Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation

Authors: Masahiko Ito, Jie Liu, Masayoshi Fukasawa, Koji Tsutsumi, Yumi Kanegae, Mitsutoshi Setou, Michinori Kohara, Tetsuro Suzuki

Source: JHEP Reports, Vol 7, Iss 1, Pp 101225- (2025)

Subject Terms: HCV, liver steatosis, human hepatocyte chimeric mice, lipidome analysis, PLA2G4C, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555924002295; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/fdf11cc526dc486cabaf1a0434e8d00a

Deep learning-based segmentation of subcellular organelles in high-resolution phase-contrast images

Authors: Kentaro Shimasaki, Yuko Okemoto-Nakamura, Kyoko Saito, Masayoshi Fukasawa, Kaoru Katoh, Kentaro Hanada

Source: Cell Structure and Function, Vol 49, Iss 2, Pp 57-65 (2024)

Subject Terms: label-free imaging, organelle dynamics, apodized phase contrast, deep learning-based segmentation, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.jstage.jst.go.jp/article/csf/49/2/49_24036/_html/-char/en; https://doaj.org/toc/0386-7196; https://doaj.org/toc/1347-3700

Access URL: https://doaj.org/article/0801d6745853447e834a1921871feded

A high-resolution phase-contrast microscopy system for label-free imaging in living cells

Authors: Kentaro Shimasaki, Yuko Okemoto-Nakamura, Kyoko Saito, Masayoshi Fukasawa, Kaoru Katoh, Kentaro Hanada

Source: Cell Structure and Function, Vol 49, Iss 1, Pp 21-29 (2024)

Subject Terms: label-free imaging, organelle dynamics, virus infections, apodized phase contrast, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.jstage.jst.go.jp/article/csf/49/1/49_24018/_html/-char/en; https://doaj.org/toc/0386-7196; https://doaj.org/toc/1347-3700

Access URL: https://doaj.org/article/fedac218b93c496babd0b7ff33e13732

Global and Targeted Metabolomics for Revealing Metabolomic Alteration in Niemann-Pick Disease Type C Model Cells

Authors: Masahiro Watanabe, Masamitsu Maekawa, Keitaro Miyoshi, Toshihiro Sato, Yu Sato, Masaki Kumondai, Masayoshi Fukasawa, Nariyasu Mano

Source: Metabolites, Vol 14, Iss 10, p 515 (2024)

Subject Terms: Niemann-Pick disease type C, metabolomics, amino acids, model cells, LC-MS/MS, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/14/10/515; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/3ff37a64e698467e9c8910ecc6474854

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

Authors: Tetsuya Inoue, Yuichiro Yamamoto, Kaoru Sato, Yuko Okemoto-Nakamura, Yoshimi Shimizu, Motohiko Ogawa, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Mika K. Kaneko, Masayoshi Fukasawa, Yukinari Kato, Kohji Noguchi

Source: iScience, Vol 27, Iss 4, Pp 109363- (2024)

Subject Terms: Natural sciences, Biological sciences, Biochemistry, Immunology, Microbiology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224005844; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/249593eb8a2848489d26e0422c0f2000

A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection

Authors: Yoshitaka Shirasago, Hidesuke Fukazawa, Shotaro Nagase, Yoshimi Shimizu, Tomoharu Mizukami, Takaji Wakita, Tetsuro Suzuki, Hideki Tani, Masuo Kondoh, Takuya Kuroda, Satoshi Yasuda, Yoji Sato, Kentaro Hanada, Masayoshi Fukasawa

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6ab2437809074c90b54dbaa6bfc1c9e2

Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-1

Authors: Keisuke Ohta, Naoki Saka, Masayoshi Fukasawa, Machiko Nishio

Source: Frontiers in Microbiology, Vol 14 (2023)

Subject Terms: Hazara orthonairovirus, Crimean-Congo hemorrhagic fever virus, nucleoprotein, tight junction, claudin-1, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2023.1192956/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/36643847318c4745999b419d84172002

Seroprevalence of Flavivirus Neutralizing Antibodies in Thailand by High-Throughput Neutralization Assay: Endemic Circulation of Zika Virus before 2012

Authors: Atsushi Yamanaka, Mami Matsuda, Tamaki Okabayashi, Pannamthip Pitaksajjakul, Pongrama Ramasoota, Kyoko Saito, Masayoshi Fukasawa, Kentaro Hanada, Tomokazu Matsuura, Masamichi Muramatsu, Tatsuo Shioda, Ryosuke Suzuki

Source: mSphere, Vol 6, Iss 4 (2021)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/9b294130256f447d9eb4d3d829ad38d4

Assessment of SARS-CoV-2 infectivity of upper respiratory specimens from COVID-19 patients by virus isolation using VeroE6/TMPRSS2 cells

Authors: Hiroshi Ishii, Tadaki Suzuki, Souichi Yamada, Shuetsu Fukushi, Hitomi Kinoshita, Makoto Ohnishi, Tsuguto Fujimoto, Masayuki Saijo, Ken Maeda, Nozomu Hanaoka, Naomi Nojiri, Ai Kawana-Tachikawa, Shigeru Kusagawa, Koichi Ishikawa, Shigeyoshi Harada, Saori Matsuoka, Tadashi Kikuchi, Sayuri Seki, Midori Nakamura-Hoshi, Shoji Miki, Lucky Ronald Runtuwene, Nobuo Koizumi, Sunao Iyoda, Hideyuki Takahashi, Hidemasa Izumiya, Jiro Mitobe, Shouji Yamamoto, Masatomo Morita, Ken-ichi Lee, Ken Shimuta, Kyoko Saito, Masayoshi Fukasawa, Yasutaka Hoshino, Ken Miyazawa, Minoru Nagi, Chikako Shimokawa, Yasuyuki Morishima, Takashi Sakudoh, Yoshihiro Kaku, Chang Kweng Lim, Shigeru Tajima, Takahiro Maeki, Eri Nakayama, Satoshi Taniguchi, Motohiko Ogawa, Takanobu Kato, Hussein Hassan Aly, Kousho Wakae, Kento Fukano

