Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneys

Authors: Xiaohang Shao, Huaming Xu, Hyojin Kim, Sadaf ljaz, Fabian Beier, Vera Jankowski, Michaela Lellig, Lucia Vankann, Jan Niklas Werner, Lu Chen, Susanne Ziegler, Christoph Kuppe, Martin Zenke, Rebekka K. Schneider, Sikander Hayat, Turgay Saritas, Rafael Kramann

Source: Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/3e88d27537d14315a94d3bfb522b83d2

Automated CRISPR/Cas9-based genome editing of human pluripotent stem cells using the StemCellFactory

Authors: Bastian Nießing, Yannik Breitkreuz, Andreas Elanzew, Marcelo A. S. de Toledo, Peter Vajs, Marina Nolden, Frederik Erkens, Paul Wanek, Si Wah Christina Au Yeung, Simone Haupt, Niels König, Michael Peitz, Robert H. Schmitt, Martin Zenke, Oliver Brüstle

Source: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Subject Terms: genome editing, CRISPR/Cas9, automation, StemCellFactory, induced pluripotent stem cells, iPS cells, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2024.1459273/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/b94f36ec1c0945b49157e1bf435b896d

Cellular aging is accelerated in the malignant clone of myeloproliferative neoplasms

Authors: Margherita Vieri, Vithurithra Tharmapalan, Milena Kalmer, Julian Baumeister, Miloš Nikolić, Matthis Schnitker, Martin Kirschner, Niclas Flosdorf, Marcelo A. S. de Toledo, Martin Zenke, Steffen Koschmieder, Tim H. Brümmendorf, Fabian Beier, Wolfgang Wagner

Source: Blood Cancer Journal, Vol 13, Iss 1, Pp 1-5 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/98f8abd43ae948e2878075a3b9c72d2e

Generation of a TMEM43 knockout human induced pluripotent stem cell line (HDZi003-A-1) using CRISPR/Cas9

Authors: Sandra Ratnavadivel, Joline Dammeier, Anna Gaertner, Marcelo A. Szymanski de Toledo, Martin Zenke, Jan Gummert, Torsten Bloch Rasmussen, Nora Klinke, Kai Jürgens, Heiko Meyer, Achim Paululat, Hendrik Milting

Source: Stem Cell Research, Vol 76, Iss , Pp 103354- (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506124000527; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/27366aabbbcd488c818d9ec778f6ef6a

RGT: a toolbox for the integrative analysis of high throughput regulatory genomics data

Authors: Zhijian Li, Chao-Chung Kuo, Fabio Ticconi, Mina Shaigan, Julia Gehrmann, Eduardo Gade Gusmao, Manuel Allhoff, Martin Manolov, Martin Zenke, Ivan G. Costa

Source: BMC Bioinformatics, Vol 24, Iss 1, Pp 1-12 (2023)

Subject Terms: Regulatory genomics, Motif analysis, Intersection algebra, Visualization, Footprinting, Differential peaks, Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2105

Access URL: https://doaj.org/article/ebd553fe4f374c11b81204a9c95da07a

The telomerase inhibitor imetelstat differentially targets JAK2V617F versus CALR mutant myeloproliferative neoplasm cells and inhibits JAK-STAT signaling

Authors: Kathrin Olschok, Bianca Altenburg, Marcelo A. S. de Toledo, Angela Maurer, Anne Abels, Fabian Beier, Deniz Gezer, Susanne Isfort, Katrin Paeschke, Tim H. Brümmendorf, Martin Zenke, Nicolas Chatain, Steffen Koschmieder

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: Myeloproliferative neoplasms (MPN), imetelstat (GRN163L), myelofibrosis (MF), induced pluripotent stem cells, telomere length (TL), JAK2V617F, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1277453/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/22f86771bc0443b6890a712facd8c199

P1365: HUMAN CD117 AS AN IMMUNOTHERAPEUTIC TARGET IN PRECLINICAL MODELS OF ADVANCED SYSTEMIC MASTOCYTOSIS

Authors: Anne Kaiser, Renier Myburgh, Laura Volta, Christian Pellegrino, Veronika Lysenko, Alexandre Theocharides, Tim H Brümmendorf, Marcelo A.S. de Toledo, Martin Zenke, Markus Manz

