Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders

Authors: Dernovšek, Jaka, Goričan, Tjaša, Gedgaudas, Marius, Zajec, Živa, Urbančič, Dunja, Jug, Ana, Skok, Žiga, Sturtzel, Caterina, Distel, Martin, Grdadolnik, Simona Golič, Babu, Kesavan, Panchamatia, Ashna, Stachowski, Timothy R., Fischer, Marcus, Ilaš, Janez, Zubrienė, Asta, Matulis, Daumantas, Zidar, Nace, Tomašič, Tihomir

Source: In European Journal of Medicinal Chemistry 15 December 2024 280

Comprehensive analysis of resorcinyl-imidazole Hsp90 inhibitor design

Authors: Gedgaudas, Marius, Kaziukonytė, Paulina, Kairys, Visvaldas, Mickevičiūtė, Aurelija, Zubrienė, Asta, Brukštus, Algirdas, Matulis, Daumantas, Kazlauskas, Egidijus

Source: In European Journal of Medicinal Chemistry 5 July 2024 273

Inhibitor binding to metal-substituted metalloenzyme: Sulfonamide affinity for carbonic anhydrase IX

Authors: Baronas, Denis, Knašienė, Birutė, Mickevičiūtė, Aurelija, Jachno, Jelena, Naujalis, Evaldas, Zubrienė, Asta, Matulis, Daumantas

Source: In Journal of Inorganic Biochemistry July 2024 256

Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation

Authors: Hadi Ali Janvand, Saeid, Ladefoged, Lucy Kate, Zubrienė, Asta, Sakalauskas, Andrius, Christiansen, Gunna, Dudutienė, Virginija, Schiøtt, Birgit, Matulis, Daumantas, Smirnovas, Vytautas, Otzen, Daniel E.

Source: International journal of biological macromolecules. 227:590-600

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178701782.0x000001&indx=1&recIds=ETOCvdc_100178701782.0x000001

Thermott: A comprehensive online tool for protein–ligand binding constant determination

Authors: Gedgaudas, Marius, Baronas, Denis, Kazlauskas, Egidijus, Petrauskas, Vytautas, Matulis, Daumantas

Source: Drug discovery today. 27(8):2076-2079

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167459478.0x000001&indx=1&recIds=ETOCvdc_100167459478.0x000001

Denaturant- or ligand-induced changes in protein volume by pressure shift assay

Authors: Skvarnavičius, Gediminas, Toleikis, Zigmantas, Matulis, Daumantas, Petrauskas, Vytautas

Source: Physical chemistry chemical physics. 24(28):17279-17288

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156169245.0x000001&indx=1&recIds=ETOCvdc_100156169245.0x000001

Intrinsic affinity of protein – ligand binding by differential scanning calorimetry

Authors: Linkuvienė, Vaida, Zubrienė, Asta, Matulis, Daumantas

Source: In BBA - Proteins and Proteomics 1 September 2022 1870(9)

Biphenyl substituted lysine derivatives as recognition elements for the matrix metalloproteinases MMP-2 and MMP-9

Authors: Kirchhain, Arno, Zubrienė, Asta, Kairys, Visvaldas, Vivaldi, Federico, Bonini, Andrea, Biagini, Denise, Santalucia, Delio, Matulis, Daumantas, Di Francesco, Fabio

Source: In Bioorganic Chemistry October 2021 115

Design and Synthesis of Hydrazone‐Bearing Benzenesulfonamides as Carbonic Anhydrase VB Inhibitors

Authors: Urbelytė, Liucija, Bagdonas, Martynas, Grybaitė, Birutė, Vaickelionienė, Rita, Mickevičiūtė, Aurelija, Michailovienė, Vilma, Matulis, Daumantas, Mickevičius, Vytautas, Zubrienė, Asta

Source: ChemistrySelect. 6(47):13506-13513

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137369231.0x000001&indx=1&recIds=ETOCvdc_100137369231.0x000001

Switching the Inhibitor‐Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII

Authors: Smirnovienė, Joana, Smirnov, Alexey, Zakšauskas, Audrius, Zubrienė, Asta, Petrauskas, Vytautas, Mickevičiūtė, Aurelija, Michailovienė, Vilma, Čapkauskaitė, Edita, Manakova, Elena, Gražulis, Saulius, Baranauskienė, Lina, Chen, Wen‐Yih, Ladbury, John E., Matulis, Daumantas

Source: ChemistryOpen. 10(5):567-580

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132985654.0x000001&indx=1&recIds=ETOCvdc_100132985654.0x000001

Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures

Authors: Gulla, Aistė, Kazlauskas, Egidijus, Liang, Hong, Strupas, Kestutis, Petrauskas, Vytautas, Matulis, Daumantas, Eshleman, James R.

