Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia

Authors: David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó

Source: Translational Psychiatry, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/700f4d0d32494281ba829a18ded9f05c

Effects of the PAM of mGluR2, JNJ-46356479, on brain apoptotic protein levels in a mouse model of schizophrenia

Authors: Olivares-Berjaga, David, Martínez-Pinteño, Albert, Rodríguez, Natalia, Madero, Santiago, Prohens, Llucía, Martínez-Serrano, Irene, Mas, Sergi, Morén, Constanza, Parellada, Eduard, Gassó, Patricia

Source: In Progress in Neuropsychopharmacology & Biological Psychiatry 20 April 2024 131

Polygenic risk scores mediating functioning outcomes through cognitive and clinical features in youth at family risk and controls

Authors: Segura, Alex G, Serna, Elena de la, Sugranyes, Gisela, Baeza, Inmaculada, Valli, Isabel, Martínez-Serrano, Irene, Díaz-Caneja, Covadonga M, Andreu-Bernabeu, Álvaro, Moreno, Dolores M, Gassó, Patricia, Rodríguez, Natalia, Martínez-Pinteño, Albert, Prohens, Llucia, Torrent, Carla, García-Rizo, Clemente, Mas, Sergi, Castro-Fornieles, Josefina

Source: In European Neuropsychopharmacology April 2024 81:28-37

Gene expression imputation provides clinical and biological insights into treatment-resistant schizophrenia polygenic risk

Authors: Prohens, Llucia, Rodríguez, Natalia, Segura, Àlex-Gonzàlez, Martínez-Pinteño, Albert, Olivares-Berjaga, David, Martínez, Irene, González, Aitor, Mezquida, Gisela, Parellada, Mara, Cuesta, Manuel J, Bernardo, Miquel, Gassó, Patricia, Mas, Sergi

Source: In Psychiatry Research February 2024 332

Early treatment with JNJ-46356479, a mGluR2 modulator, improves behavioral and neuropathological deficits in a postnatal ketamine mouse model of schizophrenia

Authors: Martínez-Pinteño, A., Rodríguez, N., Olivares, D., Madero, S., Gómez, M., Prohens, L., García-Rizo, C., Mas, S., Morén, C., Parellada, E., Gassó, P.

Source: In Biomedicine & Pharmacotherapy February 2023 158

Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation: A longitudinal study in a first episode psychosis cohort

Authors: Segura, Àlex G., Martínez-Pinteño, Albert, Gassó, Patricia, Rodríguez, Natalia, Bioque, Miquel, Cuesta, Manuel J., González-Peñas, Javier, García-Rizo, Clemente, Lobo, Antonio, González-Pinto, Ana, García-Alcón, Alicia, Roldán, Alexandra, Vieta, Eduard, Castro-Fornieles, Josefina, Mané, Anna, Saiz, Jeronimo, Bernardo, Miguel, Mas, Sergi

Source: Schizophrenia research. 244:101-110

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165931143.0x000001&indx=1&recIds=ETOCvdc_100165931143.0x000001

The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal study

Authors: Martínez-Pinteño, Albert, Mezquida, Gisela, Bioque, Miquel, López-Ilundain, Jose M, Andreu-Bernabeu, Álvaro, Zorrilla, Iñaki, Mané, Anna, Rodríguez-Jiménez, Roberto, Corripio, Iluminada, Sarró, Salvador, Ibáñez, Ángela, Usall, Judith, Rivero, Olga, Gassó, Patricia, Leza, Juan Carlos, Cuesta, Manuel J, Parellada, Mara, González-Pinto, Ana, Berrocoso, Esther, Mas, Sergi, Bernardo, Miguel

Source: European neuropsychopharmacology. 57:105-117

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159057561.0x000001&indx=1&recIds=ETOCvdc_100159057561.0x000001

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia.

Authors: Olivares-Berjaga, David, Martínez-Pinteño, Albert, Rodríguez, Natalia, Mas, Sergi, Morén, Constanza, Parellada, Eduard, Gassó, Patricia

Source: Translational Psychiatry; 1/14/2025, Vol. 15 Issue 1, p1-14, 14p

The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal study

Authors: Amoretti, S, Morén, C, Urbiola, E, González-Peñas, J, Roldán, A, Catalán, A, González-Ortega, I, Toll, A, Legido, T, Sanchez-Pastor, L, Dompablo, M, Pomarol-Clotet, E, R, Landín-Romero, Butjosa, A, Rubio, E, Lorente-OmeñacaR, Ribeiro, M, López-Torres, I, León-Quismondo, L, Nácher, J, Contretas, F, Lobo, A, Gutiérrez-Fraile, M, Sáiz, PA, Martínez-Pinteño, Albert, Mezquida, Gisela, Bioque, Miquel, López-Ilundain, Jose M, Andreu-Bernabeu, Álvaro, Zorrilla, Iñaki, Mané, Anna, Rodríguez-Jiménez, Roberto, Corripio, Iluminada, Sarró, Salvador, Ibáñez, Ángela, Usall, Judith, Rivero, Olga, Gassó, Patricia, Leza, Juan Carlos, Cuesta, Manuel J, Parellada, Mara, González-Pinto, Ana, Berrocoso, Esther, Mas, Sergi, Bernardo, Miguel

Source: In European Neuropsychopharmacology April 2022 57:105-117

Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients

Authors: Natalia Rodríguez, Patricia Gassó, Albert Martínez-Pinteño, Àlex-González Segura, Gisela Mezquida, Lucia Moreno-Izco, Javier González-Peñas, Iñaki Zorrilla, Marta Martin, Roberto Rodriguez-Jimenez, Iluminada Corripio, Salvador Sarró, Angela Ibáñez, Anna Butjosa, Fernando Contreras, Miquel Bioque, Manuel-Jesús Cuesta, Mara Parellada, Ana González-Pinto, Esther Berrocoso, Miquel Bernardo, Sergi Mas, EPS group

Source: npj Schizophrenia, Vol 8, Iss 1, Pp 1-9 (2022)

Subject Terms: Psychiatry, RC435-571

File Description: electronic resource

Relation: https://doaj.org/toc/2334-265X

Access URL: https://doaj.org/article/ff6cd5c9e1aa4f43abd0d34b246239df

Gene expression study in monocytes: evidence of inflammatory dysregulation in early-onset obsessive-compulsive disorder

Authors: Natalia Rodríguez, Luisa Lázaro, Ana E. Ortiz, Astrid Morer, Albert Martínez-Pinteño, Alex G. Segura, Patricia Gassó, Sergi Mas

Source: Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/404f3abd55e549919b103f4a0fc7d431

A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood

Authors: P. Gassó, N. Rodríguez, A. Martínez-Pinteño, G. Mezquida, M. Ribeiro, J. González-Peñas, I. Zorrilla, L. Martínez-Sadurni, R. Rodriguez-Jimenez, I. Corripio, S. Sarró, A. Ibáñez, J. Usall, A. Lobo, C. Moren, M. J. Cuesta, M. Parellada, A. González-Pinto, E. Berrocoso, M. Bernardo, S. Mas, EPs Group

Source: Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/65dbc294dc444064bdd2b3abc81d512e

Effects of uric acid on oxidative and nitrosative stress and other related parameters in SH-SY5Y human neuroblastoma cells.

Authors: Mármol, Frederic, Sanchez, Juan, Martínez-Pinteño, Albert

Source: In Prostaglandins, Leukotrienes and Essential Fatty Acids February 2021 165

The positive allosteric modulator of the mGlu2 receptor JNJ-46356479 partially improves neuropathological deficits and schizophrenia-like behaviors in a postnatal ketamine mice model

Authors: Martínez-Pinteño, Albert, García-Cerro, Susana, Mas, Sergi, Torres, Teresa, Boloc, Daniel, Rodríguez, Natalia, Lafuente, Amalia, Gassó, Patricia, Arnaiz, Joan Albert, Parellada, Eduard

Source: In Journal of Psychiatric Research July 2020 126:8-18

Altered frequencies of Th17 and Treg cells in children and adolescents with obsessive-compulsive disorder

Authors: Rodríguez, Natalia, Morer, Astrid, González-Navarro, E. Azucena, Serra-Pages, Carles, Boloc, Daniel, Torres, Teresa, Martinez-Pinteño, Albert, Mas, Sergi, Lafuente, Amalia, Gassó, Patricia, Lázaro, Luisa

Source: In Brain Behavior and Immunity October 2019 81:608-616

Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures.

Authors: Gassó, Patricia^1,2,3 (AUTHOR) pgasso@ub.edu, Martínez-Pinteño, Albert¹ (AUTHOR), Rodríguez, Natalia^1,2 (AUTHOR), Madero, Santiago^2,3,4 (AUTHOR), Gómez, Marta^2,3,4 (AUTHOR), Segura, Alex G.¹ (AUTHOR), García-Rizo, Clemente^2,3,4 (AUTHOR), Morén, Constanza^2,4,5 (AUTHOR), Mas, Sergi^1,2,3 (AUTHOR), Parellada, Eduard^2,3,4 (AUTHOR) pgasso@ub.edu

Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 3, p2054. 19p.

Subject Terms: *GLUTAMATE receptors, *HUMAN cell culture, *DOPAMINE receptors, *CLOZAPINE, *NEUROPROTECTIVE agents, *CELL death

The Effect of Clozapine and Novel Glutamate Modulator JNJ-46356479 on Nitrosative Stress in a Postnatal Murine Ketamine Model of Schizophrenia.

Authors: Treder, Nina¹ (AUTHOR), Martínez-Pinteño, Albert² (AUTHOR), Rodríguez, Natalia^2,3 (AUTHOR), Arbelo, Néstor⁴ (AUTHOR), Madero, Santiago^3,4,5 (AUTHOR), Gómez, Marta^3,5,6,7 (AUTHOR), García-Rizo, Clemente^4,5 (AUTHOR), Mas, Sergi^2,3,5 (AUTHOR), Gassó, Patricia^2,3,5 (AUTHOR) pgasso@ub.edu, Parellada, Eduard^3,4,5 (AUTHOR), Morén, Constanza^2,4,8 (AUTHOR) pgasso@ub.edu

Source: International Journal of Molecular Sciences. Jan2023, Vol. 24 Issue 2, p1022. 12p.

Subject Terms: *GLUTAMATE receptors, *KETAMINE, *CLOZAPINE, *PYRAMIDAL neurons, *GLUTAMIC acid, *METHYL aspartate receptors, *SCHIZOPHRENIA

Systematic Review of the Therapeutic Role of Apoptotic Inhibitors in Neurodegeneration and Their Potential Use in Schizophrenia

Authors: Constanza Morén, Nina Treder, Albert Martínez-Pinteño, Natàlia Rodríguez, Néstor Arbelo, Santiago Madero, Marta Gómez, Sergi Mas, Patricia Gassó, Eduard Parellada

Source: Antioxidants, Vol 11, Iss 11, p 2275 (2022)

Subject Terms: apoptosis, apoptotic inhibitors, schizophrenia, systematic review, therapy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/11/11/2275; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/3e9f690ab3c64f159799e4f8c0929a7f

Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene Expression Data

Authors: Albert Martínez-Pinteño, Patricia Gassó, Llucia Prohens, Alex G. Segura, Mara Parellada, Jerónimo Saiz-Ruiz, Manuel J. Cuesta, Miguel Bernardo, Amalia Lafuente, Sergi Mas, Natalia Rodríguez

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: antipsychotics, weight gain, metabolic syndrome, pharmacogenetics, EP300, gene, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.729474/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/05652b2e8938444fa91c73adb12bc746

Effect of glutamate modulator jnj-46356479 and clozapine on glutamate and gaba brain-levels in a postnatal ketamine mouse model of schizophrenia

Authors: Martínez-Pinteño, A., Rodríguez, N., Olivares-Berjaga, D., Madero, S., Prohens, L., Morén, C., García-RIzo, C., Arbelo, N., González-Segura, À., Martínez-Serrano, I., Mas, S., Parellada, E., Gassó, P.

Source: In Neuroscience Applied 2023 2 Supplement 2