Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study

Authors: Manina M. Etter, Tomás A. Martins, Laila Kulsvehagen, Elisabeth Pössnecker, Wandrille Duchemin, Sabrina Hogan, Gretel Sanabria-Diaz, Jannis Müller, Alessio Chiappini, Jonathan Rychen, Noëmi Eberhard, Raphael Guzman, Luigi Mariani, Lester Melie-Garcia, Emanuela Keller, Ilijas Jelcic, Hans Pargger, Martin Siegemund, Jens Kuhle, Johanna Oechtering, Caroline Eich, Alexandar Tzankov, Matthias S. Matter, Sarp Uzun, Özgür Yaldizli, Johanna M. Lieb, Marios-Nikos Psychogios, Karoline Leuzinger, Hans H. Hirsch, Cristina Granziera, Anne-Katrin Pröbstel, Gregor Hutter

Source: Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f0470cc90c504832a493429d193b5b41

Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report

Authors: Marie-Anne Meier, Sandro Nuciforo, Mairene Coto-Llerena, John Gallon, Matthias S. Matter, Caner Ercan, Jürg Vosbeck, Luigi M. Terracciano, Savas D. Soysal, Daniel Boll, Otto Kollmar, Raphaël Delaloye, Salvatore Piscuoglio, Markus H. Heim

Source: Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/092df1cdee254031870f4d0caaa0bd75

miR‐579‐3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3‐Kinase–Protein Kinase B Pathway in Chronically Inflamed Liver

Authors: Cristina Quintavalle, Nathalie Meyer‐Schaller, Stephanie Roessler, Diego Calabrese, Romina Marone, Tobias Riedl, Silvia Picco‐Rey, Orestis A. Panagiotou, Sarp Uzun, Salvatore Piscuoglio, Tuyana Boldanova, Chaoran B. Bian, David Semela, Wolfram Jochum, Gieri Cathomas, Kirsten D. Mertz, Joachim Diebold, Luca Mazzucchelli, Viktor H. Koelzer, Achim Weber, Thomas Decaens, Luigi M. Terracciano, Mathias Heikenwalder, Yujin Hoshida, Jesper B. Andersen, Snorri S. Thorgeirsson, Matthias S. Matter

Source: Hepatology Communications, Vol 6, Iss 6, Pp 1467-1481 (2022)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/baec932dd7004118b6b3ef62cac7625e

Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages

Authors: Charlotte K. Y. Ng, Eva Dazert, Tuyana Boldanova, Mairene Coto-Llerena, Sandro Nuciforo, Caner Ercan, Aleksei Suslov, Marie-Anne Meier, Thomas Bock, Alexander Schmidt, Sylvia Ketterer, Xueya Wang, Stefan Wieland, Matthias S. Matter, Marco Colombi, Salvatore Piscuoglio, Luigi M. Terracciano, Michael N. Hall, Markus H. Heim

Source: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0be87e27f0b443f98c2f8990e784ddcb

Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report

Authors: Caner Ercan, Mairene Coto-Llerena, John Gallon, Lana Fourie, Mattia Marinucci, Gabriel F. Hess, Jürg Vosbeck, Stephanie Taha-Mehlitz, Tuyana Boldanova, Marie-Anne Meier, Alexandar Tzankov, Matthias S. Matter, Martin H. K. Hoffmann, Luca Di Tommaso, Markus von Flüe, Charlotte K. Y. Ng, Markus H. Heim, Savas D. Soysal, Luigi M. Terracciano, Otto Kollmar, Salvatore Piscuoglio

Source: Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/49161dc05fb841fc951e15d1ae5a8794

Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma

Authors: Christos Dimitrakopoulos, Sravanth Kumar Hindupur, Marco Colombi, Dritan Liko, Charlotte K. Y. Ng, Salvatore Piscuoglio, Jonas Behr, Ariane L. Moore, Jochen Singer, Hans-Joachim Ruscheweyh, Matthias S. Matter, Dirk Mossmann, Luigi M. Terracciano, Michael N. Hall, Niko Beerenwinkel

Source: BMC Genomics, Vol 22, Iss 1, Pp 1-26 (2021)

Subject Terms: HCC, mTOR signaling, NetICS, Omics, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/224fb61594c44244800fcd87efa2b40b

Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo‐Independent Regulation of Heat Shock Protein 70 Family Members

Authors: Mairene Coto‐Llerena, Nadia Tosti, Stephanie Taha‐Mehlitz, Venkatesh Kancherla, Viola Paradiso, John Gallon, Gaia Bianco, Andrea Garofoli, Souvik Ghosh, Fengyuan Tang, Caner Ercan, Gerhard M. Christofori, Matthias S. Matter, Raoul A. Droeser, Mihaela Zavolan, Savas D. Soysal, Markus vonFlüe, Otto Kollmar, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio

Source: Hepatology Communications, Vol 5, Iss 4, Pp 661-674 (2021)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/ad421c0d13494136915e7f00b44e48ef

ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs

Authors: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev, Sizun Jiang, Phillip A. Gall, Chun-Kang Liao, Liang-Chun Shih, Christian M. Schürch, David R. McIlwain, Pauline Chu, Nicole A. Borchard, David Zarabanda, Sachi S. Dholakia, Angela Yang, Dayoung Kim, Han Chen, Tomoharu Kanie, Chia-Der Lin, Ming-Hsui Tsai, Katie M. Phillips, Raymond Kim, Jonathan B. Overdevest, Matthew A. Tyler, Carol H. Yan, Chih-Feng Lin, Yi-Tsen Lin, Da-Tian Bau, Gregory J. Tsay, Zara M. Patel, Yung-An Tsou, Alexandar Tzankov, Matthias S. Matter, Chih-Jaan Tai, Te-Huei Yeh, Peter H. Hwang, Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson

Source: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/46b19154257e4119b14a2d65b124b2f3

Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19

Authors: Jasmin D. Haslbauer, Carl Zinner, Anna K. Stalder, Jan Schneeberger, Thomas Menter, Stefano Bassetti, Kirsten D. Mertz, Philip Went, Matthias S. Matter, Alexandar Tzankov

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: COVID-19, immunopathology, lymph nodes, macrophage activation, plasmablasts, thrombosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.763098/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ad2017d5d58b4550ad9bcd296a222194

Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers

Authors: Tsuguhisa Nakayama, Ivan T. Lee, Sizun Jiang, Matthias S. Matter, Carol H. Yan, Jonathan B. Overdevest, Chien-Ting Wu, Yury Goltsev, Liang-Chun Shih, Chun-Kang Liao, Bokai Zhu, Yunhao Bai, Peter Lidsky, Yinghong Xiao, David Zarabanda, Angela Yang, Meena Easwaran, Christian M. Schürch, Pauline Chu, Han Chen, Anna K. Stalder, David R. McIlwain, Nicole A. Borchard, Phillip A. Gall, Sachi S. Dholakia, Wei Le, Le Xu, Chih-Jaan Tai, Te-Huei Yeh, Elizabeth Erickson-Direnzo, Jason M. Duran, Kirsten D. Mertz, Peter H. Hwang, Jasmin D. Haslbauer, Peter K. Jackson, Thomas Menter, Raul Andino, Peter D. Canoll, Adam S. DeConde, Zara M. Patel, Alexandar Tzankov, Garry P. Nolan, Jayakar V. Nayak

Source: Cell Reports Medicine, Vol 2, Iss 10, Pp 100421- (2021)

Subject Terms: SARS-CoV-2, COVID-19, ACE2, TMPRSS2, ciliated epithelial cell, IFN-β1, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379121002834; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/77b4712ecccd4b4dbf1453cd3b8dff8e

Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors

Authors: Tanja Blumer, Isabel Fofana, Matthias S. Matter, Xueya Wang, Hesam Montazeri, Diego Calabrese, Mairene Coto‐Llerena, Tujana Boldanova, Sandro Nuciforo, Venkatesh Kancherla, Luigi Tornillo, Salvatore Piscuoglio, Stefan Wieland, Luigi M. Terracciano, Charlotte K.Y. Ng, Markus H. Heim

Source: Hepatology Communications, Vol 3, Iss 7, Pp 971-986 (2019)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/eae88299032b4b1a82fc109e9ddd17dc

MIS-C-Implications for the Pediatric Surgeon: An Algorithm for Differential Diagnostic Considerations

Authors: Nora Manz, Claudia Höfele-Behrendt, Julia Bielicki, Hanna Schmid, Matthias S. Matter, Isabella Bielicki, Stefan Holland-Cunz, Stephanie J. Gros

Source: Children, Vol 8, Iss 8, p 712 (2021)

Subject Terms: multisystem inflammatory syndrome in children, pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2, PIMS-TS, pediatric surgery, acute abdomen, differential diagnosis of appendicitis, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9067/8/8/712; https://doaj.org/toc/2227-9067

Access URL: https://doaj.org/article/16f7063ca864423c98f014cec00ba9f0

The T cell repertoire in tumors overlaps with pulmonary inflammatory lesions in patients treated with checkpoint inhibitors

Authors: Heinz Läubli, Viktor H. Koelzer, Matthias S. Matter, Petra Herzig, Béatrice Dolder Schlienger, Mark Nikolaj Wiese, Didier Lardinois, Kirsten D. Mertz, Alfred Zippelius

Source: OncoImmunology, Vol 7, Iss 2 (2018)

Subject Terms: cancer immunotherapy, immune-related adverse event, pd-1, tumor-infiltrating t cells, t cell receptor, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/798022384f2747deb8d7739f4959e7ed

Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma

Authors: Venkatesh Kancherla, Samir Abdullazade, Matthias S. Matter, Manuela Lanzafame, Luca Quagliata, Guglielmo Roma, Yujin Hoshida, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio

Source: Frontiers in Genetics, Vol 9 (2018)

Subject Terms: TP53 mutations, somatic mutations, copy number alterations, mutational signature, oncogenic signature, Genetics, QH426-470

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fgene.2018.00002/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/72d96652e5ac4337856c9b70247960f1

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Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes.

Authors: Katharina Burmeister, Luca Quagliata, Mariacarla Andreozzi, Serenella Eppenberger-Castori, Matthias S Matter, Valeria Perrina, Rainer Grobholz, Wolfram Jochum, Daniel Horber, Peter Moosmann, Frank Lehmann, Dieter Köberle, Charlotte K Y Ng, Salvatore Piscuoglio, Luigi Tornillo, Luigi M Terracciano

Source: PLoS ONE, Vol 12, Iss 4, p e0175563 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5389821?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c6d2a8a320584496ab6344e75b74821f

Destruction of lymphoid organ architecture and hepatitis caused by CD4+ T cells.

Authors: Matthias S Matter, Tamara Hilmenyuk, Christina Claus, Romina Marone, Christian Schürch, Marianne Tinguely, Luigi Terracciano, Sanjiv A Luther, Adrian F Ochsenbein

Source: PLoS ONE, Vol 6, Iss 9, p e24772 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21966366/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6b2107be46614b62937adb8ce22240da