Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer

Authors: Reiner Hoppe, Stefan Winter, Wing-Yee Lo, Kyriaki Michailidou, Manjeet K. Bolla, Renske Keeman, Qin Wang, Joe Dennis, Michael Lush, Krishna R. Kalari, Matthew P. Goetz, Liewei Wang, Junmei Cairns, Richard Weinshilboum, Lois Shepherd, Bingshu E. Chen, Lothar Häberle, Matthias Ruebner, Matthias W. Beckmann, Wei He, Nicole L. Larson, Sebastian M. Armasu, Werner Schroth, Balram Chowbay, Chiea Chuen Khor, Mustapha Abubakar, Antonis C. Antoniou, Thomas Brüning, Jose E. Castelao, Jenny Chang-Claude, NBCS Collaborators, Thilo Dörk, Diana M. Eccles, Jonine D. Figueroa, Manuela Gago-Dominguez, José A. García-Sáenz, Melanie Gündert, Carolin C. Hack, Ute Hamann, Sileny Han, Maartje J. Hooning, Hanna Huebner, ABCTB Investigators, Esther M. John, Yon-Dschun Ko, Vessela N. Kristensen, Sabine Linn, Sara Margolin, Dimitrios Mavroudis, Heli Nevanlinna, Patrick Neven, Nadia Obi, Tjoung-Won Park-Simon, Katri Pylkäs, Muhammad U. Rashid, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, William J. Tapper, Ian Tomlinson, Camilla Wendt, Robert Winqvist, Alison M. Dunning, Jacques Simard, Per Hall, Paul D. P. Pharoah, Matthias Schwab, Fergus J. Couch, Kamila Czene, Peter A. Fasching, Douglas F. Easton, Marjanka K. Schmidt, James N. Ingle, Hiltrud Brauch

Source: npj Breast Cancer, Vol 11, Iss 1, Pp 1-15 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/58333a05b41848a8aeca2d504c31376c

A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer

Authors: Rita A. Mukhtar, Soumya Gottipati, Christina Yau, Sara López-Tarruella, Helena Earl, Larry Hayward, Louise Hiller, Marie Osdoit, Marieke van der Noordaa, Diane de Croze, Anne-Sophie Hamy, Marick Laé, Fabien Reyal, Gabe S. Sonke, Tessa G. Steenbruggen, Maartje van Seijen, Jelle Wesseling, Miguel Martín, Maria del Monte-Millán, Judy C. Boughey, Matthew P. Goetz, Tanya Hoskin, Vicente Valero, Stephen B. Edge, Jean E. Abraham, John M. S. Bartlett, Carlos Caldas, Janet Dunn, Elena Provenzano, Stephen-John Sammut, Jeremy S. Thomas, Ashley Graham, Peter Hall, Lorna Mackintosh, Fang Fan, Andrew K. Godwin, Kelsey Schwensen, Priyanka Sharma, Angela M. DeMichele, Kimberly Cole, Lajos Pusztai, Mi-Ok Kim, Laura J van ’t Veer, David Cameron, Laura J. Esserman, W. Fraser Symmans

Source: npj Breast Cancer, Vol 11, Iss 1, Pp 1-11 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/83af1b3ae385492b84438b6ce139a056

Abemaciclib in combination with therapies for patients with metastatic breast cancer: a phase 1b study

Authors: Sara M. Tolaney, Komal Jhaveri, Teresa Helsten, Shannon L. Puhalla, Alison Conlin, E. Claire Dees, Muralidhar Beeram, Sonya C. Chapman, Andrew Lithio, Lacey M. Litchfield, Matthew P. Goetz

Source: Frontiers in Oncology, Vol 15 (2025)

Subject Terms: abemaciclib, metastatic breast cancer, CDK4, CDK6, everolimus, exemestane, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2025.1555921/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e103c481c50146c49f246016e0728d6d

Pre-treatment peripheral blood immunophenotyping and response to neoadjuvant chemotherapy in operable breast cancer