Source: BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)

Subject Terms: Medicine, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://bmjopenrespres.bmj.com/content/8/1/e000830.full; https://doaj.org/toc/2052-4439

Access URL: https://doaj.org/article/b9d2ad04ff3d4af5a4c6a118be36fca9

Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines

Authors: Masaki Kawamoto, Toshiyuki Yamaji, Kyoko Saito, Yoshitaka Shirasago, Kazuhiro Satomura, Toshinori Endo, Masayoshi Fukasawa, Kentaro Hanada, Naoki Osada

Source: Frontiers in Genetics, Vol 11 (2020)

Subject Terms: Huh7 cell line, genome sequencing, cell lines, hepatitis C virus, cell substrate, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fgene.2020.546106/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/fff265a0fa874da382eca2efef6b497c

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Authors: Yuko Murakami, Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Keisuke Ojiro, Po-sung Chu, Nobuhito Taniki, Yoshimasa Saito, Toshiaki Teratani, Yuzo Koda, Takahiro Suzuki, Kyoko Saito, Masayoshi Fukasawa, Masanori Ikeda, Nobuyuki Kato, Takanori Kanai, Hidetsugu Saito

Source: BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)

Subject Terms: Hepatitis C virus, Hepatocellular carcinoma, Nuclear factor E2-related factor 2, Chemotherapy, Brusatol, Sorafenib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-018-4588-y; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/d927885653d9472a9a1f17560ba29dc0

Comparative characterization of flavivirus production in two cell lines: Human hepatoma-derived Huh7.5.1-8 and African green monkey kidney-derived Vero.

Authors: Kyoko Saito, Masayoshi Fukasawa, Yoshitaka Shirasago, Ryosuke Suzuki, Naoki Osada, Toshiyuki Yamaji, Takaji Wakita, Eiji Konishi, Kentaro Hanada

Source: PLoS ONE, Vol 15, Iss 4, p e0232274 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ec34812137774efbbe033bc2f75ff954

Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.

Authors: Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Noriko Sakasegawa, Yuko Murakami, Po-Sung Chu, Shingo Usui, Yuka Ishibashi, Yuko Wakayama, Nobuhito Taniki, Hiroko Murata, Yoshimasa Saito, Masayoshi Fukasawa, Kyoko Saito, Yoshiyuki Yamagishi, Takaji Wakita, Hiroshi Takaku, Toshifumi Hibi, Hidetsugu Saito, Takanori Kanai

Source: PLoS ONE, Vol 9, Iss 4, p e94460 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24718268/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b88f0306f3f440e2847b7f9c87059aa4

Hepatitis C virus reveals a novel early control in acute immune response.

Authors: Noëlla Arnaud, Stéphanie Dabo, Daisuke Akazawa, Masayoshi Fukasawa, Fumiko Shinkai-Ouchi, Jacques Hugon, Takaji Wakita, Eliane F Meurs

Source: PLoS Pathogens, Vol 7, Iss 10, p e1002289 (2011)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22022264/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/42eb46a6ee4545ccbb80de57cfe1f871

Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model.

Authors: Masayoshi Fukasawa¹ fuka@nih.go.jp, Shotaro Nagase², Yoshitaka Shirasago^1,3, Manami Iida², Mayo Yamashita², Kohki Endo⁴, Kiyohito Yagi², Tetsuro Suzuki⁵, Takaji Wakita⁶, Kentaro Hanada¹, Hiroki Kuniyasu⁷, Masuo Kondoh² masuo@phs.osaka-u.ac.jp

Source: Journal of Virology. May2015, Vol. 89 Issue 9, p4866-4879. 14p.

Subject Terms: *HEPATITIS C virus, *MICROARRAY technology, *HYBRIDOMAS, *MONOCLONAL antibodies, *HIV infections

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Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack.

Authors: Allen, Volchuk, Mariella, Ravazzola, Alain, Perrelet, S, Eng William, Maurizio, Di Liberto, Oleg, Varlamov, Masayoshi, Fukasawa, Thomas, Engel, H, Sllner Thomas, E, Rothman James, Lelio, Orci

Source: Molecular Biology of the Cell; April 2004, Vol. 15 Issue: 4 p1506-18, 13p

Sphingomyelin Is Essential for the Structure and Function of the Double-Membrane Vesicles in Hepatitis C Virus RNA Replication Factories.

Authors: Gewaid, Hossam^1,2, Haruyo Aoyagi¹, Minetaro Arita¹, Koichi Watashi¹, Ryosuke Suzuki¹, Shota Sakai³, Keigo Kumagai³, Toshiyuki Yamaji³, Masayoshi Fukasawa³, Fumihiro Kato⁴, Takayuki Hishiki⁵, Ayako Mimata⁶, Yuriko Sakamaki⁶, Shizuko Ichinose⁶, Kentaro Hanada³, Masamichi Muramatsu¹, Takaji Wakita^1,2, Hideki Aizaki¹

Source: Journal of Virology. Dec2020, Vol. 94 Issue 23, p1-22. 22p.

Subject Terms: *RNA viruses, *SPHINGOMYELIN, *PROTEIN expression, *VIRAL replication, *VIRAL nonstructural proteins, *ENDOPLASMIC reticulum, *DENGUE viruses, *HEPATITIS C virus

Company/Entity: COMPUTER Emergency Response Team