Correlative light and X-ray tomography jointly unveil the critical role of connexin43 channels on inflammation-induced cellular ultrastructural alterations

Authors: Okolo, Chidinma Adanna ^{a, ⁎, 1}, Maran, Jack Jonathan ^b, Watts, Amy ^a, Maripillan, Jaime ^c, Harkiolaki, Maria ^a, Martínez, Agustín D. ^c, Green, Colin R. ^d, Mugisho, Odunayo Omolola ^b

Source: In Heliyon 15 April 2024 10(7)

MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity

Authors: Waissbluth, Sofia, Martínez, Agustín D., Figueroa-Cares, Cindel, Sánchez, Helmuth A., Maass, Juan C.

Source: Acta oto-laryngologica. 143(3):242-249

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178622053.0x000001&indx=1&recIds=ETOCvdc_100178622053.0x000001

A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII

Authors: López, Ximena, Palacios-Prado, Nicolás, Güiza, Juan, Escamilla, Rosalba, Fernández, Paola, Vega, José L., Rojas, Maximiliano, Marquez-Miranda, Valeria, Chamorro, Eduardo, Cárdenas, Ana M., Maldifassi, María Constanza, Martínez, Agustín D., Duarte, Yorley, González-Nilo, Fernando D., Sáez, Juan C.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Aug 01. 118(32), 1-10.

Access URL: https://www.jstor.org/stable/27052753

The interplay between α7 nicotinic acetylcholine receptors, pannexin‐1 channels and P2X7 receptors elicit exocytosis in chromaffin cells

Authors: Maldifassi, María C., Momboisse, Fanny, Guerra, María J., Vielma, Alex H., Maripillán, Jaime, Báez‐Matus, Ximena, Flores‐Muñoz, Carolina, Cádiz, Bárbara, Schmachtenberg, Oliver, Martínez, Agustín D., Cárdenas, Ana M.

Source: Journal of neurochemistry. 157(6):1789-1808

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123874675.0x000001&indx=1&recIds=ETOCvdc_100123874675.0x000001

β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation

Authors: Pinto, Cristina, Medinas, Danilo B., Fuentes-Villalobos, Francisco, Maripillán, Jaime, Castro, Ariel F., Martínez, Agustín D., Osses, Nelson, Hetz, Claudio, Henríquez, Juan P.

Source: In Neurobiology of Disease October 2019 130

Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells.

Authors: Maldifassi, María Constanza, Guerra‐Fernández, María José, Ponce, Daniela, Alfonso‐Bueno, Samuel, Maripillán, Jaime, Vielma, Alex H., Báez‐Matus, Ximena, Marengo, Fernando D., Acuña‐Castillo, Claudio, Sáez, Juan C., Martínez, Agustín D., Cárdenas, Ana M.

Source: British Journal of Pharmacology; Aug2024, Vol. 181 Issue 16, p2905-2922, 18p

Subject Terms: CHROMAFFIN cells, PURINERGIC receptors, SMALL interfering RNA, SECRETORY granules, ENDOCRINE cells, NICOTINIC agonists

Differential Regulation of Hemichannels and Gap Junction Channels by RhoA GTPase and Actin Cytoskeleton: A Comparative Analysis of Cx43 and Cx26.

Authors: Jara, Oscar, Maripillán, Jaime, Momboisse, Fanny, Cárdenas, Ana María, García, Isaac E., Martínez, Agustín D.

Source: International Journal of Molecular Sciences; Jul2024, Vol. 25 Issue 13, p7246, 22p

Subject Terms: CELL membrane formation, CYTOSKELETON, GUANOSINE triphosphatase, MEMBRANE proteins, BIOLOGICAL transport

Redox-mediated regulation of connexin proteins; focus on nitric oxide

Authors: García, Isaac E., Sánchez, Helmuth A., Martínez, Agustín D., Retamal, Mauricio A.

Source: In BBA - Biomembranes January 2018 1860(1):91-95

The Ca2+ channel subunit CaVβ2a‐subunit down‐regulates voltage‐activated ion current densities by disrupting actin‐dependent traffic in chromaffin cells

Authors: Guerra, María J., González‐Jamett, Arlek M., Báez‐Matus, Ximena, Navarro‐Quezada, Nieves, Martínez, Agustín D., Neely, Alan, Cárdenas, Ana M.

Source: Journal of neurochemistry. 151(6):703-715

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100095107948.0x000001&indx=1&recIds=ETOCvdc_100095107948.0x000001

Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket.

Authors: Villanelo, Felipe, Minogue, Peter J., Maripillán, Jaime, Reyna-Jeldes, Mauricio, Jensen-Flores, Joaquin, García, Isaac E., Beyer, Eric C., Pérez-Acle, Tomás, Berthoud, Viviana M., Martínez, Agustín D.

Source: Biological Research; 5/23/2024, Vol. 57 Issue 1, p1-18, 18p

The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels

Authors: García, Isaac E., Villanelo, Felipe, Contreras, Gustavo F., Pupo, Amaury, Pinto, Bernardo I., Contreras, Jorge E., Pérez-Acle, Tomás, Alvarez, Osvaldo, Latorre, Ramon, Martínez, Agustín D.

Source: Journal of general physiology. 150(5):697-712

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615832399&indx=1&recIds=ETOCRN615832399

Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins

Authors: Pinto, Bernardo I., García, Isaac E., Pupo, Amaury, Retamal, Mauricio A., Martínez, Agustín D., Latorre, Ramón, González, Carlos

Source: In Journal of Biological Chemistry 22 July 2016 291(30):15740-15752

From Hyperactive Connexin26 Hemichannels to Impairments in Epidermal Calcium Gradient and Permeability Barrier in the Keratitis-Ichthyosis-Deafness Syndrome

Authors: García, Isaac E., Bosen, Felicitas, Mujica, Paula, Pupo, Amaury, Flores-Muñoz, Carolina, Jara, Oscar, González, Carlos, Willecke, Klaus, Martínez, Agustín D.

Source: In Journal of Investigative Dermatology March 2016 136(3):574-583

Keratitis-Ichthyosis-Deafness Syndrome-Associated Cx26 Mutants Produce Nonfunctional Gap Junctions but Hyperactive Hemichannels When Co-Expressed With Wild Type Cx43

Authors: García, Isaac E., Maripillán, Jaime, Jara, Oscar, Ceriani, Ricardo, Palacios-Muñoz, Angelina, Ramachandran, Jayalakshmi, Olivero, Pablo, Perez-Acle, Tomas, González, Carlos, Sáez, Juan C., Contreras, Jorge E., Martínez, Agustín D. ^*

Source: In Journal of Investigative Dermatology May 2015 135(5):1338-1347

Characterization of a Novel Water Pocket Inside the Human Cx26 Hemichannel Structure

Authors: Araya-Secchi, Raul, Perez-Acle, Tomas, Kang, Seung-gu, Huynh, Tien, Bernardin, Alejandro, Escalona, Yerko, Garate, Jose-Antonio, Martínez, Agustin D., García, Isaac E., Sáez, Juan C., Zhou, Ruhong

Source: In Biophysical Journal 5 August 2014 107(3):599-612

Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules

Authors: Orellana, Juan A., Martinez, Agustín D., Retamal, Mauricio A.

Source: In Neuropharmacology December 2013 75:567-582

Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca2 +-dependent pathway

Authors: Figueroa, Vania, Sáez, Pablo J., Salas, José D., Salas, Daniela, Jara, Oscar, Martínez, Agustín D., Sáez, Juan C., Retamal, Mauricio A.

Source: In BBA - Biomembranes March 2013 1828(3):1169-1179

Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms.

Authors: Juan Güiza, Solís, Francisco, Valenzuela, Bernardita, Arancibia, Duxan, Zamorano, Pedro, González, Jorge, Saavedra, Jonathan, Neely, Alan, Salgado, Magdiel, Martínez, Agustín D., Sáez, Juan C., Vega, José L.

Source: Proceedings of the National Academy of Sciences of the United States of America; 8/1/2023, Vol. 120 Issue 31, p1-8, 14p

Subject Terms: UNICELLULAR organisms, TRANSMEMBRANE domains, SMALL molecules, PROTEIN subunits, TRYPANOSOMA cruzi

Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity.

Authors: García-Rojas, Francisca, Flores-Muñoz, Carolina, Santander, Odra, Solis, Pamela, Martínez, Agustín D., Ardiles, Álvaro O., Fuenzalida, Marco

Source: Biomolecules (2218-273X); Jun2023, Vol. 13 Issue 6, p887, 17p

Subject Terms: NEUROPLASTICITY, NEURAL transmission, CANNABINOID receptors, HEBBIAN memory, ION channels, PYRAMIDAL neurons, LONG-term potentiation, PEPTIDES

The Long-Term Pannexin 1 Ablation Produces Structural and Functional Modifications in Hippocampal Neurons.

Authors: Flores-Muñoz, Carolina, García-Rojas, Francisca, Pérez, Miguel A., Santander, Odra, Mery, Elena, Ordenes, Stefany, Illanes-González, Javiera, López-Espíndola, Daniela, González-Jamett, Arlek M., Fuenzalida, Marco, Martínez, Agustín D., Ardiles, Álvaro O.

Source: Cells (2073-4409); Nov2022, Vol. 11 Issue 22, p3646, 31p

Subject Terms: DENDRITIC spines, NEURONS, HIPPOCAMPUS (Brain), ALZHEIMER'S disease, RHO GTPases, NEUROPLASTICITY