Osmotic stress influences microtubule drug response via WNK1 kinase signaling

Authors: Monfort-Vengut, Ana ^{a, 1}, Sanz-Gómez, Natalia ^{a, b, 1}, Ballesteros-Sánchez, Sandra ^{a, b}, Ortigosa, Beatriz ^a, Cambón, Aitana ^a, Ramos, Maria ^c, Lorenzo, Ángela Montes-San ^{a, b}, Escribano-Cebrián, María ^{a, b}, Rosa-Rosa, Juan Manuel ^{d, e}, Martínez-López, Joaquín ^{d, e, f}, Sánchez-Prieto, Ricardo ^{b, g, h, i, j, 2}, Sotillo, Rocío ^c, de Cárcer, Guillermo ^{b, i, j, ⁎, 2}

Source: In Drug Resistance Updates March 2025 79

Clinical impact of [18F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma

Authors: Zugasti, Inés ¹, Tormo-Ratera, Marta ¹, Oliver-Caldés, Aina ^{1, 2}, Soler-Perromat, Juan Carlos ¹, González-Calle, Verónica ³, Moreno, David F. ¹, Cabañas, Valentín ⁴, López-Muñoz, Nieves ⁵, Bartolomé-Solanas, Álvaro ¹, Español-Rego, Marta ¹, Reguera-Ortega, Juan Luis ⁶, Rosiñol, Laura ¹, López-Corral, Lucía ³, Tovar, Natalia ¹, Rodríguez-Lobato, Luis Gerardo ¹, Alvarez Perez, Rosa Maria ⁶, Varea, Sara ¹, Olesti, Eulàlia ¹, Gomez-Grande, Adolfo ⁵, Frutos, Laura ⁴, Tamayo, Pilar ³, Juan, Manel ¹, Moraleda, José M. ⁴, Urbano-Ispizua, Álvaro ¹, González-Navarro, E. Azucena ¹, Martínez-López, Joaquín ⁵, Mateos, Maria-Victoria ³, Tomás, Xavier ¹, Setoain, Xavier ^{1, 7}, Fernández de Larrea, Carlos ^{1, ∗}

Source: In Blood Advances 11 February 2025 9(3):571-582

Consensus guidelines and recommendations for the management and response assessment of chimeric antigen receptor T-cell therapy in clinical practice for relapsed and refractory multiple myeloma: a report from the International Myeloma Working Group Immunotherapy Committee

Authors: Lin, Yi ^*, Qiu, Lugui, Usmani, Saad, Joo, Chng Wee, Costa, Luciano, Derman, Benjamin, Du, Juan, Einsele, Hermann, Fernandez de Larrea, Carlos, Hajek, Roman, Ho, P Joy, Kastritis, Efstathios, Martinez-Lopez, Joaquin, Mateos, Maria-Victoria, Mikhael, Joseph, Moreau, Philippe, Nagarajan, Chandramouli, Nooka, Ajay, O'Dwyer, Michael, Schjesvold, Fredrik, Sidana, Surbhi, van de Donk, Niels WCJ, Weisel, Katja, Zweegman, Sonja, Raje, Noopur, Otero, Paula Rodriguez, Anderson, Larry D, Jr, Kumar, Shaji, Martin, Tom

Source: In The Lancet Oncology August 2024 25(8):e374-e387

Durable response after tisagenlecleucel in adults with relapsed/refractory follicular lymphoma: ELARA trial update

Authors: Dreyling, Martin, Fowler, Nathan Hale, Dickinson, Michael, Martinez-Lopez, Joaquin, Kolstad, Arne, Butler, Jason, Ghosh, Monalisa, Popplewell, Leslie, Chavez, Julio C., Bachy, Emmanuel, Kato, Koji, Harigae, Hideo, Kersten, Marie José, Andreadis, Charalambos, Riedell, Peter A., Ho, P. Joy, Pérez-Simón, José Antonio, Chen, Andy I., Nastoupil, Loretta J., von Tresckow, Bastian, María Ferreri, Andrés José, Teshima, Takanori, Patten, Piers E. M., McGuirk, Joseph P., Petzer, Andreas L., Offner, Fritz, Viardot, Andreas, Zinzani, Pier Luigi, Malladi, Ram, Paule, Ines, Zia, Aiesha, Awasthi, Rakesh, Han, Xia, Germano, Davide, O’Donovan, Darragh, Ramos, Roberto, Maier, Harald J., Masood, Aisha, Thieblemont, Catherine, Schuster, Stephen J.

