Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s disease

Authors: Guoqiang George Sun, Cheng Wang, Randall C. Mazzarino, Paula Andrea Perez-Corredor, Hayk Davtyan, Mathew Blurton-Jones, Francisco Lopera, Joseph F. Arboleda-Velasquez, Yanhong Shi

Source: Cell Reports, Vol 43, Iss 12, Pp 114982- (2024)

Subject Terms: CP: Neuroscience, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724013330; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/8f3af47b909f4ff1864999f8e2ce361d

Retraction Note: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

Authors: Changyoun Kim, Armine Hovakimyan, Karen Zagorski, Tatevik Antonyan, Irina Petrushina, Hayk Davtyan, Gor Chailyan, Jonathan Hasselmann, Michiyo Iba, Anthony Adame, Edward Rockenstein, Marcell Szabo, Mathew Blurton-Jones, David H. Cribbs, Anahit Ghochikyan, Eliezer Masliah, Michael G. Agadjanyan

Source: npj Vaccines, Vol 10, Iss 1, Pp 1-1 (2025)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/d0b05564b8074bbbb447ca78f01087a2

Microglial APOE4: more is less and less is more

Authors: Ghazaleh Eskandari-Sedighi, Mathew Blurton-Jones

Source: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-4 (2023)

Subject Terms: Apolipoprotein E, Microglia, APOE4, APOE3, Alzheimer’s disease, Lgals3, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/da6df28d5f434d6ea1b30a5294b6269e

Neurotoxic Microglial Activation via IFNγ‐Induced Nrf2 Reduction Exacerbating Alzheimer's Disease

Authors: You Jung Kang, Seung Jae Hyeon, Amanda McQuade, Jiwoon Lim, Seung Hyun Baek, Yen N. Diep, Khanh V. Do, Yeji Jeon, Dong‐Gyu Jo, C. Justin Lee, Mathew Blurton‐Jones, Hoon Ryu, Hansang Cho

Source: Advanced Science, Vol 11, Iss 20, Pp n/a-n/a (2024)

Subject Terms: Alzheimer's diseases, interferon‐gamma, microglia, neurodegeneration, neuroinflammation, oxidative stress, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/5e189f2581fa4244ab1a0031b7cea481

Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model

Authors: Volha Liaudanskaya, Nicholas J. Fiore, Yang Zhang, Yuka Milton, Marilyn F. Kelly, Marly Coe, Ariana Barreiro, Victoria K. Rose, Matthew R. Shapiro, Adam S. Mullis, Anna Shevzov-Zebrun, Mathew Blurton-Jones, Michael J. Whalen, Aviva J. Symes, Irene Georgakoudi, Thomas J. F. Nieland, David L. Kaplan

Source: Cell Death and Disease, Vol 14, Iss 8, Pp 1-15 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/c2e87a4a96b24b3fae0b37195524c50d

Correction: Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models

Authors: Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A. Castello, Andranik A. Agazaryan, Joy L. Davis, Franz-Josef Müller, Jeanne F. Loring, Eliezer Masliah, Frank M. LaFerla

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-2 (2024)

Subject Terms: Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/a8f7f613f4364215aed3a6cbb63b15c4

CRISPR generation of CSF1R-G795A human microglia for robust microglia replacement in a chimeric mouse model

Authors: Jean Paul Chadarevian, Hayk Davtyan, Sonia I. Lombroso, F. Chris Bennett, Mathew Blurton-Jones

Source: STAR Protocols, Vol 4, Iss 3, Pp 102490- (2023)

Subject Terms: Cell Culture, Cell Differentiation, CRISPR, Immunology, Model Organisms, Neuroscience, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166723004574; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/ab58724d49b040f8b0f8e037c243fe92

Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model

Authors: Zhenqing Liu, Jianfei Chao, Cheng Wang, Guihua Sun, Daniel Roeth, Wei Liu, Xianwei Chen, Li Li, E Tian, Lizhao Feng, Hayk Davtyan, Mathew Blurton-Jones, Markus Kalkum, Yanhong Shi

Source: Cell Reports, Vol 42, Iss 8, Pp 112841- (2023)

Subject Terms: CP: Neuroscience, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723008525; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/77cf8d20e7704cc4ab9715b8179a709d

Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features

Authors: Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Ryan Pevey, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F. Gendron, Robert H. Baloh, Kendall Van Keuren-Jensen, Rita Sattler

Source: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Subject Terms: amyotrophic lateral sclerosis, C9orf72, frontotemporal dementia, iPSC-microglia, neuroinflammation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2023.1179796/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/c5861f14d9984d6d91846ead3941a04a

