Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase

Authors: Benoît Arragain, Tim Krischuns, Martin Pelosse, Petra Drncova, Martin Blackledge, Nadia Naffakh, Stephen Cusack

Source: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/eb9333d58028408b951a16e109240b80

Revisiting the interaction between complement lectin pathway protease MASP-2 and SARS-CoV-2 nucleoprotein

Authors: Isabelle Bally, Guillaume Drumont, Véronique Rossi, Serafima Guseva, Maiia Botova, Jean-Baptiste Reiser, Michel Thépaut, Sebastian Dergan Dylon, Chantal Dumestre-Pérard, Christine Gaboriaud, Franck Fieschi, Martin Blackledge, Pascal Poignard, Nicole M. Thielens

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: complement system, lectin pathway, MASP-2, SARS-CoV-2, nucleoprotein, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1419165/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/6c84d811d1f94cc8b1bf5e243ab8d1bb

Intrinsically disordered regions in TRPV2 mediate protein-protein interactions

Authors: Raghavendar R. Sanganna Gari, Grigory Tagiltsev, Ruth A. Pumroy, Yining Jiang, Martin Blackledge, Vera Y. Moiseenkova-Bell, Simon Scheuring

Source: Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/655f0833cbc247acaeeec62f91b825ba

Structural insights into p300 regulation and acetylation-dependent genome organisation

Authors: Ziad Ibrahim, Tao Wang, Olivier Destaing, Nicola Salvi, Naghmeh Hoghoughi, Clovis Chabert, Alexandra Rusu, Jinjun Gao, Leonardo Feletto, Nicolas Reynoird, Thomas Schalch, Yingming Zhao, Martin Blackledge, Saadi Khochbin, Daniel Panne

Source: Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/df90f651ff344307887b5104e3d007a2

Cysteine oxidation and disulfide formation in the ribosomal exit tunnel

Authors: Linda Schulte, Jiafei Mao, Julian Reitz, Sridhar Sreeramulu, Denis Kudlinzki, Victor-Valentin Hodirnau, Jakob Meier-Credo, Krishna Saxena, Florian Buhr, Julian D. Langer, Martin Blackledge, Achilleas S. Frangakis, Clemens Glaubitz, Harald Schwalbe

Source: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/51d8d9f03c4049bb9442760267f33527

Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A

Authors: Aldo R. Camacho-Zarco, Sissy Kalayil, Damien Maurin, Nicola Salvi, Elise Delaforge, Sigrid Milles, Malene Ringkjøbing Jensen, Darren J. Hart, Stephen Cusack, Martin Blackledge

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f3b9b8f89aab4c209ce56f87f7cfa567

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications

Authors: Nadide Altincekic, Sophie Marianne Korn, Nusrat Shahin Qureshi, Marie Dujardin, Martí Ninot-Pedrosa, Rupert Abele, Marie Jose Abi Saad, Caterina Alfano, Fabio C. L. Almeida, Islam Alshamleh, Gisele Cardoso de Amorim, Thomas K. Anderson, Cristiane D. Anobom, Chelsea Anorma, Jasleen Kaur Bains, Adriaan Bax, Martin Blackledge, Julius Blechar, Anja Böckmann, Louis Brigandat, Anna Bula, Matthias Bütikofer, Aldo R. Camacho-Zarco, Teresa Carlomagno, Icaro Putinhon Caruso, Betül Ceylan, Apirat Chaikuad, Feixia Chu, Laura Cole, Marquise G. Crosby, Vanessa de Jesus, Karthikeyan Dhamotharan, Isabella C. Felli, Jan Ferner, Yanick Fleischmann, Marie-Laure Fogeron, Nikolaos K. Fourkiotis, Christin Fuks, Boris Fürtig, Angelo Gallo, Santosh L. Gande, Juan Atilio Gerez, Dhiman Ghosh, Francisco Gomes-Neto, Oksana Gorbatyuk, Serafima Guseva, Carolin Hacker, Sabine Häfner, Bing Hao, Bruno Hargittay, K. Henzler-Wildman, Jeffrey C. Hoch, Katharina F. Hohmann, Marie T. Hutchison, Kristaps Jaudzems, Katarina Jović, Janina Kaderli, Gints Kalniņš, Iveta Kaņepe, Robert N. Kirchdoerfer, John Kirkpatrick, Stefan Knapp, Robin Krishnathas, Felicitas Kutz, Susanne zur Lage, Roderick Lambertz, Andras Lang, Douglas Laurents, Lauriane Lecoq, Verena Linhard, Frank Löhr, Anas Malki, Luiza Mamigonian Bessa, Rachel W. Martin, Tobias Matzel, Damien Maurin, Seth W. McNutt, Nathane Cunha Mebus-Antunes, Beat H. Meier, Nathalie Meiser, Miguel Mompeán, Elisa Monaca, Roland Montserret, Laura Mariño Perez, Celine Moser, Claudia Muhle-Goll, Thais Cristtina Neves-Martins, Xiamonin Ni, Brenna Norton-Baker, Roberta Pierattelli, Letizia Pontoriero, Yulia Pustovalova, Oliver Ohlenschläger, Julien Orts, Andrea T. Da Poian, Dennis J. Pyper, Christian Richter, Roland Riek, Chad M. Rienstra, Angus Robertson, Anderson S. Pinheiro, Raffaele Sabbatella, Nicola Salvi, Krishna Saxena, Linda Schulte, Marco Schiavina, Harald Schwalbe, Mara Silber, Marcius da Silva Almeida, Marc A. Sprague-Piercy, Georgios A. Spyroulias, Sridhar Sreeramulu, Jan-Niklas Tants, Kaspars Tārs, Felix Torres, Sabrina Töws, Miguel Á. Treviño, Sven Trucks, Aikaterini C. Tsika, Krisztina Varga, Ying Wang, Marco E. Weber, Julia E. Weigand, Christoph Wiedemann, Julia Wirmer-Bartoschek, Maria Alexandra Wirtz Martin, Johannes Zehnder, Martin Hengesbach, Andreas Schlundt