Source: In Blood 25 April 2024 143(17):1713-1725

Teclistamab Improves Patient-Reported Symptoms and Health-Related Quality of Life in Relapsed or Refractory Multiple Myeloma: Results From the Phase II MajesTEC-1 Study

Authors: Martin, Thomas G., Moreau, Philippe, Usmani, Saad Z., Garfall, Alfred, Mateos, María-Victoria, San-Miguel, Jesús F., Oriol, Albert, Nooka, Ajay K., Rosinol, Laura, Chari, Ajai, Karlin, Lionel, Krishnan, Amrita, Bahlis, Nizar, Popat, Rakesh, Besemer, Britta, Martínez-López, Joaquín, Delforge, Michel, Trancucci, Danielle, Pei, Lixia, Kobos, Rachel, Fastenau, John, Gries, Katharine S., van de Donk, Niels W.C.J.

Source: In Clinical Lymphoma, Myeloma and Leukemia March 2024 24(3):194-202

Transcriptional and genomic characterization of measurable residual disease in acute myeloid leukaemia

Authors: Simoes, Catia, Villar, Sara, Ariceta, Beñat, Garcés, Juan‐José, Burgos, Leire, Alignani, Diego, Sarvide, Sarai, Martínez‐Cuadrón, David, Bergua, Juan‐Miguel, Vives, Susana, Algarra, Lorenzo, Tormo, Mar, Martinez, Pilar, Serrano, Josefina, Herrera, Pilar, Ramos, Fernando, Salamero, Olga, Lavilla, Esperanza, Gil, Cristina, Lopez‐Lorenzo, Jose‐Luis, Vidriales, Maria‐Belen, Chillon, Carmen, Labrador, Jorge, Falantes, Jose‐Francisco, Sayas, María‐José, Ayala, Rosa, Martinez‐Lopez, Joaquin, Pierola, Ana Alfonso, Calasanz, Maria‐Jose, Prosper, Felipe, San‐Miguel, Jesús F., Sanz, Miguel Á., Paiva, Bruno, Montesinos, Pau

Source: British journal of haematology. 201(6):1239-1244

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184650792.0x000001&indx=1&recIds=ETOCvdc_100184650792.0x000001

Isatuximab plus carfilzomib and dexamethasone in patients with relapsed multiple myeloma based on prior lines of treatment and refractory status: IKEMA subgroup analysis

Authors: Dimopoulos, Meletios A., Moreau, Philippe, Augustson, Bradley, Castro, Nelson, Pika, Tomas, Delimpasi, Sosana, De la Rubia, Javier, Maiolino, Angelo, Reiman, Tony, Martinez‐Lopez, Joaquin, Martin, Thomas, Mikhael, Joseph, Yong, Kwee, Risse, Marie‐Laure, Asset, Gaelle, Marion, Sylvia, Hajek, Roman

Source: American journal of hematology. 98(1):E15-E19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169845339.0x000001&indx=1&recIds=ETOCvdc_100169845339.0x000001

A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk

Authors: Dicanio, Marco, Giaccherini, Matteo, Clay‐Gilmour, Alyssa, Macauda, Angelica, Sainz, Juan, Machiela, Mitchell J., Rybicka‐Ramos, Malwina, Norman, Aaron D., Tyczyńska, Agata, Chanock, Stephen J., Barington, Torben, Kumar, Shaji K., Bhatti, Parveen, Cozen, Wendy, Brown, Elizabeth E., Suska, Anna, Haastrup, Eva K., Orlowski, Robert Z., Dudziński, Marek, Garcia‐Sanz, Ramon, Kruszewski, Marcin, Martinez‐Lopez, Joaquin, Beider, Katia, Iskierka‐Jazdzewska, Elżbieta, Pelosini, Matteo, Berndt, Sonja I., Raźny, Małgorzata, Jamroziak, Krzysztof, Rajkumar, S. Vincent, Jurczyszyn, Artur, Vangsted, Annette Juul, Collado, Pilar Garrido, Vogel, Ulla, Hofmann, Jonathan N., Petrini, Mario, Butrym, Aleksandra, Slager, Susan L., Ziv, Elad, Subocz, Edyta, Giles, Graham G., Andersen, Niels Frost, Mazur, Grzegorz, Watek, Marzena, Lesueur, Fabienne, Hildebrandt, Michelle A. T., Zawirska, Daria, Ebbesen, Lene Hyldahl, Marques, Herlander, Gemignani, Federica, Dumontet, Charles, Várkonyi, Judit, Buda, Gabriele, Nagler, Arnon, Druzd‐Sitek, Agnieszka, Wu, Xifeng, Kadar, Katalin, Camp, Nicola J., Grzasko, Norbert, Waller, Rosalie G., Vachon, Celine, Canzian, Federico, Campa, Daniele

