A type-5 metabotropic glutamate receptor-perineuronal net axis shapes the function of cortical GABAergic interneurons in chronic pain.

Authors: Mascio, Giada, Nicoletti, Ferdinando, Battaglia, Giuseppe, Notartomaso, Serena

Source: Journal of Anesthesia, Analgesia & Critical Care; 2/21/2025, Vol. 4 Issue 1, p1-7, 7p

Subject Terms: PERINEURONAL nets, PYRAMIDAL neurons, GLUTAMATE receptors, MEDICAL sciences, PAIN threshold, CHONDROITIN sulfate proteoglycan

Repeated episodes of transient reduction of oxygen exposure simulating aircraft cabin conditions enhance resilience to stress in mice

Authors: Ginerete, Roxana Paula, Mascio, Giada, Liberatore, Francesca, Bucci, Domenico, Antenucci, Nico, Di Pietro, Paola, Cannella, Milena, Imbriglio, Tiziana, Notartomaso, Serena, Nicoletti, Ferdinando, Bruno, Valeria, Battaglia, Giuseppe

Source: European journal of neuroscience. 54(9):7109-7124

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134545212.0x000001&indx=1&recIds=ETOCvdc_100134545212.0x000001

Pharmacological activation of mGlu5 receptors with the positive allosteric modulator VU0360172, modulates thalamic GABAergic transmission

Authors: Celli, Roberta, Wall, Mark J., Santolini, Ines, Vergassola, Matteo, Di Menna, Luisa, Mascio, Giada, Cannella, Milena, van Luijtelaar, Gilles, Pittaluga, Anna, Ciruela, Francisco, Bruno, Valeria, Nicoletti, Ferdinando, Ngomba, Richard T.

Source: In Neuropharmacology 1 November 2020 178

Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors

Authors: Imbriglio, Tiziana, Verhaeghe, Remy, Martinello, Katiuscia, Pascarelli, Maria Teresa, Chece, Giuseppina, Bucci, Domenico, Notartomaso, Serena, Quattromani, Miriana, Mascio, Giada, Scalabrì, Francesco, Simeone, Antonio, Maccari, Stefania, Del Percio, Claudio, Wieloch, Tadeusz, Fucile, Sergio, Babiloni, Claudio, Battaglia, Giuseppe, Limatola, Cristina, Nicoletti, Ferdinando, Cannella, Milena

Source: FASEB journal. 33(12):14204-14220

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182057602.0x000001&indx=1&recIds=ETOCvdc_100182057602.0x000001

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

Authors: Liberatore, Francesca, Bucci, Domenico, Mascio, Giada, Madonna, Michele, Di Pietro, Paola, Beneventano, Martina, Puliti, Alda Maria, Battaglia, Giuseppe, Bruno, Valeria, Nicoletti, Ferdinando, Romano, Maria Rosaria

Source: In Neuroscience 5 November 2017 363:142-149

Expression of the K+/Cl− cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors

Authors: Notartomaso, Serena, Mascio, Giada, Scarselli, Pamela, Martinello, Katiuscia, Fucile, Sergio, Gradini, Roberto, Bruno, Valeria, Battaglia, Giuseppe, Nicoletti, Ferdinando

Source: In Neuropharmacology 15 March 2017 115:51-59

MGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors

Authors: Notartomaso, Serena, Nakao, Harumi, Mascio, Giada, Scarselli, Pamela, Cannella, Milena, Zappulla, Cristina, Madonna, Michele, Motolese, Marta, Gradini, Roberto, Liberatore, Francesca, Zonta, Micaela, Carmignoto, Giorgio, Battaglia, Giuseppe, Bruno, Valeria, Watanabe, Masahiko, Aiba, Atsu, Nicoletti, Ferdinando

Source: Scientific reports. 8(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179712355.0x000001&indx=1&recIds=ETOCvdc_100179712355.0x000001

Effects of vitamin B12 on the corneal nerve regeneration in rats

Authors: Romano, Maria Rosaria, Biagioni, Francesca, Carrizzo, Albino, Lorusso, Massimo, Spadaro, Angelo, Micelli Ferrari, Tommaso, Vecchione, Carmine, Zurria, Monia, Marrazzo, Giuseppina, Mascio, Giada, Sacchetti, Benedetto, Madonna, Michele, Fornai, Francesco, Nicoletti, Ferdinando, Lograno, Marcello Diego

Source: In Experimental Eye Research March 2014 120:109-117

Common and Rare Variants in TMEM175 Gene Concur to the Pathogenesis of Parkinson's Disease in Italian Patients.

