The Effect of Spironolactone in Patients With Obesity at Risk for Heart Failure: Proteomic Insights from the HOMAGE Trial

Authors: Verdonschot, Job A.J., Ferreira, JoÃo Pedro, Pizard, Anne, Pellicori, Pierpaolo, Brunner La Rocca, Hans-Peter, Clark, Andrew L., Cosmi, Franco, Cuthbert, Joe, Girerd, Nicolas, Waring, Olivia J., Henkens, Michiel H.T.M., Mariottoni, Beatrice, Petutschnigg, Johannes, Rossignol, Patrick, Hazebroek, Mark R., Cleland, John G.F., Zannad, Faiez, Heymans, Stephane R.B.

Source: In Journal of Cardiac Failure May 2022 28(5):778-786

Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF

Authors: Ferreira, João Pedro, Verdonschot, Job, Wang, Ping, Pizard, Anne, Collier, Timothy, Ahmed, Fozia Z., Brunner-La-Rocca, Hans-Peter, Clark, Andrew L., Cosmi, Franco, Cuthbert, Joe, Díez, Javier, Edelmann, Frank, Girerd, Nicolas, González, Arantxa, Grojean, Stéphanie, Hazebroek, Mark, Khan, Javed, Latini, Roberto, Mamas, Mamas A., Mariottoni, Beatrice, Mujaj, Blerim, Pellicori, Pierpaolo, Petutschnigg, Johannes, Pieske, Burkert, Rossignol, Patrick, Rouet, Philippe, Staessen, Jan A., Cleland, John G.F., Heymans, Stephane, Zannad, Faiez

Source: In JACC: Heart Failure April 2021 9(4):268-277

Heart rate reactivity, recovery, and endurance of the incremental shuttle walk test in patients prone to heart failure.

Authors: Wei, Fang‐Fei, Mariottoni, Beatrice, An, De‐Wei, Pellicori, Pierpaolo, Yu, Yu‐Ling, Verdonschot, Job A. J., Liu, Chen, Ahmed, Fozia Z., Petutschnigg, Johannes, Rossignol, Patrick, Heymans, Stephane, Cuthbert, Joe, Girerd, Nicolas, Li, Yan, Clark, Andrew L., Nawrot, Tim S., Ferreira, João Pedro, Zannad, Faiez, Cleland, John G. F., Staessen, Jan A.

Source: ESC Heart Failure; Dec2024, Vol. 11 Issue 6, p4116-4126, 11p

Subject Terms: HEART failure patients, CORONARY disease, MINERALOCORTICOID receptors, VENTRICULAR ejection fraction, AEROBIC capacity

Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial.

Authors: Wei, Fang-Fei, Pellicori, Pierpaolo, Ferreira, João Pedro, González, Arantxa, Mariottoni, Beatrice, An, De-Wei, Verdonschot, Job A. J., Liu, Chen, Ahmed, Fozia Z., Petutschnigg, Johannes, Rossignol, Patrick, Heymans, Stephane, Cuthbert, Joe, Girerd, Nicolas, Clark, Andrew L., Li, Yan, Nawrot, Tim S., Díez, Javier, Zannad, Faiez, Cleland, John G. F.

Source: Hypertension Research; Nov2024, Vol. 47 Issue 11, p3225-3236, 12p

Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial.

Authors: Yu-Ling Yu, Siwy, Justyna, De-Wei An, González, Arantxa, Hansen, Tine, Latosinska, Agnieszka, Pellicori, Pierpaolo, Ravassa, Susana, Mariottoni, Beatrice, Verdonschot, Job A. J., Ahmed, Fozia, Petutschnigg, Johannes, Rossignol, Patrick, Heymans, Stephane, Cuthbert, Joe J., Girerd, Nicolas, Clark, Andrew L., Verhamme, Peter, Nawrot, Tim S., Janssens, Stefan

Source: Heart; Oct2024, Vol. 110 Issue 19, p1180-1187, 8p

Subject Terms: HEART failure, MOLECULAR biology, PROTEOMICS, MEDICAL sciences, MINERALOCORTICOID receptors, PEPTIDES, ALDOSTERONE antagonists, SODIUM-glucose cotransporters

Spironolactone effect on circulating procollagen type I carboxy-terminal propeptide: Pooled analysis of three randomized trials

Authors: Ferreira, João Pedro, Cleland, John G., Girerd, Nicolas, Rossignol, Patrick, Pellicori, Pierpaolo, Cosmi, Franco, Mariottoni, Beatrice, González, Arantxa, Diez, Javier, Solomon, Scott D., Claggett, Brian, Pfeffer, Marc A., Pitt, Bertram, Petutschnigg, Johannes, Pieske, Burkert, Edelmann, Frank, Zannad, Faiez

Source: In International Journal of Cardiology 15 April 2023 377:86-88

Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial.