Source: International journal of cancer. 152(2):239-248

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165486515.0x000001&indx=1&recIds=ETOCvdc_100165486515.0x000001

Lenalidomide and dexamethasone maintenance with or without ixazomib, tailored by residual disease status in myeloma

Authors: Rosiñol, Laura, Oriol, Albert, Ríos, Rafael, Blanchard, María Jesús, Jarque, Isidro, Bargay, Joan, Hernández, Miguel Teodoro, Cabañas, Valentín, Carrillo-Cruz, Estrella, Sureda, Anna, Martínez-López, Joaquín, Krsnik, Isabel, González, Maria Esther, Casado, Luis Felipe, Martí, Josep María, Encinas, Cristina, de Arriba, Felipe, Palomera, Luis, Sampol, Antonia, González-Montes, Yolanda, Cabezudo, Elena, Paiva, Bruno, Puig, Noemí, Cedena, María Teresa, de la Cruz, Javier, Mateos, María-Victoria, San Miguel, Jesús, Lahuerta, Juan José, Bladé, Joan

Source: In Blood 2 November 2023 142(18):1518-1528

CNL and aCML should be considered as a single entity based on molecular profiles and outcomes

Authors: Carreño-Tarragona, Gonzalo, Álvarez-Larrán, Alberto, Harrison, Claire, Martínez-Ávila, José Carlos, Hernández-Boluda, Juan Carlos, Ferrer-Marín, Francisca, Radia, Deepti H., Mora, Elvira, Francis, Sebastian, González-Martínez, Teresa, Goddard, Kathryn, Pérez-Encinas, Manuel, Narayanan, Srinivasan, Raya, José María, Singh, Vikram, Gutiérrez, Xabier, Toth, Peter, Amat-Martínez, Paula, Mcilwaine, Louisa, Alobaidi, Magda, Mayani, Karan, McGregor, Andrew, Stuckey, Ruth, Psaila, Bethan, Segura, Adrián, Alvares, Caroline, Davidson, Kerri, Osorio, Santiago, Cutting, Robert, Sweeney, Caroline P., Rufián, Laura, Moreno, Laura, Cuenca, Isabel, Smith, Jeffery, Morales, María Luz, Gil-Manso, Rodrigo, Koutsavlis, Ioannis, Wang, Lihui, Mead, Adam J., Rozman, María, Martínez-López, Joaquín, Ayala, Rosa, Cross, Nicholas C. P.

Source: In Blood Advances 9 May 2023 7(9):1672-1681

Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia

Authors: Simoes, Catia, Chillon, Maria-Carmen, Martínez-Cuadrón, David, Calasanz, Maria-José, Vridiales, María-Belén, Vazquez, Iria, Hernández-Ruano, Montserrat, Ariceta, Beñat, Aguirre-Ruiz, Paula, Burgos, Leire, Alignani, Diego, Sarvide, Sarai, Villar, Sara, Pierola, Ana Alfonso, Prosper, Felipe, Ayala, Rosa, Martínez-López, Joaquin, Bergua Burgues, Juan Miguel, Vives, Susana, Perez-Simon, Jose A., Garcia-Fortes, Maria, Bernal del Castillo, Teresa, Colorado, Mercedes, Olave, Mayte, Rodríguez-Gutiérrez, Juan I., Labrador, Jorge, González, Marcos, San-Miguel, Jesús F., Sanz, Miguel Ángel, Montesinos, Pau, Paiva, Bruno

Source: In Blood Advances 10 January 2023 7(1):167-173

Improving NK cell function in multiple myeloma with NKTR-255, a novel polymer-conjugated human IL-15

Authors: Fernandez, Rafael Alonso, Mayoral, Jessica Encinas, Pierre-Louis, Laetitia, Yao, Yao, Xu, Yan, Mu, Shidai, Martinez-Lopez, Joaquin, Primo, Daniel, Miyazaki, Takahiro, Prabhala, Rao, Anderson, Kenneth C., Overwijk, Willem W., Munshi, Nikhil C. ^∗∗, Fulciniti, Mariateresa ^∗

Source: In Blood Advances 10 January 2023 7(1):9-19

Comparative efficacy and safety of tisagenlecleucel and axicabtagene ciloleucel among adults with r/r follicular lymphoma.