Authors: Roberto A. Leon-Ferre, Kaitlyn R. Whitaker, Vera J. Suman, Tanya Hoskin, Karthik V. Giridhar, Raymond M. Moore, Ahmad Al-Jarrad, Sarah A. McLaughlin, Donald W. Northfelt, Katie N. Hunt, Amy Lynn Conners, Ann Moyer, Jodi M. Carter, Krishna Kalari, Richard Weinshilboum, Liewei Wang, James N. Ingle, Keith L. Knutson, Stephen M. Ansell, Judy C. Boughey, Matthew P. Goetz, Jose C. Villasboas

Source: Breast Cancer Research, Vol 26, Iss 1, Pp 1-11 (2024)

Subject Terms: Breast cancer, Immunology, Biomarkers, Chemotherapy, Translational research, Single cell technologies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/b975d37e612b41688982be8b1d8df388

Impact of dose reductions on adjuvant abemaciclib efficacy for patients with high-risk early breast cancer: analyses from the monarchE study

Authors: Matthew P. Goetz, Irfan Cicin, Laura Testa, Sara M. Tolaney, Jens Huober, Valentina Guarneri, Stephen R. D. Johnston, Miguel Martin, Priya Rastogi, Nadia Harbeck, Ashwin Shahir, Ran Wei, Valérie André, Hope S. Rugo, Joyce O’Shaughnessy

Source: npj Breast Cancer, Vol 10, Iss 1, Pp 1-7 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/1378a75d34cd4a89ad1255e30c08bb59

Automated mitotic spindle hotspot counts are highly associated with clinical outcomes in systemically untreated early-stage triple-negative breast cancer

Authors: Roberto A. Leon-Ferre, Jodi M. Carter, David Zahrieh, Jason P. Sinnwell, Roberto Salgado, Vera J. Suman, David W. Hillman, Judy C. Boughey, Krishna R. Kalari, Fergus J. Couch, James N. Ingle, Maschenka Balkenhol, Francesco Ciompi, Jeroen van der Laak, Matthew P. Goetz

Source: npj Breast Cancer, Vol 10, Iss 1, Pp 1-10 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/76fed00f45b74d1e9623e4f305759050

Identification of a Notch transcriptomic signature for breast cancer

Authors: Eike-Benjamin Braune, Felix Geist, Xiaojia Tang, Krishna Kalari, Judy Boughey, Liewei Wang, Roberto A. Leon-Ferre, Antonino B. D’Assoro, James N. Ingle, Matthew P. Goetz, Julian Kreis, Kang Wang, Theodoros Foukakis, Anita Seshire, Dirk Wienke, Urban Lendahl

Source: Breast Cancer Research, Vol 26, Iss 1, Pp 1-22 (2024)

Subject Terms: Breast cancer, Basal-like, Breast cancer stem cell, Notch signalling, Transcriptomic signature, Therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/f8003a5a92c14e34b1fab373cd274d48

Patient-specific signaling signatures predict optimal therapeutic combinations for triple negative breast cancer

Authors: Heba Alkhatib, Jason Conage-Pough, Sangita Roy Chowdhury, Denen Shian, Deema Zaid, Ariel M. Rubinstein, Amir Sonnenblick, Tamar Peretz-Yablonsky, Avital Granit, Einat Carmon, Ishwar N. Kohale, Judy C. Boughey, Matthew P. Goetz, Liewei Wang, Forest M. White, Nataly Kravchenko-Balasha

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)

Subject Terms: Personalized combined treatment, EGFR, Targeted therapy, Triple-negative breast cancer, Phosphotyrosine proteomics, Information theory, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/6e9c5a225b574c2e9c271b3e30c7bf17

Endoxifen downregulates AKT phosphorylation through protein kinase C beta 1 inhibition in ERα+ breast cancer

