Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate

Authors: Xuanrong Chen, Michael A. Augello, Deli Liu, Kevin Lin, Alex Hakansson, Martin Sjöström, Francesca Khani, Lesa D. Deonarine, Yang Liu, Jaida Travascio-Green, Jiansheng Wu, Un In Chan, Jude Owiredu, Massimo Loda, Felix Y. Feng, Brian D. Robinson, Elai Davicioni, Andrea Sboner, Christopher E. Barbieri

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/07a68e6011a946bc9d120ecc4b67fc67

The polyunsaturated fatty acid docosahexaenoic affects mitochondrial function in prostate cancer cells

Authors: Guilherme Henrique Tamarindo, Caroline Fidalgo Ribeiro, Alana Della Torre Silva, Alex Castro, Ícaro Putinhon Caruso, Fátima Pereira Souza, Sebastião Roberto Taboga, Massimo Loda, Rejane Maira Góes

Source: Cancer & Metabolism, Vol 12, Iss 1, Pp 1-16 (2024)

Subject Terms: Prostate cancer cells, Omega-3 polyunsaturated fatty acids, Docosahexaenoic acid, Mitochondria, Lipid metabolism, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2049-3002

Access URL: https://doaj.org/article/c168afd2838e45f8a054c0b7f1a802f5

Distinct mesenchymal cell states mediate prostate cancer progression

Authors: Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes de Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni, Massimo Loda

Source: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f358a6f85a6c4b2189686dbb0cfa358f

Plasma metabolomics profiling of 580 patients from an Early Detection Research Network prostate cancer cohort

Authors: Elisa Benedetti, Kelsey Chetnik, Thomas Flynn, Christopher E. Barbieri, Douglas S. Scherr, Massimo Loda, Jan Krumsiek

Source: Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/d0a20e13995d4a0ca46dac4e068bf0ec

Linking African ancestral substructure to prostate cancer health disparities

Authors: Kazzem Gheybi, Naledi Mmekwa, Maphuti Tebogo Lebelo, Sean M. Patrick, Raymond Campbell, Mukudeni Nenzhelele, Pamela X. Y. Soh, Muvhulawa Obida, Massimo Loda, Joyce Shirindi, Eboneé N. Butler, Shingai B. A. Mutambirwa, M. S. Riana Bornman, Vanessa M. Hayes

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d0fce8dd31414749a19a6f3cfa8336a2

Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures

Authors: Sandy Figiel, Wencheng Yin, Dimitrios Doultsinos, Andrew Erickson, Ninu Poulose, Reema Singh, Anette Magnussen, Thineskrishna Anbarasan, Renuka Teague, Mengxiao He, Joakim Lundeberg, Massimo Loda, Clare Verrill, Richard Colling, Pelvender S. Gill, Richard J. Bryant, Freddie C. Hamdy, Dan J. Woodcock, Ian G. Mills, Olivier Cussenot, Alastair D. Lamb

Source: Molecular Cancer, Vol 22, Iss 1, Pp 1-5 (2023)

Subject Terms: Prostate cancer, Virtual biopsy, Prognostic genetic signatures, Spatial transcriptomics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/586aa75e487c4ec0a28a445500a1ab30

PI‐RADS 3 score: A retrospective experience of clinically significant prostate cancer detection

Authors: Andrés Camacho, Fatima Salah, Camden P. Bay, Jonathan Waring, Renato Umeton, Michelle S. Hirsch, Alexander P. Cole, Adam S. Kibel, Massimo Loda, Clare M. Tempany, Fiona M. Fennessy

Source: BJUI Compass, Vol 4, Iss 4, Pp 473-481 (2023)

Subject Terms: clinically significant prostate cancer, multiparametric prostate MRI, PI‐RADS 3 assessment category, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://doaj.org/toc/2688-4526

Access URL: https://doaj.org/article/3b8230abaeff42dfbb3c80fcff5d522a

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

Authors: Xintao Qiu, Nadia Boufaied, Tarek Hallal, Avery Feit, Anna de Polo, Adrienne M. Luoma, Walaa Alahmadi, Janie Larocque, Giorgia Zadra, Yingtian Xie, Shengqing Gu, Qin Tang, Yi Zhang, Sudeepa Syamala, Ji-Heui Seo, Connor Bell, Edward O’Connor, Yang Liu, Edward M. Schaeffer, R. Jeffrey Karnes, Sheila Weinmann, Elai Davicioni, Colm Morrissey, Paloma Cejas, Leigh Ellis, Massimo Loda, Kai W. Wucherpfennig, Mark M. Pomerantz, Daniel E. Spratt, Eva Corey, Matthew L. Freedman, X. Shirley Liu, Myles Brown, Henry W. Long, David P. Labbé

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/bc90d144fd374a6387fda7079a332f9f