Authors: Dickinson, Michael¹ (AUTHOR) Michael.Dickinson@petermac.org, Martinez-Lopez, Joaquin² (AUTHOR), Jousseaume, Etienne³ (AUTHOR), Yang, Hongbo⁴ (AUTHOR), Chai, Xinglei⁴ (AUTHOR), Xiang, Cheryl⁴ (AUTHOR), Wang, Travis⁴ (AUTHOR), Zhang, Jie⁵ (AUTHOR), Ramos, Roberto⁵ (AUTHOR), Schuster, Stephen J.⁶ (AUTHOR), Fowler, Nathan⁷ (AUTHOR)

Source: Leukemia & Lymphoma. Mar2024, Vol. 65 Issue 3, p323-332. 10p.

Subject Terms: *FOLLICULAR lymphoma, *CYTOKINE release syndrome, *CHIMERIC antigen receptors, *PROGRESSION-free survival, *ADULTS

Efficacy comparison of tisagenlecleucel vs usual care in patients with relapsed or refractory follicular lymphoma

Authors: Salles, Gilles, Schuster, Stephen J., Dreyling, Martin, Fischer, Luca, Kuruvilla, John, Patten, Piers E. M., von Tresckow, Bastian, Smith, Sonali M., Jiménez-Ubieto, Ana, Davis, Keith L., Anjos, Carla, Chu, Jufen, Zhang, Jie, Lobetti Bodoni, Chiara, Thieblemont, Catherine, Fowler, Nathan H., Dickinson, Michael, Martínez-López, Joaquin, Wang, Yucai, Link, Brian K.

Source: In Blood Advances 22 November 2022 6(22):5835-5843

Bone marrow segmentation and radiomics analysis of [18F]FDG PET/CT images for measurable residual disease assessment in multiple myeloma

Authors: Milara, Eva, Gómez-Grande, Adolfo, Tomás-Soler, Sebastián, Seiffert, Alexander P., Alonso, Rafael, Gómez, Enrique J., Martínez-López, Joaquín, Sánchez-González, Patricia

Source: In Computer Methods and Programs in Biomedicine October 2022 225

Circulating Tumor Cells for the Staging of Patients With Newly Diagnosed Transplant-Eligible Multiple Myeloma

Authors: Garcés, Juan-Jose, Cedena, Maria-Teresa, Puig, Noemi, Burgos, Leire, Perez, Jose J., Cordon, Lourdes, Flores-Montero, Juan, Sanoja-Flores, Luzalba, Calasanz, Maria-Jose, Ortiol, Albert, Blanchard, María-Jesús, Rios, Rafael, Martin, Jesus, Martínez-Martinez, Rafael, Bargay, Joan, Sureda, Anna, de la Rubia, Javier, Hernandez, Miguel-Teodoro, Rodriguez-Otero, Paula, de la Cruz, Javier, Orfao, Alberto, Mateos, Maria-Victoria, Martinez-Lopez, Joaquin, Lahuerta, Juan-Jose, Rosiñol, Laura, Blade, Joan, San-Miguel, Jesus F., Paiva, Bruno

Source: Journal of clinical oncology. 40(27):3151-3161

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172269480.0x000001&indx=1&recIds=ETOCvdc_100172269480.0x000001

Ponatinib, chemotherapy, and transplant in adults with Philadelphia chromosome–positive acute lymphoblastic leukemia

Authors: Ribera, Josep-Maria ^*, García-Calduch, Olga, Ribera, Jordi, Montesinos, Pau, Cano-Ferri, Isabel, Martínez, Pilar, Esteve, Jordi, Esteban, Daniel, García-Fortes, María, Alonso, Natalia, González-Campos, José, Bermúdez, Arancha, Torrent, Anna, Genescà, Eulàlia, Mercadal, Santiago, Martínez-Lopez, Joaquín, García-Sanz, Ramón

Source: In Blood Advances 27 September 2022 6(18):5395-5402

Analysis of the factors predicting clinical response to tocilizumab therapy in patients with severe COVID-19

Authors: San-Juan, Rafael, Fernández-Ruiz, Mario, López-Medrano, Francisco, Carretero, Octavio, Lalueza, Antonio, Maestro de la Calle, Guillermo, Pérez-Jacoiste Asín, María Asunción, Bueno, Héctor, Caro-Teller, José Manuel, Catalán, Mercedes, de la Calle, Cristina, García-García, Rocío, Gómez, Carlos, Laguna-Goya, Rocío, Lizasoáin, Manuel, Martínez-López, Joaquín, Origüen, Julia, Sevillano, Ángel, Gutiérrez, Eduardo, de Miguel, Borja, Aguilar, Fernando, Parra, Patricia, Ripoll, Mar, Ruiz-Merlo, Tamara, Trujillo, Hernando, Pablos, José Luis, Paz-Artal, Estela, Lumbreras, Carlos, Aguado, José María

