PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial

Authors: Mark N. Stein, Ecaterina E. Dumbrava, Benjamin A. Teply, Usama S. Gergis, Martin E. Guiterrez, Ran Reshef, Sumit K. Subudhi, Céline F. Jacquemont, Joseph H. Senesac, J. Henri Bayle, Charity D. Scripture, Monica S. Chatwal, Mehmet A. Bilen, Walter M. Stadler, Carlos R. Becerra

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8b8ab985e3b1423eb089db02792a2030

Emapalumab for severe cytokine release syndrome in solid tumor CAR-T: a case report

Authors: Tyler Ruemmele, Rodney Macedo, Mark N. Stein, Hei Ton Chan, Markus Y. Mapara, Céline F. Jacquemont, Ran Reshef

Source: Frontiers in Oncology, Vol 15 (2025)

Subject Terms: chimeric antigen receptor (CAR T), cytokine release syndrome (CRS), emapalumab, interferon gamma (IFNγ), prostate stem cell antigen (PSCA), immune effector cell associated HLH-like syndrome (IEC-HS), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2025.1543622/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/534bd40ffb48479ba9716cde3dc30332

Randomized Phase 2 Trial of Abiraterone Acetate Plus Prednisone, Degarelix, or the Combination in Men with Biochemically Recurrent Prostate Cancer After Radical Prostatectomy

Authors: Karen A. Autio, Emmanuel S. Antonarakis, Tina M. Mayer, Daniel H. Shevrin, Mark N. Stein, Ulka N. Vaishampayan, Michael J. Morris, Susan F. Slovin, Elisabeth I. Heath, Scott T. Tagawa, Dana E. Rathkopf, Matthew I. Milowsky, Michael R. Harrison, Tomasz M. Beer, Arjun V. Balar, Andrew J. Armstrong, Daniel J. George, Channing J. Paller, Arlyn Apollo, Daniel C. Danila, Julie N. Graff, Luke Nordquist, Erica S. Dayan Cohn, Kin Tse, Nicole A. Schreiber, Glenn Heller, Howard I. Scher

Source: European Urology Open Science, Vol 34, Iss , Pp 70-78 (2021)

Subject Terms: Abiraterone, Androgen deprivation therapy, Androgen, Biochemical recurrence, Degarelix, Prostate cancer, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666168321016967; https://doaj.org/toc/2666-1683

Access URL: https://doaj.org/article/7cb29db5a1d04ef391276d51f770d34a

Marginal improvement in survival among patients diagnosed with metastatic prostate cancer in the second‐line antiandrogen therapy era

Authors: Isaac E. Kim, Thomas L. Jang, Sinae Kim, David Y. Lee, Daniel D. Kim, Eric A. Singer, Saum Ghodoussipour, Mark N. Stein, Monish Aron, Marc A. Dall’Era, Isaac Yi Kim

Source: Cancer Medicine, Vol 10, Iss 22, Pp 7909-7920 (2021)

Subject Terms: metastatic prostate cancer, M1 prostate cancer, second‐line antiandrogens, survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/f0308822a4d1411cbcaa1149414a27a7

Individual and joint effects of metformin and statins on mortality among patients with high‐risk prostate cancer

Authors: Xiang‐Lin Tan, Jian‐Yu E, Yong Lin, Timothy R. Rebbeck, Shou‐En Lu, Mingyi Shang, William K. Kelly, Anthony D'Amico, Mark N. Stein, Lanjing Zhang, Thomas L. Jang, Isaac Yi Kim, Kitaw Demissie, Anna Ferrari, Grace Lu‐Yao

Source: Cancer Medicine, Vol 9, Iss 7, Pp 2379-2389 (2020)

Subject Terms: all‐cause mortality, high‐risk prostate cancer, metformin, population‐based cohort, prostate‐cancer mortality, statins, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/c2361380119f40b3a468055abbe17f57

Results of Phase 1 study on cytoreductive radical prostatectomy in men with newly diagnosed metastatic prostate cancer

Authors: Bertram E. Yuh, Young Suk Kwon, Brian M. Shinder, Eric A. Singer, Thomas L. Jang, Sinae Kim, Mark N. Stein, Tina Mayer, Anna Ferrari, Nara Lee, Rahul R. Parikh, Nora Ruel, Wun-Jae Kim, Shigeo Horie, Seok-Soo Byun, Thomas E. Ahlering, Isaac Yi Kim

Source: Prostate International, Vol 7, Iss 3, Pp 102-107 (2019)

Subject Terms: Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2287888218301065; https://doaj.org/toc/2287-8882

Access URL: https://doaj.org/article/178a41020a2640c9a65de832c1ae514c

Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration

Authors: Mark N. Stein, Jyoti Malhotra, Rohinton S. Tarapore, Usha Malhotra, Ann W. Silk, Nancy Chan, Lorna Rodriguez, Joseph Aisner, Robert D. Aiken, Tina Mayer, Bruce G. Haffty, Jenna H. Newman, Salvatore M. Aspromonte, Praveen K. Bommareddy, Ricardo Estupinian, Charles B. Chesson, Evita T. Sadimin, Shengguo Li, Daniel J. Medina, Tracie Saunders, Melissa Frankel, Aparna Kareddula, Sherrie Damare, Elayne Wesolowsky, Christian Gabel, Wafik S. El-Deiry, Varun V. Prabhu, Joshua E. Allen, Martin Stogniew, Wolfgang Oster, Joseph R. Bertino, Steven K. Libutti, Janice M. Mehnert, Andrew Zloza

