Untargeted Metabolomics and Liquid Biopsy Investigation of Circulating Biomarkers in Soft Tissue Sarcoma.

Authors: Grasso, Daniela¹ (AUTHOR) daniela.grasso@student.unisi.it, Marzocchi, Barbara¹ (AUTHOR), Scoccianti, Guido² (AUTHOR), Palchetti, Ilaria³ (AUTHOR), Campanacci, Domenico Andrea^2,4 (AUTHOR), Antonuzzo, Lorenzo⁵ (AUTHOR), Scolari, Federico⁶ (AUTHOR), Pillozzi, Serena⁶ (AUTHOR), Bernini, Andrea¹ (AUTHOR) andrea.bernini@unisi.it

Source: Cancers. Feb2025, Vol. 17 Issue 3, p553. 16p.

Subject Terms: *SARCOMA, *RESEARCH funding, *NUCLEAR magnetic resonance spectroscopy, *TUMOR markers, *CELLULAR signal transduction, *DESCRIPTIVE statistics, *GENE expression profiling, *SOFT tissue tumors, *METABOLOMICS, *DATA analysis software, BODY fluid examination

Integrated Clinomics and Molecular Dynamics Simulation Approaches Reveal the SAA1.1 Allele as a Biomarker in Alkaptonuria Disease Severity.

Authors: Trezza, Alfonso, Roncaglia, Bianca, Visibelli, Anna, Barletta, Roberta, Peruzzi, Luana, Marzocchi, Barbara, Braconi, Daniela, Spiga, Ottavia, Santucci, Annalisa

Source: Biomolecules (2218-273X); Feb2025, Vol. 15 Issue 2, p194, 16p

Subject Terms: AMYLOID beta-protein, AMYLOIDOSIS, STRUCTURAL dynamics, INFLAMMATORY mediators, DATA integration, MOLECULAR dynamics

Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon

Authors: Millucci, Lia, Minetti, Mariagiulia, Orlandini, Maurizio, Braconi, Daniela, Schiavone, Maria Lucia, Galderisi, Silvia, Marzocchi, Barbara, Spiga, Ottavia, Rappuoli, Roberto, Spreafico, Adriano, Perretti, Giuseppe, Bernardini, Giulia, Santucci, Annalisa

Source: In Journal of Functional Foods March 2019 54:109-118

A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria

Authors: Spiga, Ottavia, Cicaloni, Vittoria, Zatkova, Andrea, Millucci, Lia, Bernardini, Giulia, Bernini, Andrea, Marzocchi, Barbara, Bianchini, Monica, Zugarini, Andrea, Rossi, Alberto, Zazzeri, Matteo, Trezza, Alfonso, Frediani, Bruno, Ranganath, Lakshminarayan, Braconi, Daniela, Santucci, Annalisa

Source: In Computers in Biology and Medicine 1 December 2018 103:1-7

Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins

Authors: Braconi, Daniela, Millucci, Lia, Bernini, Andrea, Spiga, Ottavia, Lupetti, Pietro, Marzocchi, Barbara, Niccolai, Neri, Bernardini, Giulia, Santucci, Annalisa

Source: In BBA - General Subjects February 2017 1861(2):135-146

Comparative proteomics in alkaptonuria provides insights into inflammation and oxidative stress

Authors: Braconi, Daniela, Bernardini, Giulia, Paffetti, Alessandro, Millucci, Lia, Geminiani, Michela, Laschi, Marcella, Frediani, Bruno, Marzocchi, Barbara, Santucci, Annalisa

Source: In International Journal of Biochemistry and Cell Biology December 2016 81 Part B:271-280

Untargeted NMR Metabolomics Reveals Alternative Biomarkers and Pathways in Alkaptonuria.

Authors: Grasso, Daniela, Geminiani, Michela, Galderisi, Silvia, Iacomelli, Gabriella, Peruzzi, Luana, Marzocchi, Barbara, Santucci, Annalisa, Bernini, Andrea

Source: International Journal of Molecular Sciences; Dec2022, Vol. 23 Issue 24, p15805, 12p

Subject Terms: NUCLEAR magnetic resonance, METABOLOMICS, METABOLIC disorders, BIOMARKERS, GENETIC code, CONNECTIVE tissues

Association between oxidative stress in pregnancy and preterm premature rupture of membranes

Authors: Longini, Mariangela, Perrone, Serafina, Vezzosi, Piero, Marzocchi, Barbara, Kenanidis, Antonio, Centini, Giovanni, Rosignoli, Lucia, Buonocore, Giuseppe

Source: In Clinical Biochemistry 2007 40(11):793-797

Effects of Nitisinone on Oxidative and Inflammatory Markers in Alkaptonuria: Results from SONIA1 and SONIA2 Studies.

Authors: Braconi, Daniela, Geminiani, Michela, Psarelli, Eftychia Eirini, Giustarini, Daniela, Marzocchi, Barbara, Rossi, Ranieri, Bernardini, Giulia, Spiga, Ottavia, Gallagher, James A., Le Quan Sang, Kim-Hanh, Arnoux, Jean-Baptiste, Imrich, Richard, Al-Sbou, Mohammed S., Gornall, Matthew, Jackson, Richard, Ranganath, Lakshminarayan R., Santucci, Annalisa

Source: Cells (2073-4409); Nov2022, Vol. 11 Issue 22, p3668, 14p

Subject Terms: AMYLOIDOSIS, PROTEIN analysis, INBORN errors of metabolism, OXIDATIVE stress, WESTERN immunoblotting

Isoprostanes in amniotic fluid: a predictive marker for fetal growth restriction in pregnancy

Authors: Longini, Mariangela, Perrone, Serafina, Kenanidis, Antonio, Vezzosi, Piero, Marzocchi, Barbara, Petraglia, Felice, Centini, Giovanni, Buonocore, Giuseppe

Source: In Free Radical Biology and Medicine 2005 38(11):1537-1541

Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β‐catenin signaling pathway.

Authors: Schiavone, Maria Lucia, Millucci, Lia, Bernardini, Giulia, Giustarini, Daniela, Rossi, Ranieri, Marzocchi, Barbara, Santucci, Annalisa

Source: Journal of Cellular Physiology; Oct2020, Vol. 235 Issue 10, p6808-6816, 9p

Subject Terms: OXIDATIVE stress, MELANINS, ENZYME deficiency, DEFICIENCY diseases, BONES, RARE diseases

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Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease.

Authors: Spiga, Ottavia, Cicaloni, Vittoria, Fiorini, Cosimo, Trezza, Alfonso, Visibelli, Anna, Millucci, Lia, Bernardini, Giulia, Bernini, Andrea, Marzocchi, Barbara, Braconi, Daniela, Prischi, Filippo, Santucci, Annalisa

Source: Orphanet Journal of Rare Diseases; 2/12/2020, Vol. 15 Issue 1, p1-10, 10p

Subject Terms: RARE diseases, MACHINE learning, NEAREST neighbor analysis (Statistics), PREDICTION models, BODY mass index, DATABASE management, PEARSON correlation (Statistics), MODEL-driven software architecture

Interactive alkaptonuria database: investigating clinical data to improve patient care in a rare disease.

Authors: Cicaloni, Vittoria, Spiga, Ottavia, Dimitri, Giovanna Maria, Maiocchi, Rebecca, Millucci, Lia, Giustarini, Daniela, Bernardini, Giulia, Bernini, Andrea, Marzocchi, Barbara, Braconi, Daniela, Santucci, Annalisa

Source: FASEB Journal; Nov2019, Vol. 33 Issue 11, p12696-12703, 8p

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Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria.

Authors: Bernardini, Giulia, Leone, Gemma, Millucci, Lia, Consumi, Marco, Braconi, Daniela, Spiga, Ottavia, Galderisi, Silvia, Marzocchi, Barbara, Viti, Cecilia, Giorgetti, Giovanna, Lupetti, Pietro, Magnani, Agnese, Santucci, Annalisa

Source: Journal of Cellular Physiology; May2019, Vol. 234 Issue 5, p6696-6708, 13p

Subject Terms: ALKAPTONURIA, ARTICULAR cartilage, HOMEOSTASIS, CARTILAGE cells, PROTEOGLYCANS, GLYCOSAMINOGLYCANS, MAMMALS

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