The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

Authors: Elizabeth L. Hardaker, Emilio Sanseviero, Ankur Karmokar, Devon Taylor, Marta Milo, Chrysis Michaloglou, Adina Hughes, Mimi Mai, Matthew King, Anisha Solanki, Lukasz Magiera, Ricardo Miragaia, Gozde Kar, Nathan Standifer, Michael Surace, Shaan Gill, Alison Peter, Sara Talbot, Sehmus Tohumeken, Henderson Fryer, Ali Mostafa, Kathy Mulgrew, Carolyn Lam, Scott Hoffmann, Daniel Sutton, Larissa Carnevalli, Fernando J. Calero-Nieto, Gemma N. Jones, Andrew J. Pierce, Zena Wilson, David Campbell, Lynet Nyoni, Carla P. Martins, Tamara Baker, Gilberto Serrano de Almeida, Zainab Ramlaoui, Abdel Bidar, Benjamin Phillips, Joseph Boland, Sonia Iyer, J. Carl Barrett, Arsene-Bienvenu Loembé, Serge Y. Fuchs, Umamaheswar Duvvuri, Pei-Jen Lou, Melonie A. Nance, Carlos Alberto Gomez Roca, Elaine Cadogan, Susan E. Critichlow, Steven Fawell, Mark Cobbold, Emma Dean, Viia Valge-Archer, Alan Lau, Dmitry I. Gabrilovich, Simon T. Barry

Source: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/189773f2417346dcbdf8b6281d57effa

Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer

Authors: Peter Zanvit, Dewald van Dyk, Christine Fazenbaker, Kelly McGlinchey, Weichuan Luo, Jessica M. Pezold, John Meekin, Chien-ying Chang, Rosa A. Carrasco, Shannon Breen, Crystal Sao-Fong Cheung, Ariel Endlich-Frazier, Benjamin Clark, Nina J. Chu, Alessio Vantellini, Philip L. Martin, Clare E. Hoover, Kenesha Riley, Steve M. Sweet, David Chain, Yeoun Jin Kim, Eric Tu, Nathalie Harder, Sandrina Phipps, Melissa Damschroder, Ryan N. Gilbreth, Mark Cobbold, Gordon Moody, Emily E. Bosco

Source: The Journal of Clinical Investigation, Vol 133, Iss 22 (2023)

Subject Terms: Oncology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/e772d4b790a848fcb94aa4259efad645

620 Multimodal real world data reveals immunogenomic drivers of acquired and primary resistance to immune checkpoint blockade

Authors: Ross Stewart, Mark Cobbold, Scott Hammond, Sajan Khosla, Roy Rabbie, Douglas C Palmer, Mohamed Reda Keddar, Sebastian Carrasco Pro, Kathleen Burke, Ana Stewart, Benjamin Sidders, Jonathan R Dry, Martin L Miller

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/eaffebbcc642413aa23369a36f3f84cf

235 Preclinical evaluation and anti-tumor activity of AZD6422, a CLDN18.2 targeting armored CAR-T for gastric, esophageal and pancreatic cancers

Authors: Mark Cobbold, Nicolas Giraldo, Gordon Moody, Allison Barrett, Jean-Martin Lapointe, Shannon Breen, Rosa Carrasco, Zachary Britton, Benjamin Clark, Maria AS Broggi, Bala NN Rao Attili, Amy Hatke, Christina Grigoriadou, Melissa Damschroder, Emily Bosco

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/50476fa3ecc7484c87ae588263230680

325 Armored STEAP2 CAR-T (AZD0754) alone and in combination with enzalutamide demonstrates anti-tumor activity across a range of STEAP2 expressing prostate cancer PDX models

Authors: Mark Cobbold, Gordon Moody, Kelly McGlinchey, Emily Bosco, Peter Zanvit, Christine Fazenbaker, Weichuan Luo, Jessica Pezold, Clare Hoover

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/e5e673da0a984d5aafd7bab7e39bcc6a

1169 AZD5863: a specific, potent, affinity-optimized claudin 18.2 and CD3 binding T cell-engager that elicits low cytokine release and is capable of bystander killing

Authors: Rakesh Kumar, Yun He, Simon Dovedi, Mark Cobbold, Kristen Pollizzi, Saso Cemerski, Scott Hammond, Marina Natoli, Yiping Rong, Jonathan Fitzgerald, Mary McFarlane, Kathy Mulgrew, Miguel Gaspar, Christopher Lloyd, Douglas C Palmer, Maria AS Broggi, Laure Castan, Sharif Rahmy, Cathryn Kelton, Martin Korade, Oisin Huhn, D Gareth Rees, Anna Sigurdardottir, Benjamin Ridgway, Kathryn Ball, Fred Arce Vargas, Natalia Ceaicovscaia, Gayle Pouliot, Philip Szekeres

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/b829a62d777f404facdf66726405782f

957 The ATR-inhibitor ceralasertib modulates the tumor microenvironment and improves the effect of anti-PDL1 by activating type I IFN pathway

Authors: Dmitry Gabrilovich, Simon Barry, Mark Cobbold, Sehmus Tohumeken, Kathy Mulgrew, Marta Milo, Emilio Sanseviero, Devon Taylor, Mimi Mai, Ali Mostafa, Serge Fuchs

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/cf813e0a4a104ae4b72e78732ed53681

501 AZD2796, a myeloid checkpoint inhibitor targeting LILRB2 that promotes pro-inflammatory responses by macrophages and enhances T cell anti-tumor activity

