Aging platelets shift their hemostatic properties to inflammatory functions

Authors: Anjum, Afra ^{1, 2}, Mader, Magdalena ^{1, 2}, Mahameed, Shaan ¹, Muraly, Abhinaya ^{1, 2}, Denorme, Frederik ³, Kliem, Fabian P. ⁴, Rossaro, Dario ^{1, 2}, Agköl, Sezer ^{1, 2}, Di Fina, Lea ^{1, 2}, Mulkers, Maité ^{1, 2}, Laun, Lisa ^{1, 2}, Li, Lukas ¹, Kupper, Nadja ^{1, 2}, Yue, Keyang ^{1, 2}, Hoffknecht, Marie-Louise ^{1, 2}, Akhalkatsi, Anastassia ^{1, 2}, Loew, Quentin ^{1, 2}, Pircher, Joachim ^{1, 2}, Escaig, Raphael ^{1, 2}, Strasser, Erwin ⁵, Wichmann, Christian ⁵, Pekayvaz, Kami ^{1, 2}, Nieswandt, Bernhard ⁶, Schulz, Christian ^{1, 2, 7}, Robles, Maria S. ⁴, Kaiser, Rainer ^{1, 2}, Massberg, Steffen ^{1, 2}, Campbell, Robert ³, Nicolai, Leo ^{1, 2, ∗}

Source: In Blood 3 April 2025 145(14):1568-1582

Progress of Angiographic Cardiac Allograft Vasculopathy in Patients With Long-Term Transplantation: Longitudinal Evaluation of Its Association With Dyslipidemia Patterns

Authors: Grundmann, David ^{a, †}, Neubarth-Mayer, Janina ^a, Müller, Christoph ^b, Becker, Finn ^a, Reichart, Daniel ^a, Stark, Konstantin ^{a, c}, Grabmaier, Ulrich ^{d, a}, Deseive, Simon ^a, Rizas, Konstantinos D. ^{a, c}, Hausleiter, Jörg ^{a, c}, Hagl, Christian ^{b, c}, Mehilli, Julinda ^{d, a, c}, Massberg, Steffen ^{a, c}, Orban, Madeleine ^{a, c, ⁎}

Source: In The American Journal of Cardiology 1 March 2025 238:47-54

Optimized monitoring for immune checkpoint inhibitor induced myocarditis using high-sensitivity troponin-T

Authors: Tomsitz, Dirk ^a, Grabmaier, Ulrich ^b, Spiro, Judith ^c, Nicolai, Leo ^{b, d}, French, Lars E. ^{a, e}, Massberg, Steffen ^b, Heinzerling, Lucie ^{a, f, g, ⁎}

Source: In European Journal of Cancer 5 February 2025 216

Long-term FXa inhibition attenuates thromboinflammation after acute myocardial infarction and stroke by platelet proteome alteration

Authors: Polzin, Amin ^{1, 2, 3, ∗}, Benkhoff, Marcel ^{1, 4}, Thienel, Manuela ^{5, 6}, Barcik, Maike ¹, Mourikis, Philipp ¹, Shchurovska, Khrystyna ^{5, 6}, Helten, Carolin ¹, Ehreiser, Vincent ^{7, 8, 9}, Zhe, Zhang ^{5, 6}, von Wulffen, Franziska ^{5, 6}, Theiss, Alexander ^{5, 6}, Peri, Sameera ^{5, 6}, Cremer, Sophie ¹, Ahlbrecht, Samantha ¹, Zako, Saif ¹, Wildeis, Laura ¹, Al-Kassis, Gabrielle ¹, Metzen, Daniel ¹, Utz, Amelie ¹, Hu, Hao ¹, Vornholz, Lilian ¹, Pavic, Goran ¹⁰, Lüsebrink, Enzo ^{5, 6}, Strecker, Jan ⁵, Tiedt, Steffen ¹¹, Cramer, Mareike ¹, Gliem, Michael ¹⁰, Ruck, Tobias ¹⁰, Meuth, Sven G. ¹⁰, Zeus, Tobias ¹, Mayr, Christoph ^{12, 13}, Schiller, Herbert B. ^{12, 13}, Simon, Lukas ^{14, 15}, Massberg, Steffen ^{5, 6}, Kelm, Malte ^{1, 2}, Petzold, Tobias ^{7, 8, 9, ∗∗}

Source: In Journal of Thrombosis and Haemostasis February 2025 23(2):668-683

Beyond 2-Dimensional Echocardiography: A Novel Multiparametric Assessment of Right Ventricular Dysfunction in Transcatheter Tricuspid Valve Repair