Source: HemaSphere, Vol 7, p e6858777 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000972348.68587.77; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/23607fc8a89a421ba2c5938ae055d03c

P1008: THE TELOMERASE INHIBITOR IMETELSTAT DIFFERENTIALLY TARGETS JAK2V617F- VERSUS CALR-MUTANT MYELOPROLIFERATIVE NEOPLASM CELLS AND INHIBITS JAK-STAT SIGNALING

Authors: Kathrin Olschok, Bianca Altenburg, Marcelo A.S. de Toledo, Angela Maurer, Anne Abels, Fabian Beier, Deniz Gezer, Susanne Isfort, Tim H Brümmendorf, Martin Zenke, Nicolas Chatain, Steffen Koschmieder

Source: HemaSphere, Vol 7, p e661233c (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000970936.66123.3c; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/1d8c94f874454194b3139eb4534987b7

Hematopoietic differentiation persists in human iPSCs defective in de novo DNA methylation

Authors: Olivia Cypris, Julia Franzen, Joana Frobel, Philipp Glück, Chao-Chung Kuo, Stephani Schmitz, Selina Nüchtern, Martin Zenke, Wolfgang Wagner

Source: BMC Biology, Vol 20, Iss 1, Pp 1-15 (2022)

Subject Terms: DNMT3A, Epigenetics, DNA methylation, CRISPR/Cas9, Induced pluripotent stem cells, Mesenchymal differentiation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/54d8d4109d4e496e91db066b769e99e1

PLA/Hydroxyapatite scaffolds exhibit in vitro immunological inertness and promote robust osteogenic differentiation of human mesenchymal stem cells without osteogenic stimuli

Authors: Marcela P. Bernardo, Bruna C. R. da Silva, Ahmed E. I. Hamouda, Marcelo A. S. de Toledo, Carmen Schalla, Stephan Rütten, Roman Goetzke, Luiz H. C. Mattoso, Martin Zenke, Antonio Sechi

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/24290fe61efd438ea41fb791ed562c73

A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

Authors: Huaming Xu, Zhijian Li, Chao-Chung Kuo, Katrin Götz, Thomas Look, Marcelo AS de Toledo, Kristin Seré, Ivan G Costa, Martin Zenke

Source: eLife, Vol 12 (2023)

Subject Terms: interferon regulatory factor 8, dendritic cell, enhancer, lncRNA, feedback loop, CRISPR, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/83342; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/139a4f2a2c874e089f7cdcffe49c8094

Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen

Authors: Zhijian Li, Christoph Kuppe, Susanne Ziegler, Mingbo Cheng, Nazanin Kabgani, Sylvia Menzel, Martin Zenke, Rafael Kramann, Ivan G. Costa

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f489d02ade954c108604ac36561468ad

The curious case of Merkel cell carcinoma: epigenetic youth and lack of pluripotency

Authors: Emil Chteinberg, Julia Vogt, Julia Kolarova, Felix Bormann, Joost van den Oord, Ernst Jan Speel, Véronique Winnepenninckx, Anna Kordelia Kurz, Martin Zenke, Reiner Siebert, Axel zur Hausen

Source: Epigenetics, Vol 15, Iss 12, Pp 1319-1324 (2020)

Subject Terms: horvath’s epigenetic clock, merkel cell carcinoma, merkel cell polyomavirus, pluritest, dna methylation age, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/2d32c18c53b94996b47ca34144baa1d1

Cell Cluster Sorting in Automated Differentiation of Patient-specific Induced Pluripotent Stem Cells Towards Blood Cells

Authors: Zhiyao Ma, Marcelo Augusto Szymanskide Toledo, Paul Wanek, Mohamed H. Elsafi Mabrouk, Francis Smet, Rock Pulak, Simon Pieske, Tobias Piotrowski, Werner Herfs, Christian Brecher, Robert H. Schmitt, Wolfgang Wagner, Martin Zenke