Authors: Simon Dovedi, Mark Cobbold, Georgina Bowyer, Kathy Mulgrew, Fernanda Arnaldez, Des C Jones, Lorraine Irving, Becki Dudley, Marcin Wolny, Seraina Blümli, Ellie Chatzopoulou, Alan Sandercock, Stacy Pryts

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/27c1e65ddcfa42aa9c4332c72d2c1022

877 Intermittent dosing of the ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib promotes antitumor immunity by remodelling the tumor immune microenvironment in pre-clinical models

Authors: Matthew King, Dmitry Gabrilovich, Simon Barry, Mark Cobbold, Viia Valge-Archer, Adina Hughes, Elizabeth Hardaker, Alison Peter, Anisha Solanki, Lukasz Magiera, Gozde Kar, Stephen Fawell, Ankur Karmokar, Marta Milo, Chrysiis Michaloglou, Ricardo Miragaia, Sara Talbot, Carolyn Lam, Daniel Sutton, Scott Hoffmann, Larissa Carnevalli, Zena Wilson, Alan Lau

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/4011e2f43eec424c8619525f52d29501

432 Pharmacological inhibition with anti-CD38 mAb protects NK-mediated off-the-shelf CAR T cells allorejection

Authors: Mark Cobbold, Attilio Bondanza, Gordon Moody, Gianluca Carlesso, Laura Vian, Jules Rhoo, James Steinhardt, Owanaemi Davies, Carl Simon

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/2230f1c9f1224bcca0c5c0c0c75dcb90

Tumor Infiltrating Lymphocytes Target HLA-I Phosphopeptides Derived From Cancer Signaling in Colorectal Cancer

Authors: Sarah A. Penny, Jennifer G. Abelin, Stacy A. Malaker, Paisley T. Myers, Abu Z. Saeed, Lora G. Steadman, Dina L. Bai, Stephen T. Ward, Jeffrey Shabanowitz, Donald F. Hunt, Mark Cobbold

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: Immunopeptidomics, HLA-I phosphopeptides, tumor antigens, TIL (tumor infiltrating lymphocytes), CRC (colorectal cancer), signaling pathway, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.723566/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c061e36b679342809afb621a520a51ca

Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma

Authors: Alexander Quaas, Lipika Goyal, Andrew X Zhu, Mark Cobbold, Dan G Duda, Rakesh K Jain, Kohei Shigeta, Aya Matsui, Hiroto Kikuchi, Sebastian Klein, Emilie Mamessier, Ivy X Chen, Shuichi Aoki, Shuji Kitahara, Koetsu Inoue, Ayako Shigeta, Tai Hato, Rakesh R Ramjiawan, Daniel Staiculescu, Dieter Zopf, Lukas Fiebig, Gabriela S Hobbs, Simona Dima, Irinel Popescu, Peigen Huang, Lance L Munn

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/2/e001435.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/3a16c10d09a0429d990a0dd5f6981ee3

MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma

Authors: Mark E Smolkin, Gina R Petroni, Kimberly A Chianese-bullock, Kelly T Smith, Geoffrey Weiss, Nico Buettner, Mark Cobbold, Jeffrey Shabanowitz, Nikole Varhegyi, Elizabeth Gaughan, Victor H Engelhard, Rebecca C Obeng, Kara L Cummings, Angela L Ambakhutwala, Amanda Lulu, Paisley Myers, Keira E Mahoney, Emily H Hall, Kathleen Haden, Donald F Hunt, Craig L Slingluff, Jr

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/1/e000262.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/2f1ba13970c949eeb55d8d1382a456e4

Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.

Authors: Mariam Jamal-Hanjani, Alan Hackshaw, Yenting Ngai, Jacqueline Shaw, Caroline Dive, Sergio Quezada, Gary Middleton, Elza de Bruin, John Le Quesne, Seema Shafi, Mary Falzon, Stuart Horswell, Fiona Blackhall, Iftekhar Khan, Sam Janes, Marianne Nicolson, David Lawrence, Martin Forster, Dean Fennell, Siow-Ming Lee, Jason Lester, Keith Kerr, Salli Muller, Natasha Iles, Sean Smith, Nirupa Murugaesu, Richard Mitter, Max Salm, Aengus Stuart, Nik Matthews, Haydn Adams, Tanya Ahmad, Richard Attanoos, Jonathan Bennett, Nicolai Juul Birkbak, Richard Booton, Ged Brady, Keith Buchan, Arrigo Capitano, Mahendran Chetty, Mark Cobbold, Philip Crosbie, Helen Davies, Alan Denison, Madhav Djearman, Jacki Goldman, Tom Haswell, Leena Joseph, Malgorzata Kornaszewska, Matthew Krebs, Gerald Langman, Mairead MacKenzie, Joy Millar, Bruno Morgan, Babu Naidu, Daisuke Nonaka, Karl Peggs, Catrin Pritchard, Hardy Remmen, Andrew Rowan, Rajesh Shah, Elaine Smith, Yvonne Summers, Magali Taylor, Selvaraju Veeriah, David Waller, Ben Wilcox, Maggie Wilcox, Ian Woolhouse, Nicholas McGranahan, Charles Swanton

Source: PLoS Biology, Vol 12, Iss 7, p e1001906 (2014)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25003521/pdf/?tool=EBI; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/8c969701acb64396b9868a4b3806e9e1

Metabolomic perfusate analysis during kidney machine perfusion: the pig provides an appropriate model for human studies.

Authors: Jay Nath, Alison Guy, Thomas B Smith, Mark Cobbold, Nicholas G Inston, James Hodson, Daniel A Tennant, Christian Ludwig, Andrew R Ready

Source: PLoS ONE, Vol 9, Iss 12, p e114818 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4264773?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/037b6c9358b34a1d8617dc16e178c410