Authors: Doldi, Philipp M. ^{a, b, ∗}, Weckbach, Ludwig T. ^{a, b}, Stolz, Lukas ^a, Stocker, Thomas J. ^{a, b}, Näbauer, Michael ^{a, b}, Massberg, Steffen ^{a, b}, Hahn, Rebecca T. ^c, Muraru, Denisa ^d, Hausleiter, Jörg ^{a, b}

Source: In Canadian Journal of Cardiology January 2025

Transcatheter aortic valve implantation and its impact on endothelial function in patients with aortic stenosis

Authors: Arnold, Leonie, Haas, Nikolaus Alexander, Jakob, André, Fischer, Julius, Massberg, Steffen, Deseive, Simon, Oberhoffer, Felix Sebastian

Source: In Microvascular Research January 2025 157

A randomized comparison of the treatment sequence of percutaneous coronary intervention and transcatheter aortic valve implantation: Rationale and design of the TAVI PCI trial

Authors: Stähli, Barbara E., Linke, Axel, Westermann, Dirk, Van Mieghem, Nicolas M., Leistner, David M., Massberg, Steffen, Alber, Hannes, Mügge, Andreas, Musumeci, Giuseppe, Kesterke, Rahel, Schneider, Steffen, Kastrati, Adnan, Ford, Ian, Ruschitzka, Frank, Kasel, Markus A., Kasel, Markus, Van Mieghem, Nicolas, Savonitto, Stefano, Witzenbichler, Bernhard, Swaans, Martin, Swedberg, Karl, Pocock, Stuart, Maggioni, Aldo

Source: In American Heart Journal November 2024 277:104-113

Myeloid cells take ischemic insult to heart

Authors: Nicolai, Leo, Massberg, Steffen

Source: In Trends in Immunology October 2024 45(10):735-737

Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

Authors: Burkhoff, Daniel, Cohen, Howard, Brunckhorst, Corinna, O'Neill, William W., Thiele, Holger Thiele, Sick, Peter, Boudriot, Enno, Diederich, Klaus-Werner, Hambrecht, Rainer, Niebauer, Josef, Schuler, Gerhard, Seyfarth, Melchior, Sibbing, Dirk, Bauer, Iris, Fröhlich, Georg, Bott-Flügel, Lorenz, Byrne, Robert, Dirschinger, Josef, Kastrati, Adnan, Schömig, Albert, Ouweneel, Dagmar M., Eriksen, Erlend, Sjauw, Krischan D., van Dongen, Ivo M., Hirsch, Alexander, Packer, Erik J.S, Vis, M. Marie, Wykrzykowska, Joanna J., Koch, Karel T., Baan, Jan, De Winter, Robbert J, Piek, Jan J., Lagrand, Wim K, de Mol, Bas A.J.M, Tijssen, Jan G.P., Henriques, José P.S., Møller, Jacob E., Engstrøm, Thomas, Jensen, Lisette Okkels, Eiskjær, Hans, Mangner, Norman, Polzin, Amin, Schulze, P. Christian, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Panoulas, Vasileios, Zimmer, Sebastian, Schäfer, Andreas, Werner, Nikos, Frydland, Martin, Holmvang, Lene, Kjærgaard, Jesper, Sørensen, Rikke, Lønborg, Jacob, Greve, Matias, Christiansen, Evald H., Linke, Axel, Woitek, Felix J., Westenfeld, Ralf, Moebius-Winkler, Sven, Wachtell, Kristian, Ravn, Hanne Berg, Lassen, Jens Flensted, Boesgaard, Søren, Gerke, Oke, Hassager, Christian, Lackermair, Korbinian, Brunner, Stefan, Orban, Mathias, Peterss, Sven, Orban, Martin, Theiss, Hans D., Huber, Bruno C., Juchem, Gerd, Born, Frank, Boulesteix, Anne-Laure, Bauer, Axel, Pichlmaier, Maximilian, Hausleiter, Jörg, Massberg, Steffen, Hagl, Christian, Guenther, Sabina P.W., Ostadal, Petr, Rokyta, Richard, Karasek, Jiri, Kruger, Andreas, Vondrakova, Dagmar, Janotka, Marek, Naar, Jan, Smalcova, Jana, Hubatova, Marketa, Hromadk, Milan, Volovar, Stefan, Seyfrydova, Miroslava, Jarkovsky, Jiri, Svoboda, Michal, Linhart, Ales, Belohlavek, Jan, Banning, Amerjeet S., Sabaté, Manel, Gracey, Jay, López-Sobrino, Teresa, Bogaerts, Kris, Adriaenssens, Tom, Berry, Colin, Erglis, Andrejs, Haine, Steven, Myrmel, Truls, Patel, Sameer, Buera, Irene, Sionis, Alessandro, Vilalta, Victoria, Yusuff, Hakeem, Vrints, Christiaan, Adlam, David, Flather, Marcus, Gershlick, Anthony H., Thiele, Holger, Zeymer, Uwe, Akin, Ibrahim, Behnes, Michael, Rassaf, Tienush, Mahabadi, Amir-Abbas, Lehmann, Ralf, Eitel, Ingo, Graf, Tobias, Seidler, Tim, Schuster, Andreas, Duerschmied, Daniel, Hennersdorf, Marcus, Fichtlscherer, Stephan, Voigt, Ingo, John, Stefan, Ewen, Sebastian, Tigges, Eike, Nordbeck, Peter Steffen, Bruch, Leonhard, Jung, Christian, Franz, Jutta, Lauten, Philipp, Goslar, Tomaz, Feistritzer, Hans-Josef, Pöss, Janine, Kirchhof, Eva, Ouarrak, Taoufik, Schneider, Steffen, Desch, Steffen, Freund, Anne, Møller, Jacob E ^*, Henriques, Jose P S, Bogerd, Margriet, Hochadel, Matthias, Schulze, P Christian