O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage

Authors: Aishwarya Gondane, Samuel Girmay, Alma Helevä, Satu Pallasaho, Massimo Loda, Harri M. Itkonen

Source: Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-12 (2022)

Subject Terms: DNA damage, Cyclin-dependent kinase 9, O-GlcNAc transferase, MRE11, Castration-resistant prostate cancer, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/3795e5a214124a5dbb301896e57e4916

Inflammatory metabolic profile of South African patients with prostate cancer

Authors: Stefano Cacciatore, Martha Wium, Cristina Licari, Aderonke Ajayi-Smith, Lorenzo Masieri, Chanelle Anderson, Azola Samkele Salukazana, Lisa Kaestner, Marco Carini, Giuseppina M. Carbone, Carlo V. Catapano, Massimo Loda, Towia A. Libermann, Luiz F. Zerbini

Source: Cancer & Metabolism, Vol 9, Iss 1, Pp 1-14 (2021)

Subject Terms: Metabolomics, NMR spectroscopy, GlycA, GlycB, Histidine, Prostate cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2049-3002

Access URL: https://doaj.org/article/455b5f98b8da4e75a5af428d053f1584

Transcriptional landscape of PTEN loss in primary prostate cancer

Authors: Eddie Luidy Imada, Diego Fernando Sanchez, Wikum Dinalankara, Thiago Vidotto, Ericka M. Ebot, Svitlana Tyekucheva, Gloria Regina Franco, Lorelei Ann Mucci, Massimo Loda, Edward Matthew Schaeffer, Tamara Lotan, Luigi Marchionni

Source: BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)

Subject Terms: Prostate Cancer, PTEN deletion, PTEN loss, Non-coding RNA, lncRNA, Meta-analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/691966c326904d4cbfd10d1a8e31843d

Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer

Authors: Nicholas J. Brady, Alyssa M. Bagadion, Richa Singh, Vincenza Conteduca, Lucie Van Emmenis, Elisa Arceci, Hubert Pakula, Ryan Carelli, Francesca Khani, Martin Bakht, Michael Sigouros, Rohan Bareja, Andrea Sboner, Olivier Elemento, Scott Tagawa, David M. Nanus, Massimo Loda, Himisha Beltran, Brian Robinson, David S. Rickman

Source: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/02a3612e2f2a462990758033d59bb602

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

Authors: Daniel Butler, Christopher Mozsary, Cem Meydan, Jonathan Foox, Joel Rosiene, Alon Shaiber, David Danko, Ebrahim Afshinnekoo, Matthew MacKay, Fritz J. Sedlazeck, Nikolay A. Ivanov, Maria Sierra, Diana Pohle, Michael Zietz, Undina Gisladottir, Vijendra Ramlall, Evan T. Sholle, Edward J. Schenck, Craig D. Westover, Ciaran Hassan, Krista Ryon, Benjamin Young, Chandrima Bhattacharya, Dianna L. Ng, Andrea C. Granados, Yale A. Santos, Venice Servellita, Scot Federman, Phyllis Ruggiero, Arkarachai Fungtammasan, Chen-Shan Chin, Nathaniel M. Pearson, Bradley W. Langhorst, Nathan A. Tanner, Youngmi Kim, Jason W. Reeves, Tyler D. Hether, Sarah E. Warren, Michael Bailey, Justyna Gawrys, Dmitry Meleshko, Dong Xu, Mara Couto-Rodriguez, Dorottya Nagy-Szakal, Joseph Barrows, Heather Wells, Niamh B. O’Hara, Jeffrey A. Rosenfeld, Ying Chen, Peter A. D. Steel, Amos J. Shemesh, Jenny Xiang, Jean Thierry-Mieg, Danielle Thierry-Mieg, Angelika Iftner, Daniela Bezdan, Elizabeth Sanchez, Thomas R. Campion, John Sipley, Lin Cong, Arryn Craney, Priya Velu, Ari M. Melnick, Sagi Shapira, Iman Hajirasouliha, Alain Borczuk, Thomas Iftner, Mirella Salvatore, Massimo Loda, Lars F. Westblade, Melissa Cushing, Shixiu Wu, Shawn Levy, Charles Chiu, Robert E. Schwartz, Nicholas Tatonetti, Hanna Rennert, Marcin Imielinski, Christopher E. Mason

Source: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e049d27579f84e2b9f12b7b11bc7c436

Fatty acid synthase as a potential new therapeutic target for cervical cancer

Authors: JÉSSICA NASCIMENTO, CAMILA MARIOT, DÉBORA R.B. VIANNA, LÚCIA M. KLIEMANN, PAULA S. CHAVES, MASSIMO LODA, ANDRÉIA BUFFON, RUY C.R. BECK, DIOGO A. PILGER

Source: Anais da Academia Brasileira de Ciências, Vol 94, Iss 2 (2022)

