MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.

Authors: Kelsen, Anne¹, Kent, Robyn S.¹, Snyder, Anne K.¹, Wehri, Eddie², Bishop, Stephen J.³, Stadler, Rachel V.¹, Powell, Cameron⁴, Martorelli di Genova, Bruno¹, Rompikuntal, Pramod K.¹, Boulanger, Martin J.⁴, Warshaw, David M.⁵, Westwood, Nicholas J.³, Schaletzky, Julia², Ward, Gary E.¹, Gary.Ward@uvm.edu

Source: PLoS Biology; 5/8/2023, Vol. 21 Issue 5, p1-36, 36p, 3 Color Photographs, 1 Black and White Photograph, 5 Graphs

VESPA: an optimized protocol for accurate metabarcoding-based characterization of vertebrate eukaryotic endosymbiont and parasite assemblages.

Authors: Owens, Leah A., Friant, Sagan, Martorelli Di Genova, Bruno, Knoll, Laura J., Contreras, Monica, Noya-Alarcon, Oscar, Dominguez-Bello, Maria G., Goldberg, Tony L.

Source: Nature Communications; 1/9/2024, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: PARASITES, GENETIC barcoding, DNA sequencing, VERTEBRATES, MICROBIAL communities, WOLBACHIA

Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capability.

Authors: Olson, William J.¹ (AUTHOR), Martorelli Di Genova, Bruno¹ (AUTHOR), Gallego-Lopez, Gina^1,2 (AUTHOR), Dawson, Anthony R.¹ (AUTHOR), Stevenson, David³ (AUTHOR), Amador-Noguez, Daniel³ (AUTHOR) amadornoguez@wisc.edu, Knoll, Laura J.¹ (AUTHOR) amadornoguez@wisc.edu

Source: PLoS Pathogens. 4/7/2020, Vol. 16 Issue 4, p1-30. 30p.

Subject Terms: *INTRACELLULAR pathogens, *PENTOSE phosphate pathway, *KREBS cycle, *TOXOPLASMA gondii, *CARBON metabolism, *AMINO acid metabolism, *AMINO acid synthesis, *TOXOPLASMA

A transcriptional network required for bradyzoite development in Toxoplasma gondii is dispensable for recrudescent disease.

Authors: Sokol-Borrelli, Sarah L., Reilly, Sarah M., Holmes, Michael J., Orchanian, Stephanie B., Massmann, Mackenzie D., Sharp, Katherine G., Cabo, Leah F., Alrubaye, Hisham S., Martorelli Di Genova, Bruno, Lodoen, Melissa B., Sullivan Jr., William J., Boyle, Jon P.

Source: Nature Communications; 9/28/2023, Vol. 14 Issue 1, p1-20, 20p

Subject Terms: TOXOPLASMA gondii, GENE regulatory networks, RNA-binding proteins

Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction.

Authors: Martorelli Di Genova, Bruno¹, Wilson, Sarah K.¹, Dubey, J. P.², Knoll, Laura J.¹ ljknoll@wisc.edu

Source: PLoS Biology. 8/20/2019, Vol. 17 Issue 8, p1-19. 19p. 2 Color Photographs, 4 Graphs.

Subject Terms: *SEXUAL cycle, *TOXOPLASMA gondii, *SPECIES specificity, *LINOLEIC acid, *TOXOPLASMA, *FELIDAE, *DEVELOPMENTAL biology

A Toxoplasma gondii patatin-like phospholipase contributes to host cell invasion.

Authors: Wilson, Sarah K.¹, Heckendorn, Justine², Martorelli Di Genova, Bruno¹, Koch, Lindsey L.¹, Rooney, Peggy J.³, Morrissette, Naomi⁴, Lebrun, Maryse², Knoll, Laura J.¹, ljknoll@wisc.edu

Source: PLoS Pathogens; 7/6/2020, Vol. 16 Issue 7, p1-25, 25p

Comparisons of the Sexual Cycles for the Coccidian Parasites Eimeria and Toxoplasma.

Authors: Martorelli Di Genova, Bruno, Knoll, Laura J.

Source: Frontiers in Cellular & Infection Microbiology; 12/14/2020, Vol. 10, pN.PAG-N.PAG, 11p

Subject Terms: SEXUAL cycle, EIMERIA, TOXOPLASMA, PARASITES, TOXOPLASMA gondii, DEVELOPMENTAL biology

Dual-Stage Picolinic Acid-Derived Inhibitors of Toxoplasma gondii.

Authors: Khalifa, Muhammad M., Martorelli Di Genova, Bruno, McAlpine, Sarah G., Gallego-Lopez, Gina M., Stevenson, David M., Rozema, Soren D., Monaghan, Neil P., Morris, James C., Knoll, Laura J., Golden, Jennifer E.

Source: ACS Medicinal Chemistry Letters; 12/10/2020, Vol. 11 Issue 12, p2382-2388, 7p

RIPK3 Facilitates Host Resistance to Oral Toxoplasma gondiiInfection

Authors: Cervantes, Patrick W., Martorelli Di Genova, Bruno, Erazo Flores, Billy Joel, Knoll, Laura J.

Source: Infection and Immunity; 2021, Vol. 89 Issue: 5 pe00021-21-e00021-21, 210002101p

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