Authors: Santos‐Ferreira, Diogo, Diaz, Sílvia O., Ferreira, João Pedro, Girerd, Nicolas, Pellicori, Pierpaolo, Mariottoni, Beatrice, Cosmi, Franco, Hazebroek, Mark, Verdonschot, Job A.J., Cuthbert, Joe, Petutschnigg, Johannes, Heymans, Stephane, Staessen, Jan A., Pieske, Burkert, Edelmann, Frank, Clark, Andrew L., Rossignol, Patrick, Fontes‐Carvalho, Ricardo, Cleland, John G.F., Zannad, Faiez

Source: ESC Heart Failure; Feb2024, Vol. 11 Issue 1, p209-218, 10p

Subject Terms: CARDIAC patients, HEART failure, PULMONARY surfactant-associated protein D, FAILURE analysis, PLASMINOGEN activator inhibitors, ALDOSTERONE antagonists

Spironolactone effect on cardiac structure and function of patients with heart failure and preserved ejection fraction: a pooled analysis of three randomized trials.

Authors: Ferreira, João Pedro, Cleland, John G., Girerd, Nicolas, Bozec, Erwan, Rossignol, Patrick, Pellicori, Pierpaolo, Cosmi, Franco, Mariottoni, Beatrice, Solomon, Scott D., Pitt, Bertram, Pfeffer, Marc A., Shah, Amil M., Petutschnigg, Johannes, Pieske, Burkert, Edelmann, Frank, Zannad, Faiez

Source: European Journal of Heart Failure; Jan2023, Vol. 25 Issue 1, p108-113, 6p, 1 Chart, 1 Graph

Subject Terms: HEART failure patients, VENTRICULAR ejection fraction, SPIRONOLACTONE, LEFT heart atrium, ANALYSIS of covariance

Dyskalemia in people at increased risk for heart failure: findings from the heart 'OMics' in AGEing (HOMAGE) trial.

Authors: Monzo, Luca, Ferreira, João Pedro, Cleland, John G.F., Pellicori, Pierpaolo, Mariottoni, Beatrice, Verdonschot, Job A.J., Hazebroek, Mark R., Collier, Tim J., Cuthbert, Joe J., Pieske, Burkert, Edelmann, Frank, Petutschnigg, Johannes, Khan, Javed, Ahmed, Fozia Z., Girerd, Nicolas, Bozec, Erwan, Díez, Javier, González, Arantxa, Clark, Andrew L., Cosmi, Franco

Source: ESC Heart Failure; Dec2022, Vol. 9 Issue 6, p4352-4357, 6p

Subject Terms: HEART failure, NATRIURETIC peptides, GLOMERULAR filtration rate, AT-risk people, BLOOD pressure

The association between markers of type I collagen synthesis and echocardiographic response to spironolactone in patients at risk of heart failure: findings from the HOMAGE trial.

Authors: Kobayashi, Masatake, Girerd, Nicolas, Ferreira, João Pedro, Kevin, Duarte, Huttin, Olivier, González, Arantxa, Bozec, Erwan, Clark, Andrew L., Cosmi, Franco, Cuthbert, Joe, Diez, Javier, Edelmann, Frank, Hazebroek, Mark, Heymans, Stephane, Mariottoni, Beatrice, Pellicori, Pierpaolo, Petutschnigg, Johannes, Pieske, Burkert, Staessen, Jan A., Verdonschot, Job A.J.

Source: European Journal of Heart Failure; Sep2022, Vol. 24 Issue 9, p1559-1568, 10p, 1 Color Photograph, 5 Charts

Influence of ejection fraction on biomarker expression and response to spironolactone in people at risk of heart failure: findings from the HOMAGE trial.

Authors: Ferreira, João Pedro, Verdonschot, Job A.J., Girerd, Nicolas, Bozec, Erwan, Pellicori, Pierpaolo, Collier, Timothy, Mariottoni, Beatrice, Cosmi, Franco, Hazebroek, Mark, Cuthbert, Joe, Petutschnigg, Johannes, Heymans, Stephane, Staessen, Jan A., Pieske, Burkert, Edelman, Frank, Clark, Andrew L., Díez, Javier, González, Arantxa, Rossignol, Patrick, Cleland, John G.

Source: European Journal of Heart Failure; May2022, Vol. 24 Issue 5, p771-778, 8p, 1 Diagram, 4 Charts, 1 Graph

Biomarker-based assessment of collagen cross-linking identifies patients at risk of heart failure more likely to benefit from spironolactone effects on left atrial remodelling. Insights from the HOMAGE clinical trial.

