Advancements in Pulsed Stable Isotope-Resolved Metabolomics

Authors: Forbes, Martin, Geisberger, Sabrina, Pietzke, Matthias, Mastrobuoni, Guido, Kempa, Stefan

Source: Handbook of experimental pharmacology. 277:165-180

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Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN‐amplified neuroblastoma

Authors: Arlt, Birte, Zasada, Christin, Baum, Katharina, Wuenschel, Jasmin, Mastrobuoni, Guido, Lodrini, Marco, Astrahantseff, Kathy, Winkler, Annika, Schulte, Johannes H., Finkler, Sabine, Forbes, Martin, Hundsdoerfer, Patrick, Guergen, Dennis, Hoffmann, Jens, Wolf, Jana, Eggert, Angelika, Kempa, Stefan, Deubzer, Hedwig E.

Source: International journal of cancer. 148(5):1219-1232

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Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect

Authors: Arlt, Birte, Mastrobuoni, Guido, Wuenschel, Jasmin, Astrahantseff, Kathy, Eggert, Angelika, Kempa, Stefan, Deubzer, Hedwig E.

Source: Journal of enzyme inhibition and medicinal chemistry. 36(1):1282-1289

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Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

Authors: Cossa, Giacomo, Roeschert, Isabelle, Prinz, Florian, Baluapuri, Apoorva, Silveira Vidal, Raphael, Schülein-Völk, Christina, Chang, Yun-Chien, Ade, Carsten Patrick, Mastrobuoni, Guido, Girard, Cyrille, Kumar, Amit, Wortmann, Lars, Walz, Susanne, Lührmann, Reinhard, Kempa, Stefan, Kuster, Bernhard, Wolf, Elmar, Mumberg, Dominik, Eilers, Martin

Source: In Molecular Cell 19 March 2020 77(6):1322-1339

Proteomic analysis of chemosensory organs in the honey bee parasite Varroa destructor: A comprehensive examination of the potential carriers for semiochemicals

Authors: Iovinella, Immacolata, McAfee, Alison, Mastrobuoni, Guido, Kempa, Stefan, Foster, Leonard J., Pelosi, Paolo, Dani, Francesca Romana

Source: In Journal of Proteomics 15 June 2018 181:131-141

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

Authors: Labi, Verena, Peng, Siying, Klironomos, Filippos, Munschauer, Mathias, Kastelic, Nicolai, Chakraborty, Tirtha, Schoeler, Katia, Derudder, Emmanuel, Martella, Manuela, Mastrobuoni, Guido

Source: Genes & development. 33(23/24):1673-1687

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C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice

Authors: Ackermann, Tobias, Hartleben, Götz, Müller, Christine, Mastrobuoni, Guido, Groth, Marco, Sterken, Britt, Zaini, Mohamad, Youssef, Sameh, Zuidhof, Hidde, Krauss, Sara, Kortman, Gertrud, de Haan, Gerald, de Bruin, Alain, Wang, Zhao-Qi, Platzer, Matthias, Kempa, Stefan, Calkhoven, Cornelis

Source: Communications biology. 2(1):1-15

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Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia

Authors: Mochmann, Liliana H., Treue, Denise, Bockmayr, Michael, Silva, Patricia, Zasada, Christin, Mastrobuoni, Guido, Bayram, Safak, Forbes, Martin, Jurmeister, Philipp, Liebig, Sven, Blau, Olga, Schleich, Konstanze, Splettstoesser, Bianca, Nordmann, Thierry M., von der Heide, Eva K., Isaakidis, Konstandina, Schulze, Veronika, Busch, Caroline, Siddiq, Hafsa, Schlee, Cornelia, Hester, Svenja, Fransecky, Lars, Neumann, Martin, Kempa, Stefan, Klauschen, Frederick, Baldus, Claudia D.

Source: Cancer Gene Therapy; September 2024, Vol. 31 Issue: 9 p1344-1356, 13p

L-Glyceraldehyde Inhibits Neuroblastoma Cell Growth via a Multi-Modal Mechanism on Metabolism and Signaling.

Authors: Forbes, Martin, Kempa, Richard, Mastrobuoni, Guido, Rayman, Liam, Pietzke, Matthias, Bayram, Safak, Arlt, Birte, Spruessel, Annika, Deubzer, Hedwig E., Kempa, Stefan

Source: Cancers; May2024, Vol. 16 Issue 9, p1664, 27p

Subject Terms: COMBINATION drug therapy, RESEARCH funding, ALDEHYDES, CELL proliferation, OXIDATIVE stress, CELL lines, FIBROBLASTS, NUCLEOTIDES, CELL death, DISEASE relapse, NEUROBLASTOMA

Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations

Authors: Fritsche-Guenther, Raphaela, Zasada, Christin, Mastrobuoni, Guido, Royla, Nadine, Rainer, Roman, Roßner, Florian, Pietzke, Matthias, Klipp, Edda, Sers, Christine, Kempa, Stefan

Source: Scientific reports. 8(1):1-17

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Protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters.

