Heightened IDO1 levels predict Bacillus Calmette-Guèrin failure in high-risk non-muscle-invasive bladder cancer patients

Authors: Alice Turdo, Gabriele Tulone, Sebastiano Di Bella, Gaetana Porcelli, Caterina D’Accardo, Miriam Gaggianesi, Chiara Modica, Simone Di Franco, Francesca Angeloro, Giulia Bozzari, Vincenzo Davide Pantina, Melania Lo Iacono, Cristina Minasola, Rosa Giaimo, Anna Martorana, Nicola Pavan, Matilde Todaro, Alchiede Simonato, Giorgio Stassi

Source: Cell Death Discovery, Vol 11, Iss 1, Pp 1-10 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/81863ebf13f740cab9a45f9098ccad34

C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation

Authors: Veronica Veschi, Francesco Verona, Sebastiano Di Bella, Alice Turdo, Miriam Gaggianesi, Simone Di Franco, Laura Rosa Mangiapane, Chiara Modica, Melania Lo Iacono, Paola Bianca, Ornella Roberta Brancato, Caterina D’Accardo, Gaetana Porcelli, Vincenzo Luca Lentini, Isabella Sperduti, Elisabetta Sciacca, Peter Fitzgerald, David Lopez-Perez, Pierre Martine, Kate Brown, Giuseppe Giannini, Ettore Appella, Giorgio Stassi, Matilde Todaro

Source: Molecular Cancer, Vol 24, Iss 1, Pp 1-27 (2025)

Subject Terms: SETD8, P53K382me1, Cancer stem cells, C1Q+ TPP1+ macrophages, IBD, CRC, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/45c7d36539ec41d3b0082179ea763110

The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses

Authors: Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan, Sahar Da’as, Yosra Bejaoui, Nady El Hajj, Karama Makni Maalej, Said Dermime, Kakil Rasul, Paolo Dellabona, Giulia Casorati, Alice Turdo, Matilde Todaro, Giorgio Stassi, Soldano Ferrone, Xinhui Wang, Cristina Maccalli

Source: Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-24 (2025)

Subject Terms: Colorectal cancer, Cancer initiating cells, MicroRNAs, T-cell responses, Combination therapies, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/f6261c3f95e24e7a8f60d995b4ab1cb0

Deep Learning Approaches for Morphological Classification of Intestinal Organoids

Authors: Giovanni Cicceri, Sebastiano Di Bella, Simone Di Franco, Giorgio Stassi, Matilde Todaro, Salvatore Vitabile

Source: IEEE Access, Vol 13, Pp 62267-62287 (2025)

Subject Terms: Deep learning, image classification, intestinal organoids, stem cells, cancer, Electrical engineering. Electronics. Nuclear engineering, TK1-9971

File Description: electronic resource

Relation: https://ieeexplore.ieee.org/document/10955206/; https://doaj.org/toc/2169-3536

Access URL: https://doaj.org/article/692f8421f40c4232a1fb3a328ddb8b25

Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction

Authors: Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: cancer stem cells, TAMs, single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, signaling pathway analysis, trajectory analysis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529847/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ca3576d034f14253ab10e6b1a69b3cef

Protocol for generation and engineering of thyroid cell lineages using CRISPR-Cas9 editing to recapitulate thyroid cancer histotype progression

Authors: Vincenzo Davide Pantina, Francesco Verona, Alice Turdo, Veronica Veschi, Chiara Modica, Melania Lo Iacono, Miriam Gaggianesi, Sebastiano Di Bella, Matilde Todaro, Simone Di Franco, Giorgio Stassi

Source: STAR Protocols, Vol 5, Iss 3, Pp 103263- (2024)

Subject Terms: Cell culture, Cancer, CRISPR, Cell Differentiation, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166724004283; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/dd606eab211b4944bc3174b843fc756f

Lipid droplets and small extracellular vesicles: More than two independent entities

Authors: Géraldine C. Genard, Luca Tirinato, Francesca Pagliari, Jessica Da Silva, Alessandro Giammona, Fatema Alquraish, Maria Parra Reyes, Marie Bordas, Maria Grazia Marafioti, Simone Di Franco, Jeannette Janssen, Daniel Garcia‐Calderón, Rachel Hanley, Clelia Nistico, Yoshinori Fukasawa, Torsten Müller, Jeroen Krijgsveld, Matilde Todaro, Francesco Saverio Costanzo, Giorgio Stassi, Michelle Nessling, Karsten Richter, Kendra K. Maass, Carlo Liberale, Joao Seco