Source: Pancreas. 50(4):625-632

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182313679.0x000001&indx=1&recIds=ETOCvdc_100182313679.0x000001

Experimental Approaches to Identify Selective Picomolar Inhibitors for Carbonic Anhydrase IX

Authors: Kazokaitė-Adomaitienė, Justina, Becker, Holger M., Smirnovienė, Joana, Dubois, Ludwig J., Matulis, Daumantas

Source: Current medicinal chemistry. 28(17):3361-3384

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123193705.0x000001&indx=1&recIds=ETOCvdc_100123193705.0x000001

Structure‐Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid‐β Aggregation.

Authors: Žvirblis, Mantas¹, Sakalauskas, Andrius², Ali Janvand, Saeid Hadi³, Dudutienė, Virginija¹, Žiaunys, Mantas², Sniečkutė, Rūta², Otzen, Daniel E.³, Smirnovas, Vytautas², Matulis, Daumantas¹, matulis@ibt.lt

Source: Chemistry - A European Journal; 10/17/2024, Vol. 30 Issue 58, p1-27, 27p

Studies of the interactions mechanism between DNA and silica surfaces by Isothermal Titration Calorimetry

Authors: Chen, Wen-Yih, Matulis, Daumantas, Hu, Wen-Pin, Lai, Yi-Fang, Wang, Wei-How

Source: In Journal of the Taiwan Institute of Chemical Engineers November 2020 116:62-66

Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle

Authors: Dudutienė, Virginija, Zubrienė, Asta, Kairys, Visvaldas, Smirnov, Alexey, Smirnovienė, Joana, Leitans, Janis, Kazaks, Andris, Tars, Kaspars, Manakova, Lena, Gražulis, Saulius, Matulis, Daumantas

Source: In Biophysical Journal 20 October 2020 119(8):1513-1524

Reduction of interstrand charge repulsion of DNA duplexes by salts and by neutral phosphotriesters – Contrary effects for harnessing duplex formation

Authors: Kuo, Tai-Chih, Wu, Meng-Wei, Lin, Wei-Chen, Matulis, Daumantas, Yang, Yuh-Shyong, Li, Si-Yu, Chen, Wen-Yih

Source: In Journal of the Taiwan Institute of Chemical Engineers May 2020 110:1-7

Synthesis and structure–affinity relationship of chlorinated pyrrolidinone-bearing benzenesulfonamides as human carbonic anhydrase inhibitors

Authors: Balandis, Benas, Ivanauskaitė, Guostė, Smirnovienė, Joana, Kantminienė, Kristina, Matulis, Daumantas, Mickevičius, Vytautas, Zubrienė, Asta

Source: In Bioorganic Chemistry April 2020 97

Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms

Authors: Zakšauskas, Audrius, Čapkauskaitė, Edita, Jezepčikas, Linas, Linkuvienė, Vaida, Paketurytė, Vaida, Smirnov, Alexey, Leitans, Janis, Kazaks, Andris, Dvinskis, Elviss, Manakova, Elena, Gražulis, Saulius, Tars, Kaspars, Matulis, Daumantas

Source: In European Journal of Medicinal Chemistry 1 January 2020 185

Molecular self-interactions of ribonuclease A revealed by isothermal titration calorimetry and self-interaction chromatography – Effects of anisotropy of protein surface charges

Authors: Kuo, Tai-Chih, Huang, Yu-Chiang, Matulis, Daumantas, Chen, Wen-Yih

Source: In Journal of the Taiwan Institute of Chemical Engineers March 2019 96:74-81

Advancing 3D Spheroid Research through 3D Scaffolds Made by Two-Photon Polymerization.

Authors: Vitkūnaitė, Eglė, Žymantaitė, Eglė, Mlynska, Agata, Andrijec, Dovilė, Limanovskaja, Karolina, Kaszynski, Grzegorz, Matulis, Daumantas, Šakalys, Vidmantas, Jonušauskas, Linas

Source: Bioengineering (Basel); Sep2024, Vol. 11 Issue 9, p902, 16p

Subject Terms: CELL culture, CELL lines, ARCHITECTURAL design, GENE expression, DRUG target, CANCER cell culture, TISSUE scaffolds