Authors: Alves, Luiz Gustavo Teixeira, Baumgardt, Morris, Langner, Christine, Fischer, Mara, Adler, Julia Maria, Bushe, Judith, Firsching, Theresa Catharina, Mastrobuoni, Guido, Grobe, Jenny, Hoenzke, Katja, Kempa, Stefan, Gruber, Achim Dieter, Hocke, Andreas Christian, Trimpert, Jakob, Wyler, Emanuel, Landthaler, Markus

Source: BMJ Open Respiratory Research; 2024, Vol. 11 Issue 1, p1-12, 12p

Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex

Authors: Weigt, Martina, Gao, Qingsong, Ban, Hyoju, He, Haijin, Mastrobuoni, Guido, Kempa, Stefan, Chen, Wei, Li, Fei

Source: Epigenetics & chromatin. 14(1)

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The MYC mRNA 3′‐UTR couples RNA polymerase II function to glutamine and ribonucleotide levels

Authors: Dejure, Francesca R, Royla, Nadine, Herold, Steffi, Kalb, Jacqueline, Walz, Susanne, Ade, Carsten P, Mastrobuoni, Guido, Vanselow, Jens T, Schlosser, Andreas, Wolf, Elmar, Kempa, Stefan, Eilers, Martin

Source: EMBO journal. 36(13):1854-1868

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On Mass Ambiguities in High-Resolution Shotgun Lipidomics

Authors: Bielow, Chris, Mastrobuoni, Guido, Orioli, Marica, Kempa, Stefan

Source: Analytical chemistry. 89(5):2986-2994

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MOV10 Is a 5′ to 3′ RNA Helicase Contributing to UPF1 mRNA Target Degradation by Translocation along 3′ UTRs

Authors: Gregersen, Lea H., Schueler, Markus, Munschauer, Mathias, Mastrobuoni, Guido, Chen, Wei, Kempa, Stefan, Dieterich, Christoph, Landthaler, Markus

Source: In Molecular Cell 22 May 2014 54(4):573-585

Proteomics Quality Control: Quality Control Software for MaxQuant Results

Authors: Bielow, Chris, Mastrobuoni, Guido, Kempa, Stefan

Source: Journal of proteome research. 15(3):777-787

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Integrative functional genomics decodes herpes simplex virus 1

Authors: Whisnant, Adam W., Jürges, Christopher S., Hennig, Thomas, Wyler, Emanuel, Prusty, Bhupesh, Rutkowski, Andrzej J., L'hernault, Anne, Djakovic, Lara, Göbel, Margarete, Döring, Kristina, Menegatti, Jennifer, Antrobus, Robin, Matheson, Nicholas J., Künzig, Florian W. H., Mastrobuoni, Guido, Bielow, Chris, Kempa, Stefan, Liang, Chunguang, Dandekar, Thomas, Zimmer, Ralf, Landthaler, Markus, Grässer, Friedrich, Lehner, Paul J., Friedel, Caroline C., Erhard, Florian, Dölken, Lars

Source: Nature communications. 11(1)

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Spatiotemporal, optogenetic control of gene expression in organoids

Authors: Legnini, Ivano, Emmenegger, Lisa, Zappulo, Alessandra, Rybak-Wolf, Agnieszka, Wurmus, Ricardo, Martinez, Anna Oliveras, Jara, Cledi Cerda, Boltengagen, Anastasiya, Hessler, Talé, Mastrobuoni, Guido, Kempa, Stefan, Zinzen, Robert, Woehler, Andrew, Rajewsky, Nikolaus

Source: Nature Methods; October 2023, Vol. 20 Issue: 10 p1544-1552, 9p

In Vivo and Transcriptome-wide Identification of RNA Binding Protein Target Sites

Authors: Jungkamp, Anna-Carina, Stoeckius, Marlon, Mecenas, Desirea, Grün, Dominic, Mastrobuoni, Guido, Kempa, Stefan, Rajewsky, Nikolaus

Source: In Molecular Cell 2011 44(5):828-840

Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation

Authors: Graf, Robin, Munschauer, Mathias, Mastrobuoni, Guido, Mayr, Florian, Heinemann, Udo, Kempa, Stefan, Rajewsky, Nikolaus, Landthaler, Markus

Source: RNA biology. 10(7):1146-1159

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