Source: In The Lancet 14-20 September 2024 404(10457):1019-1028

Antibodies and complement are key drivers of thrombosis

Authors: Stark, Konstantin, Kilani, Badr, Stockhausen, Sven, Busse, Johanna, Schubert, Irene, Tran, Thuy-Duong, Gaertner, Florian, Leunig, Alexander, Pekayvaz, Kami, Nicolai, Leo, Fumagalli, Valeria, Stermann, Julia, Stephan, Felix, David, Christian, Müller, Martin B., Heyman, Birgitta, Lux, Anja, da Palma Guerreiro, Alexandra, Frenzel, Lukas P., Schmidt, Christoph Q., Dopler, Arthur, Moser, Markus, Chandraratne, Sue, von Brühl, Marie-Luise, Lorenz, Michael, Korff, Thomas, Rudelius, Martina, Popp, Oliver, Kirchner, Marieluise, Mertins, Philipp, Nimmerjahn, Falk, Iannacone, Matteo, Sperandio, Markus, Engelmann, Bernd, Verschoor, Admar, Massberg, Steffen

Source: In Immunity 10 September 2024 57(9):2140-2156

Platelets: Orchestrators of immunity in host defense and beyond

Authors: Nicolai, Leo ^{1, 2, ∗}, Pekayvaz, Kami ^{1, 2}, Massberg, Steffen ^{1, 2, ∗∗}

Source: In Immunity 14 May 2024 57(5):957-972

Jak2V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk

Authors: Liu, Wenli, Pircher, Joachim, Schuermans, Art, Ul Ain, Qurrat, Zhang, Zhe, Honigberg, Michael C., Yalcinkaya, Mustafa, Nakao, Tetsushi, Pournamadri, Ashley, Xiao, Tong, Hajebrahimi, Mohammad Ali, Wasner, Lisa, Stegner, David, Petzold, Tobias, Natarajan, Pradeep, Massberg, Steffen, Tall, Alan R., Schulz, Christian, Wang, Nan

Source: In Blood 11 April 2024 143(15):1539-1550

Aortic arch blood flow measurements as a predictor of successful ECMO weaning in cardiogenic shock

Authors: Kellnar, Antonia ^{a, b}, Naumann, Dominik ^{a, b}, Scherer, Clemens ^{a, b}, Lüsebrink, Enzo ^{a, b}, Joskowiak, Dominik ^c, Peterß, Sven ^c, Hagl, Christian ^c, Massberg, Steffen ^{a, b}, Orban, Martin ^{a, b}, Stremmel, Christopher ^{a, b, ∗}

Source: In Heliyon 15 March 2024 10(5)

Applying the TRILUMINATE Eligibility Criteria to Real-World Patients Receiving Tricuspid Valve Transcatheter Edge-to-Edge Repair

Authors: Stolz, Lukas, Doldi, Philipp M., Kresoja, Karl-Patrik, Bombace, Sara, Koell, Benedikt, Kassar, Mohammad, Kirchner, Johannes, Weckbach, Ludwig T., Ludwig, Sebastian, Stocker, Thomas J., Glaser, Hannah, Schöber, Anne R., Massberg, Steffen, Näbauer, Michael, Rudolph, Volker, Kalbacher, Daniel, Praz, Fabien, Lurz, Philipp, Hausleiter, Jörg

Source: In JACC: Cardiovascular Interventions 26 February 2024 17(4):535-548

Atrial Functional Tricuspid Regurgitation in Patients Undergoing Transcatheter Aortic Valve Replacement

Authors: Löw, Kornelia, Steffen, Julius, Lux, Melanie, Doldi, Philipp M., Haum, Magda, Fischer, Julius, Stolz, Lukas, Orban, Martin, Stocker, Thomas J., Rizas, Konstantinos D., Theiss, Hans, Braun, Daniel, Massberg, Steffen, Hausleiter, Jörg, Deseive, Simon

Source: In JACC: Cardiovascular Interventions 8 January 2024 17(1):76-87

Venoarterial extracorporeal membrane oxygenation in patients with infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials

Authors: Zeymer, Uwe ^{†, *}, Freund, Anne ^†, Hochadel, Matthias, Ostadal, Petr, Belohlavek, Jan, Rokyta, Richard, Massberg, Steffen, Brunner, Stefan, Lüsebrink, Enzo, Flather, Marcus, Adlam, David, Bogaerts, Kris, Banning, Amerjeet, Sabaté, Manel, Akin, Ibrahim, Jobs, Alexander, Schneider, Steffen, Desch, Steffen, Thiele, Holger ^**

Source: In The Lancet 14-20 October 2023 402(10410):1338-1346

Transcatheter Aortic Valve Replacement for Isolated Aortic Regurgitation Using a New Self-Expanding TAVR System

Authors: Adam, Matti, Tamm, Alexander R., Wienemann, Hendrik, Unbehaun, Axel, Klein, Christoph, Arnold, Martin, Marwan, Mohamed, Theiss, Hans, Braun, Daniel, Bleiziffer, Sabine, Geyer, Martin, Goncharov, Arseniy, Kuhn, Elmar, Falk, Volkmar, von Bardeleben, Ralph Stephan, Achenbach, Stephan, Massberg, Steffen, Baldus, Stephan, Treede, Hendrik, Rudolph, Tanja Katharina

Source: In JACC: Cardiovascular Interventions 28 August 2023 16(16):1965-1973

Mechanosensing via a GpIIb/Src/14-3-3ζ axis critically regulates platelet migration in vascular inflammation

Authors: Kaiser, Rainer, Anjum, Afra, Kammerer, Lisa, Loew, Quentin, Akhalkatsi, Anastassia, Rossaro, Dario, Escaig, Raphael, Droste zu Senden, Augustin, Raude, Ben, Lorenz, Michael, Gold, Christoph, Pekayvaz, Kami, Brocker, Thomas, Kranich, Jan, Holch, Julian Walter, Spiekermann, Karsten, Massberg, Steffen, Gaertner, Florian, Nicolai, Leo

Source: In Blood 15 June 2023 141(24):2973-2992

Quantification of physical activity with prospective activity tracking after transfemoral aortic valve replacement

Authors: Haum, Magda, Humpfer, Fabian, Steffen, Julius, Fischer, Julius, Stocker, Thomas J., Sadoni, Sebastian, Theiss, Hans, Braun, Daniel, Orban, Martin, Rizas, Konstantinos, Massberg, Steffen, Hausleiter, Jörg, Deseive, Simon

Source: In International Journal of Cardiology 1 April 2023 376:100-107

Staging Heart Failure Patients With Secondary Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair

Authors: Stolz, Lukas, Doldi, Philipp M., Orban, Mathias, Karam, Nicole, Puscas, Tania, Wild, Mirjam G., Popescu, Aniela, von Bardeleben, Ralph Stephan, Iliadis, Christos, Baldus, Stephan, Adamo, Marianna, Thiele, Holger, Besler, Christian, Unterhuber, Matthias, Ruf, Tobias, Pfister, Roman, Higuchi, Satoshi, Koell, Benedikt, Giannini, Christina, Petronio, Anna, Kassar, Mohammad, Weckbach, Ludwig T., Butter, Christian, Stocker, Thomas J., Neuss, Michael, Melica, Bruno, Braun, Daniel, Windecker, Stephan, Massberg, Steffen, Praz, Fabien, Näbauer, Micheal, Kalbacher, Daniel, Lurz, Philipp, Metra, Marco, Bax, Jeroen J., Hausleiter, Jörg

Source: In JACC: Cardiovascular Interventions 23 January 2023 16(2):140-151