Authors: Swaathi Jayaraman, Xinyan Wu, Krishna R. Kalari, Xiaojia Tang, Mary J. Kuffel, Elizabeth S. Bruinsma, Shahrzad Jalali, Kevin L. Peterson, Cristina Correia, Rachel A. Kudgus, Scott H. Kaufmann, Santosh Renuse, James N. Ingle, Joel M. Reid, Matthew M. Ames, Alan P. Fields, Matthew J. Schellenberg, John R. Hawse, Akhilesh Pandey, Matthew P. Goetz

Source: npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/809fda6ff0ea4cad83dc611d55814884

Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors

Authors: Xiaojia Tang, Kevin J. Thompson, Krishna R. Kalari, Jason P. Sinnwell, Vera J. Suman, Peter T. Vedell, Sarah A. McLaughlin, Donald W. Northfelt, Alvaro Moreno Aspitia, Richard J. Gray, Jodi M. Carter, Richard Weinshilboum, Liewei Wang, Judy C. Boughey, Matthew P. Goetz

Source: Breast Cancer Research, Vol 25, Iss 1, Pp 1-18 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/3af3f74d177a4754a631cf8c8eef5d57

Distinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer

Authors: Jodi M. Carter, Saranya Chumsri, Douglas A. Hinerfeld, Yaohua Ma, Xue Wang, David Zahrieh, David W. Hillman, Kathleen S. Tenner, Jennifer M. Kachergus, Heather Ann Brauer, Sarah E. Warren, David Henderson, Ji Shi, Yi Liu, Heikki Joensuu, Henrik Lindman, Roberto A. Leon-Ferre, Judy C. Boughey, Minetta C. Liu, James N. Ingle, Krishna R. Kalari, Fergus J. Couch, Keith L. Knutson, Matthew P. Goetz, Edith A. Perez, E. Aubrey Thompson

Source: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d5560e60b96445c4af2242dfe42eae7f

PDJ amplicon in triple negative breast cancer

Authors: Alexander S. Roesler, Smriti Malasi, Lori Koslosky, Peter Hartmayer, Tammey J. Naab, Jodi M. Carter, David Zahrieh, David Hillman, Roberto A. Leon-Ferre, Fergus J. Couch, Matthew P. Goetz, Karen S. Anderson, Barbara A. Pockaj, Michael T. Barrett

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/526e7363bd93472aa3e9d9c8d2011eda

Oncolytic Urabe mumps virus: A promising virotherapy for triple-negative breast cancer

Authors: Marshall D. Behrens, Robert J. Stiles, Gennett M. Pike, Laura A. Sikkink, Yongxian Zhuang, Jia Yu, Liewei Wang, Judy C. Boughey, Matthew P. Goetz, Mark J. Federspiel

Source: Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 239-255 (2022)

Subject Terms: Urabe mumps virus, oncolytic virotherapy, human breast cancer, triple-negative breast cancer, MDA-MB-231 breast tumor xenograft nude mouse model, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770522001371; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/b9ed91b0cb974385bc37be3b4a346fb0

Preclinical safety assessment of MV-s-NAP, a novel oncolytic measles virus strain armed with an H. pylori immunostimulatory bacterial transgene

Authors: Kimberly B. Viker, Michael B. Steele, Ianko D. Iankov, Susanna C. Concilio, Arun Ammayappan, Brad Bolon, Nathan J. Jenks, Matthew P. Goetz, Eleni Panagioti, Mark J. Federspiel, Minetta C. Liu, Kah Whye Peng, Evanthia Galanis

Source: Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 532-546 (2022)

Subject Terms: measles, neutrophil activating protein, NAP, MV-s-NAP, metastatic breast cancer, IFNAR KO-CD46Ge mouse model, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050122001061; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/57a8d49639d54665a6d7814a47ceb75e

Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

Authors: Kirsten G. M. Aspros, Jodi M. Carter, Tanya L. Hoskin, Vera J. Suman, Malayannan Subramaniam, Michael J. Emch, Zhenqing Ye, Zhifu Sun, Jason P. Sinnwell, Kevin J. Thompson, Xiaojia Tang, Esther P. B. Rodman, Xiyin Wang, Adam W. Nelson, Igor Chernukhin, Feda H. Hamdan, Elizabeth S. Bruinsma, Jason S. Carroll, Martin E. Fernandez-Zapico, Steven A. Johnsen, Krishna R. Kalari, Haojie Huang, Roberto A. Leon-Ferre, Fergus J. Couch, James N. Ingle, Matthew P. Goetz, John R. Hawse

Source: npj Breast Cancer, Vol 8, Iss 1, Pp 1-15 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/cb14a3f8cc2f47efa372c800d589e31a

Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities

Authors: Nicola Cosgrove, Damir Varešlija, Stephen Keelan, Ashuvinee Elangovan, Jennifer M. Atkinson, Sinéad Cocchiglia, Fiona T. Bane, Vikrant Singh, Simon Furney, Chunling Hu, Jodi M. Carter, Steven N. Hart, Siddhartha Yadav, Matthew P. Goetz, Arnold D. K. Hill, Steffi Oesterreich, Adrian V. Lee, Fergus J. Couch, Leonie S. Young

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/55e3acfd61844f0f8a60e2f4411af4cc

Efficacy and safety results by menopausal status in monarchE: adjuvant abemaciclib combined with endocrine therapy in patients with HR+, HER2−, node-positive, high-risk early breast cancer

Authors: Shani Paluch-Shimon, Patrick Neven, Jens Huober, Irfan Cicin, Matthew P. Goetz, Chikako Shimizu, Chiun-Sheng Huang, Hans Joachim Lueck, Jane Beith, Eriko Tokunaga, Jessica Reyes Contreras, Rosane Oliveira de Sant’Ana, Ran Wei, Ashwin Shahir, Sarah C. Nabinger, Tammy Forrester, Stephen R. D. Johnston, Nadia Harbeck

Source: Therapeutic Advances in Medical Oncology, Vol 15 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1758-8359

Access URL: https://doaj.org/article/9dbf86693a4a460dbf6601907c6ba0ed

Disruption of estrogen receptor beta’s DNA binding domain impairs its tumor suppressive effects in triple negative breast cancer

Authors: Kirsten G. M. Aspros, Michael J. Emch, Xiyin Wang, Malayannan Subramaniam, Megan L. Hinkle, Esther P. B. Rodman, Matthew P. Goetz, John R. Hawse

Source: Frontiers in Medicine, Vol 10 (2023)

Subject Terms: estrogen receptor beta, breast cancer, triple negative breast cancer, NFκB, EZH2, DNA binding domain mutation, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2023.1047166/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/02caffd096eb485c9156f9741c54c9a7

Abemaciclib plus fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer in premenopausal women: subgroup analysis from the MONARCH 2 trial

Authors: Patrick Neven, Hope S. Rugo, Sara M. Tolaney, Hiroji Iwata, Masakazu Toi, Matthew P. Goetz, Peter A. Kaufman, Yi Lu, Nadine Haddad, Karla C. Hurt, George W. Sledge

Source: Breast Cancer Research, Vol 23, Iss 1, Pp 1-10 (2021)

Subject Terms: Abemaciclib, Advanced breast cancer, CDK4 and 6 inhibitor, Fulvestrant, Premenopausal women, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/948e86d5e61a41fa9e5a470962c1bc83

Abemaciclib as initial therapy for advanced breast cancer: MONARCH 3 updated results in prognostic subgroups

Authors: Stephen Johnston, Joyce O’Shaughnessy, Miguel Martin, Jens Huober, Masakazu Toi, Joohyuk Sohn, Valérie A. M. André, Holly R. Martin, Molly C. Hardebeck, Matthew P. Goetz

Source: npj Breast Cancer, Vol 7, Iss 1, Pp 1-5 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/cf9cf9b9d25d4a93984071353e442e17