Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

Authors: Adriana Ibarra Urizar, Michala Prause, Lars Roed Ingerslev, Matthew Wortham, Yinghui Sui, Maike Sander, Kristine Williams, Romain Barrès, Martin R. Larsen, Gitte Lund Christensen, Nils Billestrup

Source: Cell Death and Disease, Vol 14, Iss 7, Pp 1-16 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/ff71f86b08274f6ea980a103f69cf1c4

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

Authors: Matthew Wortham, Fenfen Liu, Austin R. Harrington, Johanna Y. Fleischman, Martina Wallace, Francesca Mulas, Medhavi Mallick, Nicholas K. Vinckier, Benjamin R. Cross, Joshua Chiou, Nisha A. Patel, Yinghui Sui, Carolyn McGrail, Yesl Jun, Gaowei Wang, Ulupi S. Jhala, Roland Schüle, Orian S. Shirihai, Mark O. Huising, Kyle J. Gaulton, Christian M. Metallo, Maike Sander

Source: The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)

Subject Terms: Endocrinology, Metabolism, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/b59ff5cf14e54435855ccfd8a98f4b14

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development

Authors: Nicholas K. Vinckier, Nisha A. Patel, Ryan J. Geusz, Allen Wang, Jinzhao Wang, Ileana Matta, Austin R. Harrington, Matthew Wortham, Nichole Wetton, Jianxun Wang, Ulupi S. Jhala, Michael G. Rosenfeld, Christopher W. Benner, Hung-Ping Shih, Maike Sander

Source: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/219e2bb5225f43dcb77d228c096f4de8

Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance

Authors: Michael Shum, Mayuko Segawa, Raffi Gharakhanian, Ana Viñuela, Matthew Wortham, Siyouneh Baghdasarian, Dane M. Wolf, Samuel B. Sereda, Laura Nocito, Linsey Stiles, Zhiqiang Zhou, Vincent Gutierrez, Maike Sander, Orian S. Shirihai, Marc Liesa

Source: Molecular Metabolism, Vol 55, Iss , Pp 101403- (2022)

Subject Terms: Mitochondria, Insulin resistance, Beta-cell, ABCB10, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877821002611; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/9dc2c70f85334be6a42fd766bfb0b160

Endoplasmic reticulum tubules limit the size of misfolded protein condensates

Authors: Smriti Parashar, Ravi Chidambaram, Shuliang Chen, Christina R Liem, Eric Griffis, Gerard G Lambert, Nathan C Shaner, Matthew Wortham, Jesse C Hay, Susan Ferro-Novick

Source: eLife, Vol 10 (2021)

Subject Terms: ER-phagy, protein quality control, misfolded prohormones, SEC24C, Lunapark, ER structure, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/71642; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/bfdc35449f78485fab17dbdda6923c5b

Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function

Authors: Matthew Wortham, Jacqueline R. Benthuysen, Martina Wallace, Jeffrey N. Savas, Francesca Mulas, Ajit S. Divakaruni, Fenfen Liu, Verena Albert, Brandon L. Taylor, Yinghui Sui, Enrique Saez, Anne N. Murphy, John R. Yates, III, Christian M. Metallo, Maike Sander

Source: Cell Reports, Vol 25, Iss 10, Pp 2904-2918.e8 (2018)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124718317777; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/61d4a21deb7a4e80ab3f521ac9d4dddb

Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma.

Authors: Matthew Wortham, Changcun Guo, Monica Zhang, Lingyun Song, Bum-Kyu Lee, Vishwanath R Iyer, Terrence S Furey, Gregory E Crawford, Hai Yan, Yiping He

Source: PLoS ONE, Vol 9, Iss 9, p e107156 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4157845?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8e33019866814d178ccbf7fda350fa58

Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection.

Authors: Yoichiro Shibata, Nathan C Sheffield, Olivier Fedrigo, Courtney C Babbitt, Matthew Wortham, Alok K Tewari, Darin London, Lingyun Song, Bum-Kyu Lee, Vishwanath R Iyer, Stephen C J Parker, Elliott H Margulies, Gregory A Wray, Terrence S Furey, Gregory E Crawford

Source: PLoS Genetics, Vol 8, Iss 6, p e1002789 (2012)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3386175?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/9e59bc8a7ca044b99408318226a660e2

Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells.

Authors: Matthew Wortham, Genglin Jin, Julia Lailai Sun, Darell D Bigner, Yiping He, Hai Yan

Source: PLoS ONE, Vol 7, Iss 4, p e36211 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3338642?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/98a32e772d424f1793d0d9fc7b3c047f

The Transition from Fatty Liver to NASH Associates with SAMe Depletion in db/db Mice Fed a Methionine Choline-Deficient Diet.

Authors: Matthew Wortham¹, Lin He¹, Maxwell Gyamfi¹, Bryan Copple¹, Yu-Jui Wan¹

Source: Digestive Diseases & Sciences. Oct2008, Vol. 53 Issue 10, p2761-2774. 14p.

Subject Terms: *FATTY degeneration, *REDUCING diets, *METHIONINE, *CHOLINE, *FATTY liver, *ADENOSYLMETHIONINE, *PHYSIOLOGY, *DISEASE risk factors