Source: Frontiers in Molecular Biosciences, Vol 8 (2021)

Subject Terms: COVID-19, SARS-CoV-2, nonstructural proteins, structural proteins, accessory proteins, intrinsically disordered region, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2021.653148/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/201170fa84b8450e9b468d9fb4480774

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity

Authors: Tanguy Le Marchand, Matteo de Rosa, Nicola Salvi, Benedetta Maria Sala, Loren B. Andreas, Emeline Barbet-Massin, Pietro Sormanni, Alberto Barbiroli, Riccardo Porcari, Cristiano Sousa Mota, Daniele de Sanctis, Martino Bolognesi, Lyndon Emsley, Vittorio Bellotti, Martin Blackledge, Carlo Camilloni, Guido Pintacuda, Stefano Ricagno

Source: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c01ab08a88114dd8bdfe140a87d7b465

Sendai Virus and a Unified Model of Mononegavirus RNA Synthesis

Authors: Daniel Kolakofsky, Philippe Le Mercier, Machiko Nishio, Martin Blackledge, Thibaut Crépin, Rob W. H. Ruigrok

Source: Viruses, Vol 13, Iss 12, p 2466 (2021)

Subject Terms: Sendai virus, mononegavirus, RNA synthesis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/12/2466; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/e9911b48bcbb46c2bd52252b485808af

Synergies of Single Molecule Fluorescence and NMR for the Study of Intrinsically Disordered Proteins

Authors: Samuel Naudi-Fabra, Martin Blackledge, Sigrid Milles

Source: Biomolecules, Vol 12, Iss 1, p 27 (2021)

Subject Terms: nuclear magnetic resonance (NMR), single molecule fluorescence, Förster resonance energy transfer (FRET), intrinsically disordered proteins (IDPs), Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/1/27; https://doaj.org/toc/2218-273X

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Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7

Authors: Danielle C. Desravines, Itziar Serna Martin, Robert Schneider, Philippe J. Mas, Nataliia Aleksandrova, Malene Ringkjøbing Jensen, Martin Blackledge, Darren J. Hart

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0b8d250e25a8437cb57a64f0045febb5

Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1)

Authors: Rasa Sukackaite, Daniela Cornacchia, Malene Ringkjøbing Jensen, Philippe J. Mas, Martin Blackledge, Elin Enervald, Guangyou Duan, Tania Auchynnikava, Maja Köhn, Darren J. Hart, Sara B. C. Buonomo

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9f35b459fd38478fae9ae9719311f2f5

An intrinsically disordered proteins community for ELIXIR [version 1; peer review: 2 approved]