Authors: Ravassa, Susana, López, Begoña, Ferreira, João Pedro, Girerd, Nicolas, Bozec, Erwan, Pellicori, Pierpaolo, Mariottoni, Beatrice, Cosmi, Franco, Hazebroek, Mark, Verdonschot, Job A. J., Cuthbert, Joe, Petutschnigg, Johannes, Moreno, María U., Heymans, Stephane, Staessen, Jan A., Pieske, Burkert, Edelmann, Frank, Clark, Andrew L., Cleland, John G. F., Zannad, Faiez

Source: European Journal of Heart Failure. Supplements; Feb2022, Vol. 24 Issue 2, p321-331, 11p

Subject Terms: HEART failure risk factors, COLLAGEN, BIOMARKERS, SPIRONOLACTONE, ECHOCARDIOGRAPHY, CONFIDENCE intervals, RANDOMIZED controlled trials, RESEARCH funding, STATISTICAL sampling, NATRIURETIC peptides, LEFT heart atrium

Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial.

Authors: Verdonschot, Job A. J., Ferreira, João Pedro, Pellicori, Pierpaolo, Brunner-La Rocca, Hans-Peter, Clark, Andrew L., Cosmi, Franco, Cuthbert, Joe, Girerd, Nicolas, Mariottoni, Beatrice, Petutschnigg, Johannes, Rossignol, Patrick, Cleland, John G. F., Zannad, Faiez, Heymans, Stephane R. B.

Source: Cardiovascular Diabetology; 8/9/2021, Vol. 20 Issue 1, p1-10, 10p

Subject Terms: HEART failure, PEOPLE with diabetes, PROTEOMICS, BLOOD proteins, ECHOCARDIOGRAPHY

The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial.

Authors: Cleland, John G F, Ferreira, João Pedro, Mariottoni, Beatrice, Pellicori, Pierpaolo, Cuthbert, Joe, Verdonschot, Job A J, Petutschnigg, Johannes, Ahmed, Fozia Z, Cosmi, Franco, Rocca, Hans-Peter Brunner La, Mamas, Mamas A, Clark, Andrew L, Edelmann, Frank, Pieske, Burkert, Khan, Javed, McDonald, Ken, Rouet, Philippe, Staessen, Jan A, Mujaj, Blerim, González, Arantxa

Source: European Heart Journal; 2/7/2021, Vol. 42 Issue 6, p684-696, 13p

Subject Terms: SPIRONOLACTONE, HEART failure, DISEASE risk factors, CLINICAL trials, N-terminal residues, C-terminal residues

Effects of spironolactone on serum markers of fibrosis in people at high risk of developing heart failure: rationale, design and baseline characteristics of a proof‐of‐concept, randomised, precision‐medicine, prevention trial. The Heart OMics in AGing (HOMAGE) trial

Authors: Pellicori, Pierpaolo, Ferreira, João Pedro, Mariottoni, Beatrice, Brunner‐La Rocca, Hans‐Peter, Ahmed, Fozia Z., Verdonschot, Job, Collier, Tim, Cuthbert, Joe J., Petutschnigg, Johannes, Mujaj, Blerim, Girerd, Nicolas, González, Arantxa, Clark, Andrew L., Cosmi, Franco, Staessen, Jan A., Heymans, Stephane, Latini, Roberto, Rossignol, Patrick, Zannad, Faiez, Cleland, John G.F.

Source: European Journal of Heart Failure; Sep2020, Vol. 22 Issue 9, p1711-1723, 13p, 7 Charts, 1 Graph

Subject Terms: ALDOSTERONE antagonists, BRAIN natriuretic factor, BIOMARKERS, HEART failure, LEFT heart atrium, CLINICAL trial registries, TYPE 2 diabetes

Stable atypical chest pain with negative anatomical or functional diagnostic test: Diagnosis no matter what or prevention at any cost?

Authors: Cosmi, Deborah, Mariottoni, Beatrice, Cosmi, Franco

Source: Clinical Cardiology; Oct2019, Vol. 42 Issue 10, p982-987, 6p

The shared decision-making process in stable angina From ARCA Registry to ORBITA 1 and 2, through ISCHEMIA and ISCHEMIA Extended.

Alternate Title: Il processo decisionale condiviso nell'angina stabile Dallo studio ARCA Registry, ad ISCHEMIA e ISCHEMIA Extended fino ad ORBITA 1 e 2. (Italian)

Authors: Cosmi, Franco, Mariottoni, Beatrice, Tarquini, Barbara, Cosmi, Deborah

Source: Outpatient Cardiology / Cardiologia Ambulatorial; dic2023, Vol. 31 Issue 4, p1-1, 1p

Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study.

Authors: Girerd, Nicolas, Levy, Daniel, Duarte, Kevin, Ferreira, Joao Pedro, Ballantyne, Christie, Collier, Timothy, Pizard, Anne, Björkman, Jens, Butler, Javed, Clark, Andrew, Cleland, John G., Delles, Christian, Diez, Javier, González, Arantxa, Hazebroek, Mark, Ho, Jennifer, Huby, Anne-Cécile, Hwang, Shih-Jen, Latini, Roberto, Mariottoni, Beatrice

Source: Circulation: Heart Failure; May2023, Vol. 16 Issue 5, pe009694-e009694, 1p

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