A novel long non-coding RNA connects obesity to impaired adipocyte function

Authors: Lluch, Aina, Latorre, Jèssica, Oliveras-Cañellas, Núria, Fernández-Sánchez, Ana, Moreno-Navarrete, José M., Castells-Nobau, Anna, Comas, Ferran, Buxò, Maria, Rodríguez-Hermosa, José I., Ballester, María, Espadas, Isabel, Martín-Montalvo, Alejandro, Zhang, Birong, Zhou, You, Burkhardt, Ralph, Höring, Marcus, Liebisch, Gerhard, Castellanos-Rubio, Ainara, Santin, Izortze, Kar, Asha, Laakso, Markku, Pajukanta, Päivi, Olkkonen, Vesa M., Fernández-Real, José M., Ortega, Francisco J.

Source: In Molecular Metabolism December 2024 90

NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function

Authors: Martin Vázquez, Eugenia ¹, Cobo-Vuilleumier, Nadia ¹, Araujo Legido, Raquel ¹, Marín-Cañas, Sandra ², Nola, Emanuele ¹, Dorronsoro, Akaitz ¹, López Bermudo, Lucia ^{1, 3}, Crespo, Alejandra ¹, Romero-Zerbo, Silvana Y. ^{4, 5}, García-Fernández, Maria ⁵, Martin Montalvo, Alejandro ^{1, 3}, Rojas, Anabel ^{1, 3}, Comaills, Valentine ¹, Bérmudez-Silva, Francisco J. ^{3, 4}, Gannon, Maureen ⁶, Martin, Franz ^{1, 3}, Eizirik, Decio ², Lorenzo, Petra I. ¹, Gauthier, Benoit R. ^{1, 3, 7, ∗}

Source: In iScience 20 May 2022 25(5)

Intergenerational transmission of the positive effects of physical exercise on brain and cognition

Authors: McGreevy, Kerry R., Tezanos, Patricia, Ferreiro-Villar, Iria, Pallé, Anna, Moreno-Serrano, Marta, Esteve-Codina, Anna, Lamas-Toranzo, Ismael, Bermejo-Álvarez, Pablo, Fernández-Punzano, Julia, Martín-Montalvo, Alejandro, Montalbán, Raquel, Ferrón, Sacri R., Radford, Elizabeth J., Fontán-Lozano, Ángela, Trejo, José Luis

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 May . 116(20), 10103-10112.

Access URL: https://www.jstor.org/stable/26705255

Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status.

Authors: Espadas, Isabel, Cáliz‐Molina, María Ángeles, López‐Fernández‐Sobrino, Raúl, Panadero‐Morón, Concepción, Sola‐García, Alejandro, Soriano‐Navarro, Mario, Martínez‐Force, Enrique, Venegas‐Calerón, Mónica, Salas, Joaquin J., Martín, Franz, Gauthier, Benoit R., Alfaro‐Cervelló, Clara, Martí‐Aguado, David, Capilla‐González, Vivian, Martín‐Montalvo, Alejandro

Source: Aging Cell; Sep2024, Vol. 23 Issue 9, p1-16, 16p

Subject Terms: MUSCLE regeneration, MUSCULAR atrophy, WOUND healing, MUSCLE aging, MUSCLE strength

The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis

Authors: González-Mariscal, Isabel, Martin-Montalvo, Alejandro, Vazquez-Fonseca, Luis, Pomares-Viciana, Teresa, Sánchez-Cuesta, Ana, Fernández-Ayala, Daniel José, Navas, Placido, Santos-Ocana, Carlos

Source: In BBA - Bioenergetics November 2018 1859(11):1235-1248

The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity

Authors: Mellado-Gil, Jose, Fuente-Martín, Esther, Lorenzo, Petra, Cobo-Vuilleumier, Nadia, López-Noriega, Livia, Martín-Montalvo, Alejandro, Gómez, Irene, Ceballos-Chávez, Maria, Gómez-Jaramillo, Laura, Campos-Caro, Antonio, Romero-Zerbo, Silvana, Rodríguez-Comas, Júlia, Servitja, Joan-Marc, Rojo-Martinez, Gemma, Hmadcha, Abdelkrim, Soria, Bernat, Bugliani, Marco, Marchetti, Piero, Bérmudez-Silva, Francisco, Reyes, Jose, Aguilar-Diosdado, Manuel, Gauthier, Benoit

Source: Cell death and disease. 9(3):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112269787.0x000001&indx=1&recIds=ETOCvdc_100112269787.0x000001

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

Authors: Cobo-Vuilleumier, Nadia, Lorenzo, Petra, Rodríguez, Noelia, Herrera Gómez, Irene, Fuente-Martin, Esther, López-Noriega, Livia, Mellado-Gil, José, Romero-Zerbo, Silvana-Yanina, Baquié, Mathurin, Lachaud, Christian, Stifter, Katja, Perdomo, German, Bugliani, Marco, De Tata, Vincenzo, Bosco, Domenico, Parnaud, Geraldine, Pozo, David, Hmadcha, Abdelkrim, Florido, Javier, Toscano, Miguel, de Haan, Peter, Schoonjans, Kristina, Sánchez Palazón, Luis, Marchetti, Piero, Schirmbeck, Reinhold, Martín-Montalvo, Alejandro, Meda, Paolo, Soria, Bernat, Bermúdez-Silva, Francisco-Javier, St-Onge, Luc, Gauthier, Benoit

Source: Nature communications. 9(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132427491.0x000001&indx=1&recIds=ETOCvdc_100132427491.0x000001

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

Authors: Di Biase, Stefano, Lee, Changhan, Brandhorst, Sebastian, Manes, Brianna, Buono, Roberta, Cheng, Chia-Wei, Cacciottolo, Mafalda, Martin-Montalvo, Alejandro, de Cabo, Rafael, Wei, Min, Morgan, Todd E., Longo, Valter D.

Source: In Cancer Cell 11 July 2016 30(1):136-146

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Authors: Lee, Changhan, Zeng, Jennifer, Drew, Brian G., Sallam, Tamer, Martin-Montalvo, Alejandro, Wan, Junxiang, Kim, Su-Jeong, Mehta, Hemal, Hevener, Andrea L., de Cabo, Rafael, Cohen, Pinchas

Source: In Cell Metabolism 3 March 2015 21(3):443-454

Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism

Authors: Okun, Eitan, Griffioen, Kathleen J., Rothman, Sarah, Wan, Ruiqian, Cong, Wei-Na, De Cabo, Rafael, Martin-Montalvo, Alejandro, Levette, Andrew, Maudsley, Stuart, Martin, Bronwen, Arumugam, Thiruma Valavan, Mattson, Mark P.

Source: In Brain Behavior and Immunity February 2014 36:90-100

Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet

Authors: Jimenez-Gomez, Yolanda, Mattison, Julie A., Pearson, Kevin J., Martin-Montalvo, Alejandro, Palacios, Hector H., Sossong, Alex M., Ward, Theresa M., Younts, Caitlin M., Lewis, Kaitlyn, Allard, Joanne S., Longo, Dan L., Belman, Jonathan P., Malagon, Maria M., Navas, Placido, Sanghvi, Mitesh, Moaddel, Ruin, Tilmont, Edward M., Herbert, Richard L., Morrell, Christopher H., Egan, Josephine M., Baur, Joseph A., Ferrucci, Luigi, Bogan, Jonathan S., Bernier, Michel, de Cabo, Rafael

Source: In Cell Metabolism 1 October 2013 18(4):533-545

The Phosphatase Ptc7 Induces Coenzyme Q Biosynthesis by Activating the Hydroxylase Coq7 in Yeast

Authors: Martín-Montalvo, Alejandro, González-Mariscal, Isabel, Pomares-Viciana, Teresa, Padilla-López, Sergio, Ballesteros, Manuel, Vazquez-Fonseca, Luis, Gandolfo, Pablo, Brautigan, David L., Navas, Placido, Santos-Ocaña, Carlos

Source: In Journal of Biological Chemistry 27 September 2013 288(39):28126-28137

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

Authors: Price, Nathan L., Gomes, Ana P., Ling, Alvin J.Y., Duarte, Filipe V., Martin-Montalvo, Alejandro, North, Brian J., Agarwal, Beamon, Ye, Lan, Ramadori, Giorgio, Teodoro, Joao S., Hubbard, Basil P., Varela, Ana T., Davis, James G., Varamini, Behzad, Hafner, Angela, Moaddel, Ruin, Rolo, Anabela P., Coppari, Roberto, Palmeira, Carlos M., de Cabo, Rafael, Baur, Joseph A., Sinclair, David A.

Source: In Cell Metabolism 2 May 2012 15(5):675-690

H2S serves as the immunoregulatory essence of apoptotic cell death.

Authors: Hine, Christopher, Ponti, András K., Cáliz-Molina, María Ángeles, Martín-Montalvo, Alejandro

Source: Cell Metabolism; Jan2024, Vol. 36 Issue 1, p3-5, 3p

Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

Authors: Bernier, Michel, Paul, Rajib K., Martin-Montalvo, Alejandro, Scheibye-Knudsen, Morten, Song, Shaoming, He, Hua-Jun, Armour, Sean M. ^**, Hubbard, Basil P. ^**, Bohr, Vilhelm A., Wang, Lili, Zong, Yaping, Sinclair, David A. ^**, de Cabo, Rafael

Source: In Journal of Biological Chemistry 3 June 2011 286(22):19270-19279

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

Authors: Birkenfeld, Andreas L., Lee, Hui-Young, Guebre-Egziabher, Fitsum, Alves, Tiago C., Jurczak, Michael J., Jornayvaz, Francois R., Zhang, Dongyang, Hsiao, Jennifer J., Martin-Montalvo, Alejandro, Fischer-Rosinsky, Antje, Spranger, Joachim, Pfeiffer, Andreas F., Jordan, Jens, Fromm, Martin F., König, Jörg, Lieske, Stefanie, Carmean, Christopher M., Frederick, David W., Weismann, Dirk, Knauf, Felix, Irusta, Pablo M., De Cabo, Rafael, Helfand, Stephen L., Samuel, Varman T., Shulman, Gerald I.

Source: In Cell Metabolism 2011 14(2):184-195

Synthesis of C-glycoside analogues of β-galactosamine-(1→4)-3- O-methyl- d-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Cα

Authors: Hans, Sunej K., Camara, Fatoumata, Altiti, Ahmad, Martín-Montalvo, Alejandro, Brautigan, David L., Heimark, Douglas, Larner, Joseph, Grindrod, Scott, Brown, Milton L., Mootoo, David R.

Source: In Bioorganic & Medicinal Chemistry 2010 18(3):1103-1110

Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae

Authors: Padilla-López, Sergio, Jiménez-Hidalgo, María, Martín-Montalvo, Alejandro, Clarke, Catherine F., Navas, Plácido, Santos-Ocaña, Carlos ^⁎

Source: In BBA - Biomembranes June 2009 1788(6):1238-1248

Generation of mesenchymal stromal cells from urine-derived iPSCs of pediatric brain tumor patients.

Authors: Baliña-Sánchez, Carmen, Aguilera, Yolanda, Adán, Norma, María Sierra-Párraga, Jesús, Olmedo-Moreno, Laura, Panadero-Morón, Concepción, Cabello-Laureano, Rosa, Márquez-Vega, Catalina, Martín-Montalvo, Alejandro, Capilla-González, Vivian

Source: Frontiers in Immunology; 1/26/2023, Vol. 13, p1-13, 13p, 1 Chart, 7 Graphs

WITHDRAWN: Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression

Authors: Cabré, Noemí, Luciano-Mateo, Fedra, Chapski, Douglas J., Baiges-Gaya, Gerard, Fernández-Arroyo, Salvador, Hernández-Aguilera, Anna, Castañé, Helena, Rodríguez-Tomàs, Elisabet, París, Marta, Sabench, Fàtima, Del Castillo, Daniel, del Bas, Josep M., Tomé, Mercedes, Bodineau, Clément, Sola-García, Alejandro, López-Miranda, José, Martín-Montalvo, Alejandro, Durán, Raúl V., Vondriska, Thomas M., Rosa-Garrido, Manuel, Camps, Jordi, Menéndez, Javier A., Joven, Jorge

Source: In Journal of Hepatology