The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation

Authors: Sahar Ghorbanpour, Siân Peta Cartland, Hao Chen, Sanchit Seth, Rupert C. Ecker, Claire Richards, Dunja Aksentijevic, Matthew P. Padula, Louise Cole, Majid Ebrahimi Warkiani, Mary Meltem Kavurma, Lana McClements

Source: Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-15 (2025)

Subject Terms: FKBPL, Angiogenesis, Hypoxia, Inflammation, Endothelial dysfunction, Microfluidics, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/dc572ce77b4a4ebfab18428278c0a218

Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis

Authors: Xin Tracy Liu, Yu Huang, Da Liu, Yingxin Celia Jiang, Min Zhao, Long Hoa Chung, Xingxing Daisy Han, Yinan Zhao, Jinbiao Chen, Paul Coleman, Ka Ka Ting, Collin Tran, Yingying Su, Claude Vincent Dennis, Atul Bhatnagar, Ken Liu, Anthony Simon Don, Mathew Alexander Vadas, Mark Douglas Gorrell, Shubiao Zhang, Michael Murray, Mary Meltem Kavurma, Geoffrey William McCaughan, Jennifer Ruth Gamble, Yanfei Qi

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)

Subject Terms: Sphingosine kinase, PF-543, PFKFB3, Angiogenesis, Glycolysis, Hepatocellular carcinoma, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/725a9523519a4dd6814e529374ee5107