Source: Journal of Extracellular Biology, Vol 3, Iss 9, Pp n/a-n/a (2024)

Subject Terms: exosomes, hypoxia, iron metabolism, irradiation, lipid droplets, pH, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2768-2811

Access URL: https://doaj.org/article/09fdb07410c6493fb41eb1b1e89f69c3

Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory

Authors: Daniela Michelatti, Sven Beyes, Chiara Bernardis, Maria Luce Negri, Leonardo Morelli, Naiara Garcia Bediaga, Vittoria Poli, Luca Fagnocchi, Sara Lago, Sarah D’Annunzio, Nicole Cona, Ilaria Gaspardo, Aurora Bianchi, Jovana Jovetic, Matteo Gianesello, Alice Turdo, Caterina D’Accardo, Miriam Gaggianesi, Martina Dori, Mattia Forcato, Giuliano Crispatzu, Alvaro Rada-Iglesias, Maria Soledad Sosa, H. T. Marc Timmers, Silvio Bicciato, Matilde Todaro, Luca Tiberi, Alessio Zippo

Source: Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f053b57e57204e48bf78051e5364cb8f

Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation

Authors: Annamaria Antona, Giovanni Leo, Francesco Favero, Marco Varalda, Jacopo Venetucci, Stefania Faletti, Matilde Todaro, Eleonora Mazzucco, Enrica Soligo, Chiara Saglietti, Giorgio Stassi, Marcello Manfredi, Giuliana Pelicci, Davide Corà, Guido Valente, Daniela Capello

Source: Cell Death Discovery, Vol 9, Iss 1, Pp 1-16 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/1202d4f2902d4b05b7158dd3ec8eea0d

Recapitulating thyroid cancer histotypes through engineering embryonic stem cells

Authors: Veronica Veschi, Alice Turdo, Chiara Modica, Francesco Verona, Simone Di Franco, Miriam Gaggianesi, Elena Tirrò, Sebastiano Di Bella, Melania Lo Iacono, Vincenzo Davide Pantina, Gaetana Porcelli, Laura Rosa Mangiapane, Paola Bianca, Aroldo Rizzo, Elisabetta Sciacca, Irene Pillitteri, Veronica Vella, Antonino Belfiore, Maria Rita Bongiorno, Giuseppe Pistone, Lorenzo Memeo, Lorenzo Colarossi, Dario Giuffrida, Cristina Colarossi, Paolo Vigneri, Matilde Todaro, Giorgio Stassi

Source: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ebd761e297f5412baf73304e9e1e2d72

EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas

Authors: Alice Turdo, Miriam Gaggianesi, Caterina D’Accardo, Gaetana Porcelli, Sebastiano Di Bella, Dario Cricchio, Irene Pillitteri, Rossana Porcasi, Melania Lo Iacono, Francesco Verona, Chiara Modica, Narges Roozafzay, Ada Maria Florena, Giorgio Stassi, Salvatrice Mancuso, Matilde Todaro

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: diffuse large B-cell lymphoma, R-CHOP, therapy resistance, elderly patients, gene expression signature, biomarkers of response, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1266265/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b198c3f32aad41e698a82358a2a2963c

Cancer cell targeting by CAR-T cells: A matter of stemness

Authors: Caterina D’Accardo, Gaetana Porcelli, Laura Rosa Mangiapane, Chiara Modica, Vincenzo Davide Pantina, Narges Roozafzay, Simone Di Franco, Miriam Gaggianesi, Veronica Veschi, Melania Lo Iacono, Matilde Todaro, Alice Turdo, Giorgio Stassi

Source: Frontiers in Molecular Medicine, Vol 2 (2022)

Subject Terms: CAR-T cell therapy, immunotherapy, cancer stem cells, anti-cancer therapy, tumor microenvironment, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmmed.2022.1055028/full; https://doaj.org/toc/2674-0095

Access URL: https://doaj.org/article/f21ca7d13dd34ced9dfd9a36acf1683f

Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery

Authors: Simone Di Franco, Paola Bianca, Davide Stefano Sardina, Alice Turdo, Miriam Gaggianesi, Veronica Veschi, Annalisa Nicotra, Laura Rosa Mangiapane, Melania Lo Iacono, Irene Pillitteri, Sander van Hooff, Federica Martorana, Gianmarco Motta, Eliana Gulotta, Vincenzo Luca Lentini, Emanuele Martorana, Micol Eleonora Fiori, Salvatore Vieni, Maria Rita Bongiorno, Giorgio Giannone, Dario Giuffrida, Lorenzo Memeo, Lorenzo Colarossi, Marzia Mare, Paolo Vigneri, Matilde Todaro, Ruggero De Maria, Jan Paul Medema, Giorgio Stassi