Source: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Subject Terms: cell cluster sorter, large particle flow cytometry, induced pluripotent stem cells, iPS cells, embryoid body, EB formation, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2022.755983/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/d3caee09401e46bba16e600fbbd455a7

CRISPR/Cas9-engineered human ES cells harboring heterozygous and homozygous c-KIT knockout

Authors: Marcelo A.S. de Toledo, Xuhuang Fu, Frederick Kluge, Katrin Götz, Susanne Schmitz, Paul Wanek, Herdit M. Schüler, Kristina Pannen, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Martin Zenke

Source: Stem Cell Research, Vol 60, Iss , Pp 102732- (2022)

Subject Terms: Embryonic stem cells, ES cells, c-KIT, CD117, Stem cell factor receptor, CRISPR, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506122000812; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/b4c89ee1dd1e4d999c46911c9926efdf

Enhancement of proliferation of human umbilical cord blood–derived CD34+ hematopoietic stem cells by a combination of hyper-interleukin-6 and small molecules

Authors: Yo Seph Park, Yukyeong Lee, Na Young Choi, Han Sung Hwang, Stefan Rose-John, Martin Zenke, Kinarm Ko

Source: Biochemistry and Biophysics Reports, Vol 29, Iss , Pp 101214- (2022)

Subject Terms: Hematopoietic stem cells, Umbilical cord blood, Proliferation, Hyper-interleukin-6, Small molecule, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580822000152; https://doaj.org/toc/2405-5808

Access URL: https://doaj.org/article/165a477adb6f4688b4908ad90210630b

Genetic barcoding reveals clonal dominance in iPSC-derived mesenchymal stromal cells

Authors: Jonathan Hollmann, Johanna Brecht, Roman Goetzke, Julia Franzen, Anton Selich, Marco Schmidt, Monika Eipel, Alina Ostrowska, Jan Hapala, Eduardo Fernandez-Rebollo, Gerhard Müller-Newen, Michael Rothe, Thomas Eggermann, Martin Zenke, Wolfgang Wagner

Source: Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Mesenchymal stromal cells, Induced pluripotent stem cells, Clonality, RGB marking, Genetic barcoding, Limiting dilution, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13287-020-01619-5; https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/df179f3bd39144b6b52fc3d37e4a90fc

Polyelectrolyte Coating of Ferumoxytol Differentially Impacts the Labeling of Inflammatory and Steady-State Dendritic Cell Subtypes

Authors: Nehar Celikkin, John E. Wong, Martin Zenke, Thomas Hieronymus

Source: Biomedicines, Vol 10, Iss 12, p 3137 (2022)

Subject Terms: nanoparticles, ferumoxytol, polyelectrolytes, dendritic cells, tracking, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/12/3137; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/6ce8955714ea4d79919eee6062a26beb

Glucocorticoid Effects on Tissue Residing Immune Cells in Giant Cell Arteritis: Importance of GM-CSF

Authors: Annette D. Wagner, Ulrike Wittkop, Jessica Thalmann, Tina Willmen, Vega Gödecke, Justyna Hodam, Simon Ronicke, Martin Zenke

Source: Frontiers in Medicine, Vol 8 (2021)

Subject Terms: glucocorticoids, dendritic cells, giant cell arteritis, GM-CSF, apoptosis, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.709404/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/4c26e13bab8445dab1d872fb75db2b05

CRISPR/Cas9 mediated CXCL4 knockout in human iPS cells of polycythemia vera patient with JAK2 V617F mutation

Authors: Janik Boehnke, Salim Atakhanov, Marcelo A.S. Toledo, Herdit M. Schüler, Stephanie Sontag, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Rafael Kramann, Martin Zenke

Source: Stem Cell Research, Vol 55, Iss , Pp 102490- (2021)

Subject Terms: Induced pluripotent stem cell, iPS cells, Hematopoiesis, CXCL4, PF4, JAK2 V617F, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506121003378; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/d5201e98c76548fb80312315e5bbd47d