Subject Terms: Fatty acid synthase, FASN, Cervical cancer, Orlistat, Science

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300705&lng=en&tlng=en; http://www.scielo.br/pdf/aabc/v94n2/0001-3765-aabc-94-02-e20210670.pdf; https://doaj.org/toc/1678-2690

Access URL: https://doaj.org/article/c510aca16e044c8eae6b7246ab0ec8ec

Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

Authors: Konrad H Stopsack, Svitlana Tyekucheva, Molin Wang, Travis A Gerke, J Bailey Vaselkiv, Kathryn L Penney, Philip W Kantoff, Stephen P Finn, Michelangelo Fiorentino, Massimo Loda, Tamara L Lotan, Giovanni Parmigiani, Lorelei A Mucci

Source: eLife, Vol 10 (2021)

Subject Terms: tissue microarray, batch effect, measurement error, batchtma, R package, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/71265; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/5d3559e372204133ba3415106d7b03ea

BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins

Authors: Meng Jiang, Yue Kang, Tomasz Sewastianik, Jiao Wang, Helen Tanton, Keith Alder, Peter Dennis, Yu Xin, Zhongqiu Wang, Ruiyang Liu, Mengyun Zhang, Ying Huang, Massimo Loda, Amitabh Srivastava, Runsheng Chen, Ming Liu, Ruben D. Carrasco

Source: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c701f702b6ee44eb8abe1ba9329267b9

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

Authors: David P. Labbé, Giorgia Zadra, Meng Yang, Jaime M. Reyes, Charles Y. Lin, Stefano Cacciatore, Ericka M. Ebot, Amanda L. Creech, Francesca Giunchi, Michelangelo Fiorentino, Habiba Elfandy, Sudeepa Syamala, Edward D. Karoly, Mohammed Alshalalfa, Nicholas Erho, Ashley Ross, Edward M. Schaeffer, Ewan A. Gibb, Mandeep Takhar, Robert B. Den, Jonathan Lehrer, R. Jeffrey Karnes, Stephen J. Freedland, Elai Davicioni, Daniel E. Spratt, Leigh Ellis, Jacob D. Jaffe, Anthony V. DʼAmico, Philip W. Kantoff, James E. Bradner, Lorelei A. Mucci, Jorge E. Chavarro, Massimo Loda, Myles Brown

Source: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ad31beb7d54c47838760eb7ff3f13cf9

Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer

Authors: Stephen Y. C. Choi, Caroline Fidalgo Ribeiro, Yuzhuo Wang, Massimo Loda, Stephen R. Plymate, Takuma Uo

Source: Biomolecules, Vol 12, Iss 11, p 1590 (2022)

Subject Terms: androgen receptor, cancer metabolism, prostate cancer, Warburg’s effect, lactate, fatty acids, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/11/1590; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/97827942c8504da9b13c9ad5b3361fa1

The New York State SARS-CoV-2 Testing Consortium: Regional Communication in Response to the COVID-19 Pandemic

Authors: James M. Crawford MD, PhD, Maria E. Aguero-Rosenfeld MD, Ioannis Aifantis PhD, Evan M. Cadoff MD, Joan F. Cangiarella MD, Carlos Cordon-Cardo MD, Melissa Cushing MD, Aldolfo Firpo-Betancourt MD, Amy S. Fox MD, Yoko Furuya MD, Sean Hacking MD, Jeffrey Jhang MD, Debra G. B. Leonard MD, PhD, Jenny Libien MD, PhD, Massimo Loda MD, Damadora Rao Mendu MD, Mark J. Mulligan MD, Michel R. Nasr MD, Nicole D. Pecora MD, Melissa S. Pessin MD, PhD, Michael B. Prystowsky MD, PhD, Lakshmi V. Ramanathan PhD, Kathleen R. Rauch BSN, RN, Scott Riddell PhD, Karen Roach MPH, Kevin A. Roth MD, PhD, Kenneth R. Shroyer MD, PhD, Bruce R. Smoller MD, Steven L. Spitalnik MD, PhD, Eric D. Spitzer MD, PhD, John E. Tomaszewski MD, Susan Waltman Esq, Loretta Willis BSN, RN, CPHQ, CCM, Zeynep Sumer-King MS

Source: Academic Pathology, Vol 8 (2021)

Subject Terms: Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/2374-2895

Access URL: https://doaj.org/article/8663148cdd3a4b7291170a116ac88ffb

Phase I study of the 177Lu-DOTA0-Tyr3-Octreotate (lutathera) in combination with nivolumab in patients with neuroendocrine tumors of the lung

Authors: Giuseppe Esposito, Giuseppe Giaccone, Chul Kim, Stephen V Liu, Deepa S Subramaniam, Tisdrey Torres, Massimo Loda

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/2/e000980.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/339800a96f024e289659dbef437ef846