Author Correction: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

Authors: Changyoun Kim, Armine Hovakimyan, Karen Zagorski, Tatevik Antonyan, Irina Petrushina, Hayk Davtyan, Gor Chailyan, Jonathan Hasselmann, Michiyo Iba, Anthony Adame, Edward Rockenstein, Marcell Szabo, Mathew Blurton-Jones, David H. Cribbs, Anahit Ghochikyan, Eliezer Masliah, Michael G. Agadjanyan

Source: npj Vaccines, Vol 8, Iss 1, Pp 1-2 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/92d97849f98d4a9a9c4f3f8781ae3d9c

RETRACTED ARTICLE: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

Authors: Changyoun Kim, Armine Hovakimyan, Karen Zagorski, Tatevik Antonyan, Irina Petrushina, Hayk Davtyan, Gor Chailyan, Jonathan Hasselmann, Michiyo Iba, Anthony Adame, Edward Rockenstein, Marcell Szabo, Mathew Blurton-Jones, David H. Cribbs, Anahit Ghochikyan, Eliezer Masliah, Michael G. Agadjanyan

Source: npj Vaccines, Vol 7, Iss 1, Pp 1-16 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/425670cfb6aa4afca2c9a769b05704c9

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

Authors: Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns, Jie Wu, Sarah J. Hernandez, Nicolette McClure, Keona Q. Wang, Corey J. Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, David Van Vactor, John C. Reidling, Mathew Blurton-Jones, Vivek Swarup, Wayne W. Poon, Ryan G. Lim, Leslie M. Thompson

Source: iScience, Vol 26, Iss 1, Pp 105732- (2023)

Subject Terms: Neurology, Omics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222020053; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/3051cef5c5b24f3ebdab019b1d8be6cf

Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

Authors: Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E. England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C. Spitale, Hayk Davtyan, Mathew Blurton-Jones

Source: Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-11 (2021)

Subject Terms: TREM2, Human microglia, Chimeric Alzheimer mice, Lipid droplets, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/c0e75e997897499ba66b3c9ec6115f97

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

Authors: Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones

Source: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2fc5155c4b834bdf97f0aa5db0218942

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

Authors: Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C. Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A. Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jones

Source: Cell Reports, Vol 39, Iss 11, Pp 110961- (2022)

Subject Terms: CP: Neuroscience, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124722007434; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/def9c689b7ba47e59182ba5cb0a6929b

Using Advanced Diffusion-Weighted Imaging to Predict Cell Counts in Gray Matter: Potential and Pitfalls

Authors: Hamsanandini Radhakrishnan, Sepideh Kiani Shabestari, Mathew Blurton-Jones, Andre Obenaus, Craig E. L. Stark

Source: Frontiers in Neuroscience, Vol 16 (2022)

Subject Terms: MRI, diffusion weighted imaging (DWI), cell count, non-invasive biomarkers, prediction model, High Angular Resolution Diffusion Imaging (HARDI), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2022.881713/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/06acafe28c1e4039b699193284e99c4a

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

Authors: Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael D Cahalan

Source: eLife, Vol 11 (2022)

Subject Terms: iPSC-derived microglia, TREM2, Alzheimer's disease, P2Y receptor, Ca2+ signaling, store-operated Ca2+ entry, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/73021; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/69b87460172149e083d3a847b9a787f6

Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain

Authors: Yang You, Satoshi Muraoka, Mark P. Jedrychowski, Jianqiao Hu, Amanda K. McQuade, Tracy Young‐Pearse, Roshanak Aslebagh, Scott A. Shaffer, Steven P. Gygi, Mathew Blurton‐Jones, Wayne W. Poon, Tsuneya Ikezu

Source: Journal of Extracellular Vesicles, Vol 11, Iss 1, Pp n/a-n/a (2022)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2001-3078

Access URL: https://doaj.org/article/10a771972cb944f08b28b85ac902d334

Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

Authors: Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones

Source: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d74b2e4cb1a84ae98fd95f8389c0a7c0

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice

Authors: Hayk Davtyan, Armine Hovakimyan, Sepideh Kiani Shabestari, Tatevik Antonyan, Morgan A. Coburn, Karen Zagorski, Gor Chailyan, Irina Petrushina, Olga Svystun, Emma Danhash, Nikolai Petrovsky, David H. Cribbs, Michael G. Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikyan

Source: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)

Subject Terms: MultiTEP platform, Alzheimer’s disease, Protein epitope vaccine, Antibody, Adjuvant, Bigenic mice, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/5972ea523f564c8fabf6e4f05a708840