Source: In International Journal of Infectious Diseases April 2022 117:56-64

Acute leukemia arising from myeloproliferative or myelodysplastic/myeloproliferative neoplasms: A series of 372 patients from the PETHEMA AML registry

Authors: Hernández-Boluda, Juan-Carlos, Martínez-Cuadrón, David, Pereira, Arturo, Rodríguez-Veiga, Rebeca, Boluda, Blanca, Gil, Cristina, Casal-Marini, Sandra, Serrano, Josefina, Martínez-López, Joaquín, Bergua, Juan, Algarra, Lorenzo, Bernal, Teresa, López-Lorenzo, Jose-Luis, Colorado, Mercedes, López, Aurelio, Tormo, Mar, Sayas, María-José, Trigo, Fernanda, López-Pavía, María, Pérez-Simón, José-Antonio, Lavilla-Rubira, Esperanza, Rodríguez-Medina, Carlos, Rodríguez-Gutiérrez, Juan-Ignacio, Sanz-Caballer, Miguel-Angel, Montesinos, Pau

Source: In Leukemia Research April 2022 115

Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study

Authors: Schjesvold, Fredrik, Delimpasi, Sosana, Robak, Pawel, Coriu, Daniel, Nikolayeva, Anna, Tomczak, Waldemar, Pour, Ludek, Spicka, Ivan, Dimopoulos, Meletios-Athanasios, Masszi, Tamas, Doronin, Vadim, Minarik, Jiri, Salogub, Galina, Alekseeva, Yulia, Maisnar, Vladimir, Mikala, Gabor, Rosinol, Laura, Konstantinova, Tatiana, Lazzaro, Antonio, Liberati, Anna Marina, Symeonidis, Anargyros, Gatt, Moshe, Illes, Arpad, Abdulhaq, Haifaa, Dungarwalla, Moez, Grosicki, Sebastian, Hajek, Roman, Leleu, Xavier, Myasnikov, Alexander, Richardson, Paul G., Avivi, Irit, Deeren, Dries, Gironella, Mercedes, Hernandez-Garcia, Miguel Teodoro, Martinez Lopez, Joaquin, Newinger-Porte, Muriel, Ribas, Paz, Samoilova, Olga, Voog, Eric, Arnao-Herraiz, Mario, Carrillo-Cruz, Estrella, Corradini, Paolo, Dodlapati, Jyothi, Granell Gorrochategui, Miquel, Huang, Shang-Yi, Jenner, Matthew, Karlin, Lionel, Kim, Jin Seok, Kopacz, Agnieszka, Medvedeva, Nadezhda, Min, Chang-Ki, Mina, Roberto, Palk, Katrin, Shin, Ho-Jin, Sohn, Sang Kyun, Sonneveld, Pieter, Tache, Jason, Anagnostopoulos, Achilles, Arguiñano, Jose-Maria, Cavo, Michele, Filicko, Joanne, Garnes, Margaret, Halka, Janusz, Herzog-Tzarfati, Kathrin, Ipatova, Natalia, Kim, Kihyun, Krauth, Maria-Theresa, Kryuchkova, Irina, Lazaroiu, Mihaela Cornelia, Luppi, Mario, Proydakov, Andrei, Rambaldi, Alessandro, Rudzianskiene, Milda, Yeh, Su-Peng, Alcalá-Peña, Maria Magdalena, Alegre Amor, Adrian, Alizadeh, Hussain, Bendandi, Maurizio, Brearton, Gillian, Brown, Randall, Cavet, Jim, Dally, Najib, Egyed, Miklos, Hernández-Rivas, José Ángel, Kaare, Ain, Karsenti, Jean-Michel, Kloczko, Janusz, Kreisle, William, Lee, Je-Jung, Legiec, Wojciech, Machherndl-Spandl, Sigrid, Manda, Sudhir, Mateos, Maria-Victoria, Moiseev, Ivan, Moreb, Jan, Nagy, Zsolt, Nair, Santosh, Oriol-Rocafiguera, Albert, Osswald, Michael, Otero-Rodriguez, Paula, Peceliunas, Valdas, Plesner, Torben, Rey, Philippe, Rossi, Giuseppe, Stevens, Don, Suriu, Celia, Tarella, Corrado, Verlinden, Anke, Zannetti, Alain, Schjesvold, Fredrik H ^*, Pour, Luděk, Špička, Ivan, Mikala, Gábor, Rosiñol, Laura, Symeonidis, Argiris, Moody, Victoria, Thuresson, Marcus, Byrne, Catriona, Harmenberg, Johan, Bakker, Nicolaas A, Hájek, Roman, Richardson, Paul G

Source: In The Lancet Haematology February 2022 9(2):e98-e110