A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2

Authors: Dederer, Verena, Sanz Murillo, Marta, Karasmanis, Eva P., Hatch, Kathryn S., Chatterjee, Deep, Preuss, Franziska, Abdul Azeez, Kamal R., Nguyen, Landon Vu, Galicia, Christian, Dreier, Birgit, Plückthun, Andreas, Versees, Wim, Mathea, Sebastian, Leschziner, Andres E., Reck-Peterson, Samara L., Knapp, Stefan

Source: In Journal of Biological Chemistry July 2024 300(7)

Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization

Authors: Champiré, Anthony, Berabez, Rayan, Braka, Abdennour, Cosson, Aurélie, Corret, Justine, Girardin, Caroline, Serrano, Amandine, Aci-Sèche, Samia, Bonnet, Pascal, Josselin, Béatrice, Brindeau, Pierre, Ruchaud, Sandrine, Leguevel, Rémy, Chatterjee, Deep, Mathea, Sebastian, Knapp, Stefan, Brion, Régis, Verrecchia, Franck, Vallée, Béatrice, Plé, Karen, Bénédetti, Hélène, Routier, Sylvain

Source: In European Journal of Medicinal Chemistry 5 May 2024 271

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

Authors: Schmidt, Sven H., Weng, Jui-Hung, Aoto, Phillip C., Boassa, Daniela, Mathea, Sebastian, Silletti, Steve, Hu, Junru, Wallbott, Maximilian, Komives, Elizabeth A., Knapp, Stefan, Herberg, Friedrich W., Taylor, Susan S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jun 01. 118(23), 1-12.

Access URL: https://www.jstor.org/stable/27040869

Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

Authors: Richters, André, Doyle, Shelby K., Freeman, David B., Lee, Christina, Leifer, Becky S., Jagannathan, Sajjeev, Kabinger, Florian, Koren, Jošt Vrabič, Struntz, Nicholas B., Urgiles, Julie, Stagg, Ryan A., Curtin, Brice H., Chatterjee, Deep, Mathea, Sebastian, Mikochik, Peter J., Hopkins, Tamara D., Gao, Hua, Branch, Jonathan R., Xin, Hong, Westover, Lori, Bignan, Gilles C., Rupnow, Brent A., Karlin, Kristen L., Olson, Calla M., Westbrook, Thomas F., Vacca, Joseph, Wilfong, Chris M., Trotter, B. Wesley, Saffran, Douglas C., Bischofberger, Norbert, Knapp, Stefan, Russo, Joshua W., Hickson, Ian, Bischoff, James R., Gottardis, Marco M., Balk, Steven P., Lin, Charles Y., Pop, Marius S., Koehler, Angela N.

Source: In Cell Chemical Biology 18 February 2021 28(2):134-147

Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4

Authors: Preuss, Franziska, Chatterjee, Deep, Mathea, Sebastian, Shrestha, Safal, St-Germain, Jonathan, Saha, Manipa, Kannan, Natarajan, Raught, Brian, Rottapel, Robert, Knapp, Stefan

Source: In Structure 3 November 2020 28(11):1184-1196

Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases

Authors: Sheetz, Joshua B., Mathea, Sebastian, Karvonen, Hanna, Malhotra, Ketan, Chatterjee, Deep, Niininen, Wilhelmiina, Perttilä, Robert, Preuss, Franziska, Suresh, Krishna, Stayrook, Steven E., Tsutsui, Yuko, Radhakrishnan, Ravi, Ungureanu, Daniela, Knapp, Stefan, Lemmon, Mark A.

Source: In Molecular Cell 6 August 2020 79(3):390-405

Regulation of the Minichromosome Maintenance Protein 3 (MCM3) Chromatin Binding by the Prolyl Isomerase Pin1

Authors: Schumann, Michael, Malešević, Miroslav, Hinze, Erik, Mathea, Sebastian, Meleshin, Marat, Schutkowski, Mike, Haehnel, Wolfgang, Schiene-Fischer, Cordelia

Source: In Journal of Molecular Biology 7 December 2018 430(24):5169-5181

Correction: LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.

Authors: Weng, Jui-Hung, Aoto, Phillip C., Lorenz, Robin, Wu, Jian, Schmidt, Sven H., Manschwetus, Jascha T., Kaila-Sharma, Pallavi, Silletti, Steve, Torres-Paris, Constanza, Mathea, Sebastian, Chatterjee, Deep, Knapp, Stefan, Herberg, Friedrich W., Taylor, Susan S.

Source: PLoS Biology; 2/3/2025, Vol. 23 Issue 1, p1-1, 1p

A Pseudo-Kinase Double Act

Authors: Preuß, Franziska, Mathea, Sebastian, Knapp, Stefan

Source: In Structure 3 April 2018 26(4):527-528

Sfp-Type 4'-Phosphopantetheinyl Transferase Is Indispensable for Fungal Pathogenicity

Authors: Horbach, Ralf, Graf, Alexander, Weihmann, Fabian, Antelo, Luis, Mathea, Sebastian, Liermann, Johannes C., Opatz, Till, Thines, Eckhard, Aguirre, Jesús, Deising, Holger B.

Source: The Plant Cell, 2009 Oct 01. 21(10), 3379-3396.

Access URL: https://www.jstor.org/stable/40537513

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.