Source: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4290ce7ba4614241baeb5615eb552e3e

ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells

Authors: Luca Tirinato, Francesca Pagliari, Simone Di Franco, Elisa Sogne, Maria Grazia Marafioti, Jeanette Jansen, Andrea Falqui, Matilde Todaro, Patrizio Candeloro, Carlo Liberale, Joao Seco, Giorgio Stassi, Enzo Di Fabrizio

Source: Genes and Diseases, Vol 7, Iss 4, Pp 620-635 (2020)

Subject Terms: Cholesterol metabolism, Colorectal cancer stem cells, Fatty acid metabolism, High glucose, Lipid droplets, Oncogenes, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352304219300819; https://doaj.org/toc/2352-3042

Access URL: https://doaj.org/article/ce8a6e4fe3ff45f5a3af11390da5a555

Interleukin-30 feeds breast cancer stem cells via CXCL10 and IL23 autocrine loops and shapes immune contexture and host outcome

Authors: Carlo Sorrentino, Paola Lanuti, Emma Di Carlo, Alice Turdo, Matilde Todaro, Stefania Livia Ciummo, Luigi D'Antonio, Cristiano Fieni

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/10/e002966.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/c7c2aa33d19743d48f3a0b54d1a785c6

Targeting Phosphatases and Kinases: How to Checkmate Cancer

Authors: Alice Turdo, Caterina D’Accardo, Antonino Glaviano, Gaetana Porcelli, Cristina Colarossi, Lorenzo Colarossi, Marzia Mare, Naida Faldetta, Chiara Modica, Giuseppe Pistone, Maria Rita Bongiorno, Matilde Todaro, Giorgio Stassi

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: phosphatase, kinase, cancer stem cell, phosphatase and kinase inhibitors, targeted therapies, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.690306/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/58dfb70100534e7283684ca2cdfd567e

Messing Up the Cancer Stem Cell Chemoresistance Mechanisms Supported by Tumor Microenvironment

Authors: Miriam Gaggianesi, Simone Di Franco, Vincenzo Davide Pantina, Gaetana Porcelli, Caterina D'Accardo, Francesco Verona, Veronica Veschi, Lorenzo Colarossi, Naida Faldetta, Giuseppe Pistone, Maria Rita Bongiorno, Matilde Todaro, Giorgio Stassi

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: cancer stem cells, tumor microenvironment, anticancer drugs, chemoresistance, targeted therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.702642/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/502d50a59340474785ae6f38ef225402

The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs

Authors: Stefania Livia Ciummo, Luigi D’Antonio, Carlo Sorrentino, Cristiano Fieni, Paola Lanuti, Giorgio Stassi, Matilde Todaro, Emma Di Carlo

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: breast cancer stem cells, chemokines, CXCL1, tumor microenvironment, immunity genes, triple-negative breast cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.689286/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/b9bc7a2a020e4ea6b56f7b136474e3c4

CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin

Authors: Simone Di Franco, Barbara Parrino, Miriam Gaggianesi, Vincenzo Davide Pantina, Paola Bianca, Annalisa Nicotra, Laura Rosa Mangiapane, Melania Lo Iacono, Gloria Ganduscio, Veronica Veschi, Ornella Roberta Brancato, Antonino Glaviano, Alice Turdo, Irene Pillitteri, Lorenzo Colarossi, Stella Cascioferro, Daniela Carbone, Camilla Pecoraro, Micol Eleonora Fiori, Ruggero De Maria, Matilde Todaro, Isabella Screpanti, Girolamo Cirrincione, Patrizia Diana, Giorgio Stassi

Source: iScience, Vol 24, Iss 6, Pp 102664- (2021)

Subject Terms: Cancer, Cell Biology, Drugs, Molecular Physiology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221006325; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/cd172be541ee44bea2e1885792013fb0

Cancer Stem Cells in Thyroid Tumors: From the Origin to Metastasis

Authors: Veronica Veschi, Francesco Verona, Melania Lo Iacono, Caterina D'Accardo, Gaetana Porcelli, Alice Turdo, Miriam Gaggianesi, Stefano Forte, Dario Giuffrida, Lorenzo Memeo, Matilde Todaro

Source: Frontiers in Endocrinology, Vol 11 (2020)

Subject Terms: cancer stem cells, thyroid tumors, epigenetic alterations, microenvironment, immune system, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fendo.2020.00566/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/7541cba227ac469b9eb16e3712244a71