Authors: Norman E. Davey, M. Madan Babu, Martin Blackledge, Alan Bridge, Salvador Capella-Gutierrez, Zsuzsanna Dosztanyi, Rachel Drysdale, Richard J. Edwards, Arne Elofsson, Isabella C. Felli, Toby J. Gibson, Aleksandras Gutmanas, John M. Hancock, Jen Harrow, Desmond Higgins, Cy M. Jeffries, Philippe Le Mercier, Balint Mészáros, Marco Necci, Cedric Notredame, Sandra Orchard, Christos A. Ouzounis, Rita Pancsa, Elena Papaleo, Roberta Pierattelli, Damiano Piovesan, Vasilis J. Promponas, Patrick Ruch, Gabriella Rustici, Pedro Romero, Sirarat Sarntivijai, Gary Saunders, Benjamin Schuler, Malvika Sharan, Denis C. Shields, Joel L. Sussman, Jonathan A. Tedds, Peter Tompa, Michael Turewicz, Jiri Vondrasek, Wim F. Vranken, Bonnie Ann Wallace, Kanin Wichapong, Silvio C. E. Tosatto

Source: F1000Research, Vol 8 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://f1000research.com/articles/8-1753/v1; https://doaj.org/toc/2046-1402

Access URL: https://doaj.org/article/394ab68cdf814790908372f98b29dde4

The Nucleoprotein and Phosphoprotein of Measles Virus

Authors: Serafima Guseva, Sigrid Milles, Martin Blackledge, Rob W. H. Ruigrok

Source: Frontiers in Microbiology, Vol 10 (2019)

Subject Terms: measles virus, nucleoprotein, phosphoprotein, Cryo-EM, NMR, X-ray crystallography, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2019.01832/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/736dc9e6c57c43979806c2dbfbcc16f6

Enthalpy–Entropy Compensation in the Promiscuous Interaction of an Intrinsically Disordered Protein with Homologous Protein Partners

Authors: Jaka Kragelj, Thibault Orand, Elise Delaforge, Laura Tengo, Martin Blackledge, Andrés Palencia, Malene Ringkjøbing Jensen

Source: Biomolecules, Vol 11, Iss 8, p 1204 (2021)

Subject Terms: NMR spectroscopy, isothermal titration calorimetry, intrinsically disordered protein (IDP), mitogen-activated protein kinase (MAPK), enthalpy–entropy compensation, folding-upon-binding, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/8/1204; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/3ab4ff216dac4200bd7a824cf22b4641

Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions

Authors: Elise Delaforge, Sigrid Milles, Jie-rong Huang, Denis Bouvier, Malene Ringkjøbing Jensen, Darren Hart, Michael Sattler, Martin Blackledge

Source: Frontiers in Molecular Biosciences, Vol 3 (2016)

Subject Terms: Nuclear Magnetic Resonance, protein, Conformational selection, Small-angle scattering, Chemical exchange saturation transfer (CEST), conformational dynamics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00054/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/9537d8253b004956ad2b6d6e21dfa9a2

Binding mechanisms of intrinsically disordered proteins: theory, simulation, and experiment

Authors: Luca Mollica, Luiza Mamigonian Bessa, Xavier Hanoulle, Malene Ringkjøbing Jensen, Martin Blackledge, Robert Schneider

Source: Frontiers in Molecular Biosciences, Vol 3 (2016)

Subject Terms: Kinetics, protein-protein interactions, nuclear magnetic resonance (NMR), intrinsically disordered proteins, molecular dynamics simulations, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00052/full; https://doaj.org/toc/2296-889X

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Structure and Functions of Microtubule Associated Proteins Tau and MAP2c: Similarities and Differences

Authors: Kateřina Melková, Vojtěch Zapletal, Subhash Narasimhan, Séverine Jansen, Jozef Hritz, Rostislav Škrabana, Markus Zweckstetter, Malene Ringkjøbing Jensen, Martin Blackledge, Lukáš Žídek

Source: Biomolecules, Vol 9, Iss 3, p 105 (2019)

Subject Terms: microtubule associated protein, tau, intrinsically disordered protein, phosphorylation, nuclear magnetic resonance, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.mdpi.com/2218-273X/9/3/105; https://doaj.org/toc/2218-273X

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Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications.

Authors: Jose L Ortega Roldan, Salvador Casares, Malene Ringkjøbing Jensen, Nayra Cárdenes, Jerónimo Bravo, Martin Blackledge, Ana I Azuaga, Nico A J van Nuland

Source: PLoS ONE, Vol 8, Iss 9, p e73018 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24039852/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f0dfce6381094a71b4f4d8cd64cd8eef

Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus.

Authors: Guillaume Communie, Johnny Habchi, Filip Yabukarski, David Blocquel, Robert Schneider, Nicolas Tarbouriech, Nicolas Papageorgiou, Rob W H Ruigrok, Marc Jamin, Malene Ringkjøbing Jensen, Sonia Longhi, Martin Blackledge

Source: PLoS Pathogens, Vol 9, Iss 9, p e1003631 (2013)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086133/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/f545aa83c6b2468d878c9bf9a27c5149