Authors: Weng, Jui-Hung¹, Aoto, Phillip C.¹, Lorenz, Robin², Wu, Jian¹, Schmidt, Sven H.², Manschwetus, Jascha T.², Kaila-Sharma, Pallavi¹, Silletti, Steve³, Mathea, Sebastian⁴, Chatterjee, Deep⁴, Knapp, Stefan⁴, Herberg, Friedrich W.², Taylor, Susan S.¹, staylor@ucsd.edu

Source: PLoS Biology; 2/22/2022, Vol. 20 Issue 2, p1-21, 21p, 6 Diagrams, 2 Graphs

Chapter Twenty-Two - Enabling pseudokinases as potential drug targets

Authors: Preuss, Franziska, Chatterjee, Deep, Dederer, Verena, Knapp, Stefan ^*, Mathea, Sebastian

Source: In Methods in Enzymology 2022 667:663-683

Prototypische PPlasen in der Signaltransduktion
Prototypical PPlases in signal transduction

Authors: Mathea, Sebastian

Contributors: Schutkowski, Mike, Fischer, Gunter, Wetzker, Reinhard

Availability: http://data.europeana.eu/aggregation/europeana/2048441/item_VOUPWR32B4JQ3VAJRN3RPQGMNNZVEJXJ

Inhibition of Parkinson’s disease-related LRRK2 by type-I and type-II kinase inhibitors: Activity and structures

Authors: Sanz Murillo, Marta M., Villagran Suarez, Amalia C., Dederer, Verena, Chatterjee, Deep, Alegrio Louro, Jaime M., Knapp, Stefan, Mathea, Sebastian, Leschziner, Andres

Source: In Biophysical Journal 8 February 2024 123(3) Supplement 1:52a-53a

Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.

Authors: Fathalla, Reem K.¹ (AUTHOR), Fröhner, Wolfgang¹ (AUTHOR), Bader, Chantal D.^2,3 (AUTHOR), Fischer, Patrick D.^1,4,5 (AUTHOR), Dahlem, Charlotte⁶ (AUTHOR), Chatterjee, Deep⁷ (AUTHOR), Mathea, Sebastian⁷ (AUTHOR), Kiemer, Alexandra K.⁶ (AUTHOR), Arthanari, Haribabu^4,5 (AUTHOR), Müller, Rolf^2,3,8 (AUTHOR), Abdel-Halim, Mohammad⁹ (AUTHOR), Ducho, Christian¹ (AUTHOR) christian.ducho@uni-saarland.de, Engel, Matthias¹ (AUTHOR) ma.engel@mx.uni-saarland.de

Source: Journal of Medicinal Chemistry. 11/10/2022, Vol. 65 Issue 21, p14740-14763. 24p.

Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.

Authors: Hanke, Thomas^1,2 (AUTHOR), Mathea, Sebastian^1,2 (AUTHOR), Woortman, Julia³ (AUTHOR), Salah, Eidarus⁴ (AUTHOR), Berger, Benedict-Tilman^1,2 (AUTHOR), Tumber, Anthony⁴ (AUTHOR), Kashima, Risa⁵ (AUTHOR), Hata, Akiko⁵ (AUTHOR), Kuster, Bernhard^3,6 (AUTHOR), Müller, Susanne^1,2 (AUTHOR), Knapp, Stefan^1,2,6 (AUTHOR) knapp@pharmchem.uni-frankfurt.de

Source: Journal of Medicinal Chemistry. 10/13/2022, Vol. 65 Issue 19, p13264-13287. 24p.

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

Authors: Malik, Asad U., Karapetsas, Athanasios, Nirujogi, Raja S., Chatterjee, Deep, Phung, Toan K., Wightman, Melanie, Gourlay, Robert, Morrice, Nick, Mathea, Sebastian, Knapp, Stefan, Alessi, Dario R.

Source: Biochemical Journal; Sep2022, Vol. 479 Issue 18, p1941-1965, 25p

Subject Terms: GUANOSINE triphosphatase, PROTEIN kinase C, PARKINSON'S disease, MISSENSE mutation, KINASES

Isoform-Specific Inhibition of Cyclophilins.

Authors: Dȧum, Sebastian, Schumann, Michael, Mathea, Sebastian

Source: Biochemistry; July 7 2009, Vol. 48 Issue 26, p118-122, 5p

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5‑a]pyrimidine-Based Macrocycles.

Authors: Kurz, Christian G.^1,2 (AUTHOR), Preuss, Franziska^1,2 (AUTHOR), Tjaden, Amelie^1,2 (AUTHOR), Cusack, Martin³ (AUTHOR), Amrhein, Jennifer Alisa^1,2 (AUTHOR), Chatterjee, Deep^1,2 (AUTHOR), Mathea, Sebastian^1,2 (AUTHOR), Berger, Lena Marie^1,2 (AUTHOR), Berger, Benedict-Tilman^1,2 (AUTHOR), Krämer, Andreas^1,2,4 (AUTHOR), Weller, Michael³ (AUTHOR), Weiss, Tobias³ (AUTHOR), Müller, Susanne^1,2 (AUTHOR), Knapp, Stefan^1,2 (AUTHOR) knapp@pharmchem.uni-frankfurt.de, Hanke, Thomas^1,2 (AUTHOR) hanke@pharmchem.uni-frankfurt.de

Source: Journal of Medicinal Chemistry. 6/9/2022, Vol. 65 Issue 11, p7799-7817. 19p.

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.

Authors: Drewry, David H.^1,2,3, Annor-Gyamfi, Joel K.^1,2, Wells, Carrow I.^1,2, Pickett, Julie E.^1,2, Dederer, Verena^4,5, Preuss, Franziska^4,5, Mathea, Sebastian^4,5, Axtman, Alison D.^1,2 alison.axtman@unc.edu

Source: Journal of Medicinal Chemistry. 1/27/2022, Vol. 65 Issue 2, p1313-1328. 16p.