Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation

Authors: Kelsey R Baron, Samantha Oviedo, Sophia Krasny, Mashiat Zaman, Rama Aldakhlallah, Prerona Bora, Prakhyat Mathur, Gerald Pfeffer, Michael J Bollong, Timothy E Shutt, Danielle A Grotjahn, R Luke Wiseman

Source: eLife, Vol 13 (2025)

Subject Terms: integrated stress response, mitochondrial morphology, mitochondrial fragmentation, stress signaling, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/100541; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/8caf1458b53d46bb8ca8e358ff2155c4

Characterization of a novel variant in the HR1 domain of MFN2 in a patient with ataxia, optic atrophy and sensorineural hearing loss [version 2; peer review: 2 approved, 1 approved with reservations]

Authors: Davide Martino, Kristina Martens, Matthew Joel, Rasha Sabouny, Mashiat Zaman, Timothy E. Shutt, Gerald Pfeffer, A.P. Jason de Koning, Govinda Sharma

Source: F1000Research, Vol 10 (2022)

Subject Terms: Mitochondria, MFN2, Mitochondrial Fusion, Ataxia, eng, Medicine, Science

File Description: electronic resource

Relation: https://f1000research.com/articles/10-606/v2; https://doaj.org/toc/2046-1402

Access URL: https://doaj.org/article/3e32624fbeac4668a777c63592bc7744

The Role of Impaired Mitochondrial Dynamics in MFN2-Mediated Pathology

Authors: Mashiat Zaman, Timothy E. Shutt

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: mitochondria, MFN2, CMT2A, mitochondrial endoplasmic reticulum contact sites, mitochondrial dynamics, mtDNA, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.858286/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/6a5845706afe491b9800c5986226f2ca