Chromosomal Instability Characterizes Pediatric Medulloblastoma but Is Not Tolerated in the Developing Cerebellum.

Authors: Bočkaj, Irena¹ (AUTHOR), Martini, Tosca E. I.¹ (AUTHOR), Smit, Marlinde J.¹ (AUTHOR), Armandari, Inna¹ (AUTHOR), Bakker, Bjorn¹ (AUTHOR), Wardenaar, René¹ (AUTHOR), Meeuwsen-de Boer, Tiny G. J.² (AUTHOR), Bakker, Petra L.¹ (AUTHOR), Spierings, Diana C. J.¹ (AUTHOR), Hoving, Eelco W.³ (AUTHOR), Guryev, Victor¹ (AUTHOR), Foijer, Floris¹ (AUTHOR) f.foijer@umcg.nl, Bruggeman, Sophia W. M.¹ (AUTHOR) f.foijer@umcg.nl

Source: International Journal of Molecular Sciences. Sep2022, Vol. 23 Issue 17, p9852. 15p.

Subject Terms: *MEDULLOBLASTOMA, *CEREBELLUM, *DNA replication, *CHROMOSOME abnormalities, *CEREBELLAR tumors, *PLANT chromosomes

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.

Authors: Bočkaj, Irena¹ (AUTHOR), Martini, Tosca E. I.¹ (AUTHOR), de Camargo Magalhães, Eduardo S.^1,2 (AUTHOR), Bakker, Petra L.¹ (AUTHOR), Meeuwsen-de Boer, Tiny G. J.³ (AUTHOR), Armandari, Inna^1,4 (AUTHOR), Meuleman, Saskia L.¹ (AUTHOR), Mondria, Marin T.¹ (AUTHOR), Stok, Colin⁵ (AUTHOR), Kok, Yannick P.⁵ (AUTHOR), Bakker, Bjorn¹ (AUTHOR), Wardenaar, René¹ (AUTHOR), Seiler, Jonas^1,6 (AUTHOR), Broekhuis, Mathilde J. C.^1,6 (AUTHOR), van den Bos, Hilda¹ (AUTHOR), Spierings, Diana C. J.¹ (AUTHOR), Ringnalda, Femke C. A.⁷ (AUTHOR), Clevers, Hans^7,8 (AUTHOR), Schüller, Ulrich^9,10,11 (AUTHOR), van Vugt, Marcel A. T. M.⁵ (AUTHOR)

Source: PLoS Genetics. 11/9/2021, Vol. 17 Issue 11, p1-28. 28p.

Subject Terms: *GLIOMAS, *DNA replication, *BRAIN cancer, *CHROMATIN, *CHILDHOOD cancer, *CELL culture

The developmental stage of the medulloblastoma cell-of-origin restricts Sonic hedgehog pathway usage and drug sensitivity.

Authors: Smit, Marlinde J.¹, Martini, Tosca E. I.¹, Armandari, Inna¹, Bǒkaj, Irena¹, Zomerman, Walderik W.², de Camargo Magalhães, Eduardo S.^1,3, Siragna, Zillah¹, Meeuwsen, Tiny G. J.⁴, Scherpen, Frank J. G.⁴, Schoots, Mirthe H.⁴, Ritsema, Martha¹, den Dunnen, Wilfred F. A.⁴, Hoving, Eelco W.⁵, Paridaen, Judith T. M. L.¹, de Haan, Gerald¹, Guryev, Victor¹, Bruggeman, Sophia W. M.¹ s.w.m.bruggeman@umcg.nl

Source: Journal of Cell Science. Jun2022, Vol. 135 Issue 11, p1-14. 14p.

Subject Terms: *HEDGEHOG signaling proteins, *MEDULLOBLASTOMA, *GENE expression, *TRANSCRIPTOMES, *INFANTS

CREB signaling activity correlates with differentiation and survival in medulloblastoma.

Authors: Armandari, Inna, Zomerman, Walderik W., Plasschaert, Sabine L. A., Smit, Marlinde J., Martini, Tosca. E. I., de Camargo Magalhães, Eduardo S., Hogeling, Shanna M., Rozema-Huizinga, Geesina C., Lourens, Harm J., Meeuwsen-de Boer, Tiny G. J., Scherpen, Frank J. G., de Bont, Eveline S. J. M., Bruggeman, Sophia W. M.

Source: Scientific Reports; 8/9/2021, Vol. 11 Issue 1, p1-12, 12p

Subject Terms: CREB protein, CELLULAR signal transduction, MEDULLOBLASTOMA, CANCER cell differentiation, PHOSPHORYLATION