Authors: Palomba, Nicole Piera, Fortunato, Giorgio, Pepe, Giuseppe, Modugno, Nicola, Pietracupa, Sara, Damiano, Immacolata, Mascio, Giada, Carrillo, Federica, Di Giovannantonio, Luca Giovanni, Ianiro, Laura, Martinello, Katiuscia, Volpato, Viola, Desiato, Vincenzo, Acri, Riccardo, Storto, Marianna, Nicoletti, Ferdinando, Webber, Caleb, Simeone, Antonio, Fucile, Sergio, Maglione, Vittorio

Source: Molecular Neurobiology; Apr2023, Vol. 60 Issue 4, p2150-2173, 24p

Targeting mGlu1 Receptors in the Treatment of Motor and Cognitive Dysfunctions in Mice Modeling Type 1 Spinocerebellar Ataxia.

Authors: Liberatore, Francesca, Antenucci, Nico, Tortolani, Daniel, Mascio, Giada, Fanti, Federico, Sergi, Manuel, Battaglia, Giuseppe, Bruno, Valeria, Nicoletti, Ferdinando, Maccarrone, Mauro, Notartomaso, Serena

Source: Cells (2073-4409); Dec2022, Vol. 11 Issue 23, p3916, 17p

Subject Terms: SPINOCEREBELLAR ataxia, CANNABINOID receptors, COGNITION disorders, ANIMAL disease models, LABORATORY mice, TRANSGENIC mice

X-ray multiscale 3D neuroimaging to quantify cellular aging and neurodegeneration postmortem in a model of Alzheimer's disease.

Authors: Barbone, Giacomo E., Bravin, Alberto, Mittone, Alberto, Pacureanu, Alexandra, Mascio, Giada, Di Pietro, Paola, Kraiger, Markus J., Eckermann, Marina, Romano, Mariele, Hrabě de Angelis, Martin, Cloetens, Peter, Bruno, Valeria, Battaglia, Giuseppe, Coan, Paola

Source: European Journal of Nuclear Medicine & Molecular Imaging; Nov2022, Vol. 49 Issue 13, p4338-4357, 20p, 4 Color Photographs, 2 Graphs

Subject Terms: CELLULAR aging, NEURODEGENERATION, BRAIN imaging, ALZHEIMER'S disease, NEUROPROTECTIVE agents

Light-Induced Activation of a Specific Type-5 Metabotropic Glutamate Receptor Antagonist in the Ventrobasal Thalamus Causes Analgesia in a Mouse Model of Breakthrough Cancer Pain.

Authors: Notartomaso, Serena, Antenucci, Nico, Liberatore, Francesca, Mascio, Giada, Boccadamo Pompili, Stefano Vito, Font, Joan, Scioli, Mariarosaria, Luongo, Livio, Arcella, Antonietta, Gradini, Roberto, Llebaria, Amadeu, Nicoletti, Ferdinando

Source: International Journal of Molecular Sciences; Jul2022, Vol. 23 Issue 14, p8018-8018, 10p

Subject Terms: EXCITATORY amino acid antagonists, GLUTAMATE receptors, CANCER pain, THALAMUS, LABORATORY mice, ANALGESIA, OPIOID receptors

Analgesic Activity of Cinnabarinic Acid in Models of Inflammatory and Neuropathic Pain.

Authors: Notartomaso, Serena, Boccella, Serena, Antenucci, N., Ricciardi, Flavia, Fazio, Francesco, Liberatore, F., Scarselli, P., Scioli, M., Mascio, Giada, Bruno, V., Battaglia, Giuseppe, Nicoletti, Ferdinando, Maione, Sabatino, Luongo, Livio

Source: Frontiers in Molecular Neuroscience; 6/2/2022, Vol. 15, p1-14, 14p

Subject Terms: NEURALGIA, ARYL hydrocarbon receptors, PAIN threshold, SCIATIC nerve, KNOCKOUT mice

A Progressive Build-up of Perineuronal Nets in the Somatosensory Cortex Is Associated with the Development of Chronic Pain in Mice.

Authors: Mascio, Giada¹, Notartomaso, Serena¹, Martinello, Katiuscia¹, Liberatore, Francesca¹, Bucci, Domenico¹, Imbriglio, Tiziana¹, Cannella, Milena¹, Antenucci, Nico², Scarselli, Pamela¹, Lattanzi, Roberta², Bruno, Valeria^1,2, Nicoletti, Ferdinando^1,2, Fucile, Sergio^1,2, Battaglia, Giuseppe^1,2 giuseppe.battaglia@neuromed.it

Source: Journal of Neuroscience. 4/6/2022, Vol. 42 Issue 14, p3037-3048. 12p.

Subject Terms: *PERINEURONAL nets, *SOMATOSENSORY cortex, *CHRONIC pain, *PYRAMIDAL neurons, *THALAMIC nuclei, *ESSENTIAL tremor, *UTERINE rupture

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.

Authors: Notartomaso, Serena¹ (AUTHOR), Mascio, Giada¹ (AUTHOR), Bernabucci, Matteo¹ (AUTHOR), Zappulla, Cristina¹ (AUTHOR), Scarselli, Pamela¹ (AUTHOR), Cannella, Milena¹ (AUTHOR), Imbriglio, Tiziana¹ (AUTHOR), Gradini, Roberto^1,2 (AUTHOR), Battaglia, Giuseppe¹ (AUTHOR), Bruno, Valeria^1,3 (AUTHOR), Nicoletti, Ferdinando^1,3 (AUTHOR) ferdinandonicoletti@hotmail.com

Source: Molecular Pain. 3/15/2017, Vol. 13, p1-12. 12p. 5 Graphs.

Role of neuroinflammation in hypertension-induced brain amyloid pathology

Authors: Carnevale, Daniela, Mascio, Giada, Ajmone-Cat, Maria Antonietta, D'Andrea, Ivana, Cifelli, Giuseppe, Madonna, Michele, Cocozza, Germana, Frati, Alessandro, Carullo, Pierluigi, Carnevale, Lorenzo, Alleva, Enrico, Branchi, Igor, Lembo, Giuseppe, Minghetti, Luisa

Source: In Neurobiology of Aging January 2012 33(1):205-205

Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice.

Authors: Mastroiacovo, Federica, Zinni, Manuela, Mascio, Giada, Bruno, Valeria, Battaglia, Giuseppe, Pansiot, Julien, Imbriglio, Tiziana, Mairesse, Jerome, Baud, Olivier, Nicoletti, Ferdinando

Source: Frontiers in Neurology; 6/17/2021, Vol. 12, p1-13, 13p

Subject Terms: NEURAL transmission, GLIAL cell line-derived neurotrophic factor, GLUTAMATE receptors, BRAIN damage, NEUROINFLAMMATION, ISCHEMIC stroke

Perineuronal nets are under the control of type-5 metabotropic glutamate receptors in the developing somatosensory cortex.

Authors: Mascio, Giada, Bucci, Domenico, Notartomaso, Serena, Liberatore, Francesca, Antenucci, Nico, Scarselli, Pamela, Imbriglio, Tiziana, Caruso, Stefano, Gradini, Roberto, Cannella, Milena, Di Menna, Luisa, Bruno, Valeria, Battaglia, Giuseppe, Nicoletti, Ferdinando

Source: Translational Psychiatry; 2/18/2021, Vol. 11 Issue 1, p1-13, 13p

The Trace Kynurenine, Cinnabarinic Acid, Displays Potent Antipsychotic-Like Activity in Mice and Its Levels Are Reduced in the Prefrontal Cortex of Individuals Affected by Schizophrenia.

Authors: Ulivieri, Martina, Wierońska, Joanna Monika, Lionetto, Luana, Martinello, Katiuscia, Cieslik, Paulina, Chocyk, Agnieszka, Curto, Martina, Menna, Luisa Di, Iacovelli, Luisa, Traficante, Anna, Liberatore, Francesca, Mascio, Giada, Antenucci, Nico, Giannino, Giuseppe, Vergassola, Matteo, Pittaluga, Anna, Bruno, Valeria, Battaglia, Giuseppe, Fucile, Sergio, Simmaco, Maurizio

Source: Schizophrenia Bulletin; Nov2020, Vol. 46 Issue 6, p1471-1481, 11p

Subject Terms: AMINO acids, ANIMAL experimentation, ANTIPSYCHOTIC agents, CELL receptors, FRONTAL lobe, GLUTAMIC acid, HETEROCYCLIC compounds, HIGH performance liquid chromatography, MASS spectrometry, MICE, NEURAL transmission, RATS, SCHIZOPHRENIA

Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia.

Authors: Nicoletti, Ferdinando, Orlando, Rosamaria, Di Menna, Luisa, Cannella, Milena, Notartomaso, Serena, Mascio, Giada, Iacovelli, Luisa, Matrisciano, Francesco, Fazio, Francesco, Caraci, Filippo, Copani, Agata, Battaglia, Giuseppe, Bruno, Valeria

Source: Frontiers in Psychiatry; 2/14/2019, pN.PAG-N.PAG, 10p

Subject Terms: SCHIZOPHRENIA, GLUTAMATE receptors, LIGANDS (Chemistry), DOPAMINE, INTERNEURONS, PATHOLOGICAL physiology