Tristan S.

Source: In European Journal of Pharmaceutical Sciences 14 February 2014 52:109-124

A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships

Authors: Guerrero, Yadir A., Desai, Diti, Sullivan, Connor, Kindt, Erick, Spilker, Mary E., Maurer, Tristan S., Solomon, Deepak E., Bartlett, Derek W.

Source: AAPS journal. 22(2)

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Impact of Recovery on Fraction Unbound Using Equilibrium Dialysis

Authors: Di, Li ^*, Umland, John P., Trapa, Patrick E., Maurer, Tristan S.

Source: In Journal of Pharmaceutical Sciences March 2012 101(3):1327-1335

Theoretical Considerations for Direct Translation of Unbound Liver-to-Plasma Partition Coefficient from In Vitro to In Vivo

Authors: Li, Zhenhong, Di, Li, Maurer, Tristan S.

Source: AAPS journal. 21(3)

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Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Parathyroid Hormone-Calcium Homeostasis in Rats and Humans

Authors: Abraham, Anson K., Mager, Donald E., Gao, Xiang, Li, Mei, Healy, David R., Maurer, Tristan S. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics July 2009 330(1):169-178

In Silico Modeling of Nonspecific Binding to Human Liver Microsomes

Authors: Gao, Hua, Yao, Lili, Mathieu, Heather W., Zhang, Ying, Maurer, Tristan S., Troutman, Matthew D., Scott, Dennis O., Ruggeri, Roger B., Lin, Jing ^*

Source: In Drug Metabolism and Disposition October 2008 36(10):2130-2135