Source: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)

Subject Terms: ONC201, Cancer, Solid tumors, Immunotherapy, Immuno-oncology, Dopamine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-019-0599-8; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/cc2e3e6b70b34104941a2588a1bfa557

Phase II Study of Ipilimumab in Men With Metastatic Prostate Cancer With an Incomplete Response to Androgen Deprivation Therapy

Authors: Julie N. Graff, Mark N. Stein, Rishi Surana, Luai Al Rabadi, Eric Liu, Lawrence Fong, Shawna Bailey, Emile Latour, Timothy A. Newby, Amy E. Moran, Tomasz M. Beer

Source: Frontiers in Oncology, Vol 10 (2020)

Subject Terms: prostate cancer, immunotherapy, CTLA-4, metastatic, checkpoint inhibitor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2020.01381/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/a0ffdd59fa0b4fb68cbe0074fba89eec

Impact of Phosphoproteomics in the Era of Precision Medicine for Prostate Cancer

Authors: Johnny R. Ramroop, Mark N. Stein, Justin M. Drake

Source: Frontiers in Oncology, Vol 8 (2018)

Subject Terms: clinical trials, kinases, kinase inhibitors, signaling pathways, phosphoproteomics, prostate cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fonc.2018.00028/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/2dd28c9ab7bc413cb3d33dc1000686df

Surgical Management of Advanced and Metastatic Renal Cell Carcinoma: A Multidisciplinary Approach

Authors: Brian M. Shinder, Kevin Rhee, Douglas Farrell, Nicholas J. Farber, Mark N. Stein, Thomas L. Jang, Eric A. Singer

Source: Frontiers in Oncology, Vol 7 (2017)

Subject Terms: renal cell carcinoma, targeted therapy, cytoreductive nephrectomy, cytoreductive partial nephrectomy, lymphadenectomy, neoadjuvant, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fonc.2017.00107/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/187838f69ce748f8bb95ee2132d451e8

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of prostate carcinoma

Authors: Daniel P. Petrylak, Lawrence Fong, Charles G. Drake, Mark N. Stein, Douglas G. McNeel, Ravi A. Madan, James L. Gulley, Neil H. Bander, Tomasz M. Beer, Stacey Harrelson, Philip W. Kantoff, William K. Oh, David J. Peace, Hank Porterfield, Oliver Sartor, Neal D. Shore, Susan F. Slovin, Johannes Vieweg

Source: Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/4/1/92.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/95b49601510e476591b41345b52e8b6d

665 Immunotherapeutic trial in men with biochemical recurrence after definitive local therapy for prostate cancer: A clinical trial in progress

Authors: Neal Shore, Robert Dreicer, Matthew Zibelman, Mark N Stein, Ralph J Hauke, Russell Pachynski, Bethan Jones, Jessica Hawley, Charlotte Davis, Katie Anderson, Antonella Vardeu, Margaret A Marshall, Vicky Wheeler, Sarah Sebastian, Kevin Kayvan Zarrabi, Brian Miles, Jennifer Bendall

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/e0e13c728f9a4c02b598c703342fa0f8

764 A phase 1, first-in-human (FIH), open-label, dose-finding and expansion study of XmAb808, a B7H3 x CD28 bispecific antibody, in combination with pembrolizumab in patients with advanced solid tumors

Authors: Benjamin Thompson, Li Yao, Yana G Najjar, Siwen Hu-Lieskovan, Raphael Clynes, Bartosz Chmielowski, Mark N Stein, Sarina A Piha-Paul, Patricia McGovern, Judy S Wang, Benjamin Garmezy, Manojkumar Bupathi, Jitendra Kanodia

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/4e505ba3340346a2a833640f1301e0f0

Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer

Authors: Mark N Stein, Neal Patel, Alexander Bershadskiy, Alisa Sokoloff, Eric A Singer

Source: Asian Journal of Andrology, Vol 16, Iss 3, Pp 387-400 (2014)

Subject Terms: androgen synthesis, castration-resistant prostate cancer, treatment, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=3;spage=387;epage=400;aulast=Stein; https://doaj.org/toc/1008-682X; https://doaj.org/toc/1745-7262

Access URL: https://doaj.org/article/a52f2be9f22949439f381b549de3511a

Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced colorectal carcinoma.

Authors: Bert H O'Neil, John M Wallmark, David Lorente, Elena Elez, Judith Raimbourg, Carlos Gomez-Roca, Samuel Ejadi, Sarina A Piha-Paul, Mark N Stein, Albiruni R Abdul Razak, Katia Dotti, Armando Santoro, Roger B Cohen, Marlena Gould, Sanatan Saraf, Karen Stein, Sae-Won Han

Source: PLoS ONE, Vol 12, Iss 12, p e0189848 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5746232?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c0847406128e44e7a361d970f9fd4df6

Identification of the DNA repair defects in a case of Dubowitz syndrome.

Authors: Jingyin Yue, Huimei Lu, Shijie Lan, Jingmei Liu, Mark N Stein, Bruce G Haffty, Zhiyuan Shen

Source: PLoS ONE, Vol 8, Iss 1, p e54389 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3556036?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/735c06fc3726